Clinical trials: Radiation Injury
Radiodermatitis
Photobiomodulation for Prevention of Radiodermatitis in Women With Breast Cancer Undergoing Adjuvant Radiotherapy
This is a Randomized Controlled Clinical Trial Women with breast cancer who are indicated for treatment with adjuvant radiotherapy will be eligible.
- Trial name
- NCT05535452
- Testing
- Photobiomodulation through LED board
- Volunteers
- 148 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Head and Neck Cancer, Oral Complications
Sargramostim to Prevent Mucositis in Patients Receiving Radiation Therapy for Laryngeal Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs such as sargramostim may protect normal cells from the side effects of radiation therapy.
- Conditions
- Head and Neck Cancer, Oral Complications, Radiation Toxicity
- Trial name
- NCT00004256
- Testing
- sargramostim, quality-of-life assessment, radiation therapy
- Where
- United Kingdom
- Sponsor
- Royal Marsden NHS Foundation Trust
Radiation Injuries, Telangiectasis
Trial of Endoscopy Bipolar and Argon of Chronic Rectal Bleeding From Radiation Telangiectasias
Aim: To compare the efficacy, safety and number of sessions of bipolar eletrocoagulation (BEC) and argon plasma coagulation (APC) in the management of the bleeding telangiectasias from chronic radiation coloproctopathy (CRCP).
- Trial name
- NCT00725244
- Testing
- Bipolar eletrocoagulation, Argon Plasma Coagulation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of São Paulo
Myocardial Infarction (MI), Radiation Toxicity
A MAajor RAdiation-based PCI Study in STEMI and NSTEMI
In France and Italy, approximately 240,000 percutaneous coronary angioplasties (PCI) are performed annually, with an increasing number of complex procedures, including those involving the left coronary common trunk, a…
- Conditions
- Myocardial Infarction (MI), Radiation Toxicity, Coronary Stenosis, Coronary Thrombosis
- Trial name
- MARAA (NCT06565793)
- Testing
- Non Complex PCI, Complex PCI
- Where
- France
- Volunteers
- 15,630 people
- Sponsor
- Centre Cardiologique du Nord
Cystitis, Radio Induced, Soft Tissue Radionecrosis (STRN)
Soft Tissue Radiation Injury; Patient Reported Evaluation in a Single Centre Cohort Study (STRIPE)
Radiotherapy cures many cancers but can cause late radiation-induced tissue injury (LRTI), leading to long-term symptoms from the bladder and bowel and reduced health-related quality of life (HRQoL).
- Conditions
- Cystitis, Radio Induced, Soft Tissue Radionecrosis (STRN), Radiation Proctitis
- Trial name
- karolinskaUH (NCT07611864)
- Where
- Sweden
- Volunteers
- 1,000 people
- Sponsor
- Karolinska University Hospital
Adverse Reaction, Cardiotoxicity
Risk Analysis of Cardiotoxic Medication Use Due to Sodium Arsenite Chloride Injection
To study the current status of cardiotoxicity of arsenious acid by analyzing the literature, monitoring data, and real-world applications, and to discuss risk factors and preventive and control measures.
- Conditions
- Adverse Reaction, Cardiotoxicity, Evaluation Study
- Trial name
- NCT06060132
- Testing
- Sodium arsenite chloride injection
- Where
- 2 sites in China
- Volunteers
- 400 people
- Sponsor
- Qianfoshan Hospital
Breast Cancer, Radiodermatitis
Photobiomodulation for Breast Cancer Radiodermatitis
A prospective single blind controlled randomized trial to evaluate the superiority of photobiomodulation (PBM) using LED-therapy in reducing the prevalence of radiodermatitis in breast cancer compared to usual local care.
- Conditions
- Breast Cancer, Radiodermatitis, Radiotherapy Side Effect, Radiation Dermatitis
- Trial name
- NCT04059809
- Testing
- Photobiomodulation
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- AC Camargo Cancer Center
Pneumothorax, Pleural Effusion
Multicenter Validation Study of an Artificial Intelligence Tool for Automatic Classification of Chest X-rays
A current problem in Radiology Departments is the constant increase in the number of studies performed. Currently the largest volume of studies belongs to plain x-rays.
- Conditions
- Pneumothorax, Pleural Effusion, Bone Fracture, Consolidation
- Trial name
- NCT04991987
- Where
- Argentina
- Volunteers
- 385 people
- Sponsor
- Hospital Italiano de Buenos Aires
Cardiac Toxicity, Early-stage Breast Cancer
Statins for Reduction of Cardiac Toxicity in Patients Receiving HER2 Targeted
This study proposes that the addition of statins reduces the treatment delays or early discontinuations secondary to cardiotoxicity in patients with Stage I-III HER2 positive breast being treated with anti-HER2 therapy.
- Trial name
- NCT05559164
- Testing
- Lipitor 40mg Tablet
- Where
- 10 sites in United States
- Volunteers
- 60 people
- Sponsor
- Rutgers, The State University of New Jersey
Locally Advanced Malignant Neoplasm
Registry Trial to Evaluate the Safety and Efficacy of Hyperthermia in Locally Advanced Cancers
Mahatma Gandhi Institute of Medical Sciences (MGIMS), Sevagram, District Wardha, Maharashtra, India is located in a rural setup and caters to a very underprivileged patient population with limited resources to even pay for their…
- Trial name
- RESHMART (NCT05099809)
- Testing
- Hyperthermia
- Where
- India
- Volunteers
- 500 people
- Sponsor
- Mahatma Gandhi Institute of Medical Sciences
Lymphoma, Non-Hodgkin, Lymphoma, Hodgkin
Early Detection of Patients at Risk of Developing Anthracycline Cardiotoxicity With TEP/CT -FDG
Management of patients with lymphoma is based on the administration of a chemotherapy containing anthracyclines (ATC), and allows cure rates of 65% to 80% at 5 years.
- Trial name
- DETECT (NCT04892667)
- Testing
- Intervention
- Where
- France
- Volunteers
- 128 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Radiotherapy Side Effect, Chemotherapy Effect
Neoadjuvant Chemotherapy or Chemoradiotherapy in Resectable Oesophageal Carcinoma（NewEC Study）
To provide comprehensive efficacy and safety profiles of neoadjuvant chemoradiotherapy (NCRT) versus neoadjuvant chemotherapy (NCT) versus surgery alone in resectable oesophageal carcinoma.
- Conditions
- Radiotherapy Side Effect, Chemotherapy Effect, Oesophageal Carcinoma, Effect of Drugs
- Trial name
- NCT04027543
- Testing
- Neoadjuvant chemoradiotherapy, Oesophagectomy, Neoadjuvant chemotherapy
- Where
- 3 sites in United States, China
- Volunteers
- 423 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Doxorubicin Induced Cardiomyopathy
Role of Statin Therapy in Prevention of Anthracycline-Induced Cardiotoxicity
This study aims at evaluating the role of Atorvastatin in prevention of Anthracycline induced cardiotoxicity
- Trial name
- NCT05792293
- Testing
- Atorvastatin 40 Mg Oral Tablet
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Radiation Lung Injury
Dead Mesenchymal Stem Cells for Radiation Lung Injury
The aim of this single center, single arm and prospective study is to explore the safety and efficacy of hDMSCs in the treatment of radiation pneumonitis.
- Trial name
- NCT06021067
- Testing
- Death mesenchymal stem cell
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Sichuan University
Breast Cancer
Generation of Heart Muscle Cells From Blood or Skin Cells of Breast Cancer Patients
The purpose of this study is to investigate whether cells from a biopsy taken from the patient skin can be transformed into cardiomyocytes the changes in cardiomyocyte (heart muscle cells) when grown in a special culture medium…
- Trial name
- NCT02772367
- Testing
- skin punch biopsy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Radiodermatitis, Breast Cancer
Photobiomodulation Therapy for the Prevention of Acute Radiodermatitis in Breast Cancer Patients Undergoing Radiotherapy
Radiodermatitis (RD), an inflammatory skin reaction, occurs in more than 90 percent of cancer patients treated with radiotherapy (RT). This is the result of the radiation causing damage to the epidermal basal skin stem cells.
- Trial name
- LABRA (NCT03924011)
- Testing
- Photobiomodulation therapy (PBMT)
- Where
- 2 sites in Belgium
- Volunteers
- 71 people
- Sponsor
- Hasselt University
Non Small Cell Lung Cancer, Stage III NSCLC
A Phase 2 Trial of Almonertinib With Concurrent Radiotherapy in The Treatment of Local Advanced EGFR-mutant NSCLC
Previous clinical studies showed there is a potential value of EGFR-TKI in local advanced EGFR-mutant NSCLC, while the risk of radiation pneumonia in combination of EGFR-TKI with thoracic radiotherapy is unknown.
- Conditions
- Non Small Cell Lung Cancer, Stage III NSCLC, EGFR Activating Mutation
- Trial name
- NCT04636593
- Testing
- Almonertinib
- Where
- China
- Volunteers
- 43 people
- Sponsor
- First People's Hospital of Hangzhou
Radiation Fibrosis
PhysioTouch for Treatment of Radiation Fibrosis
A quarter of a million women will develop breast cancer (BC) in this year alone. Many of these women will have side effects as a result of their breast cancer treatment.
- Trial name
- NCT03496909
- Testing
- Standard OT, PhysioTouch
- Sponsor
- University of Michigan
Adverse Effect of Radiation Therapy
IORT-Boost-Study, Prospective Observational Study for Intraoperative Radiotherapy of the Breast as a Boost
In this study the investigators observe the investigation, whether the new method for Boost-Irradiation with the Intrabeam Device of Zeiss Germany influences local recurrence, acute and late effects of Radiotherapy, overall…
- Trial name
- NCT02114086
- Where
- Switzerland
- Volunteers
- 163 people
- Sponsor
- Kantonsspital Münsterlingen
Sarcoma, Alveolar Soft Part Sarcoma
Hypofractionated Radiotherapy With Hyperthermia in Unresectable or Marginally Resectable Soft Tissue Sarcomas
After a screening, which consists of biopsy, physical examination, initial diffusion-weighted magnetic resonance imaging (DWI-MRI) or body computed tomography (CT) scan, blood tests and case analysis on Multidisciplinary Team…
- Conditions
- Sarcoma, Alveolar Soft Part Sarcoma, Clear Cell Sarcoma, Malignant Peripheral Nerve Sheath Tumors
- Trial name
- SINDIR (NCT03989596)
- Testing
- Hypofractionated radiotherapy, Hyperthermia
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
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