Clinical trials: Radiation Injury
Spinal Metastases, Metastatic Epidural Spinal Cord Compression
Postoperative Edge (RapidArc) Stereotactic Body Radiotherapy for Spinal Metastases
This study observes the effectiveness of high-precision radiation therapy using the Edge system after surgery for patients with spinal metastases.
- Conditions
- Spinal Metastases, Metastatic Epidural Spinal Cord Compression, Spinal Cord Compression
- Trial name
- NCT07801274
- Testing
- Stereotactic Body Radiotherapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Radiation Dermatitis, Breast Cancer
Topical Dermaprazole for Radiation Dermatitis in Breast Cancer Patients (TOPAZ)
Radiotherapy is a mainstay of treatment in breast cancer treatment, in the adjuvant setting. Radiation dermatitis occurs in up to 65% of these patients; currently, there is no standard of care for this treatment-related toxicity.
- Trial name
- NCT05269160
- Testing
- Dermaprazole 1%, Dermaprazole 2%
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Baylor College of Medicine
Lymphoma Cancer, Breast Cancer
Positron Emission Tomography (PET) Imaging of Chemotherapy-Induced Cardiotoxicity
This study is a single center, phase 1 clinical imaging study designed to assess the role of 68Ga-Galmydar Positron Emission Tomography (PET) imaging for detection of cardiotoxicity in human subjects with breast cancer or…
- Conditions
- Lymphoma Cancer, Breast Cancer, Cancer of the Breast, Non-Hodgkin Lymphoma
- Trial name
- NCT07838649
- Testing
- 68Ga-Galmydar, PET/MRI, 18F-FDG
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Washington University School of Medicine
Lung Cancer (Non-Small Cell), Radiation
Early Prophylactic Versus Late Salvage Recombinant Human Endostatin in Managing Radiosurgery-Induced Brain Injury for NSCLC Brain Metastases
Primary Purpose:To preliminarily evaluate the efficacy and safety of recombinant human endostatin (Endostar) in the early prophylactic cohort (Cohort A) and late salvage cohort (Cohort B) for radiation-induced brain injury after…
- Conditions
- Lung Cancer (Non-Small Cell), Radiation, Brain Injury, Brain Edema
- Trial name
- NCT07841106
- Testing
- Recombinant Human Endostatin (Endostar)
- Volunteers
- 49 people
- Sponsor
- Jiangmen Central Hospital
Radiotherapy Side Effect, NSCLC
CPAP or BiPAP for Motion Mitigation During Radiotherapy
When using highly conformal radiotherapy techniques, such as proton therapy, a controlled breathing pattern and a minimal breathing amplitude could greatly benefit the treatment of mobile tumors.
- Conditions
- Radiotherapy Side Effect, NSCLC, Esophageal Cancer, Malignant Lymphoma
- Trial name
- SISTER (NCT04986293)
- Testing
- CPAP
- Where
- Netherlands
- Volunteers
- 31 people
- Sponsor
- University Medical Center Groningen
Radiodermatitis
Dose-Response Curve: Interventions to Prevent and Treat Radiodermatitis
Dose response curve to define the security and tolerable dose to be used for prevention and treatment of radiodermatitis in patients with breast or head and neck cancer.
- Trial name
- DRCPTR (NCT02249884)
- Testing
- Urea Dose A, Urea Dose B, Urea Dose C
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Brasilia
Limbal Stem Cell Deficiency
Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated Stem Cell (CALEC) Graft
The main aim of the study is to determine the safety and feasibility of a cultivated autologous limbal epithelial cell (CALEC) transplantation in the treatment of limbal stem cell deficiency.
- Trial name
- CALEC (NCT02592330)
- Testing
- Biopsy to collect limbal epithelial stem cells that will be cultivated into a graft, Cultivation of Limbal epithelial cells into a graft, CALEC Transplant
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Sarcoma,Soft Tissue, Extremity
Preoperative IMRT With Concurrent Apatinib for Localised Extremity or Trunk Sarcoma （SPARE-02）
To investigate the safety and efficacy of preoperative IMRT and concurrent Apatinib for primary truncal or extremity soft tissue sarcoma; To investigate the Quality of life and extremity function post-combination treatment; To…
- Conditions
- Sarcoma,Soft Tissue, Extremity, Trunk, Intensity-modulated Radiotherapy
- Trial name
- SPARE-02 (NCT05235100)
- Testing
- Apatinib Mesylate
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Prostate Cancer
Exploring Genomic, Proteomic and Dosimetric Determinants of Late Toxicity After Three Dimensional Conformal Radiotherapy (RT) for Prostate Cancer
Prostate cancer is the most common malignancy in males, and radiotherapy is a commonly chosen treatment option for patients with localized disease.
- Trial name
- NCT00122265
- Where
- Canada
- Volunteers
- 83 people
- Sponsor
- AHS Cancer Control Alberta
Cardiotoxicity, Heart Failure
Novel Biomarkers and Echocardiography for Subclinical Cardiac Toxicity in Breast Cancer Patients Receiving Anthracyclines
This is a pilot prospective cohort study, in adult female subjects 18-85 years old with a diagnosis of invasive breast cancer who are planned for anthracycline-inclusive chemotherapy and followed up for a time period of 6 months…
- Conditions
- Cardiotoxicity, Heart Failure, Breast Cancer, Anthracycline Induced Cardiomyopathy
- Trial name
- NCT03155802
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Stony Brook University
Non-small Cell Lung Cancer, Older People
Carbon Ion Radiotherapy for Locally Advanced Lung Cancer in Elderly Patients
To observe the effect and toxicity of carbon ion radiotherapy on local advanced non-small cell lung cancer over 75 years old patients. Systemic therapy could be targeted therapy, chemotherapy or immunotherapy.
- Conditions
- Non-small Cell Lung Cancer, Older People, Carbon Ion Radiotherapy, Radiotherapy Side Effect
- Trial name
- NCT06311981
- Testing
- carbon ion radiotherapy, targeted therapy, single regimen chemotherapy in sequence with radiotherapy
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Jian Chen
Breast Cancer, Radiation Dermatitis
Efficacy Study of Mepitel Film the Prophylaxis of Radiation-Induced Skin Reactions in Breast Cancer Patients
In patients undergoing adjuvant radiotherapy for breast cancer, radiation-induced skin toxicities are a common occurrence and adversely impact patients' quality of life (QOL).
- Trial name
- NCT03910595
- Testing
- Mepitel Film
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Sunnybrook Health Sciences Centre
Non-small Cell Lung Cancer
Methylprednisolone After Split-course Chemoradiotherapy For Bulky Local Advanced None-small Cell Lung Cancer
This Phase II randomized controlled study is to determine the efficacy of the preventively use of methylprednisolone after split-course chemoradiotherapy (CCRT) in locally advanced non-small cell lung cancer with bulky tumor.
- Trial name
- NCT03661567
- Testing
- chest radiation, concurrent chemotherapy, Methylprednisolone
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Sun Yat-sen University
Thrombocytopenia, Radiotherapy Side Effect
Hetrombopag for the Thrombocytopenia Induced by Concurrent Chemoradiotherapy
Thrombocytopenia represents one of the main toxicities of concurrent chemoradiotherapy, which may necessitate chemotherapy dose reductions, dose delays, or discontinuation, and even compromise survival.
- Trial name
- NCT06433830
- Testing
- Hetrombopag Olamine
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sir Run Run Shaw Hospital
Head and Neck Cancer
Acute and Longlasting Side Effects Caused by Radiotherapy in the Head and Neck Area
The purpose of this clinical investigation is to evaluate acute and longlasting side effects in patients undergoing radiotherapy for cancer treatment in the head and neck area.
- Trial name
- NCT00995319
- Where
- Norway
- Volunteers
- 58 people
- Sponsor
- Norwegian University of Science and Technology
Orodental Injury
Quantitative Imaging Biomarker Prospective Validation of Dynamic Contrast-enhanced MRI as a Metric of Orodental Injury After Radiotherapy (QI-ProVE-MRI)
This research will focus on the prospective qualification and validation of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) candidate biomarkers (i.e., Ktrans and Ve) to assess the natural history of…
- Trial name
- (QI-ProVE-MRI) (NCT06586892)
- Testing
- Radiotherapy followed by chemotherapy
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Implant; Complications, Breast Implant Protrusion
Standard Silicone-based vs. B-Lite® Light Weight Breast Implant After Total Mastectomy and Radiotherapy for Breast Cancer
Reconstructive surgery with breast implants after total mastectomy for breast cancer is invariably related to several possible complications, such as atrophy of surrounding tissues, skin thinning, capsular contracture, wound…
- Conditions
- Breast Implant; Complications, Breast Implant Protrusion, Breast Cancer, Radiotherapy Side Effect
- Trial name
- BLITE-01 (NCT03737500)
- Testing
- B-Lite® light weight breast implant, Standard silicone-based breast implant
- Where
- Italy
- Volunteers
- 49 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Cholangiopancreatography, Endoscopic Retrograde, Occupational Exposure
Radiation Exposure During Endoscopic Retrograde Cholangiopancreatography
Radiation now becomes a dreadful effect as its outcomes are tremendous to be expected. As a result, anesthetists become an inevitable target to the radiation exposure since they have to monitor patients closely during the…
- Conditions
- Cholangiopancreatography, Endoscopic Retrograde, Occupational Exposure, Radiation Injuries
- Trial name
- NCT02985164
- Testing
- PDSa, PDSb
- Volunteers
- 222 people
- Sponsor
- Siriraj Hospital
DLBCL - Diffuse Large B Cell Lymphoma
Prevention of Anthracycline-Induced Cardiac Dysfunction With Dexrazoxane in Patients With Diffuse Large-B Cell Lymphoma
Patients treated for DLBCL are at high risk of developing AICD. This adverse event is characterized by irreversible damage to the heart muscle with a loss of cardiomyocytes and subsequent decline in cardiac pumping capacity.
- Trial name
- HO170DLBCL (NCT06220032)
- Testing
- Dexrazoxane, Rituximab, Cyclophosphamide
- Where
- 25 sites in Netherlands
- Volunteers
- 324 people
- Sponsor
- Stichting Hemato-Oncologie voor Volwassenen Nederland
Ototoxicity
Study to Evaluate Safety and Efficacy of DB-020 to Protect Hearing in Patients Receiving Cisplatin for Cancer Treatment
The purpose of this study is to evaluate whether DB-020 administered via an injection in the middle ear prevents hearing loss in participants who will receive high doses of cisplatin as part of their treatment for cancer.
- Trial name
- NCT04262336
- Testing
- DB-020
- Where
- 8 sites in United States, Australia
- Volunteers
- 22 people
- Sponsor
- Decibel Therapeutics