Clinical trials: Radiation Injury
Radiation Dermatitis
Efficacy of Superoxide Dismutase Spray in Preventing Radiation Dermatitis in Patients With Head and Neck Cancer .
Radiotherapy always results in many complications such as radiation dermatitis,dry mouth, cranial nerve damage, and swallowing function.
- Trial name
- NCT07400016
- Testing
- SOD spray
- Volunteers
- healthy volunteers welcome
- Sponsor
- West China Hospital
Esophagus Cancer, Chemoradiation
Definitive (Chemo)Radiotherapy for Patients With Esophageal Cancer - 3JECROG R-01
The aim of this observational study is to retrospectively collect survival data for 3000 primary esophageal cancer patients from multicenter between January 2000 to present.
- Conditions
- Esophagus Cancer, Chemoradiation, Chemotherapy Effect, Radiotherapy Side Effect
- Trial name
- NCT03298204
- Where
- China
- Volunteers
- 2,762 people
- Sponsor
- Chinese Academy of Medical Sciences
Breast Cancer, Colorectal Cancer
Growth Factor Levels in the Blood of Patients Undergoing Radiation Therapy for Epithelial Cancer
RATIONALE: Measuring levels of transforming growth factor-beta (TGF-beta) in the blood of patients with epithelial cancers (head and neck, lung, breast, colorectal, and prostate) may help doctors predict how patients will respond…
- Conditions
- Breast Cancer, Colorectal Cancer, Head and Neck Cancer, Lung Cancer
- Trial name
- NCT00897793
- Testing
- venipuncture, radiation therapy
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Breast Cancer, Radiation Toxicity
Pre- or Postoperative Accelerated Radiotherapy
20 non-metastasized breast cancer patients receiving neoadjuvant chemotherapy will be randomized between preop or postop RT. Patients with clinically suspicious axillary lymph nodes will receive a fine needle biopsy.
- Trial name
- POP-ART (NCT03783364)
- Testing
- Radiotherapy
- Where
- 2 sites in Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Ghent
Breast Cancer, Radiation Pneumonia
Correlation Between COVID-19 and Radiation Pneumonitis in Breast Cancer
This study was designed as a single-center retrospective analysis aimed at investigating whether COVID-19 infection increases the risk or burden of radiation-induced pneumonitis in breast cancer patients.
- Conditions
- Breast Cancer, Radiation Pneumonia, COVID-19
- Trial name
- NCT07188116
- Testing
- COVID-19
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zhejiang Hospital
Prostate Cancer, Prostate Adenocarcinoma
A Behavioral Health Intervention Using Digital Technology in Radiation Therapy for Prostate Cancer Patients
The purpose of this study is to determine how to incorporate a smart water bottle to improve bladder filling for prostate cancer patients undergoing radiation therapy.
- Conditions
- Prostate Cancer, Prostate Adenocarcinoma, Radiation Toxicity
- Trial name
- HIDRATEPRO (NCT04946214)
- Testing
- Smart Water Bottle
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Miami
Head and Neck Neoplasms, Osteoradionecrosis
Radiation Field, Dose and Fractionation Related to Mandibular Complications
Radiotherapy is inhibiting the healing capacity of the mandibular bone. Late complications as bone exposure, fracture of the jaw, osteoradionecrosis might be a consequence of this vulnerability.
- Conditions
- Head and Neck Neoplasms, Osteoradionecrosis, Radiotherapy; Complications
- Trial name
- NCT05412849
- Testing
- Radiotherapy
- Where
- Sweden
- Volunteers
- 120 people
- Sponsor
- Lund University Hospital
Arrhythmias, Cardiac, Atrial Fibrillation and Flutter
cARdiotoxicity Profile of aBIraTeRone in prostAte Cancer : a pharmacoviGilancE Study
Abiraterone associated with prednisone is used in prostate cancer. Abiraterone is a selective small-molecule inhibiting cytochrome P450 17A1 (CYP17A1), a key enzyme in androgen synthesis.
- Conditions
- Arrhythmias, Cardiac, Atrial Fibrillation and Flutter, Tachycardia, Supraventricular, Cardiac Failure
- Trial name
- ARBITRAGE (NCT03243604)
- Testing
- L02 (sex hormones used in treatment of neoplastic diseases) and G03 (sex hormones)
- Where
- France
- Volunteers
- 1,717 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Cardiotoxicity, Systolic Dysfunction
Aerobic Exercise is Cardio-protective in Hemato-oncological Disease and New-onset Chemotherapy
Oncological diseases are the main cause of death in developed countries and also in Uruguay. Advances in therapeutics have made possible to aspire to cure and in other cases long-term remission with a significant increase in…
- Conditions
- Cardiotoxicity, Systolic Dysfunction, Exercise, Aerobic
- Trial name
- AEROHEMONCO (NCT04476576)
- Testing
- Aerobic exercise (experimental), Flexibility exercise (active comparator)
- Where
- Uruguay
- Volunteers
- 38 people
- Sponsor
- Lucía Florio
Pediatric ALL, Radiotherapy Side Effect
Design and Evaluation of Care Environment and Technology at Pediatric Radiotherapy
The purpose of the study is to evaluate the effect of changes in the care environment in pediatric radiotherapy. The definitions of the changes is a part of the study, and is constructed in collaboration with the institute of…
- Trial name
- DUMBO (NCT02993978)
- Volunteers
- 57 people
- Sponsor
- Umeå University
Wound Heal, Pain, Postoperative
Dry Heat Versus Sitz Bath On Episiotomy Wound Heating And Pelvic Pain
Objective: To compare the effect of dry heat versus moist heat application on episiotomy wound healing and pain among postnatal mothers.
- Trial name
- Dry_Heat (NCT05186532)
- Testing
- Dry Heat Application, Moist Heat Application
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Radiation-induced Injuries in Patients With Rectal Cancer
Effectiveness of Vitamin E and Hydrogen-Rich Water on Radiation Therapy-Induced Adverse In Patients With Rectal Cancer
Controlled studies investigating the effects of vitamin E or H2 water or comparing their effectiveness on radiation therapy-induced injuries in RC patients are generally lacking.
- Trial name
- NCT04713332
- Testing
- Vitamin E, Hydrogen rich water
- Where
- Palestinian Territories
- Volunteers
- 60 people
- Sponsor
- University of Jordan
Ototoxicity, Drug-Induced, Ototoxicity, Radiation-Induced
Analysis of Risk Factors for Hearing Loss in Survivors of Cancer Occurred During Childhood, Adolescence or Young Adulthood
This study is aimed at people treated for cancer before the age of 25, who have been followed for at least 5 years, and who are now aged between 18 and 50. It is a prospective, multicenter, non-randomized study.
- Conditions
- Ototoxicity, Drug-Induced, Ototoxicity, Radiation-Induced, Pediatric Cancer
- Trial name
- RISP-OTOTOX (NCT06957132)
- Testing
- Audiogram
- Where
- 3 sites in France
- Volunteers
- 500 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Breast Cancer, Radiotherapy Side Effect
Weekly Single Fraction Hypofractionated Adjuvant Radiotherapy for Early Stage Breast Cancer
The current study is a prospective phase II study; Eligible patients will receive hypofractionated Irradiation at a total dose of 28.5Gy in 5 once-weekly fractions of 5.7Gy in 5 weeks to the Whole Breast or chest wall with or…
- Trial name
- NCT04580784
- Testing
- Weekly hypofractionation for early breast cancer
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Mona Salem
Ankle Injury
Classification of Ankle Injury Observed With X-ray Combined With Magnetic Resonance Imaging
To verify whether X-ray combined with MRI is able to carry out correct fracture classification and postoperative evaluation in patients with ankle fractures.
- Trial name
- NCT02971943
- Testing
- internal fixation for ankle fractures
- Volunteers
- 68 people
- Sponsor
- The First Hospital of Hebei Medical University
Radiation Toxicity, Fibrosis
Pilot Study of the Predictive Value of TREM1 Expression and Activation in Inflammation and Radio-induced Mammary Fibrosis
Breast cancer is the most common cancer in the world. Half of patients with such cancer are treated with radiation therapy. Some patients will develop cutaneous or subcutaneous fibrosis, more or less bothersome.
- Conditions
- Radiation Toxicity, Fibrosis, Breast Cancer
- Trial name
- TREM-1 (NCT04948840)
- Testing
- Blood sampling
- Where
- 3 sites in France, Luxembourg
- Volunteers
- 20 people
- Sponsor
- Centre Francois Baclesse, Luxembourg
All Type of Cancers With Bony Metastasis
Comparing the Effectiveness of Combined Hyperthermia and External Beam Radiation (EBRT) Versus EBRT Alone in Treating Patients With Painful Bone Metastases
The main goals of deep hyperthermia combined with external beam radiation (EBRT) on bone metastases are the response on pain relief, duration of response and time to achieve complete pain relief.
- Trial name
- NCT01842048
- Testing
- Hyperthermia, External-beam radiotherapy
- Where
- Taiwan
- Volunteers
- 152 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Immune Checkpoint Inhibitors, Cardiotoxicity
Cardiac Magnetic Resonance Monitoring of Immune Checkpoint Inhibitor-related Cardiotoxicity
This study is a prospective cohort clinical research that analyzes the changes in CMR parameters before and after immune checkpoint inhibitors (ICIs) therapy in patients with gynecologic malignancies.
- Trial name
- NCT06132984
- Testing
- Cardiac magnetic resonance
- Where
- China
- Volunteers
- 22 people
- Sponsor
- West China Second University Hospital
Meningioma, Radiation Toxicity
Neurocognitive Impact of Different Irradiation Modalities for Patients With Grade I-II Skull Base Meningioma:
For the purpose of this research, investigator will constitute several cohorts of patients, treated either by intensity-modulated radiotherapy, stereotactic radiotherapy or proton-therapy.
- Trial name
- CANCER-COG (NCT06036706)
- Testing
- Normo-fractionated intensity-modulated brain irradiation with or without stereotactic positioning, Hypo-fractionated stereotactic brain irradiation, Normo-fractionated proton therapy brain irradiation
- Where
- 3 sites in France
- Volunteers
- 108 people
- Sponsor
- Centre Francois Baclesse
Non-small Cell Lung Cancer Stage III, Radiotherapy Side Effect
Heterogeneously Hypofractionated Radiotherapy for Locally Advanced NSCLC
Aim To test if proton therapy can improve survival compared to photon therapy in patients with locally advanced NSCLC who are not candidates for standard definitive chemo-radiotherapy.
- Conditions
- Non-small Cell Lung Cancer Stage III, Radiotherapy Side Effect, Frailty
- Trial name
- HERAN2 (NCT05548504)
- Testing
- Photon, Proton
- Volunteers
- 182 people
- Sponsor
- Odense University Hospital