Clinical trials: Radiation Proctitis
Acute Radiation Proctitis, Acute Radiation Enteritis
Efficacy of Hyaluronic Acid in Prevention of Acute Radiation Proctitis
A randomized placebo-controlled clinical trial to evaluate efficacy of hyaluronic acid in prevention of acute radiation proctitis among oncology patient population especially who are diagnosed with abdomeno-pelvic tumors and…
- Trial name
- NCT06469216
- Testing
- Hyaluronic Acid
- Where
- 2 sites in Egypt
- Volunteers
- 44 people
- Sponsor
- Assiut University
Radiation Proctitis, Gastrointestinal Hemorrhage
A Study of Chlorophyllin or Placebo With Standard Treatment for Late Radiation Induced Luminal Gastrointestinal Tract Bleeding
This multicenter, randomized, double-blind, placebo-controlled Phase III clinical trial will evaluate whether oral sodium copper chlorophyllin (CHL) is effective and safe for treating late radiation-induced gastrointestinal (GI)…
- Conditions
- Radiation Proctitis, Gastrointestinal Hemorrhage, Radiation Injuries
- Trial name
- NCT07837713
- Testing
- Chlorophyllin, Sodium Copper Complex
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Tata Memorial Centre
Radiation Proctitis, Radiation Induced Proctitis
CryoSpray Ablation(TM)to Determine Safety and Feasibility in Radiation Induced Proctitis
The purpose of this study is to evaluate the safety, feasibility, tissue response, and subject side effects of liquid nitrogen sprayed through a catheter (CryoSpray AblationTM, "CSA" or "cryospray therapy") via endoscope in…
- Trial name
- CSALGI2 (NCT00756197)
- Testing
- Cryo Spray Ablation Group 1, Cryo Spray Ablation Group 2
- Sponsor
- CSA Medical, Inc.
Radiotherapy, Radiation Proctitis
Dietary Supplements to Treat Radiation-Induced Rectal Injury
This clinical study is a prospective, single-arm, single-center trial aimed at assessing the safety and efficacy of tributyrin (TB) as dietary supplements in the treatment of chronic radiation-induced rectal injury (RRI).
- Trial name
- NCT06776016
- Testing
- Butyrate
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Chronic Radiation Proctitis
Combined Therapy in Radiation Proctopathy
The aim of this study was to compare the efficacy and safety of two treatment regimens: argon plasma coagulation (APC) alone and APC in combination with sucralfate administered for chronic hemorrhagic radiation proctopathy.
- Trial name
- NCT01613534
- Testing
- Sucralfate
- Where
- Poland
- Volunteers
- 122 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Chronic Radiation Proctitis
Thalidomide in the Treatment of Chronic Radiation Proctitis With Intractable Bleeding
Chronic radiation proctitis (CRP) is the main secondary toxic injury after pelvic radiotherapy. Hematochezia is the most common symptom for more than 80% of CRP patients.
- Trial name
- Thal-CRP (NCT04680195)
- Testing
- Thalidomide
- Volunteers
- 62 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Proctitis Radiation
Micronized Purified Flavonoid- Fraction (MPFF) in the Management of Radiation Proctitis
national and multi-center trial for medical therapy of chronic radiation proctitis inducing anorectal bleedings
- Trial name
- MiFlaPRO (NCT04335617)
- Testing
- MMPF (Micronized purified Flavonoid-Fraction)
- Where
- 11 sites in Austria
- Volunteers
- 200 people
- Sponsor
- Medical University Innsbruck
Pelvic Neoplasms
Treatment of Hemorrhagic Radiation Proctitis Using the Halo System
This study involves evaluating a procedure in which the study device, the HALO90 Ablation catheter, is used to heat a thin layer of tissue lining the rectum using radiofrequency (RF) energy in subjects suffering from radiation…
- Trial name
- NCT01103492
- Testing
- HALO90 Ablation catheter
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Radiation - Induced Proctitis
A Randomized Controlled Trial of Five - Flavor Sophora Flavescens Enteric - Coated Capsules for Radiation - Induced Proctitis After Pelvic Radiotherapy
The goal of this single - center, prospective, randomized controlled study is to assess the therapeutic effects of five - flavor sophora flavescens enteric - coated capsules on radiation - induced proctitis in patients who have…
- Trial name
- NCT07053761
- Testing
- five - flavor sophora flavescens enteric - coated capsules plus glutamine and warm - water sitz baths, glutamine and warm - water sitz baths
- Volunteers
- 124 people
- Sponsor
- Peking University First Hospital
Cystitis, Radio Induced, Soft Tissue Radionecrosis (STRN)
Soft Tissue Radiation Injury; Patient Reported Evaluation in a Single Centre Cohort Study (STRIPE)
Radiotherapy cures many cancers but can cause late radiation-induced tissue injury (LRTI), leading to long-term symptoms from the bladder and bowel and reduced health-related quality of life (HRQoL).
- Conditions
- Cystitis, Radio Induced, Soft Tissue Radionecrosis (STRN), Radiation Proctitis
- Trial name
- karolinskaUH (NCT07611864)
- Where
- Sweden
- Volunteers
- 1,000 people
- Sponsor
- Karolinska University Hospital
Chronic Radiation Proctitis
Umbilical-Cord-Derived Mesenchymal Stem Cells Injection for Chronic Radiation Proctitis
A Phase I/II study to evaluate the safety and preliminary efficacy of human umbilical cord-derived mesenchymal stem cell injection for the treatment of chronic radiation proctitis.
- Trial name
- NCT06438809
- Testing
- Mesenchymal Stem Cells (MSCs)
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Jiangsu Topcel-KH Pharmaceutical Co., Ltd.
Radiation Proctitis, Prostate Cancer
Efficacy of Symbiotic in the Reduction of Acute Radiation Proctitis Symptoms
Radiation proctitis is quite common in treatment of pelvic tumors. We investigated whether the use of symbiotic would prevent early symptoms of radiation proctitis and improve the quality of life in patients undergoing…
- Trial name
- NCT01901042
- Testing
- Symbiotic, Maltodextrin
- Volunteers
- 20 people
- Sponsor
- Federal University of Mato Grosso
Rectal Bleeding
Trial of Argon Plasma Coagulation Versus APC and APC and Hemospray in the Treatment of Radiation Proctitis
Randomized trial of Argon Plasma Coagulation compared with Argon Plasma Coagulation and Hemospray in the therapy of bleeding from Radiation Proctitis
- Trial name
- NCT02233933
- Testing
- Hemospray
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- British Columbia Cancer Agency
Radiation Proctitis
Evaluate the Distribution and Dynamic Behavior of Nuclide Labeled TH-SC01 Cells in Vivo in Patients With Radiation Proctitis
A Phase l clinical study evaluating the distribution and dynamic behavior of Nuclide labeled TH-SC01 cells in vivo in patients with Radiation proctitis
- Trial name
- NCT06925607
- Testing
- Mesenchymal Stem Cells (MSCs)
- Volunteers
- 6 people
- Sponsor
- Jiangsu Topcel-KH Pharmaceutical Co., Ltd.
Rectal Cancer, Feasibility
Feasibility of the Maastro Applicator in Rectal Cancer
The goal of this interventional pilot trial is to confirm that Maastro endoluminal HDR ( High Dose Radiation) contact brachytherapy boosting is feasible and may increase the chance of functional organ sparing of the rectum in…
- Conditions
- Rectal Cancer, Feasibility, Toxicity, Quality of Life
- Trial name
- NCT06087718
- Testing
- Maastro applicator
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Maastricht Radiation Oncology
Pelvic Toxicity, Radiation Toxicity
Gut Microbiome in Gynecological Cancer Patients With Pelvic Toxicity: Controls Versus Ozone Treatment. (MicrOzoGineTox)
Patients treated for gynecological tumors with radiotherapy (RT) and/or chemotherapy (CT) frequently develop pelvic toxicity (TPIRQT), a condition that can become persistent, progressive, and refractory to standard treatments.
- Conditions
- Pelvic Toxicity, Radiation Toxicity, Chemotherapy Toxicity, Gynecological Tumors
- Trial name
- MicrOGineTox (NCT07259681)
- Where
- 2 sites in Spain
- Volunteers
- 38 people
- Sponsor
- Bernardino Clavo, MD, PhD
Radiation Induced Proctitis
Fecal Microbiota Transplantation for Radiation-Induced Proctopathy
The goal of this single-arm trial is to learn if Fecal Microbiota Transplantation (FMT) works to treat hemorrhagic radiation-induced proctopathy.
- Trial name
- NCT06776029
- Testing
- Fecal Microbiota Transplantation Capsule
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Pelvic Cancer
Post Radiotherapy MRI Based AI System to Predict Radiation Proctitis for Pelvic Cancers
In this study, investigators utilize a Artificial Intelligence (AI) supportive system to predict radiation proctitis for patients with pelvic cancers underwent radiotherapy.
- Trial name
- MRI-RP-2021 (NCT04918992)
- Testing
- Artificial Intelligence
- Where
- 4 sites in China
- Volunteers
- 400 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Radiation Proctitis, Probiotics
The Effects of Probiotics Combined With Glutamine in the Prevention and Treatment of Radiation Proctitis
Radiation proctitis is a common complication after radiation therapy for pelvic tumors. The investigators found that live bifidobacterium and lactobacillus tablets combined with compound glutamine enteric-coated capsules can…
- Conditions
- Radiation Proctitis, Probiotics, Glutamine, Gut Microbiota
- Trial name
- NCT05406882
- Testing
- Live Combined Bifidobacterium and Lactobacillus Tablets、Compound Glutamine Entersoluble capsules
- Where
- 2 sites in China
- Volunteers
- 176 people
- Sponsor
- West China Hospital
Radiation Proctitis
Budesonide Foam Versus Placebo for Prevention of Acute Radiation Proctitis
To proof the superiority of an 8-week rectal treatment with once-daily 2 mg budesonide versus placebo for the prevention of acute radiation proctitis, and to evaluate the occurrence of chronic radiation proctitis 1 year after…
- Trial name
- NCT00828230
- Testing
- budesonide
- Where
- 3 sites in Germany
- Volunteers
- 17 people
- Sponsor
- Dr. Falk Pharma GmbH