Clinical trials: Radiation Proctitis, open to volunteers
Rectal Cancer, Locally Advanced Rectal Cancer
A Phase II Single-Arm Study of High-Bioavailability Curcumin as Neoadjuvant Chemoradiotherapy in Mid-to-Low Rectal Cancer: Integrated Clinical and Translational Analysis of Tumor Tissue
This clinical study investigates the anti-inflammatory and anti-cancer properties of a high-bioavailability formulation of curcumin (BCM-95) in patients with mid-to-low rectal cancer receiving neoadjuvant chemoradiotherapy…
- Conditions
- Rectal Cancer, Locally Advanced Rectal Cancer, Radiation-Induced Enteritis, Radiation Proctitis
- Trial name
- BCMRECRAD (NCT07248020)
- Testing
- Curcumin (BCM-95®)
- Where
- Taiwan
- Volunteers
- 72 people
- Sponsor
- Chang Gung Memorial Hospital
Radiation - Induced Proctitis
A Randomized Controlled Trial of Five - Flavor Sophora Flavescens Enteric - Coated Capsules for Radiation - Induced Proctitis After Pelvic Radiotherapy
The goal of this single - center, prospective, randomized controlled study is to assess the therapeutic effects of five - flavor sophora flavescens enteric - coated capsules on radiation - induced proctitis in patients who have…
- Trial name
- NCT07053761
- Testing
- five - flavor sophora flavescens enteric - coated capsules plus glutamine and warm - water sitz baths, glutamine and warm - water sitz baths
- Volunteers
- 124 people
- Sponsor
- Peking University First Hospital
Radiation Proctitis
Evaluate the Distribution and Dynamic Behavior of Nuclide Labeled TH-SC01 Cells in Vivo in Patients With Radiation Proctitis
A Phase l clinical study evaluating the distribution and dynamic behavior of Nuclide labeled TH-SC01 cells in vivo in patients with Radiation proctitis
- Trial name
- NCT06925607
- Testing
- Mesenchymal Stem Cells (MSCs)
- Volunteers
- 6 people
- Sponsor
- Jiangsu Topcel-KH Pharmaceutical Co., Ltd.
Chronic Radiation-induced Proctitis
KANGFUPEN Liquid Dressing for Chronic Radiation-Induced Rectal Injury
This clinical trial aims to evaluate the efficacy and safety of Kangfupen (a topical liquid dressing) in treating chronic radiation-induced proctitis (RTOG Grade 2 or higher). The key questions we aim to answer are: 1.
- Trial name
- NCT07065175
- Testing
- Kangfupen (liquid dressing) retention enema administration
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Peking Union Medical College Hospital
Cystitis, Radio Induced, Soft Tissue Radionecrosis (STRN)
Soft Tissue Radiation Injury; Patient Reported Evaluation in a Single Centre Cohort Study (STRIPE)
Radiotherapy cures many cancers but can cause late radiation-induced tissue injury (LRTI), leading to long-term symptoms from the bladder and bowel and reduced health-related quality of life (HRQoL).
- Conditions
- Cystitis, Radio Induced, Soft Tissue Radionecrosis (STRN), Radiation Proctitis
- Trial name
- karolinskaUH (NCT07611864)
- Where
- Sweden
- Volunteers
- 1,000 people
- Sponsor
- Karolinska University Hospital
Chronic Radiation Proctitis
Jianzhong Qushi in Chronic RRI
This study is a multicenter, randomized, double-blind, placebo-controlled trial. Patients diagnosed as CRP and without TCM history will be enrolled and randomly assigned to either the treatment group (receiving standard care plus…
- Trial name
- ACRON (NCT06837597)
- Testing
- Jianzhong Qushi Formula
- Volunteers
- 168 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Radiation Induced Proctitis
Fecal Microbiota Transplantation for Radiation-Induced Proctopathy
The goal of this single-arm trial is to learn if Fecal Microbiota Transplantation (FMT) works to treat hemorrhagic radiation-induced proctopathy.
- Trial name
- NCT06776029
- Testing
- Fecal Microbiota Transplantation Capsule
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Rectal Neoplasm Malignant
Metabolomics to Predict Treatment Response and Toxicities in Rectal Cancer
Background: Colorectal cancer is the leading cause of cancer-related deaths in Taiwan, with rectal cancer accounting for approximately 27% of all cases.
- Trial name
- NCT06831669
- Testing
- Collecting biospecimens
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- Chang Gung Memorial Hospital
Safety
A Phase I/II Clinical Study to Evaluate the Safety and Efficacy of Oral Teslanbaicin in Patients With Radiation Proctitis
Radiation Proctitis refers to rectal radiation injury caused by radiotherapy for pelvic malignancies. It is classified into Acute Radiation Proctitis (ARP) and Chronic Radiation Proctitis (CRP) based on onset time and disease…
- Trial name
- NCT06974123
- Testing
- A Phase I/II Clinical Study to Evaluate the Safety and Efficacy of Oral Tesilanbaiju in Patients with Radiation Proctitis, Teslanbai oral therapy
- Where
- China
- Volunteers
- 29 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Pelvic Toxicity, Radiation Toxicity
Gut Microbiome in Gynecological Cancer Patients With Pelvic Toxicity: Controls Versus Ozone Treatment. (MicrOzoGineTox)
Patients treated for gynecological tumors with radiotherapy (RT) and/or chemotherapy (CT) frequently develop pelvic toxicity (TPIRQT), a condition that can become persistent, progressive, and refractory to standard treatments.
- Conditions
- Pelvic Toxicity, Radiation Toxicity, Chemotherapy Toxicity, Gynecological Tumors
- Trial name
- MicrOGineTox (NCT07259681)
- Where
- 2 sites in Spain
- Volunteers
- 38 people
- Sponsor
- Bernardino Clavo, MD, PhD
Radiotherapy, Radiation Proctitis
Dietary Supplements to Treat Radiation-Induced Rectal Injury
This clinical study is a prospective, single-arm, single-center trial aimed at assessing the safety and efficacy of tributyrin (TB) as dietary supplements in the treatment of chronic radiation-induced rectal injury (RRI).
- Trial name
- NCT06776016
- Testing
- Butyrate
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Radiation Proctitis, Gastrointestinal Hemorrhage
A Study of Chlorophyllin or Placebo With Standard Treatment for Late Radiation Induced Luminal Gastrointestinal Tract Bleeding
This multicenter, randomized, double-blind, placebo-controlled Phase III clinical trial will evaluate whether oral sodium copper chlorophyllin (CHL) is effective and safe for treating late radiation-induced gastrointestinal (GI)…
- Conditions
- Radiation Proctitis, Gastrointestinal Hemorrhage, Radiation Injuries
- Trial name
- NCT07837713
- Testing
- Chlorophyllin, Sodium Copper Complex
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Tata Memorial Centre
Radiotherapy, Radiation Proctitis
Association Between Clinical Classification and Prognosis in Chronic Radiation Enteropathy
This is a prospective, observational study aimed at exploring the associations between the clinical classification of chronic radiation enteropathy and prognosis.
- Conditions
- Radiotherapy, Radiation Proctitis, Radiation Enteritis
- Trial name
- NCT07378631
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University