Clinical trials: Radiation Protection
Radiodermatitis, Injury, Radiation
Study Using Spray Skin Protector Versus Conventional Treatment to Prevent Acute Radiodermatitis.
This is a randomized, open-label, single-institution trial designed to evaluate the effectiveness of a spray skin protector in preventing moist desquamation caused by radiotherapy treatment.
- Trial name
- NCT04067310
- Testing
- Spray skin protector, moisturizer Dnativ Revita derm
- Where
- Brazil
- Volunteers
- 72 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Polymorphic Light Eruption
Sunscreen and After-sun-lotion Protection in Polymorphic Light Eruption
Polymorphic light eruption (PLE) is a common photodermatosis characterized by the appearance of itching, erythema, papules or vesicles on sun-exposed skin.
- Trial name
- NCT00549588
- Testing
- After-sun-lotion with DNA repair enzymes, SPF30 sunscreen, Intervention: none (only UV)
- Where
- Austria
- Volunteers
- 14 people
- Sponsor
- Medical University of Graz
Acute Coronary Syndromes, Angioplasty, Transluminal, Percutaneous Coronary
Randomized Comparison of Radiological Exposure With TRIPTable® in Patients With Acute Coronary Syndromes
Excessive radiation received by the operator has been described as a possible drawback of the radial catheterization technique when compared with the femoral access.
- Trial name
- TRIPTABLE (NCT02200783)
- Testing
- TripTable, Radial, Femoral
- Where
- Brazil
- Volunteers
- 99 people
- Sponsor
- Marilia Medicine School
Oxidative Stress, DNA Damage, Radiation Induced
Multi-Nutrient Supplement for Radio-Protection
Exposure to radiation, such as during routine CTs, bone scans, or X-rays, causes oxidative stress which can damage the DNA (your genetic material) within your white blood cells.
- Conditions
- Oxidative Stress, DNA Damage, Radiation Induced, Radiation Exposure
- Trial name
- MNSRP (NCT04781868)
- Testing
- Multi-nutrient supplement
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McMaster University
Acute Coronary Syndromes
RADIATION PROTECTion With a Pelvic Lead Shield and a Radiation Protection Cap for Operators Performing Coronary Angiography or Intervention
RADIATION PROTECT is a randomized, controlled trial of patients undergoing coronary angiography or PCI with or without a pelvic lead shield.
- Trial name
- NCT02128035
- Testing
- With Lead Shield
- Where
- Canada
- Volunteers
- 230 people
- Sponsor
- Dr. Sanjit S. Jolly
Lung Cancer, Radiation Therapy Complication
Xenon-enhanced Ventilation CT-guided Radiotherapy for Lung Cancer Treatment
The investigators aim to use xenon-enhanced ventilation computed tomography (CT) to design personalized functional lung avoidance radiotherapy for lung cancer patients who are scheduled to receive lung radiation therapy.
- Trial name
- NCT05134558
- Testing
- Xenon-enhanced Ventilation CT-guided Radiotherapy
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Kidney Failure, Acute, Myopathy; Drugs
The Potential Protective Effect of Using Muscle Relaxants During Electroporation Ablation (PFA)
The study aims to improve the safety of the electroporation ablation (PFA) procedure by using muscle relaxants to reduce skeletal muscle damage during the procedure.
- Conditions
- Kidney Failure, Acute, Myopathy; Drugs, Heart Arrhythmia, Succinylcholine Sensitivity
- Trial name
- NCT06707532
- Testing
- Propofol, Rocuronium
- Where
- Poland
- Volunteers
- 32 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland
Radiation Exposure
Reference Dose Levels During Fluoroscopically Guided Procedures in Operating Rooms
This study is conducted by a working group of the French Society of Medical Physics (SFPM). Its main aim is to establish reference dose levels for the most common procedures performed in operating rooms using mobile X-ray…
- Trial name
- NCT03649451
- Where
- France
- Volunteers
- 8,840 people
- Sponsor
- Societe Francaise de Physique Medicale
Toxic Nodular Goitre, Graves' Disease
Block-replacement Therapy During Radioiodine Therapy
Background: The use of radioactive iodine (131I) therapy as the definite cure of hyperthyroidism is widespread. According to a survey on the management of Graves' disease, thirty per cent of physicians prefer to render their…
- Trial name
- NCT00150124
- Testing
- MTZ+LT4, Methimazole
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Steen Bonnema
Drug/Agent Toxicity by Tissue/Organ, Lung Cancer
Amifostine in Treating Patients With Stage II or Stage III Non-small Cell Lung Cancer
RATIONALE: Amifostine may be an effective treatment for the toxic side effects caused by radiation therapy and chemotherapy. It is not yet known whether chemotherapy and radiation therapy are more effective with or without…
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Lung Cancer, Oral Complications, Radiation Toxicity
- Trial name
- NCT00003313
- Testing
- filgrastim, amifostine trihydrate, carboplatin
- Where
- 264 sites in United States, Canada
- Volunteers
- 243 people
- Sponsor
- Radiation Therapy Oncology Group
Peripheral Arterial Disease, Peripheral Artery Disease
Digital Variance Angiography in Diagnostic Angiographies for Effective Radiation Dose Reduction
Digital Variance Angiography (DVA) is a new tool in medical imaging with proven image quality reserve. The previously observed quality reserve of Digital Variance Angiography (DVA) in lower extremity angiographies, allowed to…
- Conditions
- Peripheral Arterial Disease, Peripheral Artery Disease, Femoral Artery Stenosis, Femoral Artery Occlusion
- Trial name
- NCT04343196
- Testing
- Diagnostic Angiography (DSA or DVA based on randomization result)
- Where
- Hungary
- Volunteers
- 114 people
- Sponsor
- Kinepict Health Ltd.
Exposure
New Fabric Attenuation Device in Endovascular Interventional Radiology (PREFER)
The PREFER Trial primary objective of the trial is to show how much radiation attenuation is provided by XPF in absolute and relative terms.
- Trial name
- PREFER (NCT01450969)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Baptist Health South Florida
Radiation Exposure
Clinical Evaluation of a Novel Textile Radiation Protection Device
This study will use procedure-specific dosimetry to evaluate whether Texray's novel woven radiation protection fabric (HeadPeace and MindPeace) reduces occupational radiation dose to the head and thyroid of interventional…
- Trial name
- NCT07768605
- Testing
- Standard PPE, Texray PPE
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Esophageal, Toxicity
MnSOD (Esophageal Protectant) to Prevent Esophagitis During Radiation/Chemotherapy Treatment for Non-Small Cell Lung Cancer (NSCLC)
This is a Phase I-II study evaluating the feasibility, safety, and efficacy of swallowed MnSOD plasmid/liposome (PL) transgene given as protection against radiation-induced esophagitis during concurrent paclitaxel and carboplatin…
- Trial name
- MnSOD (NCT00618917)
- Testing
- Manganese Superoxide Dismutase Plasmid Liposome, carboplatin, paclitaxel
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Joel Greenberger
Radiation Nephropathy
AminoMedixTM for Kidney Protection During Radionuclide Therapy
This is a phase I, and II, single-center, open-label clinical trial to evaluate the safety and preliminary efficacy information of AminoMedix™ in protecting kidneys from radiation-induced toxicity during Peptide Receptor…
- Trial name
- NCT05785663
- Volunteers
- 28 people
- Sponsor
- Excel Diagnostics and Nuclear Oncology Center
Exposure to Medical Diagnostic Radiation
Simplification of Low Level Internal Dosimetry
This is a pilot study with the primary aim being to identify the minimum number of scans and measurements necessary to determine accurately the absorbed radiation doses delivered from internal sources of radiation administered…
- Trial name
- SOLLID (NCT03580161)
- Testing
- 18-F FDG PET/CT dosimetry scans and measurements, Ga-68 PSMA PET/CT dosimetry scans and measurements, 68-Ga Dotatate PET/CT dosimetry scans and measurements
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Non Small Cell Lung Carcinoma
Phase II Study of Celecoxib and Concurrent Radiotherapy in Stage II-III NSCLC
The purpose of this study is to investigate the effect of the adminstration of celecoxib, a cox2-inhibitor in patients with stage II-III non small cell lung cancer receiving radical radiotherapy.
- Trial name
- NCT00181532
- Testing
- Celecoxib
- Where
- Netherlands
- Volunteers
- 102 people
- Sponsor
- Maastricht Radiation Oncology
Radiation Exposure to Operator
Physician Radiation Exposure During Radial Access Cardiac Catheterization Using a RAD Board
Radiation exposure to operator is an occupational hazard of invasive cardiologists. During radial access for diagnostic catheterization, a new radio-dense arm board is advertised to reduce operator radiation exposure.
- Trial name
- NCT02088788
- Testing
- Board, No Board
- Where
- United States
- Volunteers
- 265 people
- Sponsor
- Geisinger Clinic
Prostate Cancer
Nanocurcumin for Prostate Cancer Patients Undergoing Radiotherapy (RT)
There is a growing body of evidence exploring the role of curcumin as a radioprotector against radiation-induced injury in normal tissues as well as a radiosensitizer in tumor cells.
- Trial name
- NCT02724618
- Testing
- Curcumin, RT
- Where
- Iran
- Volunteers
- 64 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Radiation Induced Oral Mucositis
A Study of the Effects of GC4419 on Radiation Induced Oral Mucositis in Patients With Head/Neck Cancer
The purpose of the phase 2, GT-201 clinical study is to determine if GC4419 administered prior to intensity-modulated radiation therapy (IMRT) reduces the incidence, duration, and severity of radiation induced oral mucositis in…
- Trial name
- NCT02508389
- Testing
- Low Dose GC4419: 30mg/day, High Dose GC4419: 90mg/day, Intensity-Modulated Radiation Therapy
- Where
- 64 sites in United States, Canada and 1 more
- Volunteers
- 223 people
- Sponsor
- Galera Therapeutics, Inc.