Clinical trials: Radiation Retinopathy
Radiation Retinopathy, Visual Impairment
Intravitreal Faricimab Injections or Fluocinolone Acetonide (0.19 mg) Intravitreal Implants vs Observation for Prevention of VA Loss Due to Radiation Retinopathy
This randomized controlled trial will evaluate the effect of intravitreal faricimab or fluocinolone acetonide (FAc) intravitreal implant compared with observation on long-term visual acuity following treatment of choroidal…
- Trial name
- AL (NCT05844982)
- Testing
- Faricimab, fluocinolone acetonide
- Where
- 29 sites in United States
- Volunteers
- 600 people
- Sponsor
- Jaeb Center for Health Research
Macular Edema, Radiation Retinopathy
Episcleral Dexamethasone for Treatment of Macular Edema and Inflammatory Disorders of the Posterior Pole
This phase I trial will assess primarily the safety and secondarily anti-inflammatory effect of Episcleral Dexamethasone in patients suffering from macular edema and other disorders of the retina, choroid and vitreous.
- Conditions
- Macular Edema, Radiation Retinopathy, Branch Retinal Vein Occlusion, Epiretinal Membrane
- Trial name
- NCT04120311
- Testing
- Episcleral Dexamethasone
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Targeted Therapy Technologies, LLC
Macula Edema, Radiation Retinopathy
Phase I Study of Episcleral Celecoxib for Treatment of Macular Edema and Inflammatory Disorders of the Posterior Pole
This phase I trial will assess primarily the safety and secondarily the anti-inflammatory and anti-neovascular effect of Episcleral Celecoxib in patients suffering from macular edema and other inflammatory disorders of the…
- Conditions
- Macula Edema, Radiation Retinopathy, Branch Retinal Vein Occlusion, Epiretinal Membrane
- Trial name
- NCT04120636
- Testing
- Episcleral Celecoxib
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Targeted Therapy Technologies, LLC
Radiation Retinopathy
Steroids for Early Treatment of Radiation Retinopathy
Radiation retinopathy is a known complication of ocular radiation therapy. To date there is no known effective treatment. In addition to their anti-vascular endothelial growth factor (VEGF) properties, corticosteroids decrease…
- Trial name
- NCT03238157
- Testing
- Fluocinolone Acetonide (FA) implant
- Where
- United States
- Sponsor
- The Cleveland Clinic
Radiation Retinopathy
Study of the Efficacy and Tolerability of Intravitreal Injections of Ranibizumab Compared to Intravitreal Injections of Ranibizumab Combined With Targeted Retinal Photocoagulation to Treat Radiation Retinopathy.
The purpose of this study is to assess the tolerability and efficacy of ranibizumab treatment administered in subjects with radiation retinopathy
- Trial name
- RRR (NCT02222610)
- Testing
- 0.5 mg ranibizumab, Targeted Retinal Photocoagulation (TRP)
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Greater Houston Retina Research
Radiation Retinopathy
Intravitreal Aflibercept Injection for Radiation Retinopathy Trial
The ARRT trial will assess the safety and efficacy of 2mg aflibercept for the treatment of radiation retinopathy, including maculopathy and optic neuropathy over 52 weeks.
- Trial name
- ARRT (NCT03085784)
- Testing
- Aflibercept
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Amy C Schefler, MD
Macular Edema, Cystoid Macular Edema
Dexamethasone Intravitreal Implant for Treatment of Macular Edema After Plaque Radiotherapy of Uveal Melanoma
To evaluate the safety and efficacy of dexamethasone intravitreal implant (Ozurdex) and compare it with safety and efficacy of intravitreal bevacizumab in eyes with macular edema after plaque radiotherapy of uveal melanoma.
- Conditions
- Macular Edema, Cystoid Macular Edema, Uveal Melanoma, Radiation Maculopathy
- Trial name
- NCT01471054
- Testing
- Ozurdex, Bevacizumab
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Arman Mashayekhi
Radiation Retinopathy, Macular Edema
Intravitreal Aflibercept Injection for Radiation Retinopathy
The purpose of this study is to assess the safety of intravitreal aflibercept injection - in the treatment of macular edema associated with retinopathy secondary to previous radiation therapy.
- Trial name
- NCT01579760
- Testing
- Aflibercept every 2 months, Aflibercept monthly
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Washington University School of Medicine
Radiation Retinopathy
High Dose Intravitreal Ranibizumab for Recalcitrant Radiation Retinopathy
This study investigates the use of a high dose anti-VEGF agent for the treatment of radiation retinopathy in those patients who have recalcitrant disease.
- Trial name
- NCT01334879
- Testing
- ranibizumab 2.0 mg
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The New York Eye Cancer Center
Radiation Retinopathy, Choroidal Melanoma
Effect of Intravitreal Ranibizumab on Radiation Retinopathy Following Plaque Brachytherapy for Choroidal Melanoma
This is a Phase I clinical trial to test the safety and tolerability of intravitreal ranibizumab in the treatment of radiation retinopathy following plaque brachytherapy for patients with choroidal melanoma using the incidence…
- Trial name
- NCT00750399
- Testing
- Ranibizumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The New York Eye Cancer Center
Uveal Melanoma, Radiation Retinopathy
Intravitreal Ranibizumab for the Prevention of Radiation Maculopathy Following Plaque Radiotherapy
Uveal Melanoma is the most common primary intraocular malignancy in adulthood. Eye preserving treatments can deliver equivalent life prognosis in the management of small and medium sized uveal melanomas, as compared to…
- Conditions
- Uveal Melanoma, Radiation Retinopathy, Radiation Maculopathy
- Trial name
- NCT00540930
- Testing
- Ranibizumab
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Shields, Shields and Associates