Clinical trials: Radiation Therapy
Breast Cancer, HER2-positive Breast Cancer
Investigating the Long-term Cardiac Sequelae of Trastuzumab Therapy
The introduction of trastuzumab for the treatment of patients with human epidermal growth factor receptor 2 (HER2) positive breast cancer has had a major impact upon cancer outcomes.
- Conditions
- Breast Cancer, HER2-positive Breast Cancer, Cardiotoxicity
- Trial name
- NCT05019365
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Healthy
Novel Positron Emission Tomography (PET) Radiotracer to Image Phosphodiesterase-4B (PDE4B)
Background: The new drug 18F-PF-06445974 has a little radioactivity. This can be seen by a positron emission tomography (PET) scan. The drug helps researchers see a protein, PDE4B, in the brain.
- Trial name
- NCT03030391
- Testing
- PET, MRI
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
MNRI, Development Delay
Effects of MNRI Therapy on Fine Motor Skills in Children With Developmental Delays.
Developmental delay refers to a child's failure to achieve age-appropriate developmental milestones and may affect multiple developmental domains.
- Trial name
- NCT07764926
- Testing
- MNRI, Conventional Physiotherapy without MNRI
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Salivary Redox Biomarkers and Oral Health
Oral Health Condition Among a Group of Ionizing Radiation Field Workers
The goal of this study is to test the effect of ionizing radiation on salivary Redox status among a group of ionizing radiation workers by measuring salivary biomarkers(malondialdehyde,8_hydroxy_deoxyguanosine and catalase) and…
- Trial name
- NCT07020078
- Testing
- Salivary redox biomarkers
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Al-Mustansiriyah University
Chemotherapy Induced Cardiotoxicity
Cardiac Magnetic Resonance for Early Detection of Chemotherapy or Radiation Therapy Induced Cardiotoxicity in Breast Cancer (CareBest)
Chemotherapy or radiation therapy-induced cardiotoxicity are well-recognized side effects in patients with cancer. The clinical significance of cardiotoxicity is growing with increasing cancer survivor-ship.
- Trial name
- NCT03301389
- Testing
- Cardiac magnetic resonance imaging
- Where
- South Korea
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Photobiology
Placebo-controlled Assessment of the Effect of a Food Supplement on Skin Protection After Exposure to UV Radiation
A probiotic bacterial strain was tested in a randomized, double blind , placebo controlled clinical trial with 54 healthy male volunteers.
- Trial name
- NCT00351689
- Testing
- dietary supplement
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- L'Oreal
Radiation Dose Reduction
Tin Filter Calcium Scoring
The aim of this study is to prospectively investigate the diagnostic performance and potential radiation dose reduction in coronary artery calcium scoring using the new tin filter system of the 3rd generation DSCT scanner.
- Trial name
- NCT02855528
- Testing
- Tin Filter
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Vitamin D Deficiency, Vitamin D Insufficiency
Evaluating the Effect of SOLIUS UV Light Source in Improving Vitamin D Status
The aim of this study is to evaluate the safety and effectiveness of the SOLIUS System in improving serum levels of 25-hydroxyvitamin D in vitamin D deficient/ insufficient adults of various skin types.
- Trial name
- NCT04780776
- Testing
- UVB treatment
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Boston University
Head and Neck Cancer
Clinical Trial on the Efficacy and Safety of Chining Decoction in the Treatment of Radiation Stomatitis
This study evaluates the efficiency and safety of ChiNing decoction to head and neck cancer patients with radioactive stomatitis.
- Trial name
- NCT02303197
- Testing
- ChiNing decoction
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Glioma Tumor Recurrence, Radiation Necrosis
Diffusion Tensor MRI to Distinguish Brain Tumor Recurrence From Radiation Necrosis
This study will examine the use of a variation of standard magnetic resonance imaging (MRI) called diffusion tensor MRI (DT-MRI) for distinguishing injured brain tissue due to radiation therapy (radiation necrosis) from the…
- Conditions
- Glioma Tumor Recurrence, Radiation Necrosis, Primary Brain Tumor
- Trial name
- NCT00285324
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Prostate Cancer
Carbon-11 Labeled Sarcosine in Prostate Cancer
Men with and without prostate cancer will have a PET/CT scan that measures the level of the amino acid sarcosine. PET is a scanning method that uses short lived radioactivity.
- Trial name
- NCT02462447
- Testing
- 11C-sarcosine, 11C-choline
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Cervix Cancer, Radiotherapy, Adjuvant
Postoperative Hypofractionated Intensity-modulated Radiation Therapy in Cervical Cancer
To investigate the acute toxicities, late toxicities, and treatment results when the early cervical cancer patients are treated by hypofractionated intensity-modulated radiotherapy (2.5 Gy X 16 fractions, once a day) after…
- Conditions
- Cervix Cancer, Radiotherapy, Adjuvant, Radiotherapy, Intensity-Modulated, Hypofractionated Dose
- Trial name
- NCT03239626
- Testing
- POHIM-RT
- Where
- South Korea
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Solid Tumor Malignancies
ALI Post Radiation Therapy in Patients With Lung and Esophageal Canter
The goal of this clinical research study is to learn if giving autologous lymphocyte infusions to patients who are receiving chemotherapy and radiation for non-small cell lung cancer or esophageal cancer is safe and effective.
- Trial name
- NCT04668833
- Testing
- Autologous lymphocyte infusion (ALI)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Microvascular Dysfunction, Endothelial Dysfunction
Nailfold Capillaroscopy and Endothelial Biomarkers in Healthcare Workers Exposed to Chronic Low-Dose Ionizing Radiation
Chronic occupational exposure to low-dose ionizing radiation may lead to subclinical endothelial dysfunction and early microvascular alterations in healthcare workers.
- Conditions
- Microvascular Dysfunction, Endothelial Dysfunction, Occupational Radiation Exposure
- Trial name
- NCT07363187
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul Training and Research Hospital
Erectile Dysfunction, Erectile Dysfunction Following Radical Prostatectomy
Low Intensity Shockwave Therapy for Erectile Dysfunction
Low-intensity shockwave therapy (LiSWT) has been deemed "a safe and well-tolerated procedure but its efficacy for the treatment of ED is doubtful and deserves more investigation" by the European Society of Sexual Medicine.
- Conditions
- Erectile Dysfunction, Erectile Dysfunction Following Radical Prostatectomy, Erectile Dysfunction Following Radiation Therapy, Erectile Dysfunction Due to General Medical Condition
- Trial name
- NCT04434352
- Testing
- Storz Duolith Low-Intensity Shockwave Therapy
- Where
- United States
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Melanoma
Melanoma Risk-Reduction Among Patients and Family Members
Primary Objectives: To conduct semi-structured interviews with melanoma patients and family members to collect descriptive information on their UVR exposure, UVR exposure-reduction practices, melanoma early detection practices…
- Trial name
- NCT00510302
- Testing
- Questionnaire, Interview
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Diagnostic Agent Adverse Reaction, Radiation Exposure
18F-LY3950321-01 Biodistribution and Safety Study
18F-LY3950321 (also known as 18F-MNI-1256) is a radiolabeled positron emission tomography (PET) tracer targeting granzyme B. The overall goal of this protocol is to evaluate the safety, tolerability, and radiation dosimetry of…
- Trial name
- NCT05775601
- Testing
- 18F-LY3950321, PET Scan
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
Vaginal Stricture
Newly Designed Vaginal Stent to Improve Patient Comfort and Healing Following Vaginal Surgery or Vaginal Radiation
Each year, females need surgery to create a vaginal canal or pelvic radiation to treat cancer. The result is often a narrowing or scarring of their vagina. To aid in healing a stent is often placed.
- Trial name
- NCT04807387
- Testing
- Vaginal Stent A, Vaginal Stent B, Vaginal Stent
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Esophageal Squamous Cell Carcinoma, Oligometastatic Disease
Anti-PD-1 Immunotherapy Combined With SBRT for Patients With Oligometastatic ESCC
The goal of this phase II clinical trial is to explore the efficacy and safety of anti-PD1 combined with stereotactic body radiation therapy (SBRT) for patients with oligometastatic esophageal squamous cell carcinoma.
- Trial name
- NCT05626569
- Testing
- PD-1 combined with SBRT
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Financial Toxicity
A Survey of Financial Toxicity in Rural Cancer Patients
This project aims to elucidate the prevalence of financial toxicity, identify significant risk factors for toxicity, and understand the burdens of the specific St. Johnsbury rural population.
- Trial name
- NCT04032483
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center