Clinical trials: Radiation-Induced Parotid Gland Hypofunction
Parotid Salivary Dysfunction
Effect of AdhAQP1 on Salivary Flow in Patients Treated With Radiation for Head and Neck Cancer
This study will examine whether the experimental drug AdhAQP1 can increase salivary flow in patients whose parotid glands have been exposed to therapeutic radiation for treatment of head and neck cancer.
- Trial name
- NCT00372320
- Testing
- Gene Transfer, AdhAQP1
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Squamous Cell Head and Neck Cancer, Radiation Induced Xerostomia
Safety of a Single Administration of AAV2hAQP1, an Adeno-Associated Viral Vector Encoding Human Aquaporin-1 to One Parotid Salivary Gland in People With Irradiation-Induced Parotid Salivary Hypofunction
Background: Radiation can cause the parotid salivary glands to make less saliva (dry mouth). This can cause problems like infections and tooth decay. Researchers hope a new drug can help people with dry mouth caused by radiation.
- Conditions
- Squamous Cell Head and Neck Cancer, Radiation Induced Xerostomia, Salivary Hypofunction
- Trial name
- NCT02446249
- Testing
- AAV2hAQP1
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- MeiraGTx, LLC
Radiation-Induced Parotid Gland Hypofunction, Xerostomia Due to Radiotherapy
A Phase 1 Open-Label, Dose Escalation Study to Determine the Optimal Dose, Safety, and Activity of AAV2hAQP1 in Subjects With Radiation-Induced Parotid Gland Hypofunction and Xerostomia
Open-label, non-randomized, dose escalation trial of AAV2hAQP1 administered via Stensen's duct to a single or both parotid glands in subjects with radiation-induced xerostomia The objectives are to evaluate the safety and…
- Conditions
- Radiation-Induced Parotid Gland Hypofunction, Xerostomia Due to Radiotherapy, Head and Neck Cancer
- Trial name
- NCT04043104
- Testing
- AAV2hAQP1: 1 x 10^11 vg/gland (single gland), AAV2hAQP1: 3 x 10^10 vg/gland (both glands), AAV2hAQP1: 3 x 10^11 vg/gland (single gland)
- Where
- 6 sites in United States, Canada
- Volunteers
- 24 people
- Sponsor
- MeiraGTx UK II Ltd
Radiation-induced Xerostomia
Long-Term Follow-Up Study of AAV2hAQP1 for Radiation Induced Xerostomia
This study is a long-term follow-up study for patients who have been administered AAV2hAQP1 in the Phase 1 Open-Label, Dose Escalation Study to Determine the Optimal Dose, Safety, and Activity in Subjects with Radiation Induced…
- Trial name
- NCT05060341
- Where
- 4 sites in United States, Canada
- Volunteers
- 22 people
- Sponsor
- MeiraGTx, LLC