Clinical trials: Radiation-induced Oral Mucositis
Head and Neck Cancer, Oral Mucositis
Edible Plant Exosome Ability to Prevent Oral Mucositis Associated With Chemoradiation Treatment of Head and Neck Cancer
This study will evaluate the ability of grape exosomes, given to the subject as grape powder, as an important anti-inflammatory agent to reduce the incidence of oral mucositis during radiation and chemotherapy treatment for head…
- Trial name
- NCT01668849
- Testing
- Grape extract, Lortab, Fentanyl patch, mouthwash
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Louisville
Mucositis Oral
Glutamine Combined With Thalidomide in Preventing Radiation-induced Oral Mucositis
The goal of this study is to compare glutamine combined with thalidomide with glutamine in preventing radiation-induced oral mucositis.
- Trial name
- NCT06031012
- Testing
- glutamine combined with thalidomide, glutamine alone
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Air Force Military Medical University, China
Quality of Life, Oral Mucositis
Efficacy of a Probiotic and Microbiological Analysis on Oral Complications in Patients With HNC
The study is a Clinical Trial and the main objective is to Evaluate the effects of probiotics on oral complications induced by antineoplastic therapies in patients with head and neck cancer, attended at the radiotherapy service…
- Conditions
- Quality of Life, Oral Mucositis, Dental Plaque, Periodontal Diseases
- Trial name
- HNC (NCT06122636)
- Testing
- The probiotic to be used in the intervention corresponds to PRODEFEN Plus manufactured by ITALFARMACO S.A. laboratory
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- University of Barcelona
Radiotherapy Side Effect, Mucositis
Adjunctive Treatments for the Prevention of Radiotherapy-Induced Mucositis
Radiation therapy (RT) is used in at least 50% of cancer patients and is critical in treating and palliating tumor-related symptoms.
- Trial name
- NCT06117904
- Testing
- MEBO ointment, Symptomatic treatment only
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
Oral Mucositis
Effectiveness of Low Energy Laser Treatment in Oral Mucositis Induced by Chemotherapy and Radiotherapy in Head and Neck Cancer
The purpose of this study is to evaluate the effectiveness of using to low intensity laser as an intervention against preventive and therapeutic oral mucositis induced by radiotherapy and chemotherapy.
- Trial name
- NCT01876407
- Testing
- Low intensity laser for oral mucositis, Low intensity laser for oral mucositis switch off
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Fundación Pública Andaluza Progreso y Salud
Radiation Mucositis
Effect of Aloe Vera Gel and Manuka Honey on Radiation Induced Oral Mucositis
The goal of this [ type of study: Clinical trial] is to test effectiveness of Aloe Vera Gel and Manuka Honey in management of Radiation Induced Mucositis in head and neck cancer patients.
- Trial name
- NCT06381635
- Testing
- Manuka honey mixed with aloe vera gel
- Where
- 2 sites in Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Head and Neck Cancer, Oropharyngeal Cancer
Reflux Disease in Head and Neck Cancer Patients Undergoing Radiation Therapy
The goal of this clinical research study is to learn if radiation-induced xerostomia [RIX] (dry mouth) causes, or worsens the effects of, acid reflux (heartburn and heartburn-like symptoms) in head and neck cancer (HNC) patients…
- Conditions
- Head and Neck Cancer, Oropharyngeal Cancer, Gastroesophageal Reflux Disease
- Trial name
- NCT00928161
- Testing
- Dexlansoprazole
- Sponsor
- M.D. Anderson Cancer Center
Oral Mucositis
A Mouthwash Medicine for the Reduction or Prevention of Mouth Ulceration Caused by Radiotherapy for Head and Neck Cancer
This study is looking at a new medication called NG11-2 to see if it can reduce a side effect called severe Radiation-induced Oral Mucositis (RIOM) that can happen to people getting radiation treatment for head and neck cancer.
- Trial name
- NCT06669390
- Testing
- NG11-2
- Where
- 4 sites in United Kingdom
- Volunteers
- 15 people
- Sponsor
- VasoDynamics Ltd
Radiation-Induced Mucositis, Head and Neck Cancer
Curcumin Gel On Radiation Induced Oral Mucositis
The goal of this clinical study is to investigate the effect of a curcuma longa oral gel (curenext) on reducing radiation-induced oral mucositis severity in cancer patients and provide a context for understanding if there is a…
- Trial name
- NCT05982197
- Testing
- Curcumin Gel, Standard Preparation
- Where
- Iraq
- Volunteers
- 40 people
- Sponsor
- University of Baghdad
Chemotherapy- and/or Radiation-induced Oral Mucositis
A Trial of Episil® Oral Liquid in Cancer Patients Suffering From Chemotherapy- and/or Radiation-induced Oral Mucositis
This is a randomized, multi-center, single-use, active-controlled, two-stage open study of episil®. The purpose of this study is to assess the local analgesic effect of episil® in cancer patients suffering from chemotherapy…
- Trial name
- NCT03546985
- Testing
- episil®, Kang Su
- Where
- 7 sites in China
- Volunteers
- 60 people
- Sponsor
- Solasia Pharma K.K.
Oral Mucositis, Nausea
ZeroTolerance Mucositis: Managing Oral and Alimentary Mucositis With High Potency Sucralfate - ProThelial
RATIONALE: Polymerized (cross-linked) sucralfate malate paste (ProThelial) may be an effective single therapy approach for the management of chemoradiation mucositis, treating and preventing its occurrence in the oral cavity…
- Conditions
- Oral Mucositis, Nausea, Vomiting, Diarrhea
- Trial name
- NCT02016807
- Testing
- ProThelial
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Ashley Downs Bioscience
Radiation-induced Mucositis of Oral Mucous Membranes
Assessing the Preventing and Therapeutic Effect of Propolis in Radiotherapy Induced Mucositis of Head and Neck Cancers
The purpose of this study is to determine whether propolis is effective in the treatment and prevention of radiotherapy induced oral mucositis.
- Trial name
- NCT01375088
- Testing
- propolis
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Mashhad University of Medical Sciences
Radiation-Induced Mucositis
Effect of N-acetyl Cysteine and Zinc in Management of Head and Neck Cancer Radiotherapy Induced Oral Mucositis
The majority of individuals diagnosed with head and neck cancer, who undergo radiotherapy or concurrent Chemoradiotherapy, experience oral mucositis.
- Trial name
- NCT06482034
- Testing
- N-acetyl cysteine, Zinc sulfate, saline mouth wash
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Malignant Head and Neck Neoplasm, Mucositis
Gabapentin Compared to Standard of Care in Preventing Mucositis in Patients With Stage III-IV Head and Neck Cancer Undergoing Primary or Adjuvant Chemoradiation Therapy
This randomized phase III trial studies how well gabapentin plus standard of care work compares to standard of care without Gabapentin in preventing inflammation of the mucous membranes (mucositis) in patients with stage III-IV…
- Conditions
- Malignant Head and Neck Neoplasm, Mucositis, Radiation-Induced Disorder
- Trial name
- NCT02480114
- Testing
- Educational Intervention, Gabapentin, Pain Therapy
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Breakthrough Pain, Mucositis
Intranasal Transmucosal Fentanyl Pectin for Breakthrough Cancer Pain in Radiation-induced Oropharyngeal Mucositis
An open-label, non-randomized study to assess the titration, safety and efficacy of intranasal fentanyl pectin nasal spray for the treatment of secondary breakthrough pain secondary to radiation-induced mucositis in patients with…
- Conditions
- Breakthrough Pain, Mucositis, Radiotherapy, Chemotherapy
- Trial name
- CP073 (NCT02050503)
- Where
- Spain
- Volunteers
- 33 people
- Sponsor
- Grupo de Investigación Clínica en Oncología Radioterapia
Pain, Nasopharyngeal Carcinoma
Comparison of Transdermal Fentanyl and Morphine for Oral Mucositis Pain in Nasopharyngeal Cancer Patients
The primary purpose of this study is to explore the significance of analgesic treatment for radiation-induced oral mucositis pain in patients with nasopharyngeal carcinoma during radiotherapy, and to compare the analgesic effect…
- Conditions
- Pain, Nasopharyngeal Carcinoma, Head and Neck Cancer, Radiation Induced Oral Mucositis
- Trial name
- NCT04292990
- Testing
- Fentanyl, Morphine
- Volunteers
- 300 people
- Sponsor
- Jiarong Chen, MD
Nasopharyngeal Carcinoma, Head and Neck Cancer
Plasma SAA1 Levels in Predicting Response to Radiotherapy-induced Oral Mucositis
Head and neck squamous cell carcinoma (SCC) is the sixth most common cancer worldwide, with more than 700,000 new cases and more than 350,000 deaths each year.
- Conditions
- Nasopharyngeal Carcinoma, Head and Neck Cancer, Radiotherapy-induced Oral Mucositis, Biomarker
- Trial name
- NCT06307314
- Where
- 5 sites in China
- Volunteers
- 300 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Cancer, Mucositis
Effect of Topical Morphine (Mouthwash) on Oral Pain Due to Chemo- and/or Radiotherapy Induced Mucositis
Introduction: Oral pain due to mucosal lesion is quite frequent in oncology, geriatric as well as palliative care settings. The oncology patient is mainly suffering from radio- and/or chemotherapy induced oral mucositis.
- Trial name
- NCT00613743
- Testing
- mouth wash with morphine
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Radiation-induced Oral Mucositis
Benzydamine for Radiation-Induced Oral Mucositis in Patients Receiving High-Dose Radiotherapy
This single-center, open-label, randomized clinical trial evaluates the effect of 0.15% benzydamine hydrochloride (Difflam) oral spray on the severity of radiation-induced oral mucositis in patients with head and neck cancer…
- Trial name
- NCT07467759
- Testing
- benzydamine hydrochloride, saline mouth rinse
- Where
- Syria
- Volunteers
- 35 people
- Sponsor
- Latakia University
Oncology
Prophylactic Oral Vitamin D and Zinc for Radiation-Induced Oral Mucositis in Head and Neck Cancer
The main aim of this study was to evaluate clinically the effect of a combination between oral vitamin D and oral zinc in comparison to conventional therapy in prevention of radiotherapy-induced oral mucositis in Assiut…
- Trial name
- NCT06100692
- Testing
- Vitamin D
- Volunteers
- 100 people
- Sponsor
- Assiut University