Clinical trials: Radiodermatitis
Breast Cancer
RTA 408 Lotion in Patients at Risk for Radiation Dermatitis - PRIMROSE
Radiation dermatitis is experienced by almost all patients (up to 95%) receiving radiation therapy for cancer. Radiation dermatitis can be a serious condition because, in addition to its direct physical complications and the…
- Trial name
- NCT02142959
- Testing
- Omaveloxolone Lotion 0.5%, Omaveloxolone Lotion 3%, Vehicle Lotion
- Where
- 27 sites in United States
- Volunteers
- 187 people
- Sponsor
- Biogen
Central Nervous System Sarcoma, Ependymoma
StrataXRT in Preventing Radiation Dermatitis in Pediatric Patients Undergoing Radiation Therapy to the Brain or Spinal Cord
This phase I trial studies the side effects of a silicone topical wound dressing (StrataXRT) and to see how well it works in preventing radiation dermatitis (skin burns and side effects caused by radiation) in pediatric patients…
- Conditions
- Central Nervous System Sarcoma, Ependymoma, Glioma, Malignant Intracranial Germ Cell Tumor
- Trial name
- NCT03990597
- Testing
- Questionnaire Administration, Wound Dressing Material
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Radiation Dermatitis
Laser Therapy for the Management of Radiation Dermatitis
Low Level Laser Therapy (LLLT) is a form of phototherapy which involves the application of light to injuries and lesions to promote tissue regeneration.
- Trial name
- DERMIS (NCT01932073)
- Testing
- Low-Level Laser Therapy
- Where
- Belgium
- Volunteers
- 79 people
- Sponsor
- Hasselt University
Radiodermatitis, Breast Cancer
Photobiomodulation Therapy for the Prevention of Acute Radiodermatitis in Breast Cancer Patients Undergoing Radiotherapy
Radiodermatitis (RD), an inflammatory skin reaction, occurs in more than 90 percent of cancer patients treated with radiotherapy (RT). This is the result of the radiation causing damage to the epidermal basal skin stem cells.
- Trial name
- LABRA (NCT03924011)
- Testing
- Photobiomodulation therapy (PBMT)
- Where
- 2 sites in Belgium
- Volunteers
- 71 people
- Sponsor
- Hasselt University
Anus Neoplasms, Rectal Neoplasms
Alkagin Paste in the Prevention of Radiation Dermatitis
The purpose of this study is to determine whether Alkagin paste is effective at preventing radiodermatitis in patients receiving external beam radiation therapy to the perineal area.
- Conditions
- Anus Neoplasms, Rectal Neoplasms, Urogenital Neoplasms
- Trial name
- NCT01408407
- Testing
- Aveeno cream, Alkagin paste
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Nasopharangeal Cancer
Topical Chlorhexidine Spray for the Prevention of Acute Radiation Dermatitis in Patients With Nasopharyngeal Carcinoma:
This study investigated the effects of topical chlorhexidine spray on the incidence, severity, and quality of life during radiotherapy in nasopharyngeal carcinoma patients.
- Trial name
- NCT07559877
- Testing
- 2% chlorhexidine, Sterile Water as control
- Where
- China
- Volunteers
- 148 people
- Sponsor
- Jiangxi Provincial Cancer Hospital
Radiodermatitis; Acute
A Study of GR1014 Cutaneous Gel for the Prevention of Skin Reactions Caused by Radiation Therapy for Breast Cancer
This clinical trial is testing a new skin gel called GR1014-CG to evaluate its safety and see if it can help prevent or reduce skin irritation (such as redness, soreness, etc.) caused by radiation therapy (RT) after…
- Trial name
- GuARD (NCT07192588)
- Testing
- GR1014-CG 2.4%, Vehicle Gel, Radiation Therapy
- Where
- 4 sites in France, United Kingdom
- Volunteers
- 273 people
- Sponsor
- Graegis Pharmaceuticals Ltd
Radiodermatitis, Injury, Radiation
Study Using Spray Skin Protector Versus Conventional Treatment to Prevent Acute Radiodermatitis.
This is a randomized, open-label, single-institution trial designed to evaluate the effectiveness of a spray skin protector in preventing moist desquamation caused by radiotherapy treatment.
- Trial name
- NCT04067310
- Testing
- Spray skin protector, moisturizer Dnativ Revita derm
- Where
- Brazil
- Volunteers
- 72 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Radiodermatitis; Acute, Radiotherapy Side Effect
The Use of Photobiomodulation in the Management of Radiodermatitis in Head and Neck Cancer Patients
It is estimated that there will be 670,000 new cases of cancer worldwide in 2020-2022 and it is known that the most commonly instituted treatments in cancer are chemotherapy, radiotherapy and surgery.
- Conditions
- Radiodermatitis; Acute, Radiotherapy Side Effect, Head and Neck Cancer
- Trial name
- NCT05557825
- Testing
- Photobiomodulation Therapy
- Where
- Brazil
- Volunteers
- 3 people
- Sponsor
- University of Nove de Julho
Radiation Dermatitis
Utilizing Topical Sodium Hypochlorite to Ameliorate Radiation Dermatitis
The objective of the pilot study is to determine compliance, acceptability, and feasibility of using topical sodium hypochlorite to ameliorate or reduce radiation dermatitis, and to collect preliminary data and estimates for…
- Trial name
- NCT04630821
- Testing
- Dilute Sodium Hypochlorite solution
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Northwestern University
Dermatitis, Mucositis
ALDH2 Mutation in Taiwanese Head and Neck Cancer
The purpose of this study is to evaluate the effect of ALDH2 mutation in radiation associating dermatitis or mucositis in head and neck cancer patients who accept chemoradiation therapy
- Trial name
- NCT02761408
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Radiation Dermatitis
Efficacy of Superoxide Dismutase in Preventing Radiation Dermatitis in Patients With Head and Neck Cancer .
Radiotherapy always results in many complications such as radiation dermatitis,dry mouth, cranial nerve damage, and swallowing function.
- Trial name
- NCT07399990
- Testing
- Saline Spray, SOD spray
- Volunteers
- healthy volunteers welcome
- Sponsor
- West China Hospital
Radiodermatitis; Acute, Radiation Dermatitis
Novel Skin Care Product for the Management of Acute Radiodermatitis
Notwithstanding the continuous progress in cancer treatment, patients with cancer still have to cope with quality of life (QoL) - impairing complications.
- Trial name
- RTSkin (NCT04929808)
- Testing
- Hydrating emollient for acute radiodermatitis, Standard institutional skin care
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Jessa Hospital
Radiation Dermatitis, Head and Neck Cancer
Deep Learning-based Classification and Prediction of Radiation Dermatitis in Head and Neck Patients
to develop a deep learning-based model to grade the severity of radiation dermatitis (RD) and predict the severity of radiation dermatitis in patients with head and neck cancer undergoing radiotherapy, so as to provide support…
- Trial name
- NCT05607225
- Where
- 2 sites in China
- Volunteers
- 300 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Radiodermatitis; Acute
Use of Topical Olive Oil Cream for Prophylaxis Against Acute Radiodermatitis in Breast Cancer Patients
This study aims to compare the prophylactic effect of topical betamethasone valerate cream and topical olive oil cream in the prevention of acute radiation dermatitis (ARD) in breast cancer patients treated with radiation.
- Trial name
- NCT05285943
- Testing
- Olive oil cream, Betamethasone Valerate Cream, Base Cream
- Where
- Egypt
- Volunteers
- 132 people
- Sponsor
- Cairo University
Breast Cancer
Curcumin for the Prevention of Radiation-induced Dermatitis in Breast Cancer Patients
Ionizing radiation is a toxic agent and widely accepted form of treatment for various types of cancer. Despite advances in medical technology, radiation therapy still causes severe early and late skin effects.
- Trial name
- NCT01042938
- Testing
- Curcumin C3 Complex
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Rochester
Radiation Therapy
Study to Evaluate the Safety of Colchicine
Currently, there are no approved medications for the prevention and treatment of radiation-induced dermatitis, or skin discoloration/burning due to radiation therapy, because there is little evidence to guide treatment.
- Trial name
- NCT05335148
- Testing
- oral colchicine(0.6 mg) once a day
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Rutgers, The State University of New Jersey
Mucositis Oral, Head and Neck Cancer
Photobiomodulation for the Prevention of Radiation Induced Oral Mucositis
Radiotherapy for head and neck cancer can cause severe mucositis (ulcers in the mouth) and pain. Photobiomodulation (Light therapy) will be used before and during radiotherapy to try to reduce the occurence and severity of…
- Conditions
- Mucositis Oral, Head and Neck Cancer, Radiation Dermatitis
- Trial name
- NCT04671862
- Testing
- Photobiomodulation
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Ottawa Hospital Research Institute
Radiation Dermatitis, Radiation Dermatitis Acute
Melatonin Cream Against Acute Radiation Dermatitis in Patients With Early Breast Cancer
The aim of the present randomized double-blinded placebo-controlled clinical trial is to investigate if melatonin can protect against acute radiation dermatitis in patients with early breast cancer receiving radiation therapy…
- Conditions
- Radiation Dermatitis, Radiation Dermatitis Acute, Breast Cancer
- Trial name
- MELADERM (NCT03716583)
- Testing
- Melatonin, Dimethyl Sulfoxide
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Dennis Bregner Zetner
Breast Cancer, Dermatitis
Barrier Film vs. Standard Skin Care in Preventing Dermatitis in Women With Breast Cancer Receiving Radiation
To evaluate the effectiveness of preventing Grade II or greater radiation dermatitis induced by adjuvant radiation therapy in women with breast cancer.
- Trial name
- NCT01762020
- Testing
- 3M Cavilon No Sting Barrier Film, Standard Preparation
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's