Clinical trials: Radiosurgery
Acromegaly
Late Effects of Radiosurgery on Acromegaly Study
Transsphenoidal surgery is the first-line treatment of acromegaly. Adjunctive radiotherapy can be necessary when surgery is ineffective to avoid a prolonged medical treatment.
- Trial name
- LateRAc (NCT02296216)
- Testing
- Gamma Knife radiosurgery
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Radionecrosis, Brain Metastases
Corticosteroids + Bevacizumab vs. Corticosteroids + Placebo (BEST) for Radionecrosis After Radiosurgery for Brain Metastases
This randomized phase II study aims to investigate whether the addition of bevacizumab to standard corticosteroid therapy results in greater improvement in symptoms and less treatment-induced symptoms compared with standard…
- Trial name
- NCT02490878
- Testing
- bevacizumab, corticosteroids
- Where
- 341 sites in United States, Canada
- Volunteers
- 19 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Brain Metastases
A Proof-of-principle Study of HBO-SRS for Brain Metastases
Patients with brain metastases who are candidates for treatment with stereotactic radiosurgery (SRS) are potential study participants.
- Trial name
- NCT01850563
- Testing
- Hyperbaric oxygen given at 2.4 ATA for 30 minutes immediately prior to SRS - HBOT for 30 minutes - SRS without prior HBO
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Large Brain Mets
Fractionated Stereotactic Radiosurgery for Large Brain Metastases
This is a research trial that seeks to break up the total radiation dose into multiple smaller radiation treatments, termed fractionated stereotactic radiosurgery (FSRS) which may make the treatment feasible.
- Trial name
- NCT02054689
- Testing
- Fractionated Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Steven Burton
Non Small Cell Lung Cancer
Stereotactic Radiosurgery and Systemic Dose Chemotherapy for Locally Advanced Lung Cancer
This is a pilot study looking at using stereotactic radiosurgery and full dose chemotherapy to treat stage II and III lung cancer that is not amendable to surgical resection.
- Trial name
- NCT02568033
- Testing
- Pemetrexed, Carboplatin, Cisplatin
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- The Cooper Health System
NSCLC, EGFR Gene Mutation
A Study to Evaluate the Efficacy of Osimertinib With Early Intervention SRS Treatment Compared to the Continuation of Osimertinib Alone, in Patients With EGFR Mutated NSCLC and Asymptomatic Brain Metastases
This study involves patients with EGFR-mutated NSCLC and asymptomatic brain metastases. This is an open-label, randomized study, comparing the continuation of Osimertinib treatment alone to Osimertinib treatment combined with…
- Conditions
- NSCLC, EGFR Gene Mutation, EGF-R Positive Non-Small Cell Lung Cancer, Non-small Cell Lung Cancer
- Trial name
- NCT05033691
- Testing
- Stereotactic surgery
- Where
- Israel
- Volunteers
- 162 people
- Sponsor
- Hadassah Medical Organization
Renal Cell Carcinoma
Focal Ablative STereotactic Radiosurgery for Cancers of the Kidney
This study is evaluating the activity and efficacy of Stereotactic Ablative Body Radiotherapy (SABR) for the treatment of kidney cancers.
- Trial name
- FASTRACK II (NCT02613819)
- Testing
- SABR
- Where
- Australia
- Volunteers
- 71 people
- Sponsor
- Trans Tasman Radiation Oncology Group
Any Cancer With Multiple Bone Metastases
Treatment of Opioid-refractory Pain (WHO Level III) by Pituitary Radiosurgery
80% of palliative care cancer patients suffer from severe pain. The management of these pain improves the quality of life of these patients. The management of opioid pain refractory to date remains a difficulty for caregivers.
- Trial name
- Hyporadoul (NCT02637479)
- Testing
- GammaKnife®, 18F-2-fluoro-2-deoxy-D-glucose - positron emission tomography (FDG-PET), MRI
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Primary Central Nervous System Diffusing Large Cell Lymphoma
The Role of Surgical Resection AND Stereotactic Radiosurgery in Primary Central Nervous System -Diffuse Large B Cell Lymphoma
The objective of this observational study is to understand the long-term impact of surgery and gamma knife treatment on primary central diffuse large B-cell lymphoma.
- Trial name
- NCT07007611
- Volunteers
- 76 people
- Sponsor
- jiahong Deng
Brain Neoplasms, Adult, Malignant
Stereotactic Radiosurgery (SRS) Dose-Escalation Study for Brain Metastasis
SRS dose escalation for brain metastases in radiation-naïve patients will establish true tolerable doses, which may exceed the current standard doses.
- Trial name
- SRS (NCT02645487)
- Testing
- Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Texas Southwestern Medical Center
Non-small Cell Lung Cancer Stage I
Stereotactic Ablative Radiotherapy With Nivolumab for Early-Stage Operable Non-Small Cell Lung Cancer
Stage 1 non-small cell lung cancer (NSCLC) carries up to 30% chance of relapse in 5 years. This a phase 2 study that aims to determine the pathological complete response of the combination of stereotactic ablative radiotherapy…
- Trial name
- NCT04271384
- Testing
- nivolumab
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Hospital Israelita Albert Einstein
Spinal Metastases
Comparing SingLe- Vs Multi-Fraction Spine STereotActic Radiosurgery in Spinal Metastases
The goal of this study is to determine whether fractionated Stereotactic radiosurgery (SRS) for spine metastases is associated with improved local tumor control compared to single-fraction SRS.
- Trial name
- NCT06173401
- Testing
- Single-fraction spine SRS, Multi-fraction spine SRS
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Stanford University
Prostate Cancer
TRUEBEAM Stereotactic Body Radiotherapy for Localized Prostate Cancer
The purpose of this study is to determine the effects of TrueBeam stereotactic body radiosurgery in patients with prostate cancer.
- Trial name
- NCT04552509
- Testing
- Stereotactic Body Radiotherapy
- Where
- United States
- Volunteers
- 167 people
- Sponsor
- Linda Chan, MD
Brain Metastases
EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active
To learn if consolidative stereotactic radiosurgery (cSRS) can help to control central nervous system (CNS) disease in patients who have brain metastases and have a partial response or stable brain metastases after systemic…
- Trial name
- NCT06649058
- Testing
- Systemic Therapy, Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 316 people
- Sponsor
- M.D. Anderson Cancer Center
Lung Cancer, Brain Metastases
Clinical Evaluation of the Treatment of Intellectual Metastases by Radiosurgery Gamma Knife by Means of a Support System by Mask.
the Mask fixation isn't a new solution for the immobilization of the patient's head and has been used in current practice for long years.
- Trial name
- Mask (NCT02732769)
- Testing
- GammaKnifePerfexion®, GammaKnifeIcon®, Efficast®
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Radiotherapy
Effectiveness of Stereotactic RadioTherapy in Solid Primary Inoperable and Oligometastatic Cancer
The purpose of this study is to development of more effective treatment tactics of the stereotactic radiotherapy and radiosurgery alone and together with classic radiation therapy in primary inoperabel solid tumors and…
- Trial name
- ESRTSPIOC (NCT03461822)
- Where
- Azerbaijan
- Volunteers
- 400 people
- Sponsor
- The National Center of Oncology, Azerbaijan
Trigeminal Neuralgia Treated by Radiosurgery
Impact of Individual Radiosensitivity on Late Toxicities of Radiosurgery in Essential Trigeminal Neuralgia
Trigeminal neuralgia is intense, electric-shock-like facial pain, most often triggered by touch, chewing or speech. It results from dysfunction of the trigeminal nerve, the 5th cranial nerve.
- Trial name
- TRITON (NCT06863324)
- Testing
- Radiation induced Lymphocyte Apoptosis diagnostic test
- Where
- 2 sites in France, Monaco
- Volunteers
- 74 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Stage IV or Recurrent Carcinoma or Sarcoma
Definitive Therapy for Oligometastatic Solid Malignancies
Patients with metastatic cancer are usually treated with systemic therapy (treating the entire body) with the assumption that any localized treatment of clinically apparent metastases would not impact survival.
- Trial name
- NCT01898962
- Testing
- Complete Surgical Removal, Stereotactic Radiosurgery, Ablative external beam radiation dose
- Where
- 4 sites in United States
- Volunteers
- 110 people
- Sponsor
- Rocky Mountain Cancer Centers
Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma
Pembrolizumab and Stereotactic Radiosurgery for Melanoma or Non-Small Cell Lung Cancer Brain Metastases
This pilot trial studies the side effects of giving pembrolizumab together with stereotactic radiosurgery to treat patients with melanoma or non-small cell lung cancer that has spread to the brain.
- Conditions
- Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma, Mucosal Melanoma, Ocular Melanoma
- Trial name
- NCT02858869
- Testing
- Pembrolizumab, Stereotactic Radiosurgery
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Emory University
Adverse Radiation Effects, Radiation Necrosis
Microbiome Determinants of Adverse Effects of Stereotactic Radiosurgery
This prospective observational study will investigate the relationship between the gut microbiome and adverse effects following stereotactic radiosurgery (SRS).
- Trial name
- MICRO-ARE-SRS (NCT07767981)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Chicago