Clinical trials: Radiotherapy, Adjuvant
Bladder Cancer, Urothelial Carcinoma Bladder
Bladder Cancer Adjuvant Radiotherapy Trial
Aim and objectives: This trial aims to evaluate the role of adjuvant radiotherapy following chemotherapy in patients with high-risk features on histo-pathology after radical surgery for transitional cell carcinoma of urinary…
- Trial name
- BART (NCT02951325)
- Testing
- Adjuvant RT
- Where
- India
- Volunteers
- 153 people
- Sponsor
- Tata Memorial Centre
Prostate Cancer (Adenocarcinoma), Prostate CA
FK-PC101 as Adjuvant Therapy for Men With High-Risk Prostate Cancer
The goal of this clinical trial is to learn if the vaccine FK-PC101 works to delay or prevent the return of prostate cancer in men who have had surgery to remove their prostate cancer.
- Conditions
- Prostate Cancer (Adenocarcinoma), Prostate CA, Prostate Cancers, Prostate Cancer (Post Prostatectomy)
- Trial name
- NCT06636682
- Testing
- FK-PC101, Standard of Care (SOC)
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Cellvax Therapeutics Inc
Cancer Survivors, Cardiotoxicity
In-Bedroom Renewed Air as Anti-inflammatory Adjuvant Therapy in Cancer Survivors
The BREATHS trial aims to investigate whether overnight in-bedroom air filtration reduces inflammation and cardiac biomarkers in adult survivors of cancer who are at high risk for cardiovascular complications.
- Conditions
- Cancer Survivors, Cardiotoxicity, Cardiovascular Toxicity Induced by Antitumoral Drugs
- Trial name
- BREATHS (NCT06778122)
- Testing
- High efficiency particulate air filtration system (nightly administration), High efficiency particulate air filtration system (nightly and daily administration)
- Where
- 3 sites in Spain
- Volunteers
- 10 people
- Sponsor
- University College, London
Urothelial Cancer
Durvalumab And Radiation Therapy Followed by Adjuvant Durvalumab in Patients With Urothelial Cancer (T2-4 N0-2 M0) of the Bladder
This is an open label, multi-institutional, single arm study of a phase Ib study, followed by a phase II study of durvalumab with radiation therapy (RT) in patients with urothelial cancer (UC).
- Trial name
- DUART (NCT02891161)
- Testing
- durvalumab, Radiation Therapy
- Where
- 7 sites in United States
- Volunteers
- 26 people
- Sponsor
- Monika Joshi, MD
Uterine Cervical Neoplasm, Endometrial Neoplasms
Online Adaptive Radiotherapy for Postoperative Treatment of Endometrial and Cervical Cancer
Online adaptive radiotherapy (oART) has demonstrated to be feasible to reduce planning target volume (PTV) margins for postoperative treatment of endometrial and cervical cancer.
- Trial name
- NCT05869123
- Testing
- Online adaptive radiotherapy
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Peking Union Medical College Hospital
Nasopharyngeal Carcinoma
Therapeutic Gain by Induction-concurrent Chemoradiotherapy and/or Accelerated Fractionation for Nasopharyngeal Carcinoma
The objectives of this clinical study are threefold: 1. To compare the benefits in cancer control and survival obtained from adding induction-concurrent chemotherapy to radiation with those from adding concurrent-adjuvant…
- Trial name
- NCT00379262
- Testing
- Capecitabine, Adjuvant chemotherapy using PF (5-Fluorouracil ), Induction chemotherapy using PF (5-Fluorouracil)
- Where
- 7 sites in China
- Volunteers
- 803 people
- Sponsor
- Hong Kong Nasopharyngeal Cancer Study Group Limited
Glioblastoma Multiforme
Hypofractionated Radiation Therapy for Glioblastoma
Notwithstanding major improvements in treatment modalities, the prognosis of patients with glioblastoma is poor. Hypofractionated radiation therapy as an alternative of the standard 6-week regimen could be an attractive approach…
- Trial name
- NCT03212235
- Testing
- Hypofractionated radiation therapy
- Where
- Brazil
- Volunteers
- 58 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Lymphedema, Fibrosis
Hypofractionated Loco-regional Adjuvant Radiation Therapy of Breast Cancer Combined With a Simultaneous Integrated Boost
The purpose of the study is to investigate the difference in late radiation morbidity between hypofractionated and normofractionated loco-regional breast irradiation irrespective of mastectomy or lumpectomy.
- Trial name
- NCT02384733
- Testing
- Loco-regional RT
- Where
- Denmark
- Volunteers
- 2,963 people
- Sponsor
- Danish Breast Cancer Cooperative Group
Stage III NSCLC
Adjuvant Chemotherapy +/- Cemiplimab and Sequential Hypofractionated Radiotherapy in Unfit or Elderly Patients With Stage III Lung Cancer
The use of neoadjuvant immuno-chemotherapy could improve survival outcomes of patients eligible for sequential radio-chemotherapy comparing to the benefit already obtained with maintenance immunotherapy.
- Trial name
- SPORADIC (NCT06656598)
- Testing
- Carboplatin, Paclitaxel, Cemiplimab
- Where
- 25 sites in France
- Volunteers
- 152 people
- Sponsor
- Intergroupe Francophone de Cancerologie Thoracique
Mesothelioma, Pleural Mesothelioma
Pemetrexed (ALIMTA) Plus Cisplatin Followed by Surgery and Radiation Therapy for Mesothelioma
Despite the best surgical efforts, complete removal of mesothelioma is possible in approximately 30% of the patients. When surgical removal is complete, chemotherapy followed by radiation therapy is recommended as an effort to…
- Trial name
- NCT00895648
- Testing
- Pemetrexed, Cisplatin
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- University Health Network, Toronto
Rectal Cancer
Dose Escalation Trial of Nitroglycerin, 5-flourouracil and Rad Therapy for Rectal Cancer
The purpose of this study is to determine whether topical nitroglycerin in addition to 5-flourouracil and radiation therapy are effective in the treatment of operable rectal cancer.
- Trial name
- NCT01407107
- Testing
- Nitroglycerin 0.2 MG/HR, Nitroglycerin 0.4 MG/HR, Nitroglycerin 0.6 MG/HR
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Texas Southwestern Medical Center
Breast Cancer
Evaluating Harms and Benefits of Endocrine Therapy in Patients ≥70 Years of Age With Lower Risk Breast Cancer
The current standard of care for stage 1 hormone receptor-positive (HR+) breast cancer consists of breast-conserving surgery followed by adjuvant radiotherapy (RT) and endocrine therapy (ET) for at least 5 years.
- Trial name
- NCT04921137
- Testing
- No endocrine therapy, Endocrine therapy
- Where
- 8 sites in Canada
- Volunteers
- 500 people
- Sponsor
- Ottawa Hospital Research Institute
Endometrial Cancer
Adjuvant Hypofractionated Whole Pelvis Radiation Therapy in Endometrial Cancer
Studying adjuvant hypofractionated whole pelvis radiation therapy in Endometrial Cancer.
- Trial name
- NCT04458402
- Testing
- Hypofractionated WPRT
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Teresa Meier
Bladder Cancer
Combination Chemotherapy and Radiation Therapy With/Without Surgery In Patients With Stage II/III Bladder Cancer
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy (RT) uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00055601
- Testing
- cisplatin, fluorouracil, paclitaxel
- Where
- 2 sites in United States
- Volunteers
- 97 people
- Sponsor
- Radiation Therapy Oncology Group
Breast Cancer, Quality of Life
Compare Adjuvant Monotherapy With Endocrine or Accelerated Partial Breast Irradiation After Lumpectomy
The aim of this prospective study is to investigate quality of life and oncologic outcomes in low-risk elderly breast cancer patients randomized to adjuvant therapy with accelerated partial breast irradiation (APBI) alone or…
- Trial name
- CAMERAN (NCT05472792)
- Testing
- Accelerated Partial Breast Irradiation (APBI), tamoxifen, anastrozole, exemestane, letrozole, fulvestrant, toremifene
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Prostate Cancer Adenocarcinoma, Adjuvant Radiotherapy
Stereotactic Hypofractionated Accelerated Radiotherapy Post-Prostatectomy
The present phase I trial evaluates the feasibility of a postoperative stereotactic hypofractionated external beam radiation therapy delivered in patients who underwent radical prostatectomy with adverse pathological features or…
- Conditions
- Prostate Cancer Adenocarcinoma, Adjuvant Radiotherapy, Salvage Radiotherapy, SBRT
- Trial name
- SHARP (NCT02976402)
- Testing
- SBRT
- Where
- Portugal
- Volunteers
- 30 people
- Sponsor
- Fundacao Champalimaud
Breast Cancer
Radiation Therapy and Thymus Function in Young Women With Breast Cancer
Breast cancer treatment sometimes includes radiation to the breast or chest wall. There is a small gland, called the thymus, located in the upper chest that may receive a small amount of the radiation aimed at the breast.
- Trial name
- NCT07725172
- Testing
- Blood draw for the laboratory assessment
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Duke University
Esophageal Cancer
Pre-operative Chemotherapy and Radiation Therapy for Esophageal Carcinoma
Surgery (esophagectomy or removal of the esophagus)has been the standard treatment for cancer of the esophagus. However, evidence suggests that preoperative chemotherapy and radiation therapy may add benefit.
- Trial name
- NCT00230451
- Testing
- Radiation, Paclitaxel, Cisplatin
- Where
- United States
- Sponsor
- University of Michigan Rogel Cancer Center
Endometrial Cancer
Radiation and TSR-042 (Dostarlimab) in People With Endometrial Cancer After They Receive Surgery
This study will test whether the combination of radiation and Dostarlimab is an effective treatment for women with MMR-D/MSI-H endometrial cancer who have recently undergone surgery.
- Trial name
- NCT04774419
- Testing
- Intensity modulated radiation therapy (IMRT), Dostarlimab, Hypofractionated IMRT
- Where
- 7 sites in United States
- Volunteers
- 62 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer
PBI for Breast in Situ Carcinoma of Intermediate Low Risk As Local Adjuvant Treatment
Screening and advances in breast imaging led to a continuous increase of Ductal Carcinoma in situ (DCIS) diagnosis. Whole breast radiotherapy was reported to be effective in reducing the risk of local recurrence in all analyzed…
- Trial name
- PRISCILLA (NCT05663294)
- Testing
- external beams radiotherapy, brachytherapy
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Istituto Clinico Humanitas