Clinical trials: Radiotherapy; Complications
Gynecologic Cancer, Radiotherapy Side Effect
Advanced Radiotherapy (ART) in Gynecological Cancer Patients (GYN-ART)
This is an observational mono-institutional study. Patients with gynecologic tumors treated with advanced radiotherapy- Image Guided Radiotherapy (IGRT), Intensity Modulated Radiotherapy (IMRT), Stereotactic Body Radiotherapy…
- Conditions
- Gynecologic Cancer, Radiotherapy Side Effect, Radiotherapy; Complications, Survivorship
- Trial name
- GYN-ART (NCT06306170)
- Testing
- Image Guided Radiotherapy
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- IRCCS San Raffaele
Head and Neck Neoplasms, Mucositis Oral
Safety and Tolerability of the Use of Copaiba in Patients With Oral Cancer Submitted to Radiotherapy
This study aims to propose an alternative and auxiliary methodology for the prevention and treatment of Oral Mucositis (OM) in patients undergoing radiotherapy or radio and chemotherapy for head and neck neoplasms through the use…
- Conditions
- Head and Neck Neoplasms, Mucositis Oral, Radiotherapy; Complications
- Trial name
- NCT05308732
- Testing
- Copaiba
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Radiotherapy; Complications, Ventricular Tachycardia
Stereotactic Ablative Radiotherapy for the Treatment of Refractory Ventricular Tachycardia
Ventricular tachycardia (VT) is an abnormal rhythm arising from the bottom chambers (ventricles) of the heart. The hearts of most patients who develop VT have been previously damaged by a myocardial infarction (heart attack) or…
- Conditions
- Radiotherapy; Complications, Ventricular Tachycardia, Structural Heart Abnormality, Heart Failure
- Trial name
- SABRE-VT (NCT05696522)
- Testing
- Stereotactic ablative radiotherapy
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- Barts & The London NHS Trust
Radiotherapy, Radiation-Induced Complications
A Prospective, Single-Arm Clinical Study of a Dietary Supplement for the Prevention of Acute Radiation-Induced Rectal Injury During Neoadjuvant Chemoradiotherapy for Rectal Cancer
This clinical study is a prospective, single-arm, single-center trial aimed at assessing the safety and efficacy of tributyrin (TB) as a dietary supplement for preventing acute radiation-induced rectal injury (ARII).
- Trial name
- NCT07802002
- Testing
- Tributyrin
- Where
- China
- Volunteers
- 23 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Oropharynx Cancer, Radiotherapy; Complications
Adaptive RadioTherapy for OroPharynx Cancer
This is a phase II randomized trial, where patients with histologically proven squamous cell carcinoma of oropharynx that have primary tumor (T3 - T4) in place, treated with curative intent chemoradiation, will be randomized to…
- Conditions
- Oropharynx Cancer, Radiotherapy; Complications, Radiotherapy Side Effect, Dysphagia
- Trial name
- ART-OPC (NCT04901234)
- Testing
- Standard radiotherapy +/- chemotherapy, Experimental radiotherapy +/- chemotherapy
- Where
- 2 sites in Australia, Canada
- Volunteers
- 120 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Surgery Date, Age
Quality of Life of Patients Who Have Undergone Bilateral Mastectomy
The investigators therefore aim to determine whether the type of mastectomy (preventive in a high-risk patient or therapeutic in a patient with a history of cancer), as well as the timing (immediate or delayed) and type of breast…
- Conditions
- Surgery Date, Age, BMI, Height
- Trial name
- RM BREAST Q (NCT07699913)
- Volunteers
- 115 people
- Sponsor
- University Hospital, Grenoble
Malignant Tumor of Head and/or Neck, Radiotherapy; Complications
Systematic Oral Education for Prevention of Oral-related Complications Caused by Radiotherapy for Head and Neck Cancer
A study on the efficacy of systematic oral health education for the prevention of oral-related complications caused by radiotherapy for head and neck malignant tumors
- Trial name
- NCT06690346
- Testing
- Systematic oral health education, Routine oral health education
- Where
- China
- Volunteers
- 150 people
- Sponsor
- West China Hospital
Cancer, Lung, Radiotherapy; Complications
Follow-up of Pulmonary Radiotoxicity for Bronchopulmonary Cancer.
assess the consequences of low doses of radiation delivered by the volumetric radiotherapy, on the respiratory capacity of patients treated for bronchopulmonary carcinoma, by a follow up of functional respiratory exploration.
- Trial name
- TEFRARC (NCT03931356)
- Testing
- Pulmonary function tests
- Where
- France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Brest
Sarcoma,Soft Tissue, Extremity
Preoperative IMRT With Anlotinib and Penpulimab for Localized Sarcoma （SPARE-01）
To investigate the safety and efficacy of preoperative IMRT and concurrent Anlotinib Hydrochloride for primary truncal or extremity soft tissue sarcoma; To investigate the Quality of life and extremity function post-combination…
- Conditions
- Sarcoma,Soft Tissue, Extremity, Trunk, Anlotinib
- Trial name
- SPARE-01 (NCT05167994)
- Testing
- Anlotinib hydrochloride
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Nasopharyngeal Carcinoma, Radiotherapy; Complications
Reduced Volume of Neck Prophylactic Irradiation in Nasopharyngeal Carcinoma
This is a multi-center, non-inferiority, open-label, randomized controlled phase III clinical trial in primary diagnosed nasopharyngeal carcinoma (NPC) patients without distant metastasis.
- Trial name
- NCT05780372
- Testing
- Intensity Modulated Radiation Therapy, Chemotherapy
- Where
- 7 sites in China
- Volunteers
- 474 people
- Sponsor
- Sun Yat-sen University
Rectal Cancer, Total Neoadjuvant Treatment
Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer.
This study hypothesizes that approximately 50% of rectal cancer patients can preserve their rectum using a watch-and-wait strategy if they achieve a complete or near-complete clinical response to total neoadjuvant therapy (TNT).
- Conditions
- Rectal Cancer, Total Neoadjuvant Treatment, Neoadjuvant Therapy, Radiotherapy
- Trial name
- NCT06758830
- Testing
- Radiation Therapy, Chemoradiotherapy, Consolidation Chemotherapy
- Where
- Lithuania
- Volunteers
- 400 people
- Sponsor
- National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos
Glioblastoma, Radiotherapy; Complications
Testing Ramipril to Prevent Memory Loss in People With Glioblastoma
This study is to determine if an oral drug called Ramipril can lower the chance of memory loss in patients with glioblastoma getting chemoradiation.
- Conditions
- Glioblastoma, Radiotherapy; Complications, Cognitive Decline, Chemoradiation
- Trial name
- NCT03475186
- Testing
- Ramipril
- Where
- 423 sites in United States, Guam
- Volunteers
- 75 people
- Sponsor
- Wake Forest University Health Sciences
Cancer Therapy-related Cardiovascular Toxicity, Childhood Cancer
Early Diagnosis and Cardiovascular Risk Stratification in Children Exposed to Cancer Therapies
The goal of this prospective interventional study is to improve the detection of subclinical chronic Cancer Therapy-Related Cardiovascular Toxicity (CTRCT) and evaluate the added value of advanced cardioechography…
- Conditions
- Cancer Therapy-related Cardiovascular Toxicity, Childhood Cancer, Chemotherapeutic Toxicity, Radiotherapy Side Effect
- Trial name
- CTRCT-pedia (NCT07408362)
- Testing
- Ergospirometry
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
Sarcoma,Soft Tissue, Extremity
Preoperative IMRT With Concurrent Apatinib for Localised Extremity or Trunk Sarcoma （SPARE-02）
To investigate the safety and efficacy of preoperative IMRT and concurrent Apatinib for primary truncal or extremity soft tissue sarcoma; To investigate the Quality of life and extremity function post-combination treatment; To…
- Conditions
- Sarcoma,Soft Tissue, Extremity, Trunk, Intensity-modulated Radiotherapy
- Trial name
- SPARE-02 (NCT05235100)
- Testing
- Apatinib Mesylate
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Colorectal Cancer, Neoadjuvant Radiotherapy
Perioperative Complications After Neoadjuvant Radiotherapy for Colorectal Cancer
Neoadjuvant radiotherapy plays an important role in the treatment of locally advanced colorectal cancer. Although radiation therapy is extremely important in reducing the tumor mass, downstaging, and therefore providing…
- Conditions
- Colorectal Cancer, Neoadjuvant Radiotherapy, Perioperative Complication
- Trial name
- NCT07249333
- Where
- Serbia
- Volunteers
- 80 people
- Sponsor
- Oncology Institute of Vojvodina
Basal Cell Carcinoma, Radiotherapy; Complications
Radiotherapy by Sonic Hedgehog Pathway Inhibitors in Basal Cell Carcinoma
Locally advanced basal cell carcinoma (BCC) are large BCCs or BCCs located in areas subject to functional and aesthetic risk following surgery or radiotherapy.
- Trial name
- RADIOSONIC (NCT05561634)
- Testing
- Radiotherapy, Observation, Vismodegib
- Where
- France
- Volunteers
- 82 people
- Sponsor
- University Hospital, Lille
Radiotherapy; Complications
Radiotherapy or Observation of Liver Metastases in Small Cell Lung Cancer
The aim of this randomized study is to investigate local tumor control,survival outcomes and complications on patients of liver metastasis in small cell lung cancer.
- Trial name
- NCT05150145
- Testing
- Radiotherpy will be performed to thoracic and liver metastasis after chemotherapy.
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Guizhou Medical University
Prostate Cancer, Prostatectomy
High Dose Rate (HDR) Brachytherapy Salvage After Prostatectomy
The goal of this observational study is to learn about the long-term effects of HDR Brachytherapy in men with isolated local relapses after radical prostatectomy.
- Conditions
- Prostate Cancer, Prostatectomy, Local Recurrence of Malignant Tumor of Prostate, Radiotherapy; Complications
- Trial name
- NCT06982469
- Testing
- Brachytherapy
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Breast Cancer, Radiotherapy; Complications
Concomitant Radiotherapy and New Drugs in Metastatic Breast Cancer
The primary objective of the study is to describe the tolerance profile of radiation treatments performed during systemic treatment with new drugs (molecular targeted therapies, immunotherapy, others).
- Trial name
- COMBaRT (NCT07021911)
- Testing
- Radiotherapy
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione Policlinico Universitario Campus Bio-Medico
Radiotherapy; Adverse Effect, Radiotherapy; Complications
Analysis of Outcomes and Adverse Events of Patients Undergoing Radiation Therapy
Analysis of outcomes and adverse events of patients undergoing radiation therapy. Quality control using data base of patient records 2000-2025
- Conditions
- Radiotherapy; Adverse Effect, Radiotherapy; Complications, Quality of Life
- Trial name
- NCT05192876
- Testing
- Radiotherapy
- Where
- Switzerland
- Volunteers
- 25,000 people
- Sponsor
- Daniel Zwahlen