Clinical trials: Randomized, open to volunteers
Acute Myeloid Leukemia (AML), Elderly Patients (60-75 Years)
VAH vs VA in Newly Diagnosed Elderly AML
This is a multicenter, open-label, randomized, controlled phase III clinical trial designed to evaluate the efficacy and safety of the combination of Venetoclax, Azacitidine, and Homoharringtonine (VAH) compared to Venetoclax and…
- Trial name
- NCT07469046
- Testing
- Venetoclax, Azacitidine, Homoharringtonine
- Where
- China
- Volunteers
- 308 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Colorectal Cancer (Diagnosis), Malnutrition or Risk of Malnutrition
Short-Term Nutritional Enhancement Combined With Health Education in Postoperative Colorectal Cancer Patients: A Randomized Controlled Trial
This clinical study aims to evaluate whether short-term personalized nutritional support, when combined with structured health education, can improve nutritional status, quality of life, and clinical outcomes in patients who have…
- Trial name
- NUTRI-CRC (NCT07087561)
- Testing
- Personalized Oral Nutritional Supplementation, Personalized Parenteral Nutritional Supplementation, Structured Nutrition-Focused Health Education
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Xiaoqin Luo
Benign Prostatic Hyperplasia, Benign Prostatic Hyperplasia With Lower Urinary Tract Symptoms
A Phase III Clinical Study of H077 Sustained-Release Tablets Compared With Silodosin Capsules in the Treatment of Benign Prostatic Hyperplasia
This is a randomized, double-blind, controlled, non-inferiority multicenter Phase III clinical study to evaluate the efficacy and safety of H077 sustained-release tablets versus silodosin capsules in treating benign prostatic…
- Trial name
- NCT07146386
- Testing
- H077 sustained-release tablet, Silodosin capsules Control Group
- Where
- 66 sites in China
- Volunteers
- 728 people
- Sponsor
- Shanghai Huilun Pharmaceutical Co., Ltd.
Thoracic Pain, Back Pain
Sodium Hyaluronate for Myofascial Thoracic Pain
To determine whether the addition of sodium hyaluronate to standard ultrasoundguided lidocaine injection provides superior and sustained pain relief compared with standard lidocaine injection alone in patients with suspected…
- Trial name
- NCT07775274
- Testing
- Sodium Hyaluronate Injection, Saline Injections
- Volunteers
- 100 people
- Sponsor
- EPC Education s.r.o.
Pancreatic Cancer
A Phase II Study of GFH375 Combined With GFS202A or GFH276 Versus GFH375 in Patients With Previously Treated Locally Advanced Unresectable or Metastatic Pancreatic Cancer Harboring KRAS G12D Mutation
This is a phase 2 study. All subjects are patients with locally advanced unresectable or metastatic pancreatic cancer harboring KRAS G12D mutation who have received at least one prior line of systemic therapy.
- Trial name
- NCT07784374
- Testing
- GFH375, GFH276, GFS202A
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Genfleet Therapeutics (Shanghai) Inc.
Postpartum Depression (PPD), Self-Efficacy
NICU Utilization of Remote Voice Technology to Improve mateRnal Experience (NURTURE)
The study's objective is to conduct a Phase II randomized controlled trial examining the preliminary efficacy of the VoiceLove app compared to usual care on maternal postpartum depression in mothers with infants admitted to the…
- Conditions
- Postpartum Depression (PPD), Self-Efficacy, Parental Anxiety, Engagement, Patient
- Trial name
- NURTURE (NCT07214597)
- Testing
- VoiceLove mobile phone application
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Urology
Efficacy and Safety of Two Bladder-preserving Treatment Durations With Disitamab Vedotin Plus Toripalimab Combination in Her2-expressing Muscle-invasive Bladder Cancer: A Phase II, Open-Label, Randomized Clinical Trial
This study aims to evaluate the efficacy of disitamab vedotin combined with toripalimab as a bladder-preserving treatment combination in patients with HER2 positive locally advanced MIBC, including one year bladder-intact DFS…
- Trial name
- NCT07151560
- Testing
- 6 cycle RC48 and JS001, 12 cycle RC48 and JS001
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Renmin Hospital of Wuhan University
Acute Myocarditis
MYTHS-MR Trial (MYocarditis THerapy With Steroids in Patients With Mildly Reduced Ejection Fraction)
The goal of this clinical trial is to demonstrate the efficacy of pulsed intravenous methylprednisolone in a single-blind randomized controlled trial versus standard therapy in patients with acute myocarditis and a mildly reduced…
- Trial name
- MYTHS-MR (NCT05974462)
- Testing
- Methylprednisolone 125 MG, IV saline solution 0.9%
- Where
- 19 sites in Belgium, Italy and 2 more
- Volunteers
- 174 people
- Sponsor
- University Hospital, Antwerp
Temporomandibular Joint Disorders
The Effect of Body Awareness Therapy on Pain, Function and Psychosocial Parameters in Temporomandibular Joint Disorders
This randomized, single-blind controlled trial aims to investigate the effectiveness of Body Awareness Therapy (BAT) on pain, functional limitations, and psychosocial outcomes in individuals with temporomandibular joint disorders…
- Trial name
- BAT-TMJ (NCT07317570)
- Testing
- Body Awareness Therapy, Standard Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Endometriosis
Remote Electrical Stimulation as a Long-term Intervention for Endometriosis Flare Ups
The goal of this clinical trial is to learn if a wearable brain stimulation device called NettleEndo can reduce chronic pelvic pain and improve wellbeing in women with endometriosis.
- Trial name
- RELIEF (NCT06974773)
- Testing
- NettleEndo
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Samphire Group, Inc.
Rotator Cuff Tear
A Randomized Controlled Trial on the Effectiveness of Early Versus Conservative Rehabilitation Following Rotator Cuff Repair
Background Rotator cuff tears (RCTs) are a common, costly, and often persistent musculoskeletal complaint, with an increasing number of shoulder pain patients undergoing surgical repair each year.
- Trial name
- NCT07324174
- Testing
- Group A, Therapeutic exercises, education and advice, Group B (Control Group)
- Where
- Saudi Arabia
- Volunteers
- 86 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Breast Cancer, Chemotherapy
ALND vs ART in Positive Sentinel Node After Neoadjuvant Therapy in Breast Cancer
In the case of primary surgery, in patients with sentinel node involvement, it has already been shown that omitting axillary lymph node dissection (ALND), often combining axillary radiotherapy (RT), does not worsen the prognosis…
- Conditions
- Breast Cancer, Chemotherapy, Sentinel Lymph Node, Axillary Lymph Nodes Dissection
- Trial name
- ADARNAT (NCT04889924)
- Testing
- Axillary Radiotherapy, Lymphadenectomy
- Where
- 61 sites in Australia, Spain
- Volunteers
- 820 people
- Sponsor
- Hospital Universitari de Bellvitge
Acute Pancreatitis
The Effect of Dietary Fat Content on the Recurrence of Pancreatitis
This trial aims to test the effects of two different diets on the recurrence of acute pancreatitis, and acute pancreatitis associated mortality.
- Trial name
- EFFORT (NCT04761523)
- Testing
- Dietary intervention: reduced fat diet, Dietary intervention: standard healthy diet
- Where
- Hungary
- Volunteers
- 384 people
- Sponsor
- University of Pecs
Traumatic Brain Injury
Baricitinib for Moderate and Severe Traumatic Intracerebral Hemorrhage/Contusions
The purpose of the present study is to study the effect of baricitinib administration on outcome of participants with moderate and severe traumatic intracerebral hemorrhage/contusions.
- Trial name
- NCT06065046
- Testing
- Baricitinib 4 MG, Standard treatment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tang-Du Hospital
Irreducible Atlantoaxial Dislocation
Surgical Treatment of Irreducible Atlantoaxial Dislocation
At present, there is a lack of standardized, large-scale, and high-level evidence-based medicine research on the safety and effectiveness of treatment of irreducible atlantoaxial dislocation (IAAD).Based on this, the goal of this…
- Trial name
- NCT05847270
- Testing
- Anterior and posterior treatment strategy, Simple posterior approach treatment strategy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking University Third Hospital
Gynecologic Cancers
Communication About Sexual Health in Gynecologic Cancer
The goal of this clinical trial is to learn if an educational video and workbook can help gynecologic cancer patients talk to their cancer providers about sexual health concerns. The main questions it aims to answer are: 1.
- Trial name
- NCT06904339
- Testing
- Starting the Conversation, Sexual Health Resources
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Fox Chase Cancer Center
Advanced Age, Recurrent Pregnancy Loss(RPL)
Noninvasive Implantation Potential vs Morphology-Based Selection in IVF Single Blastocyst Transfer
Background: Morphology-based embryo selection cannot detect aneuploidy, which is common in advanced maternal age and recurrent pregnancy loss.
- Conditions
- Advanced Age, Recurrent Pregnancy Loss(RPL), Infertility (IVF Patients), Sequence Analysis
- Trial name
- NICSAI-SBT-RCT (NCT07461077)
- Testing
- NICS-AI, Morphology group
- Where
- China
- Volunteers
- 520 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Hepatitis B
A Study to Compare Blood Levels of Bepirovirsen and Safety Using Different Methods of Injecting in Healthy Adult Participants
This is an open-label study being done to compare two different methods of study medicine bepirovirsen is given in healthy adults.
- Trial name
- NCT07905157
- Testing
- Bepirovirsen
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Vitreomacular Traction (VMT)
A Study Evaluating the Efficacy and Safety of Recombinant Human Truncated Plasmin Injection (JZB32) in Patients With Vitreomacular Traction
This study aims to evaluate the efficacy of JZB32 in patients with vitreomacular traction (VMT). Based on a randomized, double-blind, multicenter, sham injection-controlled, parallel-group design, the proportion of study eyes…
- Trial name
- NCT07910630
- Testing
- Recombinant Human Truncated Plasmin Injection (JZB32)
- Where
- 15 sites in China
- Volunteers
- 48 people
- Sponsor
- Jiangsu Jingze Biopharmaceutical Co., Ltd.
Macroscopic Tumor Visualized at MRI, Tumor Size Allowing Partial Prostate Treatment Volume
Stereotactic Focal Radiotherapy as an Alternative Treatment to Active Surveillance for Low and Intermediate Risk Prostate Cancer
*Rationale : Active surveillance of prostate cancer helps to avoid the morbidity associated with curative radical prostatectomy /radiotherapy in patients with early stage disease.
- Conditions
- Macroscopic Tumor Visualized at MRI, Tumor Size Allowing Partial Prostate Treatment Volume, CAPRA SCORE ≤5
- Trial name
- TOPPGUN-RS (NCT07152067)
- Testing
- Stereotactic Body Radiation Therapy (SBRT)
- Where
- 2 sites in Belgium
- Volunteers
- 146 people
- Sponsor
- Centre Hospitalier Universitaire de Liege
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