Clinical trials: Randomized, open to volunteers
Depressive Episode
Chronotherapy for Depressive Episodes
Evidence-based treatments for depression, such as antidepressive medication, usually have a latency of 4 to 6 weeks before they achieve a therapeutic effect.
- Trial name
- NCT05691647
- Testing
- Chronotherapy, Treatment as usual
- Where
- Norway
- Volunteers
- 76 people
- Sponsor
- St. Olavs Hospital
Osteoarthritis, TKA
Comparing Articular Noise and Its Perception Between Two Different Types of Individualized Total Knee Arthroplasty
Knee osteoarthritis is a degenerative joint disorder leading to pain and limited movement. Total knee arthroplasty (TKA) has transformed the treatment of knee osteoarthritis, resulting in long-term outcomes that enhance the…
- Trial name
- ANIKA (NCT07030049)
- Testing
- Postero-stabilized total knee replacement for knee osteoarthritis, Cruciate-retaining total knee replacement for knee osteoarthritis
- Volunteers
- 210 people
- Sponsor
- Clinique Trenel
Small Cell Lung Cancer Extensive Stage
Tislelizumab in Combination with Chemotherapy ± Radiotherapy for Extensive-Stage Oligometastatic Small Cell Lung Cancer.
The goal of this clinical trial is to learn the efficacy and safety of tislelizumab in combination with chemotherapy(etoposide/cisplatin ) ± concurrent radiotherapy for extensive-stage oligometastatic small cell lung cancer.
- Trial name
- TERE (NCT06851819)
- Testing
- radiotherapy, immunechemotherapy
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Hebei Medical University Fourth Hospital
Breast Cancer
A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.
The purpose of this study is to learn about the safety and effects of the study medicine PF-07248144 when given along with fulvestrant for the possible treatment of HR-positive, HER2-negative advanced or metastatic breast cancer.
- Trial name
- NCT07062965
- Testing
- PF-07248144, Fulvestrant, Everolimus
- Where
- 433 sites in United States, Argentina and 29 more
- Volunteers
- 400 people
- Sponsor
- Pfizer
Cancer
Oncology Acute Care Follow-up Intervention Study
This pragmatic randomized controlled study evaluates an education intervention designed to increase patient engagement with Oncology Acute Care (OAC) services among patients being treated for cancer at Parkland Health.
- Trial name
- NCT07550192
- Testing
- Follow-up messaging
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Texas Southwestern Medical Center
Adolescent - Emotional Problem, Parent Child Relationship
Randomized Controlled Trial of a Family-focused Intervention for Caregivers and Young Adolescents (Phase 3 of FLOURISH)
The aim of this study is to conduct a multi-country randomized waitlist controlled trial to evaluate the effectiveness, cost-effectiveness, and scalability of the optimized Parenting for Lifelong Health (PLH) for Parents and…
- Conditions
- Adolescent - Emotional Problem, Parent Child Relationship, Family Functioning, Well-Being, Psychological
- Trial name
- FLOURISH (NCT07240571)
- Testing
- Optimized Parenting for Lifelong Health (PLH) for Parents and Teens
- Where
- 2 sites in Moldova, North Macedonia
- Volunteers
- 1,280 people, healthy volunteers welcome
- Sponsor
- University of Klagenfurt
Dry Eye
Phase III Study of OT202 in Treating Moderate to Severe Dry Eye
This is a multicenter, randomized, double-blind, placebo-controlled Phase III clinical trial, enrolling 842 subjects with moderate to severe dry eye, who will be randomized at a 1:1 ratio to receive either 1% OT202 ophthalmic…
- Trial name
- NCT07740564
- Testing
- OT202 conc 1%
- Where
- 49 sites in China
- Volunteers
- 842 people
- Sponsor
- Ocumension Therapeutics (Suzhou) Co., Ltd
First Episode Psychosis (FEP)
Digital Heart Rate Variability Biofeedback Intervention for First Episode Psychosis
The objective of the current study is to assess the impact of a five-week digital heart rate variability biofeedback (HRV-B) intervention or music listening on the well-being of first episode psychosis patients.
- Trial name
- NCT07628699
- Testing
- Heart Rate Variability Biofeedback, Music Listening
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- The University of Hong Kong
Ischemic Cerebral Infarction
Ongericimab Injection Reducing Recurrence of Ischemic Stroke
The Oris trial aims to evaluate whether the use of Ongericimab injection in patients with atherosclerotic ischemic cerebrovascular disease within 3 months of onset can reduce the risk of recurrent major cardiovascular events by…
- Trial name
- ORIS (NCT07242599)
- Testing
- High target group, Low target group
- Where
- 199 sites in China
- Volunteers
- 4,810 people
- Sponsor
- Beijing Tiantan Hospital
Blood Loss, Surgical
Assessment of Nebulized Tranexamic Acid in Functional Endoscopic Sinus Surgery Using Modena Bleeding Score
The aim of this study is to investigate the effect of preoperative administration of intravenous or nebulized tranexamic acid on surgical field, blood loss, anesthetic consumption and hemodynamics of patients undergoing FESS.
- Trial name
- NCT06725732
- Testing
- Tranexamic Acid (TXA), Tranexamic Acid
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Obesity
Intervention Study on Weight Loss in Patients With Obesity
The goal of this clinical trial is to evaluate the feasibility of using Socratic questioning as an alternative method for weight loss in adult patients with obesity (aged 18 to 65) in a primary care setting.
- Trial name
- NCT07124832
- Testing
- Socratic Questioning Method
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Sıdıka Ece Yokuş
Schizophrenia
Evaluation of the Individual Early Psychoeducation Program for Schizophrenic Disorders in Inpatients
Schizophrenia affects about 0.7% of the population. Poor insight, which is common in this disease, linked to poor drug compliance is leads to rehospitalisation with major impact on quality of life.
- Trial name
- PEPITS (NCT05329363)
- Testing
- PEPITS Programme, Usual care
- Where
- 11 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Tours
Atrial Fibrillation, Left Atrial Appendage Absent
Can Patients With Atrial Fibrillation Safely Discontinue Anticoagulant Therapy After Cardiac Surgery? (ATLAAC)
Left atrial appendage (LAA) closure has become a frequent addition to oral anticoagulation in patients with atrial fibrillation who undergo cardiac surgery.
- Conditions
- Atrial Fibrillation, Left Atrial Appendage Absent, Anticoagulant Adverse Reaction
- Trial name
- NCT06401616
- Testing
- OAC will be discontinued for the duration of the trial
- Where
- 6 sites in Denmark
- Volunteers
- 1,220 people
- Sponsor
- Odense University Hospital
Misophonia, Misophonia Treatment
The Efficacy of Lavender Herbal Tea in Misophonia
Misophonia is a disorder characterized by a high level of annoyance with certain sounds. Exposure to these sounds causes physical symptoms characterized by anger, aggression, helplessness, overwhelm, and stimulation of the…
- Conditions
- Misophonia, Misophonia Treatment, Anxiety, Depression
- Trial name
- NCT06785649
- Testing
- Lavender herbal tea
- Volunteers
- 60 people
- Sponsor
- Sakarya University
Autism Spectrum Disorder
Transcranial Temporal Interference Stimulation for Children With Autism Spectrum Disorders
The goal of this single-blinded, randomized controlled trial is to assess the safety, tolerability, and feasibility of tTIS for children with ASD.
- Trial name
- NCT07625748
- Testing
- transcranial Temporal Interference Stimulation
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Heart Failure
Clinical Prospective ranDomized Trial to Evaluate the Non-inferiority of Left Bundle Branch Area Pacing Vs Cardiac ResynchronIzatioN Therapy With ECG guIded AV Optimization
Cardiac resynchronization therapy is the gold standard therapy for patients with advanced HF left ventricle dysfunction and large QRS.
- Trial name
- DA VINCI (NCT07107048)
- Testing
- Pacemaker and defibrillator
- Where
- Italy
- Volunteers
- 194 people
- Sponsor
- Leonardo Calò, MD
Indirect Hyperbilirubinemia, Neonatal
COMPARISON OF ZINC AND PROBIOTICS ON NEONATES WITH INDIRECT HYPERBILIRUBINEMIA UNDERGOING PHOTOTHERAPY
Study will evaluate effects of oral zinc and probiotics supplementation in neonates who have indirect hyperbilirubinemia and are receiving phototherapy.
- Trial name
- ZIPP (NCT07102836)
- Testing
- Zinc sulfate, Probiotic lactobacillus rhamnosus GG
- Where
- Pakistan
- Volunteers
- 110 people
- Sponsor
- Quaid-e-Azam Medical College
Knee Osteoarthritis
A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients (MOTION-P)
This is a multicenter, prospective, randomized, double-blind, placebo-controlled, parallel-arm, Phase 3 study of intra-articular administration of PTP-001 (MOTYS) for the treatment of knee osteoarthritis.
- Trial name
- MOTION-P (NCT07219771)
- Testing
- PTP-01
- Where
- 18 sites in United States, Australia
- Volunteers
- 300 people
- Sponsor
- Doron Therapeutics Inc.
Idiopathic Hypersomnia
a Chronobiological Treatment Combining Evening Melatonin and Morning Light Therapy in Idiopathic Hypersomnia: a Prospective, Double Bind, Randomized, Placebo-controlled -Trial
Idiopathic hypersomnia (IH) is a chronic disabling disorder characterized by excessive daytime sleepiness (EDS), prolonged nighttime sleep and sleep inertia.
- Trial name
- HyperChrono (NCT06252571)
- Testing
- - Melatonin - Active light ttherapy
- Where
- France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Strasbourg, France
Metabolic Dysfunction-Associated Steatotic Liver Disease
Effects of Different Exercises on Intrahepatic Lipid in Patients With Metabolic Dysfunction-associated Steatotic Liver Disease
This is a single-center, randomized, parallel controlled study to explore the effects of aerobic exercise, resistance exercise or aerobic combined resistance exercise on liver lipid in patients with MASLD, consisting of a 12-week…
- Trial name
- NCT06994871
- Testing
- Aerobic exercise, Resistance exercise, combined exercise
- Where
- 2 sites in China
- Volunteers
- 186 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School