Clinical trials: Randomized, open to volunteers
Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8
Neurotization of the Nipple Areolar Complex to Restore Sensation for Patients With Breast Cancer Undergoing Nipple Sparing Mastectomy and Reconstruction
This phase II trial tests the willingness of patients undergoing nipple sparing mastectomy (NSM) to enroll in a randomized study of NSM with or without neurotization of the nipple areolar complex (NAC).
- Conditions
- Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IIA Breast Cancer AJCC v8
- Trial name
- NCT06153836
- Testing
- Neurotization Procedure, Questionnaire Administration, Subcutaneous Mastectomy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Mayo Clinic
Postoperative Pain, Thoracic Surgery
SPSIP Versus RISS Block in Volume-Preserving VATS
This prospective randomized controlled study aims to compare the effects of Serratus Posterior Superior Intercostal Plane (SPSIP) block and Rhomboid Intercostal and Subserratus (RISS) block on postoperative pain, respiratory…
- Trial name
- SRVATS (NCT07655336)
- Testing
- Serratus posterior superior intercostal plane block, Rhomboid Intercostal and Subserratus Block
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Ferit Yetik
Melanoma
Exercise and Nutritional Intervention in Patients With Melanoma Receiving Immunotherapy
The purpose of this randomized study is to evaluate whether a six-month program of structured resistance exercise combined with individualized nutritional support can preserve or improve skeletal muscle mass and muscle quality in…
- Trial name
- MEL-FIT-IO (NCT07761871)
- Testing
- Structured Resistance Exercise, Individualized Nutritional Support
- Where
- Slovenia
- Volunteers
- 40 people
- Sponsor
- Institute of Oncology Ljubljana
Maternal and Child Health
An Innovative Mobile Technology Intervention for Maternal and Child Health Care in Cambodia
The Innovative Mobile Technology for Maternal and Child Health Care (i-MoMCARE) project is a digital health intervention aiming to increase the coverage of and access to maternal and child health (MCH) services for pregnant women…
- Trial name
- i-MoMCARE (NCT05639595)
- Testing
- Web interface for health center staff and mobile application on smart phones for village health volunteers
- Where
- Cambodia
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Secondary Progressive Multiple Sclerosis
A Study of Orelabrutinib in Patients With Secondary Progressive Multiple Sclerosis
Orelabrutinib is a CNS-penetrable BTK inhibitor. This is a phase 3, randomized, double-blind, parallel-group, multicenter study to evaluate the efficacy and safety of orelabrutinib compared with placebo in patients with…
- Trial name
- NCT07299019
- Testing
- Orelabrutinib
- Where
- 69 sites in United States, Australia and 14 more
- Volunteers
- 990 people
- Sponsor
- Zenas BioPharma (USA), LLC
Esophageal Squamous Cell Carcinoma
Becotatug Vedotin ± Anti-PD-1 in Pretreated Advanced ESCC
This study will test a new potential treatment for advanced esophageal squamous cell cancer (ESCC) for patients whose initial treatment has stopped working.
- Trial name
- NCT07403136
- Testing
- Vebrekotuzumab, PD-1 antibody
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Fudan University
Asthma
A Study to Compare the Efficacy, Safety and Tolerability of FF/UMEC/VI With FF/VI in 12-17-year-olds With Asthma
The primary purpose of this study is to evaluate the effects of Fluticasone Furoate (FF)/ Umeclidinium (UMEC)/ Vilanterol (VI) on lung function compared with FF/VI after 24 weeks of treatment.
- Trial name
- NCT05757102
- Testing
- FF/UMEC/VI, ELLIPTA, FF/VI
- Where
- 67 sites in United States, Argentina and 7 more
- Volunteers
- 138 people
- Sponsor
- GlaxoSmithKline
Limited Stage Small Cell Lung Cancer
This is a Two-cohort, Exploratory Clinical Study Assessing the Activity of Benmelstobart Combined With Chemotherapy With or Without Anlotinib in Resectable Limited-Stage Small Cell Lung Cancer
A total of 66 patients were enrolled in this exploratory study and randomly assigned to cohort 1 and cohort 2, with 33 patients in each group.
- Trial name
- NCT06978153
- Testing
- benmelstobart combined with chemotherapy and anlotinib, benmelstobart combined with chemotherapy
- Volunteers
- 66 people
- Sponsor
- Tang-Du Hospital
Corneal Edema, Fuchs
Study of EO2002 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction
This study will evaluate the safety and effectiveness of a single injection of EO2002 at one of two dose levels (150,000 or 500,000 magnetic human corneal endothelial cells [mHCECs]), compared with a placebo injection, in…
- Conditions
- Corneal Edema, Fuchs, Fuchs Dystrophy, Fuchs' Endothelial Dystrophy
- Trial name
- EMERALD (NCT07729137)
- Testing
- 150K cells, 500K cells
- Where
- 10 sites in United States
- Volunteers
- 121 people
- Sponsor
- Emmecell
Stroke
Effects of Rhythmic Auditory Cueing Augments Cognitive Treadmill Walking Training in Individuals With Chronic Stroke
The first objective of this study is to examine the superiority of the combined rhythmic auditory cueing with cognitive treadmill training (combined group) in people with stroke as compared with the cognitive treadmill walking…
- Trial name
- NCT06392945
- Testing
- Cognitive Treadmill Walking Training with Rhythmic Auditory Cueing (CTW+RAC) group, Cognitive Treadmill Walking Training (CTW) group, Treadmill Walking Training (TW)
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Chang Gung University
Lung Neoplasms, Non-Small Cell Lung Cancer
Osimertinib With or Without Primary Lung Tumor Resection for EGFR-Mutant Oligometastatic Non-Small Cell Lung Cancer
Osimertinib is a standard first-line treatment for patients with metastatic non-small cell lung cancer harboring an epidermal growth factor receptor exon 19 deletion or exon 21 L858R mutation.
- Trial name
- PTR-2 (NCT07738172)
- Testing
- Primary Tumor Resection, Osimertinib
- Where
- Taiwan
- Volunteers
- 154 people
- Sponsor
- National Taiwan University Hospital
Muscular Invasive Bladder Cancer (MIBC)
Clinical Study on the Treatment of MIBC Patients With SHR-A2102 Injection Combined With Adebrelimab (SHR-1316)
In phase II, the main objective is to evaluate the efficacy of SHR-A2102 combined with Adebrelimab in the treatment of muscular invasive bladder cancer (MIBC); The main objective of phase III is to evaluate the efficacy of…
- Trial name
- NCT06879145
- Testing
- SHR-A2102；Adebrelimab
- Where
- China
- Volunteers
- 840 people
- Sponsor
- Suzhou Suncadia Biopharmaceuticals Co., Ltd.
Obesity, Bariatric Surgery
Opioid-Free Versus Opioid-Based Anesthesia in Bariatric
This study is designed as a prospective, randomized, controlled clinical trial. It will be conducted in the operating rooms of the University of Health Sciences, Diyarbakır Gazi Yaşargil Training and Research Hospital.
- Trial name
- NCT07105839
- Testing
- Intraoperative rescue analgesia, Intraoperative rescue analgesia:
- Volunteers
- 50 people
- Sponsor
- Siirt Training and Research Hospital
Pressure Ulcers Prevention in Prone Positioning in Intensive Care
Pressure Sore Prevention Strategy for the Prone Position
The aim of this clinical trial is to determine whether 5-layer hydrocellular dressings are effective in preventing the development of pressure sores during prone positioning in the intensive care unit.
- Trial name
- DERM-H-PROTECT (NCT06442657)
- Testing
- Hydrocellular dressing, Hydrocolloids dressing
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Caen
Knee Osteoarthristis
Clinical Outcomes of Focused Shockwave Therapy Without Adjunct Rehabilitation Compared to Standard Physical Rehabilitation in Patients With Grade I-III Knee Osteoarthritis: A Single-Blind Randomized Study
Clinical Outcomes of Focused Shockwave Therapy Without Adjunct Rehabilitation Compared to Standard Physical Rehabilitation in Patients with Grade I-III Knee Osteoarthritis: A Single-Blind Randomized Study
- Trial name
- NCT07567365
- Testing
- Physical Rehab, Focused Shockwave Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Pulse Wave USA
Autoimmune Hepatitis
Efficacy and Safety of Therapeutic Plasma Exchange vs Standard Medical Therapy in Severe Autoimmune Hepatitis.
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease that can lead to cirrhosis and liver failure. AIH can present in all ages, races, and ethnicities, but it mostly affects women.
- Trial name
- NCT06855667
- Testing
- Plasma Exchange, Steroid, Diet
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Intimate Partner Violence (IPV)
Familia Imara: A Parenting Program to Reduce Family Violence in Tanzania
This cluster-randomized controlled trial will evaluate the effectiveness, implementation, and scalability of Familia Imara, a group-based, couples-focused, community health worker (CHW)-delivered parenting program, on reducing…
- Trial name
- NCT07574567
- Testing
- Familia Imara
- Where
- Tanzania
- Volunteers
- 6,216 people, healthy volunteers welcome
- Sponsor
- Saini Das
Pathology Foundation Model
AI Models in Clinical Pathology Diagnosis: A Multicenter RCT
The investigators plan to conduct a multicenter, prospective, randomized controlled trial to systematically evaluate the incremental value of pathology-based artificial intelligence (AI) models in a pan-disease diagnostic…
- Trial name
- NCT07408167
- Testing
- AI model, Control
- Where
- 3 sites in China
- Volunteers
- 2,060 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Partial Rotator Cuff Tears, Rotator Cuff Tendinopathy
Intralesional Versus Perilesional 5% Dextrose Injection in Partial Rotator Cuff Tears
This prospective, randomized, double-blind controlled clinical trial aims to compare the clinical and ultrasonographic outcomes of intralesional and perilesional 5% dextrose injection in patients with partial rotator cuff tears.
- Conditions
- Partial Rotator Cuff Tears, Rotator Cuff Tendinopathy, Shoulder Pain Chronic, Supraspinatus Tendon Tear
- Trial name
- NCT07688902
- Testing
- Intralesional 5% Dextrose Injection, Perilesional 5% Dextrose Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ankara City Hospital Bilkent
Obesity Prevention
Better4All Personalized Intervention Pilot Study
The BETTER4U project (Preventing obesity through Biologically and bEhaviorally Tailored inTERventions for you) is funded by the European Union (EU) and involves an international consortium consisting of 28 partners across Europe…
- Trial name
- BETTER4ALL (NCT07120802)
- Testing
- BETTER4U Mobile App and Wearable Use (End-User Group), BETTER4U Intervention Platform Testing (Implementer Group)
- Where
- 7 sites in Cyprus, France and 5 more
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- Harokopio University
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