Clinical trials: Randomized, open to volunteers
Fatty Pancreas, Overweight
Efficacy of Mazdutide on Fatty Pancreas
This is a randomized, double-blind, placebo-controlled, parallel-group, single-center clinical trial designed to evaluate the efficacy and safety of mazdutide in improving fatty pancreas in patients with overweight or obesity.
- Conditions
- Fatty Pancreas, Overweight, Obesity
- Trial name
- NCT07803705
- Testing
- mazdutide
- Where
- China
- Volunteers
- 194 people
- Sponsor
- Tongji Hospital
Educational Intervention, Motivation Model
ARCS-Based Training to Improve Nursing Students' Communication, Motivation, and Self-Efficacy
This study explores the impact of an ARCS-based training program on nursing students' communication skills, learning motivation, and self-efficacy.
- Trial name
- ARCS-NCOMSE (NCT07004205)
- Testing
- The ARCS Motivation Model Education
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
Obstructive Sleep Apnea, Alzheimer Disease
ENhancing Outcomes in Cognitive Impairment Through Use of Home Sleep ApNea Testing
Obstructive sleep apnea (OSA), which causes abnormal pauses in breathing during sleep, is common in patients with vascular cognitive impairment (VCI) and Alzheimer's disease (AD), and exacerbates the cognitive deficits seen in…
- Conditions
- Obstructive Sleep Apnea, Alzheimer Disease, Vascular Dementia, Mild Cognitive Impairment
- Trial name
- ENCHANT (NCT04335994)
- Testing
- In-laboratory polysomnography, Home Sleep Apnea Test
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Sunnybrook Health Sciences Centre
Dexamethasone, Magnesium Sulphate
Dexamethasone Versus Magnesium Sulphate as an Adjuvant to Bupivacaine in Ultrasound Guided Erector Spinae Plane Block for Postoperative Analgesia in Elective Caesarean Section Under Spinal Anesthesia
This study aims to compare the efficacy of adding dexamethasone and magnesium sulfate as an adjuvant to bupivacaine in bilateral erector spinae block in postoperative pain control in patients undergoing caesarean section under…
- Conditions
- Dexamethasone, Magnesium Sulphate, Adjuvant, Ultrasound
- Trial name
- NCT07139522
- Testing
- Bupivacaine, Dexamethasone, Magnesium sulphate
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Cairo University
Stress Urinary Incontinence, Urinary Incontinence
Trial of Transurethral Bulking Agent Injection Versus Single-Incision Sling for Stress Urinary Incontinence
This is a multicentered, double-blind, randomized controlled, surgical trial of 358 women with inadequate symptom relief of stress urinary incontinence (SUI) or stress predominant mixed urinary incontinence (MUI) after…
- Conditions
- Stress Urinary Incontinence, Urinary Incontinence, Mixed Urinary Incontinence
- Trial name
- BASIS (NCT06480227)
- Testing
- Solyx Single-incision Sling, Bulkamid Transurethral Bulking Agent
- Where
- 7 sites in United States
- Volunteers
- 358 people
- Sponsor
- NICHD Pelvic Floor Disorders Network
Multiple Sclerosis
Blood Flow Restriction And Veterans With MS
There currently is a lack of evidence to support exercise interventions in people with advanced disability due to MS (i.e., need assistance to walk or use a wheelchair).
- Trial name
- BRAVe-MS (NCT05433103)
- Testing
- Low-Load Exercise with Blood Flow Restriction, Low-Load Exercise Control Group
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- VA Office of Research and Development
Low Back Pain, Radicular Syndrome
Comparison of High-Intensity and Conventional Physical Therapy in Musculoskeletal Disorders
This pilot randomized controlled trial aims to compare the clinical effectiveness of advanced high-intensity physical therapy modalities with conventional physical therapy in patients suffering from musculoskeletal disorders.
- Conditions
- Low Back Pain, Radicular Syndrome, Sacroiliac Joint Dysfunction, Shoulder Impingement Syndrome
- Trial name
- NCT07903142
- Testing
- Repetitive Peripheral Magnetic Stimulation (rPMS), High-Intensity Laser Therapy (HIL), Extracorporeal Shockwave Therapy (ESWT)
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- BTL Industries Ltd.
Cerebral Palsy
GO-PLAY - Early Family-Centered Intervention for Infants With High-Risk of Cerebral Palsy
Background. Early diagnosis of cerebral palsy (CP) is important to enable appropriate intervention at a time when neuroplasticity is at its highest.
- Trial name
- GO-PLAY (NCT05883969)
- Testing
- GO-PLAY, Usual care
- Where
- 2 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Residual Severe Ventral Curvature, Transection of the Urethral Plate
Urethral Plate Flap vs. Tunica Vaginalis Flap for Residual Severe Ventral Curvature in Hypospadias
The correction of ventral curvature in hypospadias follows a stepwise principle. Clinically, in some cases of hypospadias, residual severe ventral curvature (VC ≥ 30°) persists even after thorough skin degloving and transection…
- Conditions
- Residual Severe Ventral Curvature, Transection of the Urethral Plate, Corporoplasty, Pedicled Tunica Vaginalis Flap (TVF)
- Trial name
- NCT07404722
- Testing
- Urethral Plate Flap Corporoplasty, Tunica Vaginalis Flap Corporoplasty
- Where
- China
- Volunteers
- 90 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Cardiopulmonary Bypass
Prothrombin Complex Concentrate (PCC)
The overall objective of this study is to determine whether ROTEM (rotational thromboelastometry) guided dosing of four-factor prothrombin complex concentrate (4F-PCC) results in superior perioperative bleeding control compared…
- Trial name
- NCT07881393
- Testing
- Four Factor Prothrombin Complex Concentrate, ROTEM (Rotational Thromboelastometry) analyzer (TEM International GmbH)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Miami
Dental Caries, Dental Occlusion
Occlusal Impact of Hall Crowns in Primary Molars
Hall Technique is a non-invasive restorative approach for managing carious primary molars, increasingly used in pediatric dentistry due to its simplicity and patient tolerance.
- Conditions
- Dental Caries, Dental Occlusion, Pediatric Dentistry
- Trial name
- NCT07134114
- Testing
- Hall Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
HPV, Vaccination Hesitancy
A Bio-Psycho-Social Medical Model-Based Study on Adolescent Female HPV Vaccination Behavior and Comprehensive Intervention
Based on the biopsychosocial (BPS) medical model, this study focuses on HPV vaccination behavior among adolescent females. It aims to explore the influence of multidimensional factors-including biological characteristics…
- Conditions
- HPV, Vaccination Hesitancy, Biopsychosocial Model
- Trial name
- NCT07562984
- Testing
- the BPS-based comprehensive intervention
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Peripheral Arterial Disease(PAD), Chronic Limb Threatening Ischemia
Intravascular Ultrasound for Peripheral Artery Disease Revascularization
The purpose of this study is to determine if IVUS use, as compared to angiography alone, prevent major adverse limb events (MALE) or binary restenosis (a greater than 50% re-narrowing of the treated artery) in adult patients who…
- Conditions
- Peripheral Arterial Disease(PAD), Chronic Limb Threatening Ischemia, Intravascular Ultrasound, Major Adverse Limb Events
- Trial name
- CLARITY (NCT06979284)
- Testing
- IVUS-guided strategy
- Where
- 5 sites in Canada
- Volunteers
- 772 people
- Sponsor
- Hamilton Health Sciences Corporation
Postoperative Pain, Middle Ear Surgery
Dexmedetomidine as an Adjuvant to Greater Auricular Nerve Block in Middle Ear Surgeries
This randomized, double-blind, controlled study will evaluate whether adding dexmedetomidine to bupivacaine in an ultrasound-guided greater auricular nerve block prolongs pain relief after middle ear surgery.
- Trial name
- NCT07878533
- Testing
- Bupivacaine, Dexmedetomidine, Normal saline
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Minia University
Ovarian Cancer, Fallopian Tube Cancer
Fluzoparib With or Without Bevacizumab for Neoadjuvant Therapy in Advanced Ovarian Cancer
This study is a randomized, open-label, multi-cohort, multicenter clinical trial, aimed at evaluating the efficacy and safety of Fluzoparib monotherapy, Fluzoparib in combination with Bevacizumab, and standard chemotherapy…
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
- Trial name
- NCT06735326
- Testing
- Fluzoparib, Bevacizumab, Paclitaxel
- Where
- China
- Volunteers
- 105 people
- Sponsor
- Qilu Hospital of Shandong University
Postoperative Pain, Thoracic Surgery
Ultrasound-Guided Rhomboid-Intercostal Block Versus Thoracic Paravertebral Block for VATS Analgesia
Purpose of the study The goal of this research is to see which of two nerve-numbing techniques-the Rhomboid-Intercostal Block (RIB) or the Thoracic Paravertebral Block (PVB)-works better to control pain after chest surgery…
- Conditions
- Postoperative Pain, Thoracic Surgery, Thoracic Surgery, Video Assisted, Ultrasound Guided
- Trial name
- NCT07465887
- Testing
- Ultrasound-Guided Rhomboid-Intercostal Block (RIB), Ultrasound-Guided Thoracic Paravertebral Block (PVB)
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Georgios Kotsovolis
Recurrent Aphtous Stomatitis
Randomized Double Blind Controlled Trial Comparing the Safety and Efficacy of Apremilast Versus Placebo in Severe Forms of Recurrent Aphthous Stomatitis
The objective of the study is to assess the superiority of apremilast in comparison with placebo to achieve Complete Remission (CR) of oral ulcers at Week 12, in patients with severe Recurrent aphtous stomatitis resistant or…
- Trial name
- PREMS (NCT04227314)
- Testing
- Apremilast
- Where
- 21 sites in France
- Volunteers
- 134 people
- Sponsor
- University Hospital, Rouen
Anxiety, GAD
Transcranial Direct Current Stimulation (tDCS) and Immersive Virtual Reality Meditation (IVRM) for the Treatment of Anxiety Disorders
The goal of this RCT is to evaluate the post-intervention (week 2) and 1-month post-intervention (week 6) of a 2-week intervention (12 sessions) of combined tDCS (a non-invasive brain stimulation method, with anodal stimulation…
- Trial name
- NCT07299916
- Testing
- tDCS +IVRM (Active stimulation)
- Where
- Hong Kong
- Volunteers
- 52 people
- Sponsor
- The University of Hong Kong
Mental Health, Parenting / Maternal Behavior
Healing Hearts: A Mindfulness App for Parents Navigating Divorce or Separation
This study examines online programs for parents navigating divorce or separation. Researchers will study whether a self-guided mindfulness app called Healing Hearts, followed by a self-guided online parenting program called the…
- Conditions
- Mental Health, Parenting / Maternal Behavior, Parenting Anxiety, Parenting Behavior
- Trial name
- NCT07871916
- Testing
- Healing Hearts, electronic New Beginnings Program, Curated internet resources
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Osteoarthritis, Knee
Efficacy and Safety of NAVIO
The goal of the study is to compare the efficacy, safety and costs of the NAVIO™ system with the conventional intramedullary alignment guide for total knee replacement in a clinical setting.
- Trial name
- NCT04230616
- Testing
- total knee arthroplasty, CT scan
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- Sint-Trudo Hospital
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