Clinical trials: Randomized Controlled Study
Overweight
Phase 2 Study to Evaluate Safety and Efficacy of RM-493 in Obese Participants
The purpose of this study is to evaluate the effects of RM-493 on mean percent body weight loss, and other weight loss parameters as well as Pharmacokinetic (PK) profile, and ambulatory blood pressure in obese participants.
- Trial name
- NCT01749137
- Testing
- Setmelanotide
- Where
- 6 sites in United States
- Volunteers
- 74 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Postoperative Pain, Anxiety
Effects of Foot Reflexology on Postoperative Pain, Anxiety, Nausea, and Vomiting Among Patients After Laparoscopic Cholecystectomy
This study aims to evaluate the effect of foot reflexology on pain, anxiety, nausea, and vomiting among patients after laparoscopic cholecystectomy.
- Conditions
- Postoperative Pain, Anxiety, Nausea, Vomiting
- Trial name
- NCT07770295
- Testing
- Foot reflexology
- Where
- Egypt
- Volunteers
- 108 people
- Sponsor
- Ain Shams University
Diabetes Mellitus, Type 2
Study to Evaluate Safety, Tolerability, Pharmacokinetics & Pharmacodynamics of JTT-662 in Subjects With Type 2 Diabetes
This study will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of JTT-662 administered once daily for 28 days in subjects with Type 2 diabetes mellitus (T2DM) who are receiving metformin monotherapy
- Trial name
- NCT04465877
- Testing
- JTT-662
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Akros Pharma Inc.
Brain Neoplasms, Neoplasm Metastasis
A Trial of Postoperative Whole Brain Radiation Therapy vs. Salvage Stereotactic Radiosurgery Therapy for Metastasis
The aim of this study is to evaluate non-inferiority of salvage stereotactic radiosurgery (SRS) in the patients who received surgical resection for brain metastases in comparison with postoperative whole brain radiation therapy…
- Trial name
- NCT00280475
- Testing
- Whole brain radiation therapy arm, Salvage stereotactic radiosurgery arm
- Where
- 21 sites in Japan
- Volunteers
- 270 people
- Sponsor
- Haruhiko Fukuda
Non Segmental Vitiligo
ICP-332 in Subjects With Non-segmental Vitiligo
This a phase II/III randomized, double-blind, placebo-controlled, parallel group, adaptive design, multi-center study to evaluate the efficacy and safety of ICP-332 in subjects with non-segmental vitiligo。The study consisted an…
- Trial name
- NCT07047612
- Testing
- ICP-332 Tablets
- Where
- 45 sites in China
- Volunteers
- 603 people
- Sponsor
- Beijing InnoCare Pharma Tech Co., Ltd.
Healthy Volunteers
A Study of Plasma-Derived Human Butyrylcholinesterase Administered Intramuscularly
The purpose of this placebo-controlled study is to evaluate the safety, tolerability and pharmacokinetics of a single dosage of human butyrylcholinesterase (HuBChE) in healthy adults.
- Trial name
- NCT00333528
- Testing
- Human butyrylcholinesterase (HuBChE) derived from human plasma
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Baxalta now part of Shire
Covid19, Critical Illness
Robotic Assisted Early Mobilization in Ventilated ICU Patients With COVID-19
Feasibility trial investigating the potential higher frequency of robotic assisted early mobilization in intubated COVID19 patients on the ICU.
- Conditions
- Covid19, Critical Illness, Critical Illness Polyneuromyopathy, Early Mobilization
- Trial name
- NCT04750265
- Testing
- Robotic assisted early mobilization
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Charite University, Berlin, Germany
Psoriasis
Single-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 827
This Phase 1 study will evaluate safety, tolerability, PK and PD of AMG 827 when administered as a single SC or IV dose.
- Trial name
- NCT00867100
- Testing
- 700 mg IV, 350 mg SC, 140 mg SC
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.
Irritable Bowel Syndrome
A Trial for New Treatment of Adult Participants With Irritable Bowel Syndrome
A study to evaluate the effectiveness of oral doses of Blautix in adult participants with irritable bowel syndrome (IBS).
- Trial name
- NCT03721107
- Testing
- Blautix
- Where
- 34 sites in United States, Ireland and 1 more
- Volunteers
- 366 people
- Sponsor
- 4D pharma plc
Mechanical Ventilation, Dexmedetomidine
Dexmedetomidine vs Midazolam on Resting Energy Expenditure in Critically Ill Patients
The aim of this study is to compare the effect of dexmedetomidine on resting energy expenditure in relation to the midazolam in critically ill patients using indirect calorimetry
- Conditions
- Mechanical Ventilation, Dexmedetomidine, Midazolam, Sedation
- Trial name
- NCT03030911
- Testing
- Dexmedetomidine, Midazolam, Fentanyl
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Hepatitis B, Chronic
A Multicenter Study to Determine the Depth and Duration of Hepatitis B Surface Antigen (HBsAg) Reduction After Single or Multiple Doses of ARC-520, in Combination With Entecavir in Patients With Chronic Hepatitis B Virus (HBV) Infection
The purpose of this study is to determine whether ARC-520 in combination with entecavir is effective in the treatment of patients with chronic HBV Infection.
- Trial name
- NCT02065336
- Testing
- ARC-520, entecavir, chlorpheniramine
- Where
- 2 sites in Hong Kong
- Volunteers
- 58 people
- Sponsor
- Arrowhead Pharmaceuticals
Muscular Dystrophy, Duchenne
Modified Diet Trial: A Study of SMT C1100 in Paediatric Patients With DMD Who Follow a Balanced Diet
Placebo-controlled, multi-centre, randomized, double-blind dose escalation study. The aim is to evaluate the pharmacokinetics (PK) and safety of SMT C1100 in paediatric patients with Duchenne Muscular Dystrophy (DMD) who follow a…
- Trial name
- NCT02383511
- Testing
- SMT C1100
- Where
- 4 sites in United Kingdom
- Volunteers
- 12 people
- Sponsor
- Summit Therapeutics
Mucositis Oral
Oral Self Care Protocol and Oral Mucositis
Objective: This study was conducted in order to examine the effect of oral self-care protocol based on Orem's Self-Care Deficiency Theory on oral mucositis and self-care agency.
- Trial name
- OSCP and OM (NCT06049511)
- Testing
- oral self care protocol, standard care
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ege University
Analgesia, Postoperative Pain
The Availability and Safety Study of Remimazolam Besylate for Injection on Sedation of ERAS Patients
This trial intends to evaluate Remimazolam Besylate's availability and safety compared with propofol.
- Trial name
- NCT04947345
- Testing
- Remimazolam Besylate, Propofol
- Volunteers
- 84 people
- Sponsor
- Peking Union Medical College Hospital
Vascular Access Complication
AccuCath™ Intravenous (IV) Device Used by Vascular Access Team (VAT)
The study will test a hypothesis that the AccuCath™ System will have a higher rate of successful first attempt peripheral intravenous (PIV) placement, higher completion of therapy, fewer complications, longer dwell times, and…
- Trial name
- NCT01937195
- Testing
- AccuCath Intravenous Catheter System
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- C. R. Bard
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
A Study of Lebrikizumab (LY3650150) in Participants With Chronic Rhinosinusitis and Nasal Polyps Treated With Intranasal Corticosteroids (CONTRAST-NP)
The main purpose of this study is to evaluate the efficacy and safety of lebrikizumab in participants with chronic rhinosinusitis and nasal polyps treated with intranasal corticosteroids. The study will last about 18 months.
- Trial name
- NCT06338995
- Testing
- LY3650150, Standard therapy for INCS
- Where
- 202 sites in United States, Argentina and 18 more
- Volunteers
- 510 people
- Sponsor
- Eli Lilly and Company
Acute Coronary Syndrome
Effect of Dalcetrapib vs Placebo on CV Risk in a Genetically Defined Population With a Recent ACS
A placebo-controlled, randomized, double-blind, parallel group, phase III multicenter study in subjects recently hospitalized for ACS and with the appropriate genetic profile.
- Trial name
- dal-GenE (NCT02525939)
- Testing
- dalcetrapib
- Where
- 557 sites in United States, Argentina and 30 more
- Volunteers
- 6,147 people
- Sponsor
- DalCor Pharmaceuticals
Coronary Angiography (CAG)
Effects of White Noise and Earplugs on Patients' Physiological Parameters, Pain, Comfort and Procedure Satisfaction
Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Coronary Angiography (CAG) is an invasive method used in the diagnosis and treatment of CAD.
- Trial name
- NCT06725875
- Testing
- White Noise Group, Earplug group
- Volunteers
- 90 people
- Sponsor
- Di̇lek Soylu
Biliary Atresia
Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Obeticholic Acid (OCA) Compared to Placebo in Pediatric Participants With Biliary Atresia, Post-hepatoportoenterostomy
This study will evaluate the efficacy, safety and tolerability, as well as PK/PD of OCA in eligible pediatric participants with biliary atresia with successful hepatoportoenterostomy (HPE, also known as a Kasai portoenterostomy).
- Trial name
- NCT06121375
- Testing
- OCA
- Where
- 24 sites in Australia, Canada and 8 more
- Volunteers
- 28 people
- Sponsor
- Intercept Pharmaceuticals
Premature Ejaculation
Exploratory Study of Pagoclone in Men With Premature Ejaculation.
The purpose of this study is to evaluate pagoclone in the treatment of premature ejaculation.
- Trial name
- NCT00370981
- Testing
- pagoclone
- Where
- 16 sites in United States
- Volunteers
- 100 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company