Clinical trials: Randomized Controlled Trial, Human Study
Vitamin D Deficiency
Vitamin D Absorbance Study - Clinical Trial of the Absorbance of Nano Liquid D3
Vitamin D is a commonly available essential prohormone humans need to regulate blood calcium and has recently emerged as potentially helpful in combating severe COVID-19.
- Trial name
- ViDAS (NCT04885803)
- Testing
- Softgel Vitamin D3, Nano Liquid Vitamin D3, 25(OH)D Blood Serum Test
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Inspired Life Medical, Inc.
Infant Development, Stress
Multisensory Early Oral Administration of Human Milk in Preterm Infants
The aims of this pilot are to determine the feasibility and acceptability of the Multisensory early oral administration of human milk (M-MILK) intervention, recruitment, retention, and obtain data for sample size estimation.
- Trial name
- M-MILK (NCT06230848)
- Testing
- Multisensory Early Oral Administration of Human Milk (M-MILK)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Loyola University
Chronic Hepatitis B
Prednisolone Priming Study in Patients With Chronic Hepatitis B
Study purpose: To investigate whether ALT rebound following corticosteroid priming enhances response to telbivudine therapy. Efficacy assessments: The primary endpoint will be the 1-year HBe-Ag seroconversion rate with or without…
- Trial name
- NCT00778596
- Testing
- Prednisolone
- Where
- 4 sites in Taiwan
- Volunteers
- 160 people
- Sponsor
- Yun-Fan Liaw
Hepatitis B Vaccine
Immunogenicity and Persistence of Hepatitis B Vaccination in HIV-Infected Patients
At present, HIV-Infected Patients of Hepatitis B Vaccination in are vaccinated with hepatitis B vaccine according to the standard three-dose schedule immunization program, and the effect of preventing HBV infection is not ideal.
- Trial name
- NCT03962803
- Testing
- 20 µg recombinant hepatitis B vaccine at months 0, 1, and 6, 20 µg recombinant hepatitis B vaccine at months 0, 1, 2, and 6, 60 µg recombinant hepatitis B vaccine at months 0, 1, 2, and 6
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanxi Medical University
Hepatitis B Virus
Nucleoside (Acid) Analogues Treatment in Patients With Normal ALT and Positive HBVDNA.
This study is to investigate the clinical efficacy and safety of Nucleoside (acid) analogues treatment in patients with normal Alanine Aminotransferase and positive Hepatitis B virus DNA.
- Trial name
- ALTHBV (NCT04231565)
- Testing
- Tenofovir alafenamide Fumarate
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
HPV InfectioN, HPV-Related Carcinoma
A Study to Evaluate the Efficacy, Safety, and Immunogenicity of SCT1000 in Healthy Women Aged 18-45 Years
A total of 18000 healthy women aged 18-45 years old were divided into three age groups: 18-26 years old, 27-35 years old, and 36-45 years old. The experimental group and the placebo group were randomly assigned in a ratio of 1:1.
- Trial name
- NCT06041061
- Testing
- Recombinant 14-Valent Human Papillomavirus Vaccine（Insect Cell）
- Where
- 5 sites in China
- Volunteers
- 18,000 people, healthy volunteers welcome
- Sponsor
- Sinocelltech Ltd.
Human Papillomavirus
Immunogenicity and Tolerability of V503 Versus GARDASIL (V503-009)
Primary objective: To demonstrate that administration of V503 induces non-inferior Geometric Mean Titers (GMTs) (for serum anti-HPV16 and anti-HPV18) compared to GARDASIL.
- Trial name
- NCT01304498
- Testing
- V503, GARDASIL
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Diarrhea, Travelers Diarrhea
Clinical Study to Assess the Efficacy of Once-daily IMM-124E (Travelan®) in a Controlled Human Infection Model.
This is a randomized, double-blind, placebo-controlled study to investigate a single daily dose of Travelan® protects healthy adult volunteers from moderate-to-severe diarrhea upon challenge with Enterotoxigenic Escherichia coli…
- Conditions
- Diarrhea, Travelers Diarrhea, Infectious Diarrhea
- Trial name
- NCT05933525
- Testing
- Travelan
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Immuron Ltd.
Nonalcoholic Steatohepatitis
A Trial to Evaluate the Safety Tolerability and Pharmacokinetics of B1344 by Subcutaneous Injection in Healthy Subjects
To evaluate the safety, tolerability, and immunogenicity of B1344 by single subcutaneous (s.c.) injection in healthy subjects
- Trial name
- NCT05655221
- Testing
- B1344
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Tasly Biopharmaceuticals Co., Ltd.
Myotonic Dystrophy Type 1
Safety and Efficacy Study of Recombinant Human Insulin-Like Growth Factor-I/Recombinant Human Insulin-Like Growth Factor Binding Protein-3 (rhIGF-I/rhIGFBP-3) In Myotonic Dystrophy Type 1
To investigate the effects of rhIGF-I/rhIGFBP-3 treatment for 24 weeks on endurance, ambulation, cognitive functioning, insulin resistance, lipid levels, muscle function and strength, pain, gastrointestinal functioning, and…
- Trial name
- NCT00577577
- Testing
- rhIGF-I/rhIGFBP-3
- Where
- 12 sites in United States
- Volunteers
- 69 people
- Sponsor
- Insmed Incorporated
Chronic Hepatitis B
Efficacy Study of Thymosin alpha1 & Pegylated Interferon-alpha2a to Treat Chronic Hepatitis B
The purpose of this study is to determine the optimal treatment duration of antiviral therapy for chronic hepatitis B.
- Trial name
- NCT00291616
- Testing
- Pegylated Interferon-alpha2a, Thymosin alpha1 & Pegylated Interferon-alpha2a
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Seoul National University Hospital
Influenza
The Dynamics of the Immune Responses to Repeat Influenza Vaccination Exposures (DRIVE III) Study
This study will provide novel insight into the effects of repeat influenza vaccination with Flublok and FluMist on the strength and breadth of immune responses to influenza, the mechanisms underlying heterogeneity in vaccine…
- Trial name
- DRIVE III (NCT07240922)
- Testing
- Live attenuated influenza vaccine, recombinant hemagglutinin influenza vaccine
- Where
- Hong Kong
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Anal High Grade Squamous Intraepithelial Lesion, Anal Precancerous Condition
Artesunate Suppositories for the Treatment of HIV-negative Patients With Intra-anal HSIL
This is a phase II double blind, placebo-controlled, randomized study of Artesunate suppositories for the treatment of HIV-negative men and women who have anal high grade squamous intraepithelial lesions (anal HSIL)
- Conditions
- Anal High Grade Squamous Intraepithelial Lesion, Anal Precancerous Condition, AIN 2/3, HPV Infection
- Trial name
- anal HSIL HIV- (NCT05555862)
- Testing
- Artesunate
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Frantz Viral Therapeutics, LLC
Human Papilloma Virus
A Cohort Study of Hyperthermia and Imiquimod for the Treatment of Flat Warts
flat warts are a superficial viral skin disease, extremely common in childhood.Treatment of warts is often difficult and involves different destructive procedures.Although several pharmacological and physical topical treatments…
- Trial name
- NCT05146895
- Testing
- Imiquimod treatment, Local Hyperthermia at 44℃
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- First Hospital of China Medical University
Viremia
Yellow Fever Virus Vaccine and Immune Globulin Study
The purpose of this study is to determine whether immune globulin can limit the amount of yellow fever vaccine virus present in the blood after vaccination without compromising the immunity associated with the yellow fever…
- Trial name
- NCT00254826
- Testing
- YF-VAX® plus saline, 17D YF Vaccine plus Ig,
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Emory University
Critically Ill Patients
Human Recombinant Interferon Gamma-1b for the Prevention of Hospital-acquired Pneumonia in Critically Ill Patients: a Double-blind, International, Phase 2, Randomized, Placebo-controlled Trial - the PREV-HAP Study
PREV-HAP study is part of a larger project entitled 'Host-targeted Approaches for the Prevention and the treatment of Hospital-Acquired Pneumonia' (HAP2), funded by the European Union's H2020 research and innovation programme…
- Trial name
- PREV-HAP (NCT04793568)
- Testing
- Recombinant Interferon gamma 1b (IMUKIN®)
- Where
- 18 sites in France, Greece and 1 more
- Volunteers
- 109 people
- Sponsor
- Nantes University Hospital
Influenza, Human, HIV
Safety and Immunogenicity Study of Influenza Vaccines in HIV-infected and HIV-uninfected Pregnant Women in Western Kenya
In 2012, the WHO Strategic Advisory Group of Experts (SAGE) concluded that pregnant women are the most important risk group for season influenza vaccination based upon "compelling evidence of substantial risk of severe disease in…
- Conditions
- Influenza, Human, HIV, Malaria, Tetanus
- Trial name
- NCT01810731
- Testing
- Quadrivalent Inactivated Influenza Vaccine (QIV), Inactivated Polio Vaccine, Double Dose QIV
- Where
- Kenya
- Sponsor
- Centers for Disease Control and Prevention
Not Applicable - Healthy Adult Participants
Study of XmAb412 in Healthy Participants
This Phase 1 Study will evaluate the safety, tolerability, pharmacokinectics and pharmacodynamics of XmAb412 in healthy adult participants
- Trial name
- NCT07713485
- Testing
- XmAb412 Monoclonal Bispecific Antibody
- Where
- 2 sites in Australia
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Xencor, Inc.
Influenza
High Dose Influenza Vaccine in Nursing Home - Pilot Study
The purpose of this pilot evaluation is to help determine the feasibility and power needed to prospectively evaluate relative effectiveness of high-dose influenza vaccine in preventing influenza mortality and hospitalization in a…
- Trial name
- NCT01720277
- Testing
- HD Fluzone Vaccine, SD Fluzone Vaccine
- Where
- 2 sites in United States
- Volunteers
- 2,957 people
- Sponsor
- Insight Therapeutics, LLC
Chronic Hepatitis b
Clinical Study to Evaluate the Safety and Efficacy of Switching to Tenofovir Disoproxil From Tenofovir Disoproxil Fumarate in Patients With Chronic Hepatitis B
This is a Phase4, multicenter, open-label, randomized study to demonstrate that the Tenolid Tab switching group is non-inferior to the virologic suppression effect compared to the Viread Tab continuous administration group and…
- Trial name
- NCT05286346
- Testing
- Tenofovir disoproxil 245mg, Tenofovir disoproxil fumarate 300mg
- Where
- South Korea
- Volunteers
- 113 people
- Sponsor
- Samjin Pharmaceutical Co., Ltd.