Clinical trials: Randomized Controlled Trial (RCT)
Alveolar Bone Atrophy
Efficacy in Alveolar Bone Regeneration With Autologous MSCs and Biomaterial in Comparison to Autologous Bone Grafting
A randomized controlled clinical multi center trial to assess the efficacy of a combination of autologous mesenchymal stem cells and biomaterial in jaw bone regeneration prior to dental implant placement in comparison to standard…
- Trial name
- Maxibone (NCT04297813)
- Testing
- Advanced medicinal Therapy (MSC combined with biomaterial), Autologous bone graft
- Where
- 6 sites in Denmark, France and 2 more
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Mild Cognitive Impairment (MCI), Subjective Cognitive Decrease (SCD)
A Graphene Far-infrared Intervention Study of Cognitive Status in Older Adults
This study is a 4-week group controlled trial to explore whether graphene far-infrared intervention can improve the cognitive status of older adults presenting with symptoms of Subjective Cognitive Decline (SCD), Mild Cognitive…
- Conditions
- Mild Cognitive Impairment (MCI), Subjective Cognitive Decrease (SCD), Alzheimer's Disease(AD), Depression/Anxiety Symptoms
- Trial name
- NCT06843824
- Testing
- a custom-made graphene therapy cap, A regular cap that generates heat
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Institute of Psychology, Chinese Academy of Sciences
Periodontitis, Gingivitis
The Effect of A Dental Application to Promote Self-Administered Plaque Control: A RCT
Randomized Controlled Trial: to investigate the feasibility of the usage of a mobile dental application in the self-administration of plaque control in a two (2) parallel arm study with 52 subjects (n = 52).
- Conditions
- Periodontitis, Gingivitis, Plaque, Dental
- Trial name
- NCT05073107
- Testing
- Mobile Dental Application, Dental Monitoring ("DM")
- Where
- Singapore
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Physical Health, Mental Health
MVP RCT: Mind and Voice Project Randomized Control Trial
The study seeks to learn more about the health behaviors of young adults. Health behaviors include relationships, physical and mental health, alcohol use, and conflicts with others.
- Conditions
- Physical Health, Mental Health, Alcohol; Use, Problem, Interpersonal Violence
- Trial name
- NCT04018807
- Testing
- Resource pamphlet, Remote Therapy
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Lupus Erythematosus, Systemic
Contemplation-Based Intervention and Health Outcomes RCT in Lupus Patients
The objective of this study is to test the efficacy of an innovative contemplative-based and caregiver-inclusive intervention can modify pathogenic processes in systemic lupus erythematosus (SLE) compared to a…
- Trial name
- NCT04032496
- Testing
- Contemplative-Based Intervention for People Living with SLE, Health Enhancement Program (HEP)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Orthodontic Miniscrew Survival, Malocclusion
This RCT Compares the Clinical Performance, Stability, and Patient Perception of Different Diameters Orthodontic Miniscrews in the Posterior Maxilla Buccal Side.
Researchers will compare miniscrews with diameters of 1.3 millimeters and 1.6 millimeters. Both sizes are 8 millimeters long and will be placed between the roots of the first and second molar teeth at the back of the upper jaw.
- Trial name
- RCT (NCT07868705)
- Testing
- Orthodontic miniscrew, 1.3-mm diameter and 8-mm length, Orthodontic miniscrew, 1.6-mm diameter and 8-mm length
- Where
- Malaysia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Anterior Cruciate Ligament Rupture, Ligament Knee Injury
Association of ALL and ACL Reconstruction Versus Isolated ACL Reconstruction in High-risk Population: a RCT.
Persistent rotational instability after standard ACL reconstruction have been extensively described, and it has been shown to keep straight correlation with worse outcomes post-operatively (Chouliaras 2007, Kocher 2004).
- Trial name
- NCT03229369
- Testing
- Isolated anatomic ACL reconstruction, Combined Anterior Cruciate Ligament and Anterolateral Ligament reconstruction
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Acne Vulgaris
Application of Poly-herbal Powder for Treating Acne Vulgaris
Acne is a common problem in adolescence to young adult. But there is no such remedy available for acne treatment which has no side effects.
- Trial name
- NCT04949932
- Testing
- Mixed powder of Lens culinaris, Curcuma longa, Mentha arvensis, Azadirachta indica, and Trigonella foenumgraecum., Cicer arietinum powder
- Where
- Bangladesh
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Dr. Md. Shahab Uddin
Depression
RCT of Adjunctive Curcumin and the Meru Health Program
This is a randomized controlled trial (RCT) to compare the Meru Health Program plus adjunctive curcumin (MHP-CUR) versus Meru Health Program only (MHP-ONLY) for adults with depression.
- Trial name
- NCT04744545
- Testing
- Meru Health Program, Curcumin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Meru Health, Inc.
Gender Relations, Violence
Bandebereho 6 Year Follow up RCT in Rwanda
This study seeks to conduct a six-year follow-up of the Bandebereho randomized control trial (RCT) to assess the longer-term impact of the gender-transformative Bandebereho couples intervention on participating men, women, and…
- Conditions
- Gender Relations, Violence, Child Development, Contraception
- Trial name
- NCT04861870
- Testing
- MenCare+/Bandebereho fathers'/couples' group education
- Where
- Rwanda
- Volunteers
- 2,818 people, healthy volunteers welcome
- Sponsor
- Promundo, United States
Achilles Tendinopathy
RCT of Home-based vs Formal Physical Therapy for Treatment of New Onset Non-insertional Achilles Tendinopathy
The goal of this prospective randomized controlled trial is to compare the effectiveness of a home-based exercise protocol to formal physical therapy in patients who have been diagnosed with Achilles tendinopathy.
- Trial name
- NCT06374654
- Testing
- Home-based Exercise Protocol, Formal Physical Therapy
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Prediabetic State
RCT of a Polyherbal Dietary Supplement for Prediabetes
The primary purpose of this study is to evaluate the impact of a polyherbal dietary supplement (Designs for Health - GlucoSupreme™ Herbal) on markers of glycemic control and other structure/function outcomes among a sample of…
- Trial name
- NCT03388762
- Testing
- GlucoSupreme™ Herbal
- Where
- 4 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Cancer, Cardiovascular Disease (CVD)
West Philadelphia Consortium Randomized Control Trial
The investigators will evaluate the effects of an integrated risk counseling program on behavioral and psychological outcomes in African American men and women in a randomized trial that is implemented and evaluated…
- Trial name
- NCT01299883
- Testing
- Integrated vs Non-integrated Risk Education
- Where
- United States
- Volunteers
- 543 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Tree Nut Allergy, Food Allergy
TRADE Trial - Tree Nut Immunotherapy Route Development and Evaluation
Tree nut immunotherapy Route Assessment and DEvelopment (TRADE) is a randomized controlled trial that evaluates the efficacy and safety of sublingual immunotherapy and lower, more tolerable, doses of oral immunotherapy than…
- Trial name
- TRADE (NCT05521711)
- Testing
- Food
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Jaw, Edentulous, Partial Edentulism
Evaluation of MBL Around Implants Placed in Crestal or Subcrestal Positions: a RCT
The objective of this randomized controlled trial is to evaluate changes in marginal bone levels and soft tissue dimensions around implants placed with the IAI at different positions in relation to the alveolar crest
- Trial name
- NCT03806608
- Testing
- Crestal, Subcrestal
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Substance Addiction
Maternal Acupuncture for Substance Abuse
To determine the efficacy of daily maternal acupuncture treatments in reducing the frequency and severity of neonatal abstinence syndrome among infants born to substance-using women..
- Trial name
- NCT00225316
- Testing
- Acupuncture
- Where
- Canada
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Colorectal Cancer
RCT of Automated Telephone Outreach to Improve Colorectal Cancer Screening
This large randomized controlled trial is testing the effectiveness of automated telephone outreach with speech recognition to improve rates of screening for colorectal cancer.
- Trial name
- NCT00792285
- Testing
- Automated Telephone Outreach with Speech Recognition
- Where
- United States
- Volunteers
- 80,000 people, healthy volunteers welcome
- Sponsor
- Harvard Pilgrim Health Care
PTSD
Psychological First Aid (PFA): RCT Adults Non-intentional Trauma Emergency Room
Psychological First Aid (PFA) is currently the most recommended early intervention for people affected by recent traumatic events, especially in the aftermath of natural disasters.
- Trial name
- PFA (NCT02608086)
- Testing
- Psychoeducation, Psychological First Aid
- Where
- 5 sites in Chile
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Heart Rate, All-day Steps
Assessing the Effect of Cool Roofs on Health Using Smartwatches in Niue
Ambient air temperatures in the Pacific have broken record highs in 2024. Solutions are needed to build heat resilience in communities and adapt to increasing heat from climate change.
- Conditions
- Heart Rate, All-day Steps, Distance Walked, Active Minutes
- Trial name
- REFLECT (NCT06571019)
- Testing
- Cool roof
- Where
- Niue
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Antenatal Care and Delivery
Increasing Women's Access to Skilled Pregnancy Care to Reduce Maternal Mortality in Nigeria
Background: Nigeria has the second highest absolute number of maternal deaths and perinatal deaths in the world. The country contributes 14% of all maternal deaths worldwide, second only to India.
- Trial name
- NCT02643953
- Testing
- Incentives, Community
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Ottawa