Clinical trials: Randomized-controlled Trial
Burnout
Reducing Burnout Among Frontline Healthcare Workers During COVID-19
Physician burnout has a significant impact on the wellness and productivity of physicians as well as patient health outcomes. Managing burnout among frontline workers is critical to Canada's response to the COVID-19 pandemic, in…
- Trial name
- RESTORE (NCT04474080)
- Testing
- Virtual Peer Support Platform, Control Period
- Where
- Canada
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Dental Caries Extending Into Dentin, Root Caries
Root Caries Excavation with Air Water/powder Prophylaxis Device for ART Restorations
The main objective of this RCT is to compare the efficacy of a powder/water jet prophylaxis device and conventional hand excavation in excavating root surface caries, with regard to restoration survival/success in older adults.
- Trial name
- ART-AIRFLOW (NCT04822246)
- Testing
- Control: Hand instrumentation for caries excavation, Intervention 1: EMS Airflow device for caries excavation, Intervention 2: Hand excavation + EMS Airflow device for caries excavation
- Where
- Switzerland
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Murali Srinivasan, Dr. med. dent., BDS, MDS, MBA, MAS
Uterine Atony With Hemorrhage
Multimodal Uterotonics at the Time of Cesarean Section in Laboring Patients
Postpartum hemorrhage remains a leading cause of maternal morbidity and mortality worldwide, even in high income countries. Uterine atony is estimated to cause 70-80% of postpartum hemorrhage.
- Trial name
- NCT03904446
- Testing
- Methylergonovine
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Cynthia Wong
Myopia
Retardation of Myopia in Orthokeratology
The primary aim of this study is to evaluate and compare the eyeball elongation in children wearing orthokeratology lenses and single-vision spectacles.
- Trial name
- ROMIO (NCT00962208)
- Testing
- orthokeratology lenses, single-vision spectacle lenses
- Where
- China
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Lumbar Puncture, Topical Analgesia
Jet Injection of 1% Buffered Lidocaine Versus Topical EMLA for Local Anesthesia Before Lumbar Puncture in Children
The purpose of this study is to evaluate the effectiveness of a needle-free jet-injection system with 1% buffered lidocaine for local anesthesia for lumbar punctures compared to a topical anesthetic agent.
- Trial name
- JTIP (NCT01628874)
- Testing
- J-Tip, EMLA, Lidocaine
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Burnout, Professional, Stress, Psychological
Micronutrient Supplement for Nurse Burnout
The purpose of this study is to confirm and quantify the ability of an 8-week intervention with a supplement containing magnesium citrate and vitamin B6 to reduce anxiety, stress, and burnout among nurses working full time in…
- Trial name
- NCT05363410
- Testing
- MagnéVie B6®
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Nutraceuticals Research Institute
Depression Disorder, Anxiety
Impact of Nut Consumption on Mental Health in Young Adults
Nuts have a high nutrient density, and numerous studies have reported their cardiometabolic benefits. Although observational studies in adults have indicated a potential link between nut consumption and improved mental health…
- Conditions
- Depression Disorder, Anxiety, Mental Health, Stress
- Trial name
- NUTS4BRAIN-RCT (NCT07292610)
- Testing
- mixed nuts. Group A, mixed nuts. Group B, control group
- Where
- Spain
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Castilla-La Mancha
Chronic Low-back Pain
PCT of Pharmacopuncture Therapy for Chronic Low Back Pain : A Pilot Study
This is pilot study for a 2-arm parallel pragmatic randomized controlled trial that will compare pharmacopuncture therapy and physical therapy for chronic low back pain.
- Trial name
- NCT04576520
- Testing
- pharmacopuncture therapy, physical therapy
- Where
- 4 sites in South Korea
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Jaseng Medical Foundation
Parent of Child With Chronic Life-threatening Illness
Narrative E-Writing Intervention (NeW-I) for Parents of Children With Chronic Life-Threatening Illness
Narrative e-Writing Intervention (NeW-I) is an evidence-based, strength-focused and meaning-oriented approach that aims at enhancing well-being, alleviating burden, and reducing adverse grief outcomes among Singaporean parents…
- Trial name
- NeW-I (NCT03684382)
- Testing
- NeW-I group
- Where
- 4 sites in Singapore
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Intracranial Aneurysm
Low Dose Prasugrel vs Clopidogrel for Stenting or Flow Diverter for Unruptured Aneurysm
Low clopidogrel response has been reported in about 5-44% of the total population, which is associated with an increase in thromboembolism. Recently prasugrel drug widely accepted as a good option for these patients.
- Trial name
- NCT05359224
- Testing
- Prasugrel group, Clopidogrel group
- Where
- South Korea
- Volunteers
- 406 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Vulvar Self-Examination, Health Knowledge,Practices,Attitudes
Different Education Methods and Self Vulvar Examination (SVE)
The goal of this clinical trial is to increase students' awareness about Self-Vulvar Examination (SVE), and to evaluate the effect of a peer education module and an educational brochure on students' knowledge and behaviors…
- Conditions
- Vulvar Self-Examination, Health Knowledge,Practices,Attitudes, Vulva Disease
- Trial name
- SVE (NCT07479459)
- Testing
- Brochure, Peer Education, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
Tension-Type Headache
Trigger Point Massage in Chronic Tension Headache
Patients with IHS criteria of chronic tension headache , considering inclusion and exclusion criteria, enrolled to this study. They will be randomized to intervention or control group by block randomization method, then treat by…
- Trial name
- NCT04232046
- Testing
- Massage
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mazandaran University of Medical Sciences
Prostatic Neoplasms
Shared Decision Making for Prostate Cancer Screening: a Practice-Based Randomized Controlled Trial
The purpose of this study is to determine whether an intervention designed to help men share decisions about prostate cancer screening with their physician results in better decision making, more shared decisions, and changes in…
- Trial name
- NCT00630188
- Testing
- You Decide, Reducing Your Risks in the Crash
- Where
- 4 sites in United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of North Carolina
Obese, Overweight
The Efficacy and Safety of Liraglutide on Body Weight Loss in Obese and Overweight Patients
This is a multicenter, randomized, double-blind, placebo controlled trial to evaluate the effect and safety of Liraglutide Injection on body weight loss compared with placebo in obese or overweight adult patients with comorbidity…
- Trial name
- NCT04605861
- Testing
- Liraglutide
- Where
- China
- Volunteers
- 414 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
White Spot Lesion of Tooth
Effect of Bioactive Resin Material Containing S-PRG Filler on White Spot Lesions
the effect of bioactive resin composite containing S-PRG filler will be tested as the material of choice for attachments bonded on teeth prior to the use of orthodontic clear aligners compared to the conventionally used flowable…
- Trial name
- NCT07715942
- Testing
- Bioactive resin composite containing S-PRG filler, Conventional flowable composite is used for the attachments for the clear orthodontic aligners
- Where
- Jordan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Treatment of Female Stress Urinary Incontinence
Laparoscopic Burch Colposuspension Versus Midurethral Sling for Treatment of Female Stress Urinary Incontinence a Randomized Controlled Trial
To compare the laparoscopic Burch colposuspension with the midurethral slings (TVT, TOT) for treatment of female stress urinary incontinence as regard efficacy and safety.
- Trial name
- NCT04775186
- Testing
- Laparoscopic Burch colposuspension and Mid-urethral slings (TVT and TOT)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Smoking Cessation
Motivating Smokers at Outdoor Public Smoking Hotspots to Have Quit Attempt With Nicotine Replacement Therapy Sampling
Background About half of the daily smokers in Hong Kong have never tried and have no intention to quit smoking. 37.9% of daily smokers attempted to quit but failed.
- Trial name
- NCT02491086
- Testing
- Nicotine replacement therapy (NRT) sampling, Smoking cessation counseling
- Where
- Hong Kong
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Rheumatoid Arthritis
Phase Ⅰ Clinical Trial of Gerilimzumab Injection in Healthy Subjects
The primary objectives of this study are to evaluate the safety, tolerability and pharmacokinetic (PK) profiles of single-dose, dose-escalated, abdominal subcutaneous injection of GB224 in Chinese healthy adult subjects.
- Trial name
- NCT04178070
- Testing
- GB224 2mg, GB224 5mg, GB224 10mg
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Genor Biopharma Co., Ltd.
Chronic Periodontitis
STUDY ON THE EFFECTS OF PERIODONTAL TREATMENT ALONG WITH THE USE OF ANTIBIOTICS OVER HIGH SENSITIVE C-REACTIVE PROTEIN. RANDOMIZED CONTROLLED CLINICAL TRIAL.
Human periodontitis is a group of highly prevalent oral inflammatory diseases and infections with relatively easy treatment and preventive features.
- Trial name
- NCT01906450
- Testing
- Scaling and root planing plus Azithromycin
- Where
- Colombia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Universidad del Valle, Colombia
Mental Health Disorder, Depression
Mobile Phone Based Intervention to Protect Mental Health in Healthcare Workers at Frontline Against COVID19
This study aims at evaluating the effectiveness of a mobile phone based intervention to prevent and manage mental health problems in healthcare workers at the frontline against COVID-19 in Spain.
- Conditions
- Mental Health Disorder, Depression, Posttraumatic Stress Disorder, Burnout
- Trial name
- PsyCovid_App (NCT04393818)
- Testing
- Intervention App
- Where
- Spain
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
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