Clinical trials: Randomized-controlled Trial
Alcohol Drinking, Adult Disease
BLa80 Improve Drinkers' Gut Microbiota
The goal of this clinical trial is to understand the effects of the probiotic BLa80 on the gut health of people who drink alcohol regularly.
- Trial name
- NCT06216587
- Testing
- BLa80
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Overactive Bladder Syndrome
Vaginal Estradiol vs Oral Beta-3 Agonist for Overactive Bladder Syndrome
A single site, double-blinded, randomized controlled trial for postmenopausal women with urinary frequency, urgency, nocturia with or without urgency urinary incontinence symptoms.
- Trial name
- NCT05221021
- Testing
- Vaginal estrogen, Mirabegron 50 MG [Myrbetriq]
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Malocclusion, Angle Class I, Bimaxillary Protrusion
3D Comparison of Anterior Teeth Retraction and Anchorage Control Between En-masse and Two-step Mechanics
The aim of this study is to compare en masse (EM) and two-step anterior teeth retraction (TSR) evaluated by means of three-dimensional images superimposition.
- Conditions
- Malocclusion, Angle Class I, Bimaxillary Protrusion, Orthodontic Space Closure
- Trial name
- NCT03903575
- Testing
- En masse anterior teeth retraction, Two-Step Retraction
- Where
- Brazil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Cesarean Section Rates
Reducing Cesarean Section Rates and Enhancing Vaginal Delivery in Greece: a Stepped-Wedge Randomized Controlled Trial
It is becoming increasingly apparent that there is an urgent need to systematically investigate the rising cesarean section (CS) rates in Greece and develop interventions to substantially reduce these rates.
- Trial name
- ENGAGE (NCT04504500)
- Testing
- HSOG guidelines application, Interactive workshops and courses, Feedback through follow-up meetings
- Where
- Greece
- Volunteers
- 6,029 people, healthy volunteers welcome
- Sponsor
- Hellenic Society of Obstetrics and Gynecology
Residual Disease, Aggressive Periodontitis
Omega-3 Fatty Acids Plus Low-dose Aspirin Daily Supplementation in Surgical Therapy to Treat Aggressive Periodontitis
The aim of this randomized controlled clinical trial of superiority will be to evaluate the effect of 3 g of omega-3 polyunsaturated fatty acids and 100 mg of aspirin daily supplementation over a period of 180 days as adjunct to…
- Trial name
- NCT03093207
- Testing
- Open flap debridement, Omega-3 polyunsaturated fatty acids, Aspirin
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Kinesio Taping, Body Temperature Changes
Effect of Kinesio Taping on Lumbar Muscle Temperature
This single-blind, randomized controlled trial aims to investigate the effect of Kinesio Taping (KT) applied to lumbar paravertebral muscles with different tensions (25% and 75%) on local body temperature.
- Trial name
- NCT06760299
- Testing
- %25 tension Kinesio tape, 75% tension Kinesio tape
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Complications; Contraceptive, Female Lactation
Early Versus Standard Postpartum Insertion of the Etonogestrel Contraceptive Implant
A highly effective single rod contraceptive implant is now available for use in the US. Delays in the insertion of the device until later in the postpartum period may negatively impact initiation rates.
- Trial name
- NCT00847587
- Testing
- Etonogestrel contraceptive implant
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Utah
Hypertension, Obesity
Effectiveness of Avapro in Obese Normotensive/Hypertensive African Americans
The purpose of this study is to test the hypothesis that hypertension increases the anti-natriuretic effects of an angiotensin receptor antagonist during mental stress in overweight/obese African-American's who retain sodium…
- Conditions
- Hypertension, Obesity, Stress, Psychological, Blood Pressure
- Trial name
- Avapro3 (NCT02386293)
- Testing
- Irbesartan
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Augusta University
Insomnia
Study of Efficacy of WELT-IP in Insomnia (WCTP-I-B-02)
The purpose of the study was to determine safety and efficacy of WELT-IP in adult insomnia patients. WELT-IP is a cognitive behavioral therapy for insomnia (CBT-I) based digital therapeutics.
- Trial name
- NCT05809544
- Testing
- WELT-IP
- Where
- South Korea
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- WELT corp
Wrinkle
Association of Photobiomodulation With Platelet Rich Plasma Intradermal Injection for Facial Rejuvenation
Skin aging is an irreversible, slow and progressive process. It is influenced mainly by age, but also by external factors such as ultraviolet radiation, smoking, alcohol, among others.
- Trial name
- NCT04145999
- Testing
- PRP application, Photobiomodulation
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Acne Vulgaris
Application of Poly-herbal Powder for Treating Acne Vulgaris
Acne is a common problem in adolescence to young adult. But there is no such remedy available for acne treatment which has no side effects.
- Trial name
- NCT04949932
- Testing
- Mixed powder of Lens culinaris, Curcuma longa, Mentha arvensis, Azadirachta indica, and Trigonella foenumgraecum., Cicer arietinum powder
- Where
- Bangladesh
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Dr. Md. Shahab Uddin
Dengue Fever
Safety and Immunogenicity With Two Different Serotype 2 Potencies of Takeda's Tetravalent Dengue Vaccine Candidate (TDV) in Adults in Singapore
The purpose of this study is to assess the post-vaccination neutralizing antibody response against each dengue serotype by vaccine group.
- Trial name
- NCT02425098
- Testing
- Takeda's Tetravalent Dengue Vaccine Candidate (TDV), Takeda's High-Dose Tetravalent Dengue Vaccine Candidate (HD-TDV)
- Where
- 3 sites in Singapore
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- Takeda
Cervical Cancer Screening, Cervical Cancer
Using Artificial Intelligence-based ChatBot to Improve Women's Participation to Cervical Cancer Screening Programme
This project looks to improve the return rate of HPV self-sampling (HPVss) as well as the management of women HPVss positive.
- Trial name
- AppDate-You (NCT05286034)
- Testing
- Decision aid tailored to women with lower educational attainment,accessible via artificial intelligence-based Chatbot platforms
- Where
- France
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- International Agency for Research on Cancer
Acute Ischemic Stroke (AIS)
A Phase I Clinical Trial Evaluating the Safety, Tolerability and Pharmacokinetics of AAPB for Injection
This is a Phase I clinical to evaluate the safety and tolerability of single and multiple intravenous infusions of AAPB at different doses over 7 consecutive days.
- Trial name
- AAPB (NCT06679998)
- Testing
- Single dose, AAPB by injection, intravenous drip., Multiple dosing, AAPB for injection, intravenous drip
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Jiangsu Kanion Pharmaceutical Co., Ltd
Literacy, Child Development
Rx for Success: RCT of an App for Dialogic Reading Training
The purpose of this randomized controlled trial is to explore the efficacy of amplifying dialogic reading training provided to families of infants and toddlers in the ROR program using a novel, smartphone-based application (Rx…
- Conditions
- Literacy, Child Development, Parenting
- Trial name
- NCT03828721
- Testing
- Rx for Success Smartphone Application, Control - screen time reduction
- Where
- United States
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Immunization; Infection, SMS
Use of SMS and Interactive Reminders to Improve Timely Immunization Coverage
Pakistan has one of the highest infant mortality rates in the world. One child in eleven dies before their fifth birthday. In part, this is due to the low coverage rate of routine childhood immunizations.
- Trial name
- NCT03379467
- Testing
- SMS Reminder, Interactive Reminder
- Volunteers
- 655 people, healthy volunteers welcome
- Sponsor
- Interactive Research and Development
Joint Pain, Stiffness, Function
Instaflex and Joint Pain in Community Adults
The primary purpose of this study is to assess the effect of 8-weeks ingestion of the Instaflex Joint Support supplement (Direct Digital, Charlotte, NC) compared to placebo on joint pain, stiffness, and function (questionnaires…
- Trial name
- NCT01956500
- Testing
- Instaflex
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Participants Must be Women Aged 25 Years or Older, Participants Should Have no Self-reported History of Heart Disease or Stroke
RCT of HeartBot in Women
The goal of this clinical trial is to find out whether an app-based program called HeartBot II, which uses an artificial intelligence (AI) chatbot, can help improve women's awareness and knowledge of heart attacks in women.
- Conditions
- Participants Must be Women Aged 25 Years or Older, Participants Should Have no Self-reported History of Heart Disease or Stroke, Participants Should Have no Terminal Illness or Diagnosed Cognitive Impairment, Including Alzheimer's Disease, Participants Should Not be a Healthcare Professionals or Healthcare Trainees
- Trial name
- HeartBot II (NCT07416734)
- Testing
- HeartBot II Program, Waitlist Control
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Postprandial Lipemia
Effect of Standardized Large Yellow Tea Extract on Triglyceride Response After a High-Fat Meal in Healthy Adults
This study is a single-center, prospective, open-label, randomized 2×2 crossover controlled trial in healthy adults aged 18 to 45 years.
- Trial name
- NCT07824609
- Testing
- Standardized Large Yellow Tea Extract, Warm Water Control
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of China University of Science and Technology (Anhui Provincial)
Overweight and Obesity, Eating Disorders
Project Health: Enhancing Effectiveness of an Obesity Prevention Program
This 2-site effectiveness trial will test whether a brief dissonance-based obesity prevention program delivered in single sex groups combined with food response and attention training will produce significantly larger weight gain…
- Trial name
- NCT06067763
- Testing
- Project Health, Response and Attention Training, The Weight of the Nation
- Where
- 2 sites in United States
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Oregon Research Institute
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