Clinical trials: Randomized-controlled Trial
Alcohol Use Disorder
The Efficacy of Probiotics for the Treatment of Alcohol Use Disorder Among Adult Males
This two-armed, parallel-group, double-blind, multi-center randomized control trial (RCT) aims to evaluate the efficacy of probiotic supplement compared with placebo in ameliorating alcohol craving and severity of alcohol use…
- Trial name
- NCT05830708
- Testing
- Lactobacillus sp. probiotic
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Obstructive Sleep Apnea
Ezopiclone Improves the Quality of Overnight Polysomnography
Patients often have difficulty sleeping during overnight sleep testing in a lab environment. The purpose of this study is to determine if taking a sleep aid will improve sleep and therefore the quality of the sleep study.
- Trial name
- NCT00507117
- Testing
- Lunesta
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Pressure Ulcer (PU), Pressure Injury Prevention
Effect of a Risk-Based Perioperative Pressure Injury Prevention Bundle in Elective Surgery Patients
This study evaluates whether a risk-based perioperative pressure injury prevention bundle reduces the development of pressure injuries in patients undergoing elective surgery lasting 3 hours or longer.
- Conditions
- Pressure Ulcer (PU), Pressure Injury Prevention, Perioperative Care, Braden Scale
- Trial name
- RiPPB (NCT07725068)
- Testing
- Risk-Based Perioperative Pressure Injury Prevention Bundle
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Facial Plane Blocks
Comparison of the Efficacy of One Level and Tow Level of Bilateral Thoracic Erector Spinae Plane Block Combined With General Anesthesia in Laparoscopic Bariatric Surgery for Obese Patients: Randomized Controlled Trial
comparison of the feasibility and efficacy of the one-level and two-level thoracic ESP block and their effect on intraoperative and postoperative analgesia in bariatric surgeries.
- Trial name
- NCT06811493
- Testing
- bilateral thoracic erector spinae plane block combined with general anesthesia in laparoscopic bariatric surgery in obese patients
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Chronic Illness, Comorbidities
Advance Care Planning & Goals of Care Randomized Controlled Trial in Primary Care
Sometimes people with health conditions become ill suddenly and can no longer speak for themselves and another person (such as a family member) will make health care decisions for them.
- Trial name
- NCT03434626
- Testing
- ACP Education, Usual care
- Where
- 2 sites in Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- McMaster University
Metabolic Syndrome
Effect of Fruit and Vegetable Concentrates on Endothelial Function in Persons With Metabolic Syndrome
Dehydrated fruit and vegetable concentrates provide an accessible form of phytonutrient supplementation that may offer cardioprotective effects.
- Trial name
- NCT01224743
- Testing
- Blend 1, Blend 2
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Griffin Hospital
L-PRF, Photodynamic Therapy
The Effect of Leukocyte and Platelet-rich Fibrin With Antimicrobial Photodynamic Therapy in Aggressive Periodontitis
Antimicrobial photodynamic therapy (aPDT) is associated with photosensitizing agents which promote the generation of free radicals and singlet oxygen, which are cytotoxic to certain bacteria.
- Conditions
- L-PRF, Photodynamic Therapy, Aggressive Periodontitis
- Trial name
- NCT05043935
- Testing
- L-PRF with antimicrobial photodynamic therapy, antimicrobial photodynamic therapy without L-PRF
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Smoking Cessation
A Video-led Smoking Cessation Intervention in Helping Male Smokers Whose Partners Got Pregnant to Quit Smoking
This study aims to use a three arms randomized clinical trial study to evaluate the effectiveness of a video-led intervention in helping male smokers whose partner got pregnant in Mainland China to quit smoking.
- Trial name
- NCT03236025
- Testing
- Video+brief smoking cessation+pamphlet, Text-message+brief smoking cessation+pamphlet, brief smoking cessation+pamphlet
- Where
- Hong Kong
- Volunteers
- 1,023 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Sedentary Lifestyle, Metabolic Disorders
Concurrent Training and Metabolic Profile, Lung Function, Quality of Life and Stress
Physical inactivity and sedentary time are highly prevalent worldwide and are associated with many adverse health outcomes. Workers adults spend two-thirds of their workday sitting, so they are particularly at risk.
- Conditions
- Sedentary Lifestyle, Metabolic Disorders, Concurrent Exercise, Lung Function Decreased
- Trial name
- NCT04868240
- Testing
- Concurrent training program
- Where
- Portugal
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Coimbra
Financial Stress
Finances First: A Health Intervention in Low Income Single Mother Households
The purpose of this prospective, randomized, controlled three-year study is to compare the effect of a year-long financial education program versus usual care on health outcomes in single mother low income households.
- Trial name
- NCT03035240
- Testing
- Financial Education
- Where
- United States
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- Creighton University
Post Traumatic Stress Disorder
Department of Defense PTSD Adaptive Platform Trial - Intervention C - Daridorexant
This is a Phase 2 randomized, double-blinded, placebo-controlled study that will evaluate multiple potential pharmacotherapeutic interventions for PTSD utilizing an adaptive platform trial design.
- Trial name
- NCT05948540
- Testing
- Intervention C Daridorexant
- Where
- 9 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Global Coalition for Adaptive Research
Mobile Health, Older Adult
Effects of a Video-based mHealth Program
Homebound older adults are among the highest users in health care systems. The high use of health care services is related to their physical limitations compounded by complex health and social care needs.
- Trial name
- NCT04304989
- Testing
- mHealth program, usual care
- Where
- Hong Kong
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Dentin Sensitivity
In-office Bleaching With a 2-day Interval Between Sessions: Tooth Sensitivity
The calcium containing 35% hydrogen peroxide gel employed in this study can be re-applied 2 days after the first bleaching session without increasing the bleaching-induced tooth sensitivity
- Trial name
- NCT01959789
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Ponta Grossa
Hip Osteoarthritis, Hip Pain Chronic
Fast Track Total Hip Arthroplasty vs Standard Care
Fast-track total hip arthroplasty (THA) is a well-established concept including optimized logistics and evidence-based treatment, focusing on minimizing surgical stress and improved post-operative recovery.
- Trial name
- FastTrack-H (NCT04211987)
- Testing
- fast track care protocol, standard care protocol
- Where
- Italy
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Istituto Ortopedico Rizzoli
Bowel Preparation Solution, Colonoscopy
Comparison of Bowel Preparation Using 2 Liter Polyethylene Glycol Regimen Plus Elobixibat Versus 4-Liter Polyethylene Glycol Regimen
Comparison of bowel preparation using 2 liter polyethylene glycol regimen plus elobixibat Versus 4-Liter polyethylene glycol regimen.
- Trial name
- NCT06436833
- Testing
- 2-Liter polyethylene glycol plus elobixibat, 4-Liter polyethylene glycol
- Where
- Thailand
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Healthy Infants
Starter Infant Formula With Synbiotics
This randomized, double-blind, controlled intervention trial aims to evaluate the safety and efficacy of a starter infant formula supplemented with an HMO blend and a probiotic, and will provide evidence on the safety and…
- Trial name
- NCT06073652
- Testing
- Control 1st age starter infant formula, Experimental 1st age starter infant formula
- Where
- 3 sites in Philippines
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Malaria, Falciparum, Malaria, Asymptomatic Parasitaemia
MDA and Targeted Control Against Plasmodium Carriage in the Sahel
Strategies implemented since 2010 by the Senegalese National Malaria Control Program (NMCP) enabled a reduction of malaria transmission.
- Trial name
- AMARETI (NCT07281443)
- Testing
- MDA with DHAp and SLD Primaquine, Targeted control (10-24 years) during the malaria high tranmission season: behaviour, Targeted control (15-24 years) during the malaria high tranmission season: test and treat
- Where
- Senegal
- Volunteers
- 18,000 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche pour le Developpement
Lower Limb Surgeries
Effect of Height Based vs Conventional Dose of Spinal Anesthesia in Lower Limb Surgeries
This study aim is to compare height based dose of spinal anesthesia vs conventional dose. Hypothesis is height based dose has less hemodynamics changes compared to conventional dosing.
- Trial name
- NCT07751835
- Testing
- Height based dose of hyperbaric bupivacaine 0.5%
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Liaquat National Hospital & Medical College
Post Partum Hemorrhage
Comparative Efficacy of Carbetocin and Oxytocin in Parturients at Risk of Atonic Postpartum Hemorrhage Undergoing Elective Cesarean Delivery
The goal of this study is to compare 2 medications that are commonly used to prevent excess uterine bleeding (postpartum hemorrhage, or PPH) following cesarean delivery (CD), oxytocin and carbetocin.
- Trial name
- NCT06333340
- Testing
- Oxytocin, Carbetocin
- Where
- Canada
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Grief Disorder, Prolonged
Feasibility and Efficacy of Individual SH+ Intervention
The central aim of this research is to execute a randomized controlled trial (RCT) to assess the impact and effectiveness of the individually-delivered SH+ intervention among earthquake survivors in Türkiye.
- Trial name
- NCT06091540
- Testing
- Feasibility and Efficacy of Individual SH+ Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Koç University
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