Clinical trials: Randomized-controlled Trial
Caries,Dental
Clinical Trial Proximal Caries Infiltration and Detection
The purpose of this study is to investigate the clinical efficacy of resin infiltration (Icon, DMG, Germany) compared to fluoride varnish (Duraphat Fluoride Varnish, Colgate, USA) in the management of proximal early caries…
- Trial name
- NCT01796106
- Testing
- Resin infiltration, Fluoride varnish & Oral hygiene instruction
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- DMG Dental Material Gesellschaft mbH
Bronchiolitis
Oxygen Saturation Monitoring in Bronchiolitis
The investigators will conduct a study around the best way to monitor infants hospitalized with bronchiolitis, the most common lung infection and a leading reason for hospitalization in infants.
- Trial name
- NCT02947204
- Testing
- Intermittent oxygen monitoring, Continuous oxygen monitoring
- Where
- 6 sites in Canada
- Volunteers
- 219 people
- Sponsor
- The Hospital for Sick Children
Tonsillitis
Suprazygomatic Maxillary Nerve Block in Pediatric Tonsillectomy
Tonsillectomies are among the most common surgical procedures performed in pediatric populations, with more than 14,000 procedures performed annually in Ontario, with more than 80% being performed to treat sleep-disordered…
- Trial name
- NCT07176533
- Testing
- Suprazygomatic maxillary nerve block (SZMN) with bupivacaine
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Cervical Intraepithelial Neoplasia Grade 2, Papillomavirus Infections
ALA-PDT in Patients With CIN2 in p16-positivity and High-risk HPV Infection
Efficacy and Safety of ALA-PDT in patients with cervical intraepithelial neoplasia grade 2 (CIN2) in p16-positivity and high-risk HPV infection.
- Conditions
- Cervical Intraepithelial Neoplasia Grade 2, Papillomavirus Infections, p16 Protein
- Trial name
- NCT06439433
- Testing
- Aminolaevulinic acid (500-mg bottle), Aminolaevulinic acid (750-mg bottle)
- Where
- 5 sites in China
- Volunteers
- 119 people
- Sponsor
- Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd.
Dental Caries
Prevention of Enamel Demineralization by Use of K18-smooth Surface Sealant
This study will evaluate effectiveness of a urethane dimethacrylate (UDMA)-quaternary ammonium methacrylate (K18) resin (UDMA-K18) smooth surface sealant to prevent biofilm attachment to tooth surfaces thereby eliminating the…
- Trial name
- K18 (NCT03306433)
- Testing
- UDMA-K18 smooth surface sealant
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Esthetics, Dental
Evaluation of Dental Bleaching In-office
We aim to evaluate colorimetric changes after supervised whitening treatment, using Violet LED light associated or not with carbamide peroxide 35% gel.
- Trial name
- Bleaching (NCT03192852)
- Testing
- dental bleaching, Gingivoplasty
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Carpal Tunnel Syndrome
The Evaluation for Fu's Subcutaneous Needling (FSN) in Carpal Tunnel Syndrome.
The goal of this clinical trial is to evaluate the efficacy of Fu's Subcutaneous Needling (FSN) in carpal tunnel syndrome (CTS).
- Trial name
- NCT05627349
- Testing
- wrist splinting, FSN
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Zygomatic Fractures, Lower Eyelid Entropion
Trans-tarsal Stair-step Lateral Extension of the Transconjunctival Approach
Open reduction and internal fixation of orbito-zygomaticomaxillary complex (OMC) fractures has challenging impact on the selection of suitable surgical approach to orbital and zygomatic skeleton.
- Trial name
- NCT07044258
- Testing
- trans-tarsal stair-step lateral extension of the transconjunctival approach, transconjunctival approach
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Alexandria University
Panic Disorder, Agoraphobia
Clinical Trial of Transdiagnostic Cognitive-Behavior Therapy for Anxiety Disorders
Anxiety disorders are the most common mental disorders in community settings, and they are associated with significant psychological distress, functional and social impairment.
- Conditions
- Panic Disorder, Agoraphobia, Social Anxiety Disorder, Generalized Anxiety Disorder
- Trial name
- T-CBT (NCT02811458)
- Testing
- Transdiagnostic Cognitive-Behavioral Therapy
- Where
- 3 sites in Canada
- Volunteers
- 231 people
- Sponsor
- Université de Sherbrooke
Endoscopic Retrograde Cholangiopancreatography, Biliary Drainage
EUS-guided Biliary Drainage of First Intent With the Lumen Apposing Metal Stent vs. ERCP in the Management of Malignant Distal Biliary Obstruction (AXIOS-CPRE)
The main objective is to compare the EUS-BD with the insertion of a LAMS vs. traditional ERCP to restore biliary patency. Although ERCP has been the primary treatment for many years, it is associated with a significant risk of…
- Conditions
- Endoscopic Retrograde Cholangiopancreatography, Biliary Drainage, Echography Ultrasound
- Trial name
- AXIOS-CPRE (NCT05122858)
- Testing
- EUS guided biliary drainage, ERCP
- Where
- France
- Volunteers
- 15 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Rheumatoid Arthritis, Psoriatic Arthritis
Yoga-mindfulness for Pain Management in Inflammatory Arthritis
This study evaluates the potential effects on pain, pain-related symptoms and quality of life of a yoga-mindfulness program, compared to patient education and physiotherapy, for patients with inflammatory arthritis and persistent…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Pain
- Trial name
- NCT04065958
- Testing
- Yoga-mindfulness, Patient education and physiotherapy
- Where
- 2 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Karolinska Institutet
Large B-cell Lymphoma, Lymphoma, B-Cell
A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapy
This Phase 3 study compares rondecabtagene autoleucel (ronde-cel), a dual-targeting CD19/CD20 CAR T-cell therapy, with investigator's choice of CD19 CAR T-cell therapy in patients with relapsed or refractory large B-cell lymphoma…
- Conditions
- Large B-cell Lymphoma, Lymphoma, B-Cell, Relapsed Non-Hodgkin Lymphoma, Refractory Non-Hodgkin Lymphoma
- Trial name
- PiNACLE-H2H (NCT07188558)
- Testing
- rondecabtagene autoleucel, axicabtagene ciloleucel, lisocabtagene maraleucel
- Where
- 36 sites in United States
- Volunteers
- 400 people
- Sponsor
- Lyell Immunopharma, Inc.
Arsenic Poisoning, Toxic Effect of Arsenic and Its Compounds
Effects of Folic Acid Supplementation on Arsenic Lowering
The purpose of this study is to determine whether folic acid supplementation are effective on arsenic lowering in a chronic, low-level arsenic exposed population.
- Trial name
- NCT02235948
- Testing
- folic acid supplementation
- Volunteers
- 450 people
- Sponsor
- Wenzhou Medical University
COVID
A Single-blinded, Randomized, Placebo Controlled Phase II Trial of Prophylactic Treatment With Oral Azithromycin Versus Placebo in Cancer Patients Undergoing Antineoplastic Treatment During the Corona Virus Disease 19 (COVID-19) Pandemic
Prophylactic treatment in cancer patients undergoing antineoplastic therapy during the COVID-19 pandemic.
- Trial name
- NCT04369365
- Testing
- Azithromycin 500 milligram (mg) oral Tablet
- Where
- Austria
- Volunteers
- 74 people
- Sponsor
- Prof. Dr. Matthias Preusser
Major Depressive Disorder (MDD)
A Trial of Dextromethorphan and Bupropion Sustained-Release Tablets in Patients With Major Depressive Disorder
A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial, aim to evaluate the efficacy and safety of dextromethorphan and bupropion sustained-release tablets in Chinese adult patients with major depressive…
- Trial name
- NCT06958692
- Testing
- Dextromethorphan and Bupropion Sustained-Release Tablets
- Where
- China
- Volunteers
- 388 people
- Sponsor
- CSPC Ouyi Pharmaceutical Co., Ltd.
Death Anxiety, Occupational Stress
Effect of Expressive Arts Therapy on Death Anxiety in Intensive Care Unit Nurses
This randomized controlled trial aimed to evaluate the effect of expressive arts therapy on death anxiety among intensive care unit nurses.
- Conditions
- Death Anxiety, Occupational Stress, Psychological Distress
- Trial name
- Expressive Art (NCT07462936)
- Testing
- Expressive Arts Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Diabetes, Diabetes Mellitus, Type 2
Effect of Repaglinide and Metformin Combination Tablet or Rosiglitazone and Metformin in Fixed Dose Combination on Blood Glucose Control in Patients With Type 2 Diabetes
This trial is conducted in the United States of America (USA). This trial compares the changes in HbA1c after 26 weeks of repaglinide and metformin fixed dose combination tablet given as twice daily versus three times daily…
- Trial name
- NCT00399711
- Testing
- repaglinide and metformin combination tablet, rosiglitazone and metformin combination tablet
- Where
- 103 sites in United States, Puerto Rico
- Volunteers
- 560 people
- Sponsor
- Novo Nordisk A/S
Parenting Stress, Positive Mental Health
Preliminary Efficacy of the AdoptMindful2Care@Web: A Web-Based Mindful Parenting Post-Adoption Intervention for Adoptive Parents
The development of post-adoption interventions aimed at promoting parental well-being and positive parenting is an urgent need. Mindful Parenting-based interventions appear to be particularly promising in this field, as they…
- Trial name
- NCT07534111
- Testing
- pAdoptMindful2Care@Web
- Where
- Portugal
- Volunteers
- 90 people
- Sponsor
- University of Coimbra
Rectal Cancer
Neoadjuvant Fruquintinib Plus Tislelizumab Combined With mCapeOX Versus CapeOX for Mid-high pMMR/MSS Locally Advanced Rectal Cancer
The goal of this clinical trial is to learn if neoadjuvant Fruquintinib and Tislelizumab combined with mCapeOX works to treat mid-high pMMR/MSS locally advanced rectal cancer patients compared with CapeOX.
- Trial name
- PKUCH-R09 (NCT06443671)
- Testing
- CapeOX, Fruquintinib and Tislelizumab combined with mCapeOX
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Peking University Cancer Hospital & Institute
Covid19
Evaluation of Safety and Immunogenicity of a Novel Vaccine for Prevention of Covid-19 in Adults Previously Immunized
Randomized controlled trial to evaluate safety, immunogenicity and efficacy of three different doses (10, 25 and 50 mcg) of a novel vaccine compared with placebo in adult volunteers previously immunized against Covid-19 with…
- Trial name
- NCT05016934
- Testing
- A vaccine composed of a recombinant S1 antigen
- Volunteers
- healthy volunteers welcome
- Sponsor
- Hospital do Coracao