Clinical trials: Randomized-controlled Trial
Endometriosis
A Phase 2 Trial to Investigate Efficacy and Safety of Vipoglanstat in Women With Endometriosis
The main objective of the trial is to evaluate the efficacy of vipoglanstat on endometriosis-related non-menstrual pelvic pain (NMPP).
- Trial name
- NOVA (NCT07260669)
- Testing
- Vipoglanstat
- Where
- 44 sites in Bulgaria, Czechia and 5 more
- Volunteers
- 213 people
- Sponsor
- Gesynta Pharma AB
Major Depressive Disorder
Assessment of Transcultural Psychotherapy in Child Major Depressive Disorder
The symptomatic and clinical expression of psychiatric disorders in children and adolescents is strongly influenced by the cultural setting they are growing up in.
- Trial name
- EDPT-ADOS (NCT04206969)
- Testing
- Transcultural psychotherapy
- Where
- 4 sites in France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Physical Activity
The Causal Impact of Online Social Media on Physical Activity: A Randomized Controlled Trial
The overall objective of this research is to collect data for understanding whether messages in online environments impact fitness attitudes and behaviors.
- Trial name
- NCT02267369
- Testing
- Media-assisted fitness program, Social network-assisted fitness program, Basic fitness program
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Myofascial Pain Syndrome (Upper Trapezius)
Ultrasound-Guided Dry Needling, Lidocaine Injection, and Oxygen-Ozone Therapy for Myofascial Pain Syndrome
Prospective, assessor-blinded, randomized controlled trial comparing ultrasound-guided dry needling, lidocaine injection, and oxygen-ozone injection in patients with myofascial pain syndrome (MPS) of the upper trapezius muscle.
- Trial name
- USDLO-MPS (NCT07738783)
- Testing
- Dru Needling, Lidocaine Injection (1%, 2 mL), Oxygen-Ozone Injection (10 μg/mL, 5 mL)
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Derince Training and Research Hospital
Stroke, Intracerebral Hemorrhage Basal Ganglia
Neuroendoscopic Hematoma Evacuation Combined With Methylprednisolone Sodium Succinate in the Treatment of Basal Ganglia Intracerebral Hemorrhage at the Early Stage
The aim of this trial is to investigate whether neuroendoscopic hematoma evacuation combined with early use of methylprednisolone sodium succinate can improve the efficacy and safety in the treatment with that of simple…
- Conditions
- Stroke, Intracerebral Hemorrhage Basal Ganglia, Methylprednisolone, Surgery
- Trial name
- NEMP-BGH (NCT06924983)
- Testing
- Simple neuroendoscopic hematoma evacuation, Neuroendoscopic hematoma evacuation combined with sodium methylprednisolone succinate
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Yong Jiang
Bupivacaine, Ultrasound-Guided
Bupivacaine Liposomes or Bupivacaine for CMB on Postoperative Analgesia in Laparoscopic Hepatobiliary Pancreatic Surgery
Numerous studies have confirmed that regional analgesia using peripheral nerve block has great potential for perioperative analgesia in abdominal surgery.
- Conditions
- Bupivacaine, Ultrasound-Guided, Analgesia, Postoperative, Opioids
- Trial name
- NCT06737341
- Testing
- Bupivacaine Liposomes(BL), Bupivacaine(B)
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Huazhong University of Science and Technology
Chronic Pelvic Pain Syndrome (CPPS)
Oxiblume:CoQ10 (Ralivia) Therapy for Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)
Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) has a huge socioeconomic impact.Presently, a ''scientific dead-end'' regarding effective treatment of CP/CPPS is reported.
- Trial name
- NCT07629505
- Testing
- Oxiblume:CoQ10 (Ralivia) therapy
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- G.Gennimatas General Hospital
Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Fatty Liver
Vitamin E and DHA-EE on NAFLD - Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial (PUVENAFLD)
Multicenter, randomized, double-blinded, placebo-controlled clinical trial is focused on novel treatments for non-alcoholic fatty liver disease (NAFLD), the most common cause of chronic liver disease.
- Conditions
- Non-Alcoholic Fatty Liver Disease, Non-Alcoholic Fatty Liver, Non-Alcoholic Steatohepatitis
- Trial name
- PUVENAFLD (NCT04198805)
- Testing
- Vitamin E [(all-rac)-α-tocopheryl acetate], Omega-3 fatty acid (DHA EE), Omega-3 fatty acid (DHA EE) & Vitamin E [(all-rac)-α-tocopheryl acetate]
- Where
- 15 sites in United States
- Volunteers
- 205 people
- Sponsor
- Naga P. Chalasani
Haemophilus Influenzae Infection, Vaccines
Safety and Reactogenicity Trial of Vaccine for the Prevention of Infections Caused by Haemophilus Influenzae Type b
Trial purpose is to evaluate the safety, tolerability and reactogenicity of the Vaccine for the prevention of infections caused by Haemophilus Influenzae Type b in volunteers aged 18-50.
- Trial name
- NCT05401305
- Testing
- Vaccine for the prevention of infections caused by Haemophilus influenza type b
- Where
- Russia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- St. Petersburg Research Institute of Vaccines and Sera
COVID-19
NDV-HXP-S Vaccine Clinical Trial (COVIVAC)
This prospective, single-center, randomized, placebo-controlled (phase 1) and active-controlled (phase 2), observer-blind Phase 1/2 study includes two separate parts.
- Trial name
- NCT05940194
- Testing
- COVIVAC vaccine
- Where
- Vietnam
- Volunteers
- 374 people, healthy volunteers welcome
- Sponsor
- Institute of Vaccines and Medical Biologicals, Vietnam
Procedural Pain
The Effect of Mechanical Vibration and ShotBlocker on Pain Levels During Heel Lance in Healthy Term Neonates
This study was conducted to determine the effect of mechanical vibration and ShotBlocker methods on pain level, crying time and procedure time during heel prick blood collection in healthy term infants.
- Trial name
- NCT06380556
- Testing
- ShotBlocker, Mechanical vibration
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Agitation in Patients With Dementia of the Alzheimer's Type, Alzheimer Disease
Addressing Dementia Via Agitation-Centered Evaluation
This is a multi-center, randomized, double-blind, placebo-controlled study, to assess the efficacy and safety of AXS-05 in the treatment of agitation in patients with Alzheimer's disease.
- Conditions
- Agitation in Patients With Dementia of the Alzheimer's Type, Alzheimer Disease, Agitation,Psychomotor
- Trial name
- ADVANCE (NCT03226522)
- Testing
- AXS-05, Bupropion
- Where
- 78 sites in United States, Australia
- Volunteers
- 366 people
- Sponsor
- Axsome Therapeutics, Inc.
Invasive Candidiasis
Comparison of Uncomplicated Candidemia Therapy Duration in Children and Adults
The goal of this clinical trial is to compare antifungal therapy duration in uncomplicated candidemia. The specific aims are: Compare the desirability of outcome ranking in patients with uncomplicated candidemia randomized to 7…
- Trial name
- COUNT (NCT05763251)
- Testing
- therapy duration
- Where
- 22 sites in United States, Australia
- Volunteers
- 420 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Fear Anxiety, Discomfort
Alternatives to Manage Dental Fear
This study compares the psychological effects on patients attend the dental clinic by listening to specific audios
- Conditions
- Fear Anxiety, Discomfort, Psychotherapy Intervention Evaluation
- Trial name
- NCT06670729
- Testing
- Quran listening, silent headphones group
- Where
- Iraq
- Volunteers
- 30 people
- Sponsor
- Al-Mustansiriyah University
Charcot Foot Ulcer
Pulsed Electromagnetic Field Stimulation and Charcot Foot Ulcer
thirty-four patients with charcot foot ulcer will be included, their ages will be ranged from 50 to 70 years old and randomly distributed into two equal groups : study group includes 17 patients who will recieve pulsed…
- Trial name
- NCT06527131
- Testing
- pulsed electromagnetic field therapy, Transcutanous electrical nerve stimulation, Vancomycin
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Cairo University
Influenza, Influenza Vaccine
Clinical Trial of Quadrivalent Subunit Influenza Vaccine (Adjuvant) in Chinese Population Aged 65 Years and Older
The objective of this study was to evaluate the safety of quadrivalent subunit influenza vaccine (adjuvant) in people aged 65 years and older.
- Trial name
- NCT07421037
- Testing
- Quadrivalent Subunit Influenza Vaccine (Adjuvant), MF59, 0.9% sodium chloride injection (normal saline)
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ab&B Bio-tech Co., Ltd.JS
Pain, Anxiety
The Effect of Virtual Reality Use in Cystoscopy on Pain, Anxiety, and Comfort: A Randomized Controlled Trial
This study aims to evaluate the effects of virtual reality (VR) distraction on pain, anxiety, and comfort levels patients undergoing cystoscopy.
- Conditions
- Pain, Anxiety, Patient Comfort, Cystoscopy
- Trial name
- NCT07872137
- Testing
- Virtual Reality Distraction, Standard Care
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Karamanoğlu Mehmetbey University
Multiple System Atrophy
A Trial to Test if TEV-56286 is Effective for Treatment of Participants With Multiple System Atrophy
The primary objective of the study is to evaluate the efficacy of TEV-56286 administered orally for the treatment of adult participants with Multiple System Atrophy (MSA).
- Trial name
- TOPAS-MSA (NCT06568237)
- Testing
- TEV-56286
- Where
- 68 sites in United States, France and 6 more
- Volunteers
- 349 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D LLC
Kidney Stone, Pain, Postoperative
Perioperative Pregabalin in Ureteroscopy
This is a randomized, placebo-controlled, double-blinded study examining the use of perioperative pregabalin in ureteroscopy with stent placement.
- Conditions
- Kidney Stone, Pain, Postoperative, Addiction, Opioid Use
- Trial name
- NCT04122196
- Testing
- Pregabalin 300mg
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- University of Missouri-Columbia
Athletic Performance Enhancement
Effects of Microdosed Plyometric Training on Lower-Limb Neuromuscular Function and Sport-Specific Performance in Rope-Skipping Athletes
The goal of this clinical trial is to compare two ways of scheduling plyometric training in rope-skipping athletes. The study will examine whether short and frequent training sessions have different effects on lower-limb muscle…
- Trial name
- MPPT (NCT07740096)
- Testing
- Microdosed Plyometric Training, Traditional Concentrated Plyometric Training
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chongqing Normal University
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