Clinical trials: Randomized-controlled Trial
Breast Cancer
Capsular Contracture After PMRT Using Prepectoral Versus Subpectoral Implant-based Breast Reconstruction: PREPER Trial
The purpose of this study is to prospectively compare and analyze the incidence of complications in patients undergoing postmastectomy radiation therapy after breast reconstruction with subpectoral and prepectoral placement of…
- Trial name
- NCT04391296
- Testing
- Arm I (Prepectoral), Arm II (Subpectoral)
- Volunteers
- 114 people
- Sponsor
- Gangnam Severance Hospital
Opioid Free Anesthesia
Opioid-Free Anesthesia Versus Opioid Based Anesthesia For Adolescent Idiopathic Scoliosis
Opioid-free anesthesia (OFA) is a multimodal analgesic approach designed to eliminate the intraoperative use of systemic, neuraxial, or intracavitary opioids.
- Trial name
- NCT07389096
- Testing
- Dexmedetomidine, Fentanyl (IV)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Nashwa Ahmed
Loneliness
Testing a Nature-based Social Intervention on Loneliness: the RECETAS-BCN Trial
RECETAS (Re-imagining Environments for Connection and Engagement: Testing Actions for Social Prescribing in Natural Spaces) is an European project (H2020 No 945095) that aims to reduce loneliness by linking lonely people to…
- Trial name
- RECETAS-BCN (NCT05488496)
- Testing
- Nature-based social intervention (NBSI), referred as Friends in Nature (FiN), Usual care + menu with nature-based activities
- Where
- Spain
- Volunteers
- 317 people, healthy volunteers welcome
- Sponsor
- University of Vic - Central University of Catalonia
Pain, Postoperative, Lung Cancer
Postoperative Pain Control With Lipossomic Extended Release Bupivacaine
Randomized trial of intraoperative intercostal block with bupivacaine with epinephrine compared to lipossomal extended release bupivacaine.
- Trial name
- NCT03560362
- Testing
- Bupivacaine liposome, Bupivacaine / Epinephrine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Tennessee
Pancreatic Cancer
XB2001 in Combination With ONIVYDE + 5-FU/LV (+Folinic Acid) in Advanced Pancreatic Cancer
This trial will include 2 portions (phase 1 and phase 2). The first portion will be a Phase I, open label, dose escalation study to establish the maximum tolerated dose (MTD) of XB2001 as measured by Dose-Limiting Toxicity (DLT)…
- Trial name
- 1-BETTER (NCT04825288)
- Testing
- Phase I: XB2001 250 mg, Phase I: XB2001 500 mg, Phase I: XB2001 1000 mg
- Where
- 30 sites in United States
- Volunteers
- 76 people
- Sponsor
- XBiotech, Inc.
Anesthesia
Techniques for Perioperative Analgesia for Live Liver Donors; A Pilot Study
This study,will evaluate the efficacy of ultrasound (US)-guided subcostal oblique TAP block together with IV infusion of Dexmedetomidine and fentanyl as a type of multimodal analgesic regimen in comparison with IV fentanyl based…
- Trial name
- NCT03393988
- Testing
- Fentanyl infusion, Ultrasound guided TAP block, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Acute Upper Respiratory Tract Infections
Clinical Trial of Safety and Clinical Efficacy of Ergoferon in Liquid Dosage Form in Treatment of Acute Upper Respiratory Tract Infections in Children
The purpose of this study is: to assess safety of the liquid dosage form of Ergoferon for treatment of acute upper respiratory tract infections in children; to assess clinical efficacy of the liquid dosage form of Ergoferon for…
- Trial name
- NCT01843842
- Testing
- Ergoferon
- Where
- 11 sites in Russia
- Volunteers
- 306 people
- Sponsor
- Materia Medica Holding
HFrEF - Heart Failure With Reduced Ejection Fraction, AF - Atrial Fibrillation
Wearable Device-Assisted Remote Management in Atrial Fibrillation Complicated by Heart Failure: WARM-HF Trial
Patients with acute decompensated heart failure (HF) have a significantly high risk of death and HF re-hospitalization during the vulnerable phase post discharge.
- Trial name
- WARM-HF (NCT07411170)
- Testing
- Wearable Device-Assisted Intervention
- Volunteers
- 400 people
- Sponsor
- Beijing Anzhen Hospital
Newborn Care, Pain Management
The Effect of Breast Milk, 10% and 20% Dextrose on Pain and Physiological Variables During Heel Puncture in Infants
Pain, defined by the International Association for the Study of Pain as a subjective, sensory, and emotional experience, differs from nociception, which is merely a neural activity.
- Conditions
- Newborn Care, Pain Management, Physiological Parameters During Newborn Care İn Newborn's, Breast Milk
- Trial name
- NCT07716813
- Testing
- Administering oral breast milk in a supportive position, Administering oral 10% dextrose in a supportive position, Administering oral 20% dextrose in a supportive position
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Mersin University
Alcohol Abuse, Alcohol Problem
Efficacy of a Brief Alcohol Intervention for Non Dependant Alcohol-misusing Patients Undergoing a Scheduled Surgery
Excessive alcohol consumption is a worldwide major public health problem. Brief interventions have shown to be an efficient treatment modality for problem drinkers, but have never been tested in scheduled surgery.
- Conditions
- Alcohol Abuse, Alcohol Problem, AOD Misuse
- Trial name
- ITBCHIR (NCT01348113)
- Testing
- Brief Alcohol intervention
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Rennes University Hospital
Radiotherapy Induced Mucositis, Head and Neck Cancer
A Randomized Placebo-Controlled Trial of Manuka Honey for Oral Mucositis Due to Radiation Therapy for Cancer
The primary hypothesis of this study is that regular topical oral application of Manuka Honey will reduce the severity and duration of oral mucositis in patients who are undergoing mucotoxic radiation therapy for cancer treatment.
- Trial name
- NCT00615420
- Testing
- manuka honey
- Where
- 2 sites in Canada
- Volunteers
- 106 people
- Sponsor
- British Columbia Cancer Agency
Haemodialysis-Associated Pruritus
Cool Baby Oil for Pruritus and Sleep Quality Among Uremic Patients
This study aims to evaluate the effect of cool baby oil on pruritus and sleep quality among uremic patient Research Hypothesis: H01: There is no difference between hemodialysis patients with uremic pruritus who apply cool baby…
- Trial name
- NCT05555524
- Testing
- Baby oil
- Where
- 2 sites in Egypt
- Volunteers
- 80 people
- Sponsor
- Alexandria University
Knee Arthropathy
Motivational Feedback Following Total or Unicompartmental Knee Arthroplasty
The goal of this randomized controlled trial (RCT) nested in a prospective cohort study is to investigate whether physical activity (PA) following total knee arthroplasty (TKA) or unicompartmental knee arthroplasty (UKA) can be…
- Trial name
- KneeActivity (NCT06005623)
- Testing
- SENS Motion + Motivational Feedback
- Where
- 4 sites in Denmark
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Cough Variant Asthma
The Efficacy of Budesonide/Formoterol in Cough Variant Asthma
Cough variant asthma (CVA), subtype of bronchial asthma, is considered to be one of the most common causes of chronic cough in different cough guidelines of United States, Europe, China and other countries.
- Trial name
- NCT04171180
- Testing
- budesonide/formoterol
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Edentulous; Alveolar Process, Atrophy
Melatonin and Hyaluronic Acid in Maxillary Sinus Augmentation
melatonin proved an ability to repair bone defects and enhance osseointegration of dental implants. Also, hyaluronic acid has osteopromoting properties.
- Trial name
- NCT04625179
- Testing
- Melatonin and hyaluronic acid and sinus membrane elevation, sinus membrane elevation without any materials
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Hams Hamed Abdelrahman
Pain
Effect of Lidocaine Spray for Pain Relief During Endometrial Biopsy: a Randomized, Double-blind, Placebo-controlled Clinical Trial
The effect of lidocaine spray on pain relief during endometrial sampling.
- Trial name
- NCT02039661
- Testing
- Lidocaine Spray
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Kayseri Education and Research Hospital
Nuclear Cataract
Microinterventional Endocapsular Nuclear Fragmentation Assisted Cataract Surgery
Rationale: In cataract surgery, fragmentation of a hard nucleus requires relatively much ultrasound energy. It is suspected that the level of energy used is associated with the degree of corneal endothelial loss.
- Trial name
- NCT05736042
- Testing
- Lens fragmentation
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Oogziekenhuis Rotterdam
Oncologic Disorders
Effect of Warm Water Footbaths With Added Ginger or Mustard Powder on Psychosocial Parameters in Patients With an Oncological Disease
A randomized, controlled, three-arm trial to investigate the effects of warm water footbaths with and without the addition of ginger or mustard powder on psychosocial parameters in patients with an oncological disease and in…
- Trial name
- NCT04271670
- Testing
- Ginger powder footbaths, Mustard powder footbaths, Warm water only footbaths
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- ARCIM Institute Academic Research in Complementary and Integrative Medicine
GERD (Gastroesophageal Reflux Disease), NERD
New Topical tReatment Options for Symptomatic patiEnts With Nonerosive gastroesophageaL Reflux dIsease (The RELIEF Trial)
The goal of this randomized, double-blind, single-center clinical trial RELEIF is to learn if medical devices work to decrease symptoms of gastroesophageal reflux disease (GERD) in adults' patients.
- Conditions
- GERD (Gastroesophageal Reflux Disease), NERD, Heartburn, Regurgitation, Gastric
- Trial name
- RELIEF (NCT07624383)
- Testing
- Esophageal barrier medical device
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Cellmedis
Nasopharyngeal Carcinoma, Immune Checkpoint Inhibitor
IC Plus Low-dose Radiation Plus Cadonilimab in LANPC
This is a multi-center, open-label, randomized controlled phase III clinical trial in primary diagnosed loco-regionally advanced nasopharyngeal carcinoma (NPC) patients.
- Conditions
- Nasopharyngeal Carcinoma, Immune Checkpoint Inhibitor, Radiotherapy, Chemotherapy
- Trial name
- NCT05941741
- Testing
- Intensity Modulated Radiation Therapy, Chemotherapy, Immune checkpoint inhibitor
- Where
- 3 sites in China
- Volunteers
- 380 people
- Sponsor
- Sun Yat-sen University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.