Clinical trials: Randomized-controlled Trial
Idiopathic Pulmonary Fibrosis (IPF)
Allogeneic Human Cells (hMSC)in Patients With Idiopathic Pulmonary Fibrosis Via Intravenous Delivery (AETHER)
This is a phase I, randomized, blinded, placebo-controlled 9 subjects pilot safety run-in followed by an additional 16 randomized subjects for a total of 25 subjects.
- Trial name
- AETHER (NCT02013700)
- Testing
- Allogeneic Adult Human Mesenchymal Stem Cells (hMSCs)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Joshua M Hare
Fraily, Abdominal Surgery
Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery.
This is a bicentric, prospective, non-pharmacological, randomized study designed to compare the efficacy and safety of awake neuraxial anesthesia with sedation versus general anesthesia in frail patients undergoing elective major…
- Conditions
- Fraily, Abdominal Surgery, Postoperative Cognitive Dysfunction (POCD)
- Trial name
- SAFE-AWARENESS (NCT07486336)
- Testing
- Neuraxial anesthesia, General Anesthesia, avoidance of GABAergic-drugs strategy
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Ente Ospedaliero Ospedali Galliera
Postoperative Pain
Dose Esmolol Infusion Have an Adjuvant Effect to TAP Block for Pain Control in Laparoscopic Cholecystectomy.
Pain after laparoscopy differs considerably from that seen after laparotomy. Laparotomy results mainly in parietal pain (abdominal wall), where as Pain in laparoscopy results from stretching of the intra-abdominal cavity…
- Trial name
- NCT04752111
- Testing
- Esmolol
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Athletic Performance, Aerobic Capacity
Individualized Training to Improve Aerobic Capacity and 2,000 m Rowing Performance in Youth Rowers
The goal of this randomized clinical trial is to learn whether an individualized rowing training program based on ventilatory thresholds can improve aerobic capacity and 2,000 m rowing performance in youth rowers from Valdivia…
- Conditions
- Athletic Performance, Aerobic Capacity, Rowing Performance
- Trial name
- NCT07602244
- Testing
- Individualized Rowing Training, Usual Rowing Training
- Where
- Chile
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universidad San Sebastián
Glaucoma
Metformin as a Neuroprotective Therapy for Glaucoma
Glaucoma, a chronic degenerative disease of the optic nerve, is the leading cause of irreversible blindness worldwide. Although lowering the intraocular pressure (IOP) has been shown to be effective to slow optic nerve…
- Trial name
- NCT05426044
- Testing
- Metformin
- Where
- Hong Kong
- Volunteers
- 125 people
- Sponsor
- Christopher Kai Shun Leung
Muscle Soreness
Cold Vs Warm Water Immersion for DOMS Recovery
The study investigates the effectiveness of physical strategies in addressing Delayed Onset Muscle Soreness (DOMS) in physically active individuals.
- Trial name
- NCT06804564
- Testing
- Cold Water Immersion (CWI), Hot Water Immersion (HWI), Simulated Laser Therapy
- Where
- Poland
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Józef Piłsudski University of Physical Education
Irreversible Pulpitis
Comparison of Pain Between Supraperiosteal Injection of Dexamethasone Versus Placebo on Postoperative Pain in Teeth With Symptomatic Irreversible Pulpitis
This randomized controlled trial aims to compare the effectiveness of supra periosteal injection of dexamethasone versus placebo in reducing post operative pain in teeth diagnosed with symptomatic irreversible pulpitis.
- Trial name
- NCT07233564
- Testing
- Dexamathsone 4mg/ml associated with experimental arm, Normal saline injection
- Where
- Pakistan
- Volunteers
- 44 people
- Sponsor
- College of Physicians and Surgeons Pakistan
Proprioception Change, Balance Change
The Effects of Cognitive-motor Training in Healthy Older Adults
Currently, there is a growing concern for the elderly population and for what the increase in life expectancy entails, and that is why many authors investigate about exercise protocols that delay the appearance of both cognitive…
- Conditions
- Proprioception Change, Balance Change, Cognitive Change
- Trial name
- NCT04786132
- Testing
- Cognitive-motor training, Motor training
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Ramon Llull
Colorectal Adenoma
Enhanced White Light Endoscopy Versus Conventional White Light Endoscopy for Colorectal Adenoma Detection: A Randomized Controlled Trial
1. Study on Adenoma Detection Rate (ADR) Comparing Enhanced White Light Endoscopy (E-WLI) versus Conventional White Light Endoscopy (WLI); 2.
- Trial name
- NCT06979232
- Testing
- Enhanced White Light Imaging, White Light lmaging
- Where
- 7 sites in China
- Volunteers
- 845 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Placenta Accreta
Conservative Management for PAS Pilot
Conservative in situ management is a promising alternative treatment to hysterectomy for patients with placenta accreta spectrum and may be safer and preferable for some patients.
- Trial name
- NCT05139498
- Testing
- Conservative management for placenta accreta spectrum (PAS), Cesarean hysterectomy for placenta accreta spectrum (PAS)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Utah
Celiac Disease, Wheat Hypersensitivity
Changes in Intestinal Permeability 4 Hours After Gluten Challenge
This study evaluates why people with celiac disease and non-celiac gluten/wheat sensitivity develop rapid onset symptoms within hours of gluten exposure. Half of subjects will be given gluten and half will not.
- Conditions
- Celiac Disease, Wheat Hypersensitivity, Gluten Sensitivity, Gluten Enteropathy
- Trial name
- NCT03288831
- Testing
- Gluten
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Sport Injury
Effects of the Singapore Youth Shoulder Overuse Injury Prevention Program Among Youth Volleyball Athletes in Singapore
The Singapore Youth Shoulder Overuse Injury Prevention Program (YoSO-IPP) includes an exercise segment and an education segment.
- Trial name
- NCT06271902
- Testing
- Singapore Youth Shoulder Overuse Injury Prevention Program, Lower body stretching program
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
Primary Care, Advance Directives
Effectiveness Brief Information Advanced Directives Primary Care
The knowledge and completion of advanced directives (ADs) by the population is generally low. Primary care could develop a very important role to inform and assist in the preparation of this document because of its accessibility.
- Conditions
- Primary Care, Advance Directives, Randomized Controlled Trial
- Trial name
- NCT03302572
- Testing
- Brief information group
- Where
- Spain
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Psychological Stresses
Strengths-Based Family Psychoeducation for Youth Psychosis
The onset of Psychosis forces family members to bear a heavy burden of care. The mental well-being of the family is so complicated that it is important to relieve their psychological stresses.
- Trial name
- NCT01731977
- Testing
- Strengths-based family psychoeducation
- Where
- 4 sites in Japan
- Volunteers
- 74 people
- Sponsor
- Nagoya City University
Respiratory Viral Infection
Study to Assess the Safety and Efficacy of ZX-7101A for Oral Suspension in Chinese Pediatric Participants 2 to 11 Years of Age With Influenza
The goal of this phase III study is to learn if ZX-7101A for oral suspension works to treat uncomplicated influenza in Pediatric Participants aged 2 to 11 years.
- Trial name
- ZX-7101A-214 (NCT07095257)
- Testing
- ZX-7101A for oral suspension, Oseltamivir phosphate for oral suspension
- Where
- 2 sites in China
- Volunteers
- 169 people
- Sponsor
- Nanjing Zenshine Pharmaceuticals
CerebroSpinal Fluid (CSF) Leak
NoSeal Trial: Comparing Sealants Versus No Sealant for Preventing CSF Leak After Endonasal Skull Base Surgery
Postoperative cerebrospinal fluid (CSF) leak is a significant complication of endoscopic endonasal approaches (EEA) to the skull base.
- Trial name
- NoSeal (NCT07216157)
- Testing
- Standard multilayer closure without sealant, Fibrin sealant application, Synthetic polyethylene glycol-based sealant
- Where
- Poland
- Volunteers
- 225 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Depression, Depressive Symptoms
Does a Novel Intervention Targeting Derailment Decrease Depressive Symptoms?
The goal of this clinical trial is to explore the efficacy of a reflective journaling intervention-"Me Through Time"- in decreasing levels of derailment, and its impact on downstream depressive symptoms.
- Conditions
- Depression, Depressive Symptoms, Derailment, Anxiety
- Trial name
- NCT06265701
- Testing
- Derailment-Focused Reflective Journaling, Everyday Tasks Reflective Journaling
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Cornell University
Chronic Low Back Pain
Flurbiprofen Tape for Treatment of Chronic Low Back Pain
The purpose of this trial is to evaluate the analgesic efficacy and safety of flurbiprofen tape for chronic low back pain (lasting greater than 3 months).
- Trial name
- LBP (NCT00759330)
- Testing
- Flurbiprofen Tape (Arm 2), Flurbiprofen Tape (Arm 4)
- Where
- 10 sites in United States
- Volunteers
- 127 people
- Sponsor
- Teikoku Pharma USA, Inc.
Postoperative Cystoid Macular Edema, Irvine-Gass Syndrome
Study for Optimizing Anti-inflammatory Prophylaxis
The purpose of this study is to investigate which anti-inflammatory treatment is best at preventing postoperative inflammation following cataract surgery.
- Trial name
- SOAP (NCT03383328)
- Testing
- NSAID + prednisolone, preoperative, NSAID + prednisolone, postoperative, NSAID, preoperative
- Where
- Denmark
- Volunteers
- 470 people
- Sponsor
- Line Kessel
Healthy Young Adults
Acute Effect of Immersive VR Technology on Postural Control and Reaction Time in Young Adults
This study investigates the acute effects of short-term immersive virtual reality (VR) exposure on sensory organization and reaction time in young adults aged 18-25 years. It is designed as a randomized controlled trial.
- Trial name
- NCT07709065
- Testing
- Virtual reality gamified motor coordination task
- Where
- Poland
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Rzeszow
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