Clinical trials: Randomized-controlled Trial
Preterm Birth, Caffeine
Caffeine for Infants Born at 28 to 34 Weeks Receiving Respiratory Support
The goal of this pilot clinical trial is to test if it is possible to conduct a larger study on the use of caffeine in preterm infants who need help with their breathing.
- Conditions
- Preterm Birth, Caffeine, Neonatal Outcomes
- Trial name
- CARES-Pilot (NCT07456670)
- Testing
- Caffeine
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- Queen's University
Hemorrhoid
Comparison of Outcome of Injection Sclerotherapy Versus Rubber Band Ligation for Second Degree Hemorrhoids
Objective of this study is to compare the outcome of Injection Sclerotherapy versus Rubber Band Ligation for second degree hemorrhoids in terms of bleeding and efficacy.
- Trial name
- NCT07199673
- Testing
- Injection Sclerotherapy, Rubber Band Ligation
- Where
- Pakistan
- Volunteers
- 128 people
- Sponsor
- Gulab Devi Hospital
Advanced Cancer
Care Coach-led Integrated Palliative Surgical Oncology and Rehabilitation Care Model for Advanced Cancer Patients
Advanced cancer is a life-limiting condition that can negatively impact quality of life and function. Patients often suffer from physical, emotional, social, spiritual, and decision-making issues.
- Trial name
- NCT07133269
- Testing
- Care Coach-led Palliative Surgical Oncology (PSO), Rehabilitation
- Where
- 2 sites in Singapore
- Volunteers
- 770 people
- Sponsor
- Singapore General Hospital
Microbiome
Feasibility of a Lifestyle Intervention for Women With Triple-negative Breast Cancer Under Neoadjuvant Immunotherapy
Triple-negative breast cancer (TNBC) is considered a tumor with a high risk of recurrence and metastasis and requires aggressive systemic therapy combining immunotherapy and chemotherapy.
- Trial name
- BallastImmun (NCT07311083)
- Testing
- switching to a high-fibre diet, official dietary recommendations
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Kliniken Essen-Mitte
HIV Infections
A Randomized, Double-blinded, Placebo-controlled, Dose-escalation Phase 1 Clinical Trial to Evaluate the Safety and Immunogenicity of Recombinant HIV Envelope Protein BG505 SOSIP.664 gp140 Vaccine, Adjuvanted, in Healthy, HIV-1 Uninfected Adults
This a phase 1 first-in-human clinical trial to evaluate the safety, tolerability, and immunogenicity of BG505 SOSIP.664 gp140 Vaccine, Adjuvanted, in up to 60 healthy adult HIV-uninfected volunteers.
- Trial name
- NCT03699241
- Testing
- BG505 SOSIP.664 gp140, adjuvanted
- Where
- 3 sites in United States, Kenya
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
Radius Fracture Distal, Pain, Postoperative
Auricular Acupuncture As Part Of A Multimodal Regimen After Distal Radius Open Reduction and Internal Fixation
This randomized controlled trial will test the hypothesis that patients receiving an intraoperative auricular acupuncture protocol will require less postoperative opioid analgesic use compared to those who do not receive…
- Trial name
- NCT05974254
- Testing
- Acupuncture
- Where
- United States
- Sponsor
- Baylor College of Medicine
Postoperative Pain, Shoulder Pain
Comparative Efficacy of Buprenorphine Transdermal Patch Versus Tramadol in Postoperative Analgesia for Shoulder Arthroscopy
This study compares the efficacy, safety, and patient satisfaction of the Buprenorphine 10 mg transdermal patch versus Tramadol for postoperative analgesia in shoulder arthroscopic surgery.
- Conditions
- Postoperative Pain, Shoulder Pain, Opioid Analgesia, Tramadol
- Trial name
- NCT06742554
- Testing
- Buprenorphine transdermal patch, Tramadol
- Where
- Saudi Arabia
- Volunteers
- 70 people
- Sponsor
- medina medical center
Intrauterine Adhesion
Immediate and Delayed Intrauterine Balloon in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis
In this prospective, randomized, controlled study, the investigators wish to compare the efficacy of immediate and delayed intrauterine balloon (IUB) therapy in the prevention of adhesion reformation after hysteroscopic…
- Trial name
- NCT03171454
- Testing
- Delayed Intrauterine Balloon therapy, immediate Intrauterine Balloon therapy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Renal Cell Carcinoma (Kidney Cancer), Renal Cell Carcinoma (RCC)
Efficacy and Safety of Finerenone and Empagliflozin in Delaying Renal Function Progression After Radical Nephrectomy in High-Risk CKD Patients: A Multicenter RCT
The goal of this clinical trial is to evaluate whether Finerenone and Empagliflozin, either alone or in combination, can delay the progression of renal function decline in patients at high risk for chronic kidney disease (CKD)…
- Conditions
- Renal Cell Carcinoma (Kidney Cancer), Renal Cell Carcinoma (RCC), Nephrectomy, Chronic Kidney Disease(CKD)
- Trial name
- EmFin-Nx (NCT06818305)
- Testing
- Finerenone (BAY 94-8862), Empagliflozin 10 mg
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Jinling Hospital, China
Cholecystolithiasis
Safety and Cost-effectiveness Study of Single Port Laparoscopic Cholecystectomies
Many feasibility studies have been published on Single Port surgery, but no comparative studies have shown any advantages compared to standard laparoscopy.
- Trial name
- SPoCOT (NCT00974194)
- Testing
- Single Trocar CCK, Standard CCK
- Where
- Switzerland
- Volunteers
- 268 people
- Sponsor
- University of Lausanne Hospitals
Amnestic Mild Cognitive Impairment
COG-REAGENT: COGnitive tRaining in patiEnts With Amnestic Mild coGnitive impairmENT
This study evaluates the efficacy and mechanism of internet-based cognitive training in patients with amnestic mild cognitive impairment (aMCI).
- Trial name
- NCT04063956
- Testing
- multi-domain internet-based adaptive training program, active-control program
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Xuanwu Hospital, Beijing
STEMI
A Pilot Randomized Controlled Trial of Intravenous N-acetyl Cysteine in STEMI
The PANACEA trial is an investigator-initiated prospective, single-center, two-arm, non-blinded pilot randomized controlled trial of high-dose IV N-Acetylcysteine therapy used as an adjunct to pharmaco-invasive reperfusion in…
- Trial name
- PANACEA (NCT04023266)
- Testing
- Intravenous N-Acetylcysteine
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University of Alberta
Refractory Schizophrenia
Occupational Therapy in the Rehabilitation of Executive Functions in Patients With Schizophrenia
Primary Objective: Efficacy of Occupational Therapy (OT) based Occupational Goal Intervention (OGI) in improving executive functions in patients with refractory schizophrenia as measured by the BADS.
- Trial name
- OTSchizo (NCT01879956)
- Testing
- Craft Activities, OGI Method
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Pareses, Lower Extremity
Clinical Trial Comparing C-Brace to Knee Ankle Foot Orthosis (KAFO)/Stance Control Orthosis (SCO)
Prospective, international, multi-center, open-labeled, randomized, controlled cross-over trial to evaluate effectiveness and benefits in patients with lower limb impairment in activities of daily living comparing the C-Brace…
- Trial name
- NCT03906656
- Testing
- C-Brace, KAFO/SCO
- Where
- 13 sites in United States, Austria and 2 more
- Volunteers
- 149 people
- Sponsor
- Otto Bock Healthcare Products GmbH
Childhood Obesity, Aerobic Exercise
Effects of Progressive Neuromuscular Stabilization Exercises Versus Aerobic Exercises on Body Composition and Postural Balance in Children With Obesity
Introduction: Childhood obesity can impair postural control, balance, and motor skills, thereby limiting participation in physical activity.
- Conditions
- Childhood Obesity, Aerobic Exercise, Exercise
- Trial name
- NCT07744022
- Testing
- Progressive Neuromuscular Stabilization Exercise, Aerobic Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Istanbul University - Cerrahpasa
Mental Health Mood Disturbance Occupational Stress
Monthly Mood Improvement After Workplace Mindfulness
This randomized controlled pilot trial investigates the effects of a brief workplace mindfulness-based intervention (MBI) on mood among full-time employees in Japan.
- Trial name
- MBI-WORK (NCT07029022)
- Testing
- Mindfulness-Based Intervention (MBI)
- Where
- Japan
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Shinyu Kise
Pain, Stress Incontinence, Female
Nitrous Oxide for Analgesia During Office Urethral Bulking
This study is designed to determine primarily if there is a difference in perceived pain in patients receiving urethral bulking with calcium hydroxylapatite using local lidocaine versus local lidocaine plus nitrous oxide gas.
- Trial name
- NCT03847922
- Testing
- Nitrous Oxide + Oxygen Gas (Product), lidocaine gel 2%, Room air
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Baylor Research Institute
Restless Legs Syndrome
Transdermal Lisuride: a Trial for the Treatment of Patients With Restless Legs Syndrome (RLS)
The objective of this trial is to compare an individually optimized dose of the lisuride TTS patch against placebo and against an individually optimized dose of oral ropinirole (active- and placebo-controlled design) in…
- Trial name
- NCT00367822
- Testing
- Lisuride, Ropinirole
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Axxonis Pharma AG
Irreversible Pulpitis
the Effect of Preoperative Sodium Ibuprofen on Postoperative Endodontic Pain
The aim of this study is to clinically compare post-operative pain levels after administration of preoperative single dose of sodium ibuprofen versus placebo for patient with symptomatic irreversible pulpitis related to…
- Trial name
- NCT04964622
- Testing
- nurofen
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Hyaluronic Acid, Fat Graft
Clinical Evaluation of Interdental Papilla Reconstruction Using Injectable Autogenous Fat Versus Hyaluronic Acid Filler.
The goal of this randomized controlled trial is to evaluate the amount of interdental papilla fill following the injection of the fat graft compared to hyaluronic acid filler in patients with interdental papilla deficiency.
- Trial name
- NCT05579522
- Testing
- Fat graft injection, Hyaluronic acid injection
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
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