Clinical trials: Randomized-controlled Trial
Flumazenil Adverse Reaction, Ambulatory Surgery
Reversal of Remimazolam by a Single Dose of Flumazenil
Remimazolam, a brand-new sedative which has benzodiazepine property. It is an ultra-short acting sedative and regarded as a proper drug for procedural sedation.
- Conditions
- Flumazenil Adverse Reaction, Ambulatory Surgery, Postoperative Nausea, Remimazolam
- Trial name
- NCT05382806
- Testing
- Flumazenil
- Where
- South Korea
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Pain, Postoperative, Acute Pain
EFFECT - EFFectiveness of ESPB (Erector Spinae Plane Block) in Laparoscopic Cοlectomies Trial
The aim of the trial is to study the efficacy of continuous bilateral Erector Spinae Plane Block (ESPB) in managing perioperative pain in patients who undergo elective laparoscopic colectomy.
- Conditions
- Pain, Postoperative, Acute Pain, Postoperative Complications, Pain
- Trial name
- EFFECT (NCT04879004)
- Testing
- Ropivacaine injection
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Democritus University of Thrace
Diabetic Macular Edema (DME)
Zhuochuming®-3T&E-DME Study (Treatment-naïve Patients)
The goal of this clinical trial is to understand whether Zhuochuming® (Aflibercept Intravitreal Injection) using a 3 loading doses followed by a treat-and-extend regimen (3+T\&E) can treat patients with diabetic macular edema…
- Trial name
- NCT07612904
- Testing
- Aflibercept Intravitreous Injection
- Where
- China
- Volunteers
- 186 people
- Sponsor
- The Third Peoples Hospital of Dalian
MPOX
Study of Tecovirimat for Human Mpox Virus
The purpose of this study was to see if tecovirimat is safe and successful at treating mpox. The main questions were whether tecovirimat reduced time to lesion resolution and pain compared to placebo (no treatment).
- Trial name
- STOMP (NCT05534984)
- Testing
- Tecovirimat Oral Capsule, Tecovirimat Oral Capsule (Open Label)
- Where
- 54 sites in United States, Argentina and 4 more
- Volunteers
- 719 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Dyspepsia Chronic
Evaluating the Efficacy of "Digestive Aid" in Functional Dyspepsia
Functional Dyspepsia (FD) is diagnosed in the presence of bothersome epigastric pain or burning, early satiation and/or postprandial fullness of greater than 8 weeks duration, in the absence of alarm signs.
- Trial name
- Efficacy (NCT06958952)
- Testing
- Digestive Aid
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Tehran University of Medical Sciences
Depression
Trial to Determine the Maximum Tolerated Dose (MTD) Based on Safety and Tolerability, of Org 26576 in Participants With Major Depressive Disorder (174001/P05704/MK-8777-001)
Trial to determine the maximum tolerated dose (MTD) based on safety and tolerability of MK-8777 (Org 26576, SCH 900777) in participants with major depressive disorder.
- Trial name
- NCT00610649
- Testing
- MK-8777
- Volunteers
- 54 people
- Sponsor
- Merck Sharp & Dohme LLC
Pulmonary Hypertension, Mitral Valve Surgery
PDEI Following Mitral Valve Surgery in Patients With Pulmonary Hypertension
A randomized, placebo controlled, single center clinical trial for evaluation of efficacy and safety of Sildenafil administration in the cardiac ICU following Mitral Valve (MV) Surgery in patients with pre-operative Significant…
- Trial name
- NCT02378649
- Testing
- Sildenafil
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Dr. Robert Klempfner Heart Rehabilitation Institute
Cataract, Preoperative Sedation
Intranasal Dexmedetomidine for Adult Patients Undergoing Phacoemulsification Cataract Surgery
The investigators designed this study to examine whether the intranasal dexmedetomidine, as a preoperative drug, could improve the satisfaction of adult patients undergoing phacoemulsification cataract surgery.
- Trial name
- NCT05698758
- Testing
- Dextrometropine and 0.9% sodium chloride solution
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Guangzhou First People's Hospital
Male Prison Inmates
The Effects of the GPS Program in Offenders
This randomized controlled trial aimed to assess the efficacy of a 40-session cognitive-behavioral group program, Growing Pro-Social (GPS), in reducing early maladaptive schemas and cognitive distortions (primary outcomes), as…
- Trial name
- GPS (NCT03013738)
- Testing
- Growing Pro-Social Program, Treatment As Usual
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- University of Coimbra
Heart Failure
Inspiratory Muscular Training
Objectives: To evaluate regional lung ventilation distribution in patients suffering from chronic heart failure (CHF) after completing inspiratory muscle training (IMT) and correlate it with functional capacity and quality of…
- Trial name
- NCT01593007
- Testing
- Inspiratory muscle training, Control group
- Where
- Brazil
- Volunteers
- 19 people
- Sponsor
- Universidade Federal de Pernambuco
Aging
Health TAPESTRY Ontario
The Health Teams Advancing Patient Experience: Strengthening Quality (Health TAPESTRY) is a community-based program led by primary care teams, that creates connections between trained community volunteers, interprofessional…
- Trial name
- NCT03397836
- Testing
- Health TAPESTRY Intervention, Usual Care
- Where
- Canada
- Volunteers
- 599 people, healthy volunteers welcome
- Sponsor
- McMaster University
Polyp of Large Intestine
Hot Snare Versus Hot Snare Polypectomy With Saline Injection for Colorectal Polyps
The complete removal of colorectal polyp is required to prevent tumor recurrence and development of potential interval cancers. However, several studies have shown high incomplete resection rate in endoscopic removal of…
- Trial name
- HSPvsHSPASI (NCT02239536)
- Testing
- hot snare polypectomy, hot snare polypectomy after saline injection
- Where
- South Korea
- Volunteers
- 362 people
- Sponsor
- Bo-In Lee
Primary Biliary Cirrhosis
Efficacy and Safety of Fenofibrate Combined With UDCA in PBC Patients With an Incomplete Biochemical Response to UDCA
The purpose of this protocol is to conduct a trial in a selected population of patients with PBC based on an incomplete biochemical response after 12 months of UDCA therapy.
- Trial name
- NCT02965911
- Testing
- Fenofibrate, UDCA
- Where
- China
- Sponsor
- Beijing 302 Hospital
Colorectal Neoplasm
The Usefulness of I-scan in Screening Colonoscopy
Image-enhanced endoscopy in screening colonoscopy 1. useful tool for detecting subtle epithelial lesions 2. useful tool for predicting real-time histology of epithelial lesions.
- Trial name
- NCT01417611
- Testing
- i-scan CE, SE, TE mode
- Where
- South Korea
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- Konkuk University Hospital
Pelvic Organ Prolapse
Impact of Level III Support Procedure on Enlarged Genital Hiatus After Minimally Invasive Sacrocolpopexy
This is a randomized controlled surgical trial evaluating the use of a concomitant posterior colporrhaphy and/or perineorrhaphy at the conclusion of minimally invasive sacrocolpopexy to narrow enlarged genital hiatuses in a…
- Trial name
- MERIT (NCT04480671)
- Testing
- Level III support procedure, Minimally Invasive Sacrocolpopexy, Transperineal ultrasound of the Pelvic Floor
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- University of Pittsburgh
Leukemia, Acute Lymphoblastic
Effect of Fish Oil on Hyperlipidemia and Toxicities in Children and Young Adults With Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL) is the most common malignant disease among children. Treatment results have improved over time due to intensive risk-adapted therapy and the 5-year survival rate is now above 90%.
- Trial name
- NCT04209244
- Testing
- Eskimo-3 Pure Fish Oil, Rapeseed Oil
- Where
- 4 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Postoperative Pain, Acute, Postoperative Complications
Minimally Invasive Esophagectomy Pain Control Trial
A pilot randomized controlled trial comparing intercostal nerve blocks, cryo-ablation plus intercostal nerve blocks, and serratus plane catheter plus intercostal nerve blocks in patients undergoing esophagectomies with minimally…
- Trial name
- NCT05906134
- Testing
- Local intercostal nerve block, Cryo-analgesia and intercostal nerve block, Serratus plane catheter blocks and intercostal nerve blocks
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Swedish Medical Center
Colon Tumor, Malignant, Rectum Tumor
Use of VIrtual REAlity to Reduce Postoperative Anxiety and Pain After Surgery for Colorectal Cancer
In patients operated for colorectal cancer, pain, anxiety and depression are important factors in postoperative rehabilitation. The use of new technologies, as virtual reality immersion, could further improve their postoperative…
- Conditions
- Colon Tumor, Malignant, Rectum Tumor, Pain, Postoperative
- Trial name
- VIREA (NCT05653934)
- Testing
- Pre-operative use of virtual reality headset, Standard surgery, Post-operative use of virtual reality headset
- Where
- France
- Volunteers
- 124 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Abortion, Complete, Fetal Death
IntraCERvical Balloon Catheter in the Setting of Induction of Labor for Fetal Loss or Abortion
The goal of this research is to understand whether it is practical and safe to use an intracervical balloon catheter in addition to standard of care medications at the time of an induction of labor for an abortion or fetal death.
- Conditions
- Abortion, Complete, Fetal Death, Induction of Labor Affected Fetus / Newborn
- Trial name
- CERBI (NCT06456164)
- Testing
- Cook Cervical Ripening Balloon
- Sponsor
- University of Chicago
Hypertension,Essential
Efficacy of Songling Xuemaikang Capsules on Grade 1 Hypertension: a Randomized Controlled Trial
The purpose of this study is: 1. To evaluate the efficacy of Songling Xuemaikang Capsules(SLXMKC) with grade 1 hypertension. 2. To reveal the potiential effects of SLXMKC on vascular function and structure of patients with grade…
- Trial name
- ESCIHP (NCT06093932)
- Testing
- Songling Xuemaikang Capsules, Lifestyle intervention
- Where
- 5 sites in China
- Volunteers
- 100 people
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
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