Clinical trials: Rapid Diagnosis
Metastatic Breast Cancer
Rapid Medical Donation Programme for Breast Cancer
Treatment of breast cancer has traditionally been based on the primary tumour's features in the breast. Only recently, when cancer returns at other sites, has there been an attempt to biopsy the metastatic disease and change…
- Trial name
- LEGACY (NCT02126800)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Diabetes, Retinal Disorders
Rapid, Non-invasive, Regional Functional Imaging of the Retina. (Diabetic Retinopathy Diagnosis Device)
The basic objective of this project is to test a modification of existing technology for monitoring the responses of the pupil to light as a method for detecting regional losses of function of the retina.
- Trial name
- NCT01546766
- Testing
- Pupillometry testing.
- Where
- 2 sites in United States
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Bipolar II Disorder, Major Depressive Episode
Open-Label Study of Geodon in Non-Rapid Cycling Bipolar II Patients With Major Depression
The purpose of this study is to evaluate the antidepressant effectiveness of Geodon for the treatment of patients diagnosed with Bipolar II disorder who are currently experiencing a major depressive episode.
- Trial name
- NCT00237666
- Testing
- Ziprasidone
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- The Medical Research Network
Hepatitis C
The National Australian HCV Point-of-Care Testing Program - HCV Antibody Testing Minimal Dataset
The goal of this observational study is to learn if offering a point-of-care screening test for exposure to the Hepatitis C virus, before providing a diagnostic test for Hepatitis C infection can increase testing, diagnosis and…
- Trial name
- NCT05713136
- Testing
- Diagnostic Test: Point-of-Care Testing
- Where
- 13 sites in Australia
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Kirby Institute
Dermatomyositis, Dermatomyositis Sine Myositis
Emapalumab MDA5 Rapidly Progressive Interstitial Lung Disease (RP-ILD) Study
This is a proof of concept study to determine if Emapalumab appears effective for the treatment of anti-MDA5 antibody positive rapidly progressive interstitial lung disease (MDA5 RP-ILD).
- Conditions
- Dermatomyositis, Dermatomyositis Sine Myositis, Dermatomyositis With Myopathy, Dermatomyositis With Respiratory Involvement
- Trial name
- NCT07486869
- Testing
- Emapalumab
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Miami
Chronic Hepatitis C
EXtended Therapy in Hepatitis C Genotype 3 Infected Patients
The purpose of this study is to evaluate the effect of 48 vs 24 weeks of treatment with Peginterferon alfa-2b plus weight-based ribavirin on Sustained Virologic Response (SVR) and relapse rates in patients infected with genotype…
- Trial name
- EXACT-R(3) (NCT01095445)
- Testing
- Peginterferon alfa-2b (Pegetron) plus ribavirin (Rebetol)
- Where
- 12 sites in Canada
- Volunteers
- 2 people
- Sponsor
- University Health Network, Toronto
Diabetes Mellitus, Type 1
Automated Fully Closed-Loop Insulin Delivery in Type 1 Diabetes With Ultra-Rapid Lispro (ACOLYTE Study)
The main objective of the study is to determine whether fully closed-loop insulin delivery using ultra-rapid acting insulin lispro will improve glucose control compared to standard lispro under conditions mimicking missed meal…
- Trial name
- ACOLYTE (NCT05660941)
- Testing
- Lispro
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- Manchester University NHS Foundation Trust
Blood Stream Infections, Ventilator Associated Pneumonia
EaRly impAct theraPy With Ceftazidime-avibactam Via rapID Diagnostics
RAPID is an investigator initiated Phase 4, multinational, multicentre, open-label, randomised controlled superiority trial evaluating the clinical impact of rapid microbiological diagnostics combined with antimicrobial…
- Conditions
- Blood Stream Infections, Ventilator Associated Pneumonia, Healthcare Associated Infection, Carbapenem-Resistant Enterobacteriaceae Infection
- Trial name
- RAPID (NCT05979545)
- Testing
- Rapid Diagnostics
- Where
- 21 sites in India, Malaysia and 5 more
- Volunteers
- 1,526 people
- Sponsor
- National University of Singapore
Major Depressive Disorder
Feasibility Pilot of Accelerated Stimulation With TMS for Treatment of Major Depressive Disorder (FAST-MDD)
This is a mixed-methods study that includes three steps. The first is a focus group to collect opinions and feedback about implementation of aTMS among clinicians, technicians, nurses, and other clinical staff at the St.
- Trial name
- NCT06961851
- Testing
- aTMS utilizing the MagVenture TMS device
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Minnesota
Aging, Hearing Loss
Working Memory Changes With Aging and Hearing Loss
Hearing loss is one of the most common health concerns affecting 1 in 3 Americans over 60 years of age rising to 1 in 2 for those over 85 years old.
- Trial name
- NCT01253031
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Smoking, Excessive Drinking
WHO-HPH Recognition Project on Fast-Track Implementation of Clinical Health Promotion
The project's background is the notion that patient centred clinical health promotion has been shown to significantly improve both outcomes and patient safety.
- Conditions
- Smoking, Excessive Drinking, Lack of Physical Activity, Malnutrition
- Trial name
- RP (NCT01563575)
- Testing
- fast-track implementation process
- Where
- 11 sites in Canada, Croatia and 9 more
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Malaria, Falciparum Malaria
Malaria Molecular Surveillance in Mozambique (Phase 2)
Mozambique is among the ten countries with the highest burden of malaria worldwide, with an estimated 10.3 million cases in 2021.
- Conditions
- Malaria, Falciparum Malaria, Malaria in Pregnancy
- Trial name
- GenMoz2 (NCT06529237)
- Testing
- LDH-based malaria rapid diagnostic test, Malaria rapid diagnostic test
- Where
- Mozambique
- Volunteers
- 18,750 people, healthy volunteers welcome
- Sponsor
- Centro de Investigacao em Saude de Manhica
Stroke, Acute
F.A.S.T.-BE FAST Stroke Warning Signs Study
The goal of this randomized controlled trial is to learn whether the BE FAST (Balance, Eyes, Face, Arm, Speech, and Time) acronym works at least as well or better than the F.A.S.T.
- Trial name
- NCT06483165
- Testing
- BE FAST Educational video, F.A.S.T. Educational Video
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- American Heart Association
Genital Herpes
A Randomized Trial to Evaluated the Suppressive Effect of Acyclovir on Rapidly Cleared HSV-2 Reactivation
We propose to study the episode rate, duration, and quantity of HSV-2 genital shedding in patients taking standard, FDA approved, CDC recommended doses of acyclovir (400 mg PO BID) for HSV-2 suppression compared to taking no…
- Trial name
- NCT00723229
- Testing
- acyclovir
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Washington
Infant Overweight, Infant Obesity
Project Sueño: Sleep & Understanding Early Nutrition in Obesity
The purpose of the study is to understand how mothers think and feel about feeding their babies and putting them to sleep, understand more about programs that can support mothers taking care of babies, and how professionals can…
- Conditions
- Infant Overweight, Infant Obesity, Infant Overnutrition, Infant Development
- Trial name
- NCT06117631
- Testing
- Centering Parenting, Bright by Text
- Where
- United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Uveitis
Methotrexate and Mycophenolate Mofetil for UVEITIS
In the First-line Antimetabolites as Steroid-sparing Treatment (FAST) Uveitis Trial, the investigators propose to establish which immunosuppressive therapy, methotrexate or mycophenolate mofetil, is more effective as a…
- Trial name
- FAST (NCT01829295)
- Testing
- Mycophenolate mofetil, Methotrexate, Prednisone
- Where
- 9 sites in United States, Australia and 3 more
- Volunteers
- 216 people
- Sponsor
- University of California, San Francisco
Resectable Pancreatic Cancer
EUS vs. MDCT in Pancreatic Malignancy
Accurate staging of patients with pancreatic cancer is critical to avoid the expense, morbidity, and mortality related to unnecessary surgery.
- Trial name
- EUSPACT (NCT02115022)
- Where
- 5 sites in Romania
- Volunteers
- 45 people
- Sponsor
- Clinical Hospital Colentina
Malaria in Pregnancy
Comparison of ISTp- PYRAMAX-US-RDT to IPTp-SP to Prevent Malaria in Pregnant Women in DRC (ULTRAPYRAPREG)
In endemic settings Plasmodium falciparum (Pf) can sequester in the placenta resulting in low peripheral parasitemia and false negative malaria diagnosis in pregnant women.
- Trial name
- ULTRAPYRAPREG (NCT04783051)
- Testing
- Sulfadoxine pyrimethamine, Pyramax
- Where
- Democratic Republic of the Congo
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Kinshasa
SARS-CoV-2, Covid19
Clinical Evaluation of a Point-of-Care (POC), COVID-19 Rapid Antigen Test (CoviDx™)
Prospective study that will evaluate the clinical agreement of the CoviDx™ Rapid Antigen test compared to SARS-CoV-2 RT-PCR.
- Trial name
- CoviDx (NCT04750629)
- Testing
- POC CoviDx™ Rapid Antigen Test
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Lumos Diagnostics
Hepatitis C
Comparison of Pegasys Versus Peg-Intron for Treatment of Chronic Hepatitis C Genotype 4
Genotype 4 hepatitis C virus is the cause of approximately 20% of the 170 million cases of chronic hepatitis C in the world. Although rare in western nations, genotype 4 is the most common variant of the hepatitis C virus in…
- Trial name
- NCT00502099
- Testing
- Pegylated interferon alpha 2a, Ribavirin, Pegylated interferon alpha 2 b plus ribavirin
- Volunteers
- 217 people
- Sponsor
- Amr Hafez
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