Clinical trials: Rapid Diagnosis
Control Patients, Class III Malocclusion
Effect of Face Mask Therapy on Blood Oxygen Levels
Skeletal Class III malocclusions are characterized by maxillary retrusion, mandibular protrusion, or a combination of both. In growing individuals presenting with maxillary deficiency, the face mask appliance is widely recognized…
- Trial name
- NCT06939179
- Testing
- Class III Malocclusion
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Biruni University
Drug Use, Pre-exposure Prophylaxis (PrEP)
Pre-exposure Prophylaxis (PrEP) Rapid Access
The goal of phase 1 is to determine the feasibility and acceptability of an intervention ('Rapid PrEP Access') providing people who use drugs (PWUD) one-time access to HIV self-testing at the Victory Program.
- Conditions
- Drug Use, Pre-exposure Prophylaxis (PrEP), Opioid Use Disorder
- Trial name
- NCT05528562
- Testing
- PrEP Rapid Access, HIV self-testing, Dried blood spot testing
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Medical Center
Peptic Ulcer Perforation, Perforated Bowel
ERAS vs Conventional Approach in Peptic Perforation-RCT
This study compares 2 different ways of perioperative management in patients of peptic perforation. Experimental arm is the ERAS arm( Enhanced recovery after surgery) and the comparative arm is Conventional arm.
- Conditions
- Peptic Ulcer Perforation, Perforated Bowel, Post-Op Complication, Emergencies
- Trial name
- ERASE (NCT04194060)
- Testing
- Enhanced Recovery after Surgery group, Conventional
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Thrombotic Microangiopathies
Automated Surveillance, Alert, and Rapid Diagnosis of Thrombotic Microangiopathies: the ASARD-TMA Study
Recently a pilot study was conducted to evaluate the impact of an electronic alert (e-alert) triggered by the automated algorithm in the efficiency and rapidity in TMA patients' identification in our University Hospital A.
- Trial name
- ASARD-TMA (NCT05996679)
- Volunteers
- 29 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cystic Fibrosis
Tobramycin Inhalation Solution Administered by eFlow Rapid Nebulizer: Scintigraphy Study
This study assesses the aerosol delivery characteristics (measured by in vivo lung deposition, nebulization time, serum tobramycin concentrations, and pharmacokinetic parameters) and safety of tobramycin inhalation solution…
- Trial name
- NCT00399945
- Testing
- Tobramycin
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Novartis
Pleural Effusion, Malignant, Pleurodesis
Rapid Pleurodesis Through an Indwelling Pleural Catheter
The primary objective of the study is to evaluate whether the use of a rapid pleurodesis protocol using 10% iodopovidone immediately after tunneled pleural catheter placement improves time to IPC removal compared to patients who…
- Conditions
- Pleural Effusion, Malignant, Pleurodesis, Pleural Diseases
- Trial name
- RAPID (NCT03325192)
- Testing
- Rapid pleurodesis protocol
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Pennsylvania
Acute Coronary Syndrome (ACS)
Prospective, Randomized Trial of Ticagrelor Versus Prasugrel in Patients With Acute Coronary Syndrome
Aim of the randomized, open-label, multicenter ISAR-REACT 5 trial is to assess whether ticagrelor is superior to prasugrel in patients with acute coronary syndrome and planned invasive strategy in terms of clinical outcomes.
- Trial name
- ISAR-REACT 5 (NCT01944800)
- Testing
- Ticagrelor, Prasugrel
- Where
- 19 sites in Germany, Italy
- Volunteers
- 4,018 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Emergencies
Evaluation of Effectiveness of Two Different Doses of Mivacurium in Rapid Sequence Intubation
Mivacurium can be considered as an optimal choice for muscle relaxation in short duration surgeries, as butyrylcholinesterase can rapidly and reliably degrade this benzylisoquinoline muscle relaxant in vivo.
- Trial name
- RSI (NCT06072534)
- Testing
- "Mivacurium Chloride"
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
Infection, Heart Failure
Serum Potassium Prediction Using Machine Learning and Single-lead ECG
This is a retrospective study drawing on data from the Brigham and Women's Hospital Home Hospital Program's Database. Sociodemographic and clinical data from a training cohort were used to train a machine learning algorithm to…
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT07493798
- Testing
- Potassium estimation algorithm
- Where
- 2 sites in United States
- Sponsor
- Brigham and Women's Hospital
Iron Deficiency Anaemia
IDA-01 A Randomised, Open-Label, Comparative Study of Intravenous Iron Isomaltoside 1000 (Monofer®) and Iron Sucrose
The purpose of the trial is to evaluate and compare the effect of iron isomaltoside 1000 to iron sucrose in its ability to increase haemoglobin (Hb) in subjects with IDA when oral iron preparations are ineffective or cannot be…
- Trial name
- Provide (NCT02130063)
- Testing
- iron isomaltoside 1000 (Monofer®), iron sucrose (Venofer®)
- Where
- United States
- Volunteers
- 511 people
- Sponsor
- Pharmacosmos A/S
Endometrial Polyp, Endometrial Diseases
The Use of Drospirenone/Estetrol in Random Start Rapid Endometrial Preparation
The presence of a thin endometrium plays an important role in enabling the best conditions for hysteroscopic surgery. Recently, for this purpose, many studies have evaluated the effect of preoperative administration of a variety…
- Trial name
- NCT06316180
- Testing
- drospirenone/estetrol 3mg/14.2mg
- Where
- 2 sites in Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Palermo
Joint Effusion
Use of Infrared Spectroscopy in Fast Septic Arthritis Diagnosis
To study the diagnostic performance of infrared spectroscopy on fresh synovial fluids in early septic arthritis diagnosis in patients with acute joint effusion
- Trial name
- SYNOFRESH (NCT04004962)
- Testing
- Infrared spectroscopy
- Where
- 6 sites in France
- Volunteers
- 360 people
- Sponsor
- Rennes University Hospital
Type 2 Diabetes, Chronic Renal Failure
Rapid Effects Linagliptin on Monocyte Polarization and Endothelial Progenitor Cells in Type 2 Diabetes
Diabetes mellitus is characterized by chronic low grade inflammation, which is worsened by the co-existence of renal failure. One key aspect of chronic inflammatory diseases is the alteration in the polarization profile of…
- Trial name
- NCT01617824
- Testing
- Linagliptin
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- University of Padova
Infection, Heart Failure
Rural Home Hospital: Proof of Concept
This study examines the implications of providing hospital-level care in rural homes.
- Conditions
- Infection, Heart Failure, Chronic Obstructive Pulmonary Disease, Asthma
- Trial name
- NCT04531280
- Testing
- Home hospital care
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Brigham and Women's Hospital
Occupational Injuries, Heat Stress
Effect of Rapid Heat Stress on Firefighters Musculoskeletal Injury Risk
This study will examine the effect of heat stress on factors that influence musculoskeletal injury risk in firefighters. Participants will attend 4 data collection sessions. 1: informed consent, screening, and familiarization.
- Conditions
- Occupational Injuries, Heat Stress, Leg Injury, Back Injuries
- Trial name
- NCT06442956
- Testing
- Rapid Heat Condition, Gradual Heat Condition
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Hepatitis C Virus Infection
Simplification and Test and Treat Strategies Towards Hepatitis C Eliminationplatform" in China(STAT)
The present study aims to establish a " one-sample testing platform " and assess the prevalence of hepatitis C in individuals taking routine physical examination or outpatient visit in mainland China.
- Trial name
- STAT (NCT05906459)
- Testing
- Anti-HCV antibody and HCV core antigen testing
- Where
- 3 sites in China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Hypertension
Improving BP Control in Diverse Populations Using BP MAP
BP-MAP is a cluster randomized controlled trial (RCT) designed to compare the effectiveness of BP lowering from a clinic-based quality improvement program with Full Support (dedicated practice facilitation) vs.
- Trial name
- BP MAP (NCT03818659)
- Testing
- Self-Guided M.A.P. BP Improvement Program, Full Support M.A.P. BP Improvement Program
- Where
- 24 sites in United States
- Volunteers
- 1,238,835 people
- Sponsor
- University of California, San Francisco
Maxillary Deficiency
Maxillary Expansion: Leaf Expander Versus Hyrax Expander
The aim of the current study was to evaluate maxillary and mandibular arch widths' response to five different appliances and clinical protocols (Rapid maxillary expander RME, Leaf Expander 450g, Leaf Expander 900g, Self-expander…
- Trial name
- LEAF (NCT05135962)
- Testing
- orthodontic - rapid maxillary expansion, orthodontic - slow maxillary expansion with leaf expander, orthodontic - slow maxillary expansion with self leaf expander
- Volunteers
- 200 people
- Sponsor
- University of Genova
Ischemic Stroke, Hemorrhagic Stroke
A Randomized Trial Comparing 2 Methods for Rapid Induction of Cooling in Stroke Patients, Cold Infusions vs. EMCOOLS Brain.Pad (iCOOL 3)
Mild hypothermia improves outcome in patients with global cerebral ischemia after cardiac arrest. Hypothermia seems promising also in other acute hypoxic-ischemic or in brain swelling associated cerebrovascular disease.
- Trial name
- iCOOL 3 (NCT01584180)
- Testing
- Cold crystalloid infusions, 0.9%NaCl or Ringer's, EMCOOLS Brain.Pad
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Heidelberg
ATP1A3-related Disease, Alternating Hemiplegia of Childhood
Natural History Study of ATP1A3-related Disease
An observational study aiming to study the natural history of a UK-wide patient cohort with ATP1A3-related disease.
- Conditions
- ATP1A3-related Disease, Alternating Hemiplegia of Childhood, Rapid Onset Dystonia Parkinsonism, CAPOS
- Trial name
- NCT03857607
- Testing
- Whole exome sequencing
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Institute of Child Health
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