Clinical trials: Rapid Sequence Induction
Suxamethonium Sensitivity, Aspiration of Gastric Contents Into Respiratory Tract, Part Unspecified
Comparison on Succinylcholine Onset Time Assessed by Train of Four Stimulation Versus Clinical Judgment During Rapid Sequence Induction of Anesthesia
Succinylcholine is a myorelaxant agent often used during rapid sequence induction for patients who need to undergo general anesthesia but who are at risk of pulmonary aspiration of gastric content.
- Trial name
- CELOTOF (NCT03415607)
- Where
- France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Caen
Rapid Sequence Induction
Rapid Sequence Induction Czech Republic: Survey
Rapid sequence induction (RSI) is a common part of routine anesthesiology practice.However several steps of RSI are not based on evidence based data (EBM) and are considered controversial.
- Trial name
- RSICZ (NCT02985970)
- Testing
- questionnaire
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Brno University Hospital
Rapid Sequence Induction and Intubation
Intubation Conditions After RSI Using Rocuronium with Ephedrine Pretreatment
This trial will study if ephedrine pretreatment before low doses of rocuronium (0.6 or 0.8 mg/kg) would provide similar intubating conditions as with the high dose of 1.2 mg/kg in patients undergoing RSII.
- Trial name
- NCT05725031
- Testing
- Ephedrine, Rocuronium 0.6, Rocuronium 0.8
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Airway Control, Anesthesia
Ketamine Versus Etomidate for Rapid Sequence Intubation
The purpose of this study is to compare the effectiveness and safety of ketamine and etomidate during rapid sequence intubation (RSI).
- Conditions
- Airway Control, Anesthesia, Intubation, Complication
- Trial name
- NCT01823328
- Testing
- Ketamine, Etomidate
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- Hennepin Healthcare Research Institute
Rapid Sequence Induction and Intubation, Rocuronium
Comparison of Standard rapi̇d Sequential Intubation Protocol With Rocuronium in Emergency Department
Airway management and advanced airway management are the issues that are applied every day in emergency services and that the emergency physician should know best.
- Trial name
- NCT05343702
- Testing
- priming with rocuronium
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Respiratory Failure, Hypotension and Shock
Using Vasopressor Medication to Support Blood Pressure During Intubation Procedure
The purpose of this study is to investigate whether protocolized vasopressor use for patients with normal blood pressure undergoing rapid sequence intubation improves hemodynamic parameters and mitigates adverse events.
- Conditions
- Respiratory Failure, Hypotension and Shock, Hypotension on Induction, Intubation Complication
- Trial name
- RAPID PRESS (NCT05355974)
- Testing
- Norepinephrine, Lactated Ringers, Intravenous, normal saline
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Wright State University
Acute Hypoxemic Respiratory Failure
Benefits of Optiflow® Device for Preoxygenation Before Intubation in Acute Hypoxemic Respiratory Failure : The PREOXYFLOW Study
Oro-tracheal intubation in intensive unit care(ICU) in acute hypoxemic respiratory failure after crash induction remains a critical event.
- Trial name
- PREOXYFLOW (NCT01747109)
- Testing
- PREOXYFLOW, STANDARD FACE MASK
- Where
- 6 sites in France
- Volunteers
- 122 people
- Sponsor
- Nantes University Hospital
Intra-tracheal Intubation
Assessment of Remifentanil for Rapid Sequence Induction and Intubation in Full Stomach Patient Compared to Muscle Relaxant
REMICrush is a French multicentric non inferiority simple blind randomized clinical trial that will compare the use of Remifentanil to muscle relaxant (reference treatment) for anesthetic rapid sequence intubation in terms of…
- Trial name
- REMICRUSH (NCT03960801)
- Testing
- Remifentanil group, neuromuscular blockade group
- Where
- 13 sites in France
- Volunteers
- 1,150 people
- Sponsor
- Nantes University Hospital
Endotracheal Intubation in Bed up Head Elevation Position in Rapid Sequence Induction
Comparison of Bed up Head Elevated Position With Sniffing Position in Rapid Sequence Induction.
This study is aimed to conduct a randomised controlled trial comparing endotracheal intubation (ETI) in bed up head elevation BUHE position versus sniffing position in simulated rapid sequence induction (RSI).
- Trial name
- NCT03912935
- Testing
- comparison between two different intubating position
- Where
- Malaysia
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Rapid Sequence Induction (RSI), Preoxygenation
High Flow Oxygen in Preoxygenation During Rapid Sequence Induction in Infants and Small Children
Airway management is crucial part of the anaesthesia. There is always a considerable risk of complications or even failure during the anaesthesia induction and airway management.
- Trial name
- PRSIHFO (NCT05846919)
- Testing
- face-mask preoxygenation, HFNOC preoxygenation, HFNOC + face-mask preoxygenation
- Where
- Czechia
- Volunteers
- 4 people
- Sponsor
- Brno University Hospital
Anesthesia
Comparison of Intubation Conditions During Rapid Sequence Induction Obtained With Modified Time Principal Induction With a Standard Intubation Dose of Rocuronium Versus Succinylcholine
The purpose of this study is to assess and compare conditions for tracheal intubation obtained with modified time principal induction with 0.6 mg/kg rocuronium and 1 mg/kg succinylcholine.
- Trial name
- NCT06029049
- Testing
- Modified Time Principle Induction (MTPI) with rocuronium, RSI succinylcholine
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- The University of Texas Health Science Center, Houston
Respiratory Failure
HEAVEN Criteria: Prediction of Difficult Airway for In- Hospital Emergency Airway Management
The HEAVEN criteria were found valid to predict difficult airways during preclinical emergency intubations in a retrospective study.
- Trial name
- NCT04764799
- Testing
- Rapid sequence induction
- Where
- Switzerland
- Volunteers
- 2,800 people
- Sponsor
- Thomas Riva
Rapid Sequence Induction
EUROpE-RSI (EURopean Online Evaluation RSI Study)
The investigators want to identify and show differences in standards and procedures of in-hospital rapid sequence induction by collecting data with an online survey for anaesthetist in Europe.
- Trial name
- EUROpE-RSI (NCT02751684)
- Where
- Germany
- Volunteers
- 1,500 people
- Sponsor
- Universitätsklinikum Köln
Tachycardia
Study Evaluating the Efficacy and Safety of Remifentanil in a Rapid Sequence Induction for Fragile Subjects
The primary objective is to determine whether, during a rapid sequence intubation by etomidate, and succinylcholine Sellick maneuver, the administration of remifentanil at 2 different dosages (0.5 and 1.0 microgram per kg body…
- Trial name
- NCT01259648
- Testing
- 0.5 µg/kg remifentanil, 1.0 µg/kg remifentanil, NaCl
- Where
- 2 sites in France
- Volunteers
- 75 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Rapid Sequence Induction, Rapid Sequence Intubation
Rapid Sequence Intubation With Rocuronium in Elderly Patients
With the prolongation of life expectancy, the frequency of surgical intervention and anesthesia increases in elderly patients. The rapid Sequence Intubation(RSI) technique is preferred in patients with aspiration risk and who…
- Conditions
- Rapid Sequence Induction, Rapid Sequence Intubation, Rocuronium
- Trial name
- NCT05067829
- Testing
- Train of four(TOF)
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Ankara City Hospital Bilkent
Anesthesia, Hypoxia
Pre-oxygenation With High-flow Nasal Cannula in Adults During Rapid Sequence Induction Anesthesia
It has been demonstrated that Transnasal Humidified Rapid Insufflation Ventilatory Exchange used during preoxygenation for emergency surgery is at least equally effective as preoxygenation compared to standard tight fitting mask.
- Conditions
- Anesthesia, Hypoxia, Surgery, Acute
- Trial name
- PRIOR2 (NCT03516175)
- Testing
- High flow transnasal oxygen, Pre oxygenation using tight fitting facemask
- Where
- 6 sites in Sweden, Switzerland
- Volunteers
- 350 people
- Sponsor
- Karolinska University Hospital
Appendectomy
Ultrasound Assessment of Gastric Content Before Anesthesia for Appendectomy
Performing anesthetic induction for appendicectomy has two main risks : first aspiraion of gastric content causing pneumonia. Otherwise, anaphylactic risk to drugs used during anesthetic induction.
- Trial name
- EGASTA (NCT02983175)
- Testing
- ultrasound assessment of gastric content
- Volunteers
- 150 people
- Sponsor
- Central Hospital, Nancy, France
Septic Shock
Ketamine Versus Fentanyl for Induction of Anesthesia in Septic Shock
The aim of this work is to compare two protocols (ketamine-midazolam versus fentanyl-midazolam) for induction of anesthesia in patients with septic shock aiming to find the most safe protocol with regards to hemodynamic status of…
- Trial name
- NCT03251170
- Testing
- Ketamine, Fentanyl, Midazolam
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Cairo University
Need for Intubation, No Severe Hypoxemia
Benefits of High Flow Nasal Cannula Oxygen for Preoxygenation During Intubation in Non Severely Hypoxemic Patients
The aim of this study is to determine whether High Flow nasal cannula (HFNC) oxygen is more efficient than the standard High Flow face mask (HFFM) for preoxygenation before orotracheal intubation after crash induction in non…
- Trial name
- PROTRACH (NCT02700321)
- Testing
- OPTIFLOW/ AIRVO, STANDARD Face Mask
- Where
- 8 sites in France
- Volunteers
- 192 people
- Sponsor
- Nantes University Hospital
Pediatric Surgery, Rapid Sequence Induction
High-flow Nasal Cannula Oxygenation During Rapid Sequence Induction in Children
This randomised study aims to compare the utilization of high-flow humidified nasal oxygenation (HFNO) with standard care, using apnoeic facemask oxygenation, during rapid sequence induction (RSI) of anesthesia in young children.
- Trial name
- OPTINECK (NCT05063084)
- Testing
- Optiflow - HFNO, Classic
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris