Clinical trials: Re-irradiation
Locally Recurrent Head and Neck Squamous Cell Carcinoma, Nasopharyngeal Squamous Cell Carcinoma
Birinapant and Intensity Modulated Re-Irradiation Therapy in Treating Patients With Locally Recurrent Head and Neck Squamous Cell Carcinoma
This phase I trial studies the side effects and best dose of birinapant when given together with intensity modulated re-irradiation therapy (IMRRT) in treating patients with head and neck squamous cell carcinoma that has come…
- Conditions
- Locally Recurrent Head and Neck Squamous Cell Carcinoma, Nasopharyngeal Squamous Cell Carcinoma, Sinonasal Squamous Cell Carcinoma
- Trial name
- NCT03803774
- Testing
- Biopsy Procedure, Birinapant, Computed Tomography
- Where
- 33 sites in United States
- Volunteers
- 13 people
- Sponsor
- National Cancer Institute (NCI)
Nasopharyngeal Carcinoma
Trail Evaluating Carbon Ion Radiotherapy (3 GyE Per Fraction) for Locally Recurrent Nasopharyngeal Carcinoma
The purpose of this study is to determine the maximal tolerated dose (MTD) of re-irradiation using carbon ion radiotherapy (CIRT) with the fraction size of 3 gray equivalent (GyE) in the treatment of locally recurrent…
- Trial name
- NCT02795195
- Testing
- Carbon ion radiotherapy (CIRT)
- Where
- China
- Volunteers
- 51 people
- Sponsor
- Shanghai Proton and Heavy Ion Center
Glioblastoma Multiforme (GBM)
TAU-2014-1: Mibefradil and Hypofractionated Re-Irradiation Therapy in Recurrent GBM
This is a dose-escalation study that will assess the safety and determine the maximum tolerated dose (MTD) of mibefradil dihydrochloride, a partially selective T-type calcium channel blocker, combined with hypofractionated…
- Trial name
- NCT02202993
- Testing
- Mibefradil with Radiation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Cavion, Inc.
Thoracic Cancer, Lung Cancer
Reirradiation Dose Escalation in Thoracic Cancers
This is a study involving patients with recurrence, metastasis, or new primary malignancies in the thorax requiring radiation and who have previously received radiotherapy to the thorax, where re-irradiation is expected to exceed…
- Conditions
- Thoracic Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- REPAIR (NCT06558175)
- Testing
- stereotactic body radiation therapy (SBRT)
- Volunteers
- 48 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Metastatic Cancer, Pain
Single vs Multiple-Fraction Therapy in Treating Patients With Previously Irradiated Painful Bone Metastases
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known whether single-fraction (single-dose) re-irradiation therapy is as effective as multiple-fraction (many small doses of radiation…
- Trial name
- NCT00080912
- Testing
- radiation therapy
- Where
- 12 sites in Canada
- Volunteers
- 850 people
- Sponsor
- NCIC Clinical Trials Group
Breast Cancer
Reirradiation With Concurrent Paclitaxel for Breast Cancer
The purpose of this trial in addition to a dose finding study for concurrent Paclitaxel, will be to establish a treatment algorithm for chest wall reirradiation.
- Trial name
- NCT02058667
- Testing
- Paclitaxel+Initial Radiation+Boost
- Where
- United States
- Sponsor
- University of Kentucky
Non Small Cell Lung Cancer, Lung Metastases
SBRT Dose Escalation for Reirradiation of Inoperable Lung Lesions
Prospective phase I study to evaluate the maximum tolerated dose (MTD) of SBRT for thoracic re-irradiation. Dose limiting toxicity will be pneumonitis ≥ G3.
- Trial name
- STRILL (NCT04455438)
- Testing
- SBRT dose escalation
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Clinico Humanitas
Re-irradiation, Radiotherapy
Contribution of Multicenter Expertise and Deformable Fusion Software for Re-irradiations With Curative Intent
We propose to evaluate the contribution of a standardized process combining, a validation of re-irradiation indications by a group of multi-professional experts (radiotherapists and physicists) and, a collective validation of the…
- Trial name
- ADERE (NCT06668038)
- Testing
- Multidisciplinary and multicenter validation of re-irradiation with curative intent
- Where
- 10 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre Leon Berard
Recurrent Glioblastoma
A Phase III Study of Re-Irradiation in Recurrent Glioblastoma
The investigators hope to improve overall median survival of patients with recurrent Glioblastoma by investigating continuous low-dose daily Temozolomide plus or minus five treatments of re-irradiation.
- Trial name
- NCT01830101
- Testing
- TMZ plus concurrent re-irradiation, Temozolomide
- Where
- Canada
- Sponsor
- AHS Cancer Control Alberta
Squamous Cell Carcinoma
Trial Comparing Two Protocols of re Irradiation in an Irradiated Area for Carcinoma of the Upper Aerodigestive Tract
Patients will be randomised after surgery, provided surgery is macroscopically adequate, that there is a flap of tissue protecting the vascular axis and that wound healing allows reirradiation to begin less than 8 weeks after…
- Trial name
- JANORL2 (NCT01211938)
- Testing
- single-fraction radiotherapy with concomitant 5FU and Hydrea, hyperfractionated radiotherapy with concomitant Cetuximab
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Recurrent Glioblastoma, High-Grade Glioma (WHO III-IV)
Evaluate the Safety and Preliminary Efficacy of the Combination of NaviFUS System With Re-irradiation for rGBM Patients
This is an open label, single arm, prospective, and pilot study. Eligible patients will be enrolled after acquiring the signed informed consent and then will receive the treatment of re-RT combined with FUS (FUS + re-RT) on an…
- Conditions
- Recurrent Glioblastoma, High-Grade Glioma (WHO III-IV), Brain Tumor Recurrent, Brain Tumor Adult
- Trial name
- NCT04988750
- Testing
- NaviFUS System
- Where
- Taiwan
- Volunteers
- 7 people
- Sponsor
- NaviFUS Corporation
Squamous Cell Cancer of the Head and Neck
Image Guided Intensity Modulated Reirradiation (IG-IMRT) With Cetuximab for Locoregionally Confined Recurrent Head and Neck Squamous Cell Carcinoma
The standard treatment for head and neck cancer relapses in previously irradiated patients is controversial. Reirradiation has had some success, but many patients still die from their disease.
- Trial name
- NCT00934518
- Testing
- Radiation, Cetuximab
- Where
- United States
- Sponsor
- Milton S. Hershey Medical Center
Head and Neck Squamous Cell Carcinoma (HNSCC)
SBRT +/- Pembrolizumab in Patients With Local-Regionally Recurrent or Second Primary Head and Neck Carcinoma
This phase II trial with a safety run-in component will evaluate whether the addition of pembrolizumab to Stereotactic Body Radiation Therapy (SBRT) re-irradiation will improve the progression-free survival for patients with…
- Trial name
- KEYSTROKE (NCT03546582)
- Testing
- Pembrolizumab, Stereotactic Body Radiation Therapy (SBRT)
- Where
- 18 sites in United States, Canada
- Volunteers
- 86 people
- Sponsor
- RTOG Foundation, Inc.
Lung Cancer (NSCLC), Lung Cancer (SCLC)
Pragmatic Analysis of Complex Radiotherapy Cases In Cancer of the Lung
This study focuses on improving care for people with lung cancer who face unusual or complex treatment situations.
- Trial name
- PRACTICAL (NCT07202260)
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- The Christie NHS Foundation Trust
Recurrent Glioblastoma
Reirradiation and Niraparib in Patients With Recurrent Glioblastoma
The goal of this clinical trial is to investigate a drug called niraparib in patients with glioblastoma that was previously treated but has returned (called recurrent glioblastoma, or rGBM).
- Trial name
- RiNG (NCT05666349)
- Testing
- Niraparib, Re-irradiation (re-RT)
- Sponsor
- University College, London
Breast Cancer Recurrent
aPBI Re-irradiation
This study is to determine whether acute treatment-associated adverse events following breast re-irradiation with aPBI are acceptably low and to assess local control following breast re-irradiation with aPBI.
- Trial name
- REPEAT (NCT07612254)
- Testing
- Reirradiation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Recurrent Breast Carcinoma, Ipsilateral Recurrence
Preoperative Partial Breast Reirradiation and Repeat Breast-conserving Surgery in Patients With Recurrent Breast Cancer: the REPEAT Trial
Over the past decades, interest in second breast-conserving therapy (BCT) has increased due to, among others, advancements in radiotherapy techniques.
- Trial name
- REPEAT (NCT06640881)
- Testing
- ablative single-dose PBI
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Amsterdam UMC, location VUmc
Prostate Cancer, Radiotherapy Side Effect
Prostate Reirradiation Toxicity Outcomes Feasibility Study
The RO-PIP trial aims to determine the feasibility of recruitment to a trial randomising patients to salvage ultra-hypofractionated external beam radiotherapy or high dose rate brachytherapy and provide prospective data on…
- Trial name
- RO-PIP (NCT05614700)
- Testing
- Brachytherapy, Sterotactic Body Radiotherapy
- Volunteers
- 60 people
- Sponsor
- University of Leeds
Recurrence of Head and Cancer in Irraiated Area
Reirradiation With Concomitant Chemotherapy After Salvage Surgery for Recurrence of Head and Neck Cancer in Irradiated Area
Interest of a reirradiation with concomitant chemotherapy after salvage surgery for recurrence of head and cancer in irradiated area : a multicentric Phase III randomized trial
- Trial name
- NCT00180934
- Testing
- Reirradiation with concomitant chemotherapy
- Where
- France
- Volunteers
- 280 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Glioblastoma Multiforme
APG101 in Glioblastoma
This is a phase II study of APG101 + reirradiation (RT) versus reirradiation. Patients suffering from a malignant brain tumor called glioblastoma having a first or second progression can be included.
- Trial name
- NCT01071837
- Testing
- APG101, Blood drawing
- Where
- 21 sites in Austria, Germany
- Volunteers
- 84 people
- Sponsor
- Apogenix GmbH