Clinical trials: Re-irradiation
Metastatic Brain Cancer
Investigating the Efficacy of Hair Sparing Radiotherapy Treatment to the Whole Brain.
To investigate the use of a scalp sparing technique of radiotherapy treatment designed to treat the whole brain. Current treatment methods to treat the whole brain with radiotherapy result in complete alopecia as a side effect.
- Trial name
- SPARE (NCT02213536)
- Testing
- VMAT (Volumetric Modulated Arc Therapy)
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- HCA International Limited
Diffuse Midline Glioma, H3 K27M-Mutant, Recurrent High Grade Glioma
CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults
This is a single center Phase I study of a new adjuvant CD200 activation receptor ligand, CD200AR-L, in combination with imiquimod and GBM6-AD vaccine to treat malignant glioma in children and young adults.
- Trial name
- NCT06305910
- Testing
- Treatment with CD200AR-L
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- OX2 Therapeutics
Non-small Cell Lung Cancer
Analysis of Treatment Outcome and Toxicity in Non-small Cell Lung Cancer Patients Wither-irradiated to a High Dose for Recurrent Disease
As one of the few centers, MAASTRO also aggressively re-treats patients with recurrent non-small cell lung cancer. Even after primary radical treatment to high doses, re-irradiation (with concurrent chemotherapy) is also given in…
- Trial name
- NCT01941303
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- Maastricht Radiation Oncology
Pediatric Malignant Brain Tumor -Diffuse Intrinsic Pontine Glioma
Palliative Re-irradiation for Progressive Diffuse Intrinsic Pontine Glioma (DIPG) in Children
Although DIPG is not curable, re-irradiation with a modest total dose and short treatment time provides good palliation of symptoms, improves quality of life, delays disease progression and has minimal and manageable toxicity.
- Trial name
- NCT01777633
- Testing
- Palliative re-irradiation for progressive DIPG in children
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Hadassah Medical Organization
Recurrent Cancer, Previous Radiation
Nanoparticles and Hypofractionated Protontherapy for Reirradiation of Pantumor Relapse
This is a prospective multicenter non-randomized phase II study: proton therapy with nanoparticles based on polysiloxane and gadolinium chelates injectable intravenously
- Trial name
- NANOPRO (NCT04784221)
- Testing
- Radiation by protontherapy associated to nanoparticles injection
- Sponsor
- Centre Francois Baclesse
Breast Cancer, Radiation Therapy Patient
A Pilot Study to Evaluate the Effectiveness of Focused Massage on Pain, Mobility, and Quality of Life During Radiation Treatment for Patients With Breast Cancer
The goal of this interventional study is to to evaluate the effectiveness and acceptability of a focused upper body massage when offered after radiation treatments to participants diagnosed with breast cancer.
- Trial name
- NCT07447700
- Testing
- upper body massage
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Breast Cancer, Recurrent
Partial Breast Re-irradiation in Women in Women with Locally Recurrent Breast Cancer Previously Treated with Conservative Surgery and Whole Breast Irradiation
A prospective study of partial breast re-irradiation in patients with local recurrence of breast cancer
- Trial name
- PBReI (NCT05772390)
- Testing
- Partial breast re-irradiation
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Head and Neck Cancer
Proton Re-Irradiation for Recurrent Head and Neck Cancer
The purpose of this study is to evaluate the tumor control and the side effects of using proton therapy for head and neck cancer that has come back.
- Trial name
- NCT03217188
- Testing
- conventionally fractionated full dose re-irradiation, hypofractionated palliative re-irradiation
- Where
- 9 sites in United States
- Volunteers
- 87 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Stereotactic Body Radiation Therapy, Irradiation; Reaction
Safety and Efficacy of SBRT in the Reirradiation for Ultra-central Thoracic Malignant Tumors
The reirradiation of thoracic tumor is difficult. The possibility of surgery or re course radiotherapy is very small. In the NCCN guideline, only systemic treatment is recommended.
- Conditions
- Stereotactic Body Radiation Therapy, Irradiation; Reaction, Thoracic Tumor, Recurrent Cancer
- Trial name
- NCT05189054
- Testing
- stereotacitic body radiation therapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University Third Hospital
Abdominal Cancer, Pelvic Cancer
Ablative Stereotactic MR-Guided Adaptive Reirradiation
This research study will enroll people who have cancer in their abdomen or pelvis that was treated previously with radiation therapy.
- Trial name
- NCT06397573
- Testing
- Reirradiation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Baptist Health South Florida
Astrocytoma, Grade IV, Giant Cell Glioblastoma
Dose Escalation Trial of Re-irradiation in Good Prognosis Recurrent Glioblastoma
Background: A glioblastoma is a tumor in the brain. It is treated with surgery, chemotherapy and radiation therapy. However, most people s tumors come back after therapy.
- Conditions
- Astrocytoma, Grade IV, Giant Cell Glioblastoma, Glioblastoma Multiforme, Gliosarcoma
- Trial name
- NCT02709226
- Testing
- Radiation
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- National Cancer Institute (NCI)
Nasopharangeal Cancer, Recurrent Nasopharynx Carcinoma
PD-1 Inhibitor Plus Chemotherapy Followed by Immediate Versus Selective Re-irradiation for Locally Advanced Recurrent NPC
This phase II randomized trial evaluates PD-1 inhibitor plus chemotherapy followed by immediate versus selective re-irradiation in locally advanced recurrent nasopharyngeal carcinoma.
- Trial name
- NCT07332247
- Testing
- Selective re-irradiation, Immediate re-irradiation
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Sun Yat-sen University
Brain Cancer
Diffuse Intrinsic Pontine Glioma (DIPG) Reirradiation (ReRT)
The goal of this clinical research study is to find a safe dose of radiation that can be given to patients with brainstem glioma who have already received radiation therapy. You will receive photon radiation therapy.
- Trial name
- NCT01469247
- Testing
- Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- M.D. Anderson Cancer Center
Local Recurrence of Malignant Tumor of Prostate, Radiotherapy
Stereotactic Re-irradiation of Local Recurrences of Prostate Cancer After Radiotherapy
The goal of this clinical study is to evaluate the toxicity and efficacy of re-irradiation using focal stereotactic body radiotherapy (SBRT) in patients with local recurrence of prostate cancer after definitive or post-operative…
- Trial name
- PROSTARE (NCT06201078)
- Testing
- Stereotactic Body Radiotherapy
- Where
- Poland
- Volunteers
- 55 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Glioblastoma
Adjuvant Stereotactic Fractionated Radiotherapy to the Resection Cavity in Recurrent Glioblastoma
This multi-center randomized controlled phase II trial will investigate the impact of stereotactic fractionated radiotherapy to the resection cavity of complete resected recurrent glioblastoma on progression free survival.
- Trial name
- GlioCave/NOA17 (NCT02715297)
- Testing
- SRT to the resection cavity
- Where
- Germany
- Volunteers
- 162 people
- Sponsor
- Technical University of Munich
Non-small Cell Lung Cancer
Trial of Consolidation Pembrolizumab After Concurrent Chemotherapy and Proton Reirradiation for Thoracic Recurrences of Non-Small Cell Lung Cancer
The main purpose of this study is to assess the safety, tolerability and anti-tumor activity of the experimental study drug pembrolizumab (also known as Keytruda or MK-3475) in people with non-small cell lung cancer (NSCLC) that…
- Trial name
- NCT03087760
- Testing
- Pembrolizumab
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Tumor Recurrence, Malignant Epithelial Neoplasm of Vulva
Clinical Study on the Re-irradiation of Lateral Pelvic Recurrences of Gynecological Malignancies
The study aims to obtain a local control rate in patients with lateral pelvic relapses of gynecologycal cancers previously irradiated.
- Conditions
- Tumor Recurrence, Malignant Epithelial Neoplasm of Vulva, Malignant Epithelial Tumor of Ovary, Malignant Epithelial Neoplasm
- Trial name
- CYCLOPS (NCT05457595)
- Testing
- carbon ion radiation therapy
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- CNAO National Center of Oncological Hadrontherapy
Recurrent Head and Neck Carcinoma
Stereotactic Body Radiation Therapy Using HyperArc in Treating Patients With Recurrent Head and Neck Cancer
This phase II trial studies how well stereotactic body radiation therapy with HyperArc software technology works in treating patients with head and neck cancer that has come back.
- Trial name
- NCT03892720
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Nasopharyngeal Carcinoma (NPC), Recurrent Nasopharyngeal Neoplasms
Induction High-Low Dose Radiotherapy Plus Anti-PD-1 Followed by Definitive Radiotherapy in Recurrent Nasopharyngeal Carcinoma (Single-Arm Phase II)
This single-arm, single-center phase II trial evaluates the safety and efficacy of a non-continuous radio-immunotherapy strategy for recurrent nasopharyngeal carcinoma (NPC) unsuitable for surgery.
- Trial name
- REDEFINE (NCT07277764)
- Testing
- High-Low Dose Radiotherapy
- Where
- China
- Volunteers
- 23 people
- Sponsor
- Jiangxi Provincial Cancer Hospital
Rectal Neoplasm
Radiotherapy & Total Neoadjuvant Therapy for Recurrent Rectal Cancer in Previously Irradiated Patients, an Italian Association for Radiotherapy and Clinical Oncology (AIRO)-GI Platform: a Multi-centre Prospective Observational Study
The introduction of neoadjuvant chemoradiation therapy (CRT) and the use of advanced surgical techniques have led to a reduction in mortality and recurrence rates for rectal cancer, the rate of which currently stands at 4-8%.
- Trial name
- RETRY (NCT05984576)
- Testing
- Reirradiation
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS