Clinical trials: Re-irradiation
Metastatic Malignant Neoplasm in the Lung, Recurrent Disease
Proton Beam Re-Irradiation in Thoracic Cancers
This pilot clinical trial studies proton beam radiation therapy in treating patients with thoracic cancer that has come back and have received prior radiation therapy.
- Conditions
- Metastatic Malignant Neoplasm in the Lung, Recurrent Disease, Thoracic Neoplasm
- Trial name
- NCT02204761
- Testing
- Proton Beam Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- University of Washington
Head-and-neck Carcinoma
Re-irradiation of Recurrent Head and Neck Cancer
The goal of this observational study is to evaluate the toxicity and local tumor control of proton therapy for patients with head and neck cancer in a previously irradiated field.
- Trial name
- ReKo (NCT01973179)
- Testing
- Radiation therapy
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Technische Universität Dresden
Carcinoma, Non-Small-Cell Lung
Anti-PD-1 Re-challenge After Immune Priming by Ipilimumab and Immune Boosting by Radiotherapy in Advanced NSCLC
Still many advanced non-small cell lung cancer (NSCLC) patients do not benefit from PD-(L)1 inhibition or will eventually develop progression through secondary resistance.
- Trial name
- RAD-IO (NCT05401786)
- Testing
- Ipilimumab, Cemiplimab, SBRT
- Where
- Netherlands
- Volunteers
- 54 people
- Sponsor
- The Netherlands Cancer Institute
Non Small Cell Lung Cancer, Lung Metastases
SBRT Dose Escalation for Reirradiation of Inoperable Lung Lesions
Prospective phase I study to evaluate the maximum tolerated dose (MTD) of SBRT for thoracic re-irradiation. Dose limiting toxicity will be pneumonitis ≥ G3.
- Trial name
- STRILL (NCT04455438)
- Testing
- SBRT dose escalation
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Clinico Humanitas
Recurrent Brain Neoplasm
Radiation Therapy in Treating Patients With Recurrent Brain Tumors Who Have Undergone Previous Radiation Therapy
This pilot clinical trial studies the side effects and best dose of radiation therapy in patients with brain tumors that have come back after previous treatment with radiation therapy.
- Trial name
- NCT02698254
- Testing
- Bevacizumab, Quality-of-Life Assessment, Radiation Therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- M.D. Anderson Cancer Center
Recurrent Glioblastoma
Reirradiation and Niraparib in Patients With Recurrent Glioblastoma
The goal of this clinical trial is to investigate a drug called niraparib in patients with glioblastoma that was previously treated but has returned (called recurrent glioblastoma, or rGBM).
- Trial name
- RiNG (NCT05666349)
- Testing
- Niraparib, Re-irradiation (re-RT)
- Sponsor
- University College, London
Rectal Cancer
Chemotherapy Followed by Pelvic Reirradiation Versus Chemotherapy Alone as Pre-operative Treatment for Locally Recurrent Rectal Cancer
GRECCAR 15 is focused on Locally Recurrent Rectal Cancer (LRRC) for patients with previous pelvic radiotherapy for the primary rectal cancer.
- Trial name
- GRECCAR15 (NCT03879109)
- Testing
- Chemotherapy FOLFIRINOX, 6 cycles, Radiochemotherapy, Surgery
- Where
- 13 sites in France
- Volunteers
- 58 people
- Sponsor
- University Hospital, Bordeaux
Glioblastoma Multiforme
NOA-12: BIBF1120 and R-RT in Glioblastoma
Patients with glioblastoma at first or second progression who have failed standard treatment that must have included radiochemotherapy with temozolomide and who are a candidate for a reirradiation can be included into the trial.
- Trial name
- NCT01666600
- Testing
- BIBF 1120, radiotherapy
- Where
- 2 sites in Germany
- Volunteers
- 63 people
- Sponsor
- Prof. Dr. Wolfgang Wick
Cancer of the Pharynx, Cancer of the Larynx
Erlotinib, Celecoxib and Reirradiation for Recurrent Head and Neck Cancer
There is no optimal treatment for patients with recurrent head and neck cancer after previous radiation. Chemotherapy alone is not curative and patients survive an average of only 6 to 10 months.
- Conditions
- Cancer of the Pharynx, Cancer of the Larynx, Cancer of the Neck, Paranasal Sinus Neoplasms
- Trial name
- NCT00970502
- Testing
- erlotinib + celecoxib
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Johnny Kao
Breast Cancer, Recurrent
Partial Breast Re-irradiation in Women in Women with Locally Recurrent Breast Cancer Previously Treated with Conservative Surgery and Whole Breast Irradiation
A prospective study of partial breast re-irradiation in patients with local recurrence of breast cancer
- Trial name
- PBReI (NCT05772390)
- Testing
- Partial breast re-irradiation
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Glioblastoma
Adjuvant Stereotactic Fractionated Radiotherapy to the Resection Cavity in Recurrent Glioblastoma
This multi-center randomized controlled phase II trial will investigate the impact of stereotactic fractionated radiotherapy to the resection cavity of complete resected recurrent glioblastoma on progression free survival.
- Trial name
- GlioCave/NOA17 (NCT02715297)
- Testing
- SRT to the resection cavity
- Where
- Germany
- Volunteers
- 162 people
- Sponsor
- Technical University of Munich
Hepatocellular Carcinoma(HCC)
Comparing Re-TACE Versus SABR for Post-prior-TACE Incompletely Regressed HCC: a Randomized Controlled Trial (TASABR)
Till now, trans-arterial chemoembolization (TACE) is still one of the common modalities in treating hepatocellular carcinoma patients with unresectable intermediate stage.
- Trial name
- TASABR (NCT02921139)
- Testing
- Stereotactic ablative radiotherapy (SABR), Re-Transcatheter arterial chemoembolization (re-TACE)
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Dalin Tzu Chi General Hospital
NSCLC
Photon Versus Particle Therapy for Recurrent Lung Cancer; a Planning Study Based on a Reference Dataset of Patients.
Patients with lung cancer may develop a second primary tumor or recurrent disease after previous radiotherapy. Surgical salvage therapy is the mainstay of therapeutic options.
- Trial name
- NCT02029222
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Maastricht Radiation Oncology
Pancreas Cancer, Lung Cancer
Stereotactic Magnetic Resonance Guided Radiation Therapy
This is a master prospective Phase I-II trial evaluating feasibility and efficacy of stereotactic magnetic resonance (MR) guided adaptive radiation therapy (SMART) in patients with cancer.
- Conditions
- Pancreas Cancer, Lung Cancer, Renal Cancer, Adrenal Metastases
- Trial name
- NCT04115254
- Testing
- MR-guided Linac
- Where
- 2 sites in United States
- Volunteers
- 397 people
- Sponsor
- Dana-Farber Cancer Institute
Head and Neck Cancer
Docetaxel + Cetuximab + Concurrent Re-Irradiation (Intensity - Modulated Radiation Therapy, IMRT) for Patients With Locoregionally Recurrent Head and Neck Cancer
This is a study for patients who have head and neck cancer that has recurred in the body area where they previously received radiation, and for whom surgery is not planned.
- Trial name
- NCT00713219
- Testing
- IMRT, cetuximab, docetaxel
- Where
- 6 sites in United States
- Volunteers
- 14 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Primary Spontaneous Pneumothorax (PSP), Conservative Management (Active Observation)
Conservative Management in Primary Spontaneous Pneumothorax: a Multicenter Randomized Non-inferiority Study
The goal of this randomized clinical trial is to find out whether a conservative management strategy (active observation without an initial invasive procedure) can treat as effectively as the standard treatment with chest tube…
- Trial name
- CONNEP (NCT07331805)
- Testing
- Conservative management (active observation), Chest tube drainage
- Volunteers
- 436 people
- Sponsor
- Corporacion Parc Tauli
Head and Neck Cancer
Nab-Paclitaxel, Cetuximab, Cisplatin, and Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer
RATIONALE: Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT00833261
- Testing
- cetuximab, cisplatin, intensity-modulated radiation therapy
- Where
- 4 sites in United States
- Volunteers
- 37 people
- Sponsor
- University of Texas Southwestern Medical Center
Recurrent Glioblastoma
Calorie-restricted, Ketogenic Diet and Transient Fasting During Reirradiation for Patients With Recurrent Glioblastoma
Increased glucose metabolism is characteristic for solid tumors. Thereby, glucose is important for the generation of ATP, supply of anabolic substrates and defense against reactive oxygen species in tumor cells.
- Trial name
- ERGO2 (NCT01754350)
- Testing
- calorie-restricted ketogenic diet and transient fasting, standard nutrition
- Where
- 2 sites in Germany
- Volunteers
- 50 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Breast Cancer
Radiation Therapy in Treating Patients With Recurrent Breast Cancer
RATIONALE: Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells. It is not yet known whether a single dose of radiation therapy is more effective than implant radiation therapy for 5 days in…
- Trial name
- NCT00945061
- Testing
- intracavitary balloon brachytherapy, intraoperative radiation therapy
- Where
- 3 sites in United States
- Volunteers
- 13 people
- Sponsor
- Case Comprehensive Cancer Center
Bladder Cancer
Radiation Therapy and Chemotherapy in Treating Patients With Stage I Bladder Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal…
- Trial name
- NCT00981656
- Testing
- cisplatin, 5-fluorouracil, Mitomycin
- Where
- 13 sites in United States
- Volunteers
- 37 people
- Sponsor
- Radiation Therapy Oncology Group