Clinical trials: Reactions Adverse
Drug/Agent Toxicity by Tissue/Organ, Leukemia
05-001: Treatment of Acute Lymphoblastic Leukemia in Children
RATIONALE: L-asparaginase is an important component of treatment for childhood acute lymphoblastic leukemia, but is also associated with notable side-effects, including hypersensitivity, pancreatitis, and thrombosis.
- Trial name
- NCT00400946
- Testing
- asparaginase, cyclophosphamide, cytarabine
- Where
- 8 sites in United States, Canada
- Volunteers
- 800 people
- Sponsor
- Dana-Farber Cancer Institute
Vaccine Adverse Reaction, Gender
Anti-COVID-19 Vaccine Side Effects
In 2021 and following the COVID-19 (corona virus disease 2019) pandemic, different vaccines were initially authorized in Italy and Lebanon. Notably, vaccine side effects were poorly recorded.
- Conditions
- Vaccine Adverse Reaction, Gender, COVID-19 Vaccine Adverse Reaction
- Trial name
- VAX-IT-LEB (NCT05735769)
- Where
- Italy
- Volunteers
- 2,797 people, healthy volunteers welcome
- Sponsor
- University of Bari
Lung Cancer, Head and Neck Cancer
SPI-1005 for Prevention and Treatment of Chemotherapy Induced Hearing Loss
Chemotherapy treatment with platinum based agents is well noted to cause ototoxicity. It is the objective of this study to determine the safety and efficacy of SPI-1005 at three dose levels when delivered orally twice daily for 3…
- Conditions
- Lung Cancer, Head and Neck Cancer, Hearing Loss, Ototoxicity
- Trial name
- NCT01451853
- Testing
- SPI-1005 Low Dose, SPI-1005 Middle Dose, SPI-1005 High Dose
- Where
- United States
- Sponsor
- Sound Pharmaceuticals, Incorporated
Cancer
Prevention of Capecitabine Induced Hand and Foot Syndrome
Capecitabine is a common anti cancer drug. One of the most common side effects is a syndrome called hand and foot syndrome which comprises of hands and feet redness, swelling, dryness and painful sores.
- Trial name
- NCT01291628
- Testing
- socks containing copper-oxide fibers
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Rabin Medical Center
Breast Cancer, Drug/Agent Toxicity by Tissue/Organ
Pyridoxine and Topical Urea/Lactic Acid-Based Cream in Preventing Hand-Foot Syndrome in Patients Receiving Capecitabine for Breast Cancer or Other Cancer
RATIONALE: Pyridoxine (vitamin B6) and topical urea/lactic acid-based cream may prevent or lessen hand-foot syndrome caused by chemotherapy.
- Conditions
- Breast Cancer, Drug/Agent Toxicity by Tissue/Organ, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00296036
- Testing
- pyridoxine hydrochloride, urea/lactic acid-based topical cream
- Where
- 231 sites in United States
- Volunteers
- 137 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Drug Hypersensitivity, Quality of Life
Validation of the English Version of the Drug Hypersensitivity Quality of Life Questionnaire
We aim to validate the English (UK) translation of the DrHy-Q, and test its reliability in the UK population. This will facilitate for the subsequent economical evaluation of penicillin allergy delabelling.
- Trial name
- NCT06523192
- Testing
- Questionnaires
- Where
- United Kingdom
- Volunteers
- 146 people
- Sponsor
- University Hospitals, Leicester
Diabetes Mellitus, Corneal Endothelial Cell Loss
Effect of Intracameral Dexamethasone After Phacoemulsification in Diabetics on Corneal Endothelial Cell Density
The prevalence of diabetes mellitus (DM) is rapidly growing worldwide. One major concern with diabetes mellitus is how it may affect vision in different ways; including the increased risk of developing cataract.
- Conditions
- Diabetes Mellitus, Corneal Endothelial Cell Loss, Dexamethasone Adverse Reaction, Corneal Endothelial Decompensation
- Trial name
- DIABEDEX (NCT03361709)
- Testing
- Dexamethasone, Saline Solutions, Intraocular
- Sponsor
- Cairo University
Fractures, Bone, CKD Stage 4
The Effect of Prophylactic Anticoagulation on Major Bleeding Events in Hospitalized Chronic Kidney Disease and Lower Limb Fracture Patients.
the risk of bleeding may be greater than the benefit of antithrombotic protection when prophylactically anticoagulating a patient with a lower limb fracture and advanced CKD.
- Conditions
- Fractures, Bone, CKD Stage 4, CKD Stage 3, CKD Stage 5
- Trial name
- FAA (NCT06795698)
- Testing
- Enoxaparin
- Where
- Mexico
- Volunteers
- 61 people
- Sponsor
- Hospital Civil de Guadalajara
Fecal Microbiota Transplantation (FMT), Gastrointestinal Neoplasms
A Real-World Study of Fecal Transplants for Cancer Therapy Side Effects
The goal of this clinical trial is to learn if fecal microbiota transplantation can treat in Gastrointestinal cancer patients with chemotherapy / targeted gastrointestinal symptoms.
- Conditions
- Fecal Microbiota Transplantation (FMT), Gastrointestinal Neoplasms, Antineoplastic Agents, Drug-related Side Effects and Adverse Reactions
- Trial name
- NCT07319364
- Testing
- Fecal microbiota transplantation (FMT)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hot Weather; Adverse Effect, Heat Effect
Beat the Heat Boston
The goal of this stepped wedge trial is to assess the practical effects of air conditioners on hot weather impacts among older adults.
- Conditions
- Hot Weather; Adverse Effect, Heat Effect, Heat Stress, Heat Stroke, Heat Exhaustion
- Trial name
- NCT06982339
- Testing
- Air Conditioner, Electricity subsidy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Harvard School of Public Health (HSPH)
Adverse Drug Reactions
Adverse Drug Event Prevention Using Structured Pharmacist Review
The next four decades will see a marked expansion of the elderly population in Ireland, in particular people aged over 80 yrs. Persons aged over 80 are the highest consumers of prescription medicines in Ireland and have the…
- Trial name
- NCT01467128
- Testing
- Structured expert pharmacist review, No Intervention
- Where
- Ireland
- Volunteers
- 720 people
- Sponsor
- University College Cork
Anesthesia; Adverse Effect, Spinal and Epidural, Headache, Complications; Anesthesia, Spinal and Epidural, in Pregnancy
Comparison of Two Spinal Needles Regarding Postdural Puncture Headache
The aim of the study is to observe the rate of postdural puncture headache observed after spinal anesthesia in cesarean section patients. Two kind of spinal anesthesia needles will be used: 1.
- Trial name
- NCT01821807
- Where
- Turkey (Türkiye)
- Volunteers
- 256 people
- Sponsor
- Adiyaman University Research Hospital
Drug-Induced Liver Injury, Musculoskeletal Diseases
Liver Enzyme Abnormalities and Risk Factors in Taking Herbal Medicine
Herb-induced liver injury is an important issue in musculoskeletal diseases where herbal medicine is most frequently used. The low prevalence of drug-induced liver injury (DILI) gives rise to the need for large-scale patient…
- Trial name
- NCT02299739
- Testing
- Herbal medicine, Acupuncture, Pharmacopuncture
- Where
- South Korea
- Volunteers
- 6,894 people
- Sponsor
- Jaseng Hospital of Korean Medicine
Drug Toxicity
Phase I Clinical Study of Soy Isoflavones in Healthy, Post-Menopausal Women
The purpose of this research study is to examine the safety of specific soy components, known as isoflavones, and to find out what effects (good and bad) these components have on tissues that are sensitive to the hormone estrogen…
- Trial name
- NCT00491595
- Testing
- High Dose Soy isoflavones
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of North Carolina
Adverse Drug Event
Ametop - Friend and Foe A Prospective Study of the Incidence of Adverse Reactions With Ametop
Ametop was introduced into the formulary as it was deemed more efficacious for intravenous cannulation compared to EMLA. However, the incidences of adverse reactions seemed to be higher compared to other studies.
- Trial name
- NCT02750137
- Testing
- Tetracaine
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Hand and Foot Skin Reaction, Hand and Foot Syndrome
Efficacy of Extra Virgin Olive Oil (EVOO) Supplementation on Hand-Foot Syndrome Incidence in Patients With Capecitabine
The study was aimed to evaluate the efficacy of extra virgin olive oil (EVOO) supplementation compared to placebo to prevent HFS by observing changes in serum COX 2, malondialdehyde (MDA), and TNF α levels in breast cancer and…
- Conditions
- Hand and Foot Skin Reaction, Hand and Foot Syndrome, Capecitabine
- Trial name
- EVOO (NCT06188000)
- Testing
- Extra Virgin Olive Oil, Olive Oil
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Sriwijaya
Elderly, Adverse Drug Event
Medication Reconciliation in Comparison to an Extensive Medication Safety Check
The purpose of this study is to determine wether an extensive medication safety check has a greater impact on the incidence of adverse drug events than medication reconciliation or no intervention.
- Trial name
- NCT02413957
- Testing
- Medication Reconciliation, Pharmaceutical Care
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- RWTH Aachen University
Helicobacter Pylori Infection
Feasibility Study of the Proposed Test-and-treat Screening Program in Younger Participants With H. Pylori Infection
This prospective non-interventional study is being conducted as part of the EU4Health project Eurohelican. The main goal of this pilot study is to evaluate the feasibility and acceptability of implementing the proposed…
- Trial name
- NCT06216639
- Testing
- Bismuth Subcitrate, Esomeprazole, Metronidazole
- Where
- Slovenia
- Volunteers
- 2,000 people
- Sponsor
- National Institute of Public Health, Slovenia
Bilateral Vestibular Hypofunction, Bilateral Vestibular Deficiency
Long Term Outcomes After Vestibular Implantation
Although cochlear implants can restore hearing to individuals who have lost cochlear hair cell function, there is no widely available, adequately effective treatment for individuals suffering chronic imbalance, postural…
- Conditions
- Bilateral Vestibular Hypofunction, Bilateral Vestibular Deficiency, Bilateral Vestibulopathy, Gentamicin Ototoxicity
- Trial name
- NCT06500975
- Testing
- Labyrinth Devices MVI™ Multichannel Vestibular Implant System
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Johns Hopkins University
Adverse Effect of Other Agents Primarily Affecting the Cardiovascular System, Initial Encounter
Cardiovascular Assessment of the Effects of Tobacco and Nicotine Delivery Products
The overarching goal of this project is to develop a panel of cardiovascular risk biomarkers that can detect differences in the cardiovascular safety of various tobacco products, whether conventional, new or emerging, in order to…
- Trial name
- NCT01964807
- Testing
- Cigarette, NIDA test type with 16.6 mg nicotine, Cigarette, NIDA test type with <0.45 mg nicotine, Electronic cigarette with 18 mg/ml nicotine
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
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