Clinical trials: Reactions Adverse
Liver Fibrosis, Steatohepatitis
Liver Fibrosis in HIV-Infected Patients With Elevated Liver Enzymes on Antiretroviral Therapy
This study will provide a basis for research on the impact of liver injury caused by antiretroviral therapy in HIV-infected patients.
- Conditions
- Liver Fibrosis, Steatohepatitis, Elevated Transaminases
- Trial name
- NCT00326482
- Where
- United States
- Volunteers
- 127 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chemotherapy-Related Cognitive Impairment, Healthy
Telerehabilitation Cognitive Impairments Following Chemotherapy Usability Study
Develop a game-based upper-extremity motor and cognitive rehabilitation system using custom and adaptable virtual reality simulations.
- Trial name
- TCIFCU (NCT04839588)
- Testing
- Usability study
- Where
- 2 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Bright Cloud International Corp
Atrial Fibrillation, Medication Adherence
Adherence and Coagulation Assays in Dabigatran-treated Patients With Atrial Fibrillation
In patients with non-valvular atrial fibrillation treated with dabigatran etexilate, the level of adherence will be measured using a questionnaire, the Danish National Prescription Registry and pillcount and will be related to…
- Conditions
- Atrial Fibrillation, Medication Adherence, Blood Coagulation Tests, Anticoagulants; Circulating, Hemorrhagic Disorder
- Trial name
- ARCADE (NCT03280368)
- Testing
- Bloodtest, Questionnaires
- Where
- Denmark
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- Hospitalsenheden Vest
Pain, Postoperative
Post-Caesarean Section Incisional Infiltration With Lidocaine Versus Lidocaine and Epinephrine
Study to compare between efficacy of post-caesarean section infiltration with lidocaine and epinephrine versus lidocaine only to reduce post-incisional pain.
- Trial name
- NCT02274974
- Testing
- Lidocaine, lidocaine and Epinephrine
- Where
- Egypt
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Multiple Sclerosis
E-reporting of Adverse Drug Reactions by Patients in Relapsing-remitting Multiple Sclerosis
Adverse drug reactions are collected exhaustively during the experimental development phase of the drug, but the trial population is not representative.
- Trial name
- VigiP-SEP (NCT03029897)
- Testing
- My eReport France
- Where
- France
- Volunteers
- 161 people
- Sponsor
- University Hospital, Caen
COVID-19, Corona Virus Infection
Assessing Safety of Coronavirus Infection (COVID-19) Messenger RNA (mRNA) Vaccine Administration in the Setting of a Previous Adverse Reaction
This study will evaluate the safety of administering an additional dose of an mRNA COVID-19 vaccine or mRNA bivalent COVID-19 booster vaccine to individuals who have had adverse reactions to a previous dose or administering an…
- Trial name
- NCT05212610
- Testing
- Pfizer-BioNTech mRNA COVID-19 vaccine, Moderna mRNA COVID-19 vaccine
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- University of Michigan
Occult Hepatitis B, Biological Substance; Adverse Effect
Risk of Hepatitis Flare in Patients With Previous Hepatitis B Virus Exposure Amongst Patients
The purpose of this study is to study the risk of hepatitis flare in patients with previous hepatitis B virus exposure amongst patients on immunosuppressive and biological modifier therapies
- Conditions
- Occult Hepatitis B, Biological Substance; Adverse Effect, Immunosuppression
- Trial name
- NCT04356404
- Where
- Hong Kong
- Volunteers
- 68 people
- Sponsor
- Chinese University of Hong Kong
Vaccination; Complications, Vaccine Adverse Reaction
Effectiveness of CARD for Improving School-Based Immunizations
Vaccination is estimated to have saved more lives in Canada than any other single intervention and is considered one of the most important advances in the prevention of disease.
- Conditions
- Vaccination; Complications, Vaccine Adverse Reaction, Fear
- Trial name
- NCT03966391
- Testing
- Multi-faceted knowledge translation intervention
- Where
- Canada
- Volunteers
- 8,839 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Breast Cancer, Neoplasm Metastasis
Liposomal Doxorubicin and Docetaxel in HER2 Negative Metastatic Breast Cancer
This is an open phase II multicentre study evaluating the efficacy and safety of the non pegylated liposomal doxorubicin (Myocet®) and docetaxel (Taxotere®) combination as first-line treatment of patients with metastatic HER2/neu…
- Trial name
- MYOTAX (NCT00377559)
- Testing
- Non pegylated liposomal doxorubicin and docetaxel
- Where
- 10 sites in Netherlands
- Volunteers
- 70 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Therapeutic Drug Monitoring (TDM), Tuberculosis
Collect Data From Patients Receiving Standardized Anti-tuberculosis Therapy, Collect Monitoring Data, and Evaluate Treatment Efficacy and Potential Adverse Reactions.
The purpose of this clinical trial is to investigate the correlation between anti-tuberculosis drug concentration monitoring and treatment efficacy and safety through analytical studies.The main questions it aims to answer…
- Trial name
- Tuberculosis (NCT07607288)
- Testing
- Antituberculosis drugs Group
- Where
- China
- Volunteers
- 2,215 people
- Sponsor
- Beijing Chest Hospital
Non-small Cell Lung Cancer, Cardiac Toxicity
Evaluation of Impedance Cardiography for Assessing Hemodynamic Shifts in Patients With LA-NSCLC During Treatment.
This study aimed to investigate the role of impedance cardiography (ICG) in evaluating hemodynamic changes during the 6-minute walk test (6MWT) in patients with locally advanced non-small cell lung cancer (LA-NSCLC) who underwent…
- Trial name
- NCT06277388
- Testing
- Impedance cardiography
- Where
- China
- Volunteers
- 231 people
- Sponsor
- Sun Yat-sen University
Cerebral Stroke, Thrombosis, Deep Vein
A Study of Adverse Events and Suspected Adverse Drug Reactions in Patients Under Apixaban for Prevention of Stroke and Systemic Embolism With Non-Valvular Atrial Fibrillation and Venous Thromboembolic Events in Patients Who Have Undergone Elective Hip or Knee Replacement Surgery
To characterize and analyze the number, type and incidence of adverse events/suspected adverse drug reactions in patients treated with Apixaban, according to therapeutic indications approved in Mexico.
- Conditions
- Cerebral Stroke, Thrombosis, Deep Vein, Pulmonary Embolism
- Trial name
- NCT03804125
- Sponsor
- Pfizer
Carcinoid Syndrome
TELESTAR (Telotristat Etiprate for Somatostatin Analogue Not Adequately Controlled Carcinoid Syndrome)
The primary objective of the study is to confirm that at least 1 or more doses of telotristat etiprate compared to placebo is effective in reducing the number of daily bowel movements (BMs) from baseline averaged over the 12-week…
- Trial name
- NCT01677910
- Testing
- Telotristat etiprate
- Where
- 75 sites in United States, Australia and 10 more
- Volunteers
- 135 people
- Sponsor
- Lexicon Pharmaceuticals
EGFR Gene Mutation, Drug-Related Side Effects and Adverse Reactions
Applying Mobile Healthcare Education to Improve Cutaneous Self-care Capability
The goal of this clinical interventional study is to compare the efficacy of mobile healthcare education in two ways (game-based or text-based) to improve cutaneous self-care capability in cancer patients receiving EGFR-based…
- Conditions
- EGFR Gene Mutation, Drug-Related Side Effects and Adverse Reactions, Cancer, Treatment-Related, Cancer
- Trial name
- NCT06291688
- Testing
- Mobile healthcare education game, Mobile healthcare education application
- Where
- Taiwan
- Volunteers
- 110 people
- Sponsor
- National Taiwan University Hospital
Medication Administered in Error, Medication Adverse Effects
Identifying Drug-related Problems at ED Triage (DRP-EDiT) V1
Up to a third of patients who visit emergency departments (EDs) do so because they have an issue with medicines prescribed by their doctor or purchased over the counter.
- Conditions
- Medication Administered in Error, Medication Adverse Effects, Medication Reaction
- Trial name
- DRP-EDiT (NCT05476705)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Anglia Ruskin University
Allergic Rhinitis
Intralymphatic Immunotherapy (ILIT) for House Dust Mite, Cat, and Dog Allergen in Allergic Rhinitis Patients
We will perform double-blinded placebo-controlled randomized clinical trial which evaluates the efficacy and safety of allergen-specific intralymphatic immunotherapy (ILIT) for allergens including Dermatophagoides farinae (Df)…
- Trial name
- ILIT (NCT02269566)
- Testing
- HollisterStier, Normal saline
- Where
- South Korea
- Volunteers
- 24 people
- Sponsor
- Gachon University Gil Medical Center
Cytochrome P450 CYP2D6 Enzyme Deficiency, Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant
Drug & Gene Interaction Risk Analysis With & Without Genetic Testing Among Patients Undergoing MTM
This randomized controlled trial will evaluate whether the use of pharmacogenetic testing through a Medication Therapy Management (MTM) program has a beneficial impact on drug therapy problems.
- Conditions
- Cytochrome P450 CYP2D6 Enzyme Deficiency, Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant, Ultrarapid Metabolizer Due to Cytochrome P450 CYP2D6 Variant, Extensive Metabolizer Due to Cytochrome P450 CYP2D6 Variant
- Trial name
- NCT02428660
- Testing
- Pharmacogenetic testing, Software-based drug & gene interaction risk analysis, MTM
- Where
- United States
- Volunteers
- 341 people
- Sponsor
- Genelex Corporation
Sarcoma, Chemotherapy-induced Nausea and Vomiting
Fosaprepitant in Patients Receiving Ifosfamide-based Regimen
The goal of this clinical research study is to learn how different doses of fosaprepitant may effect how ifosfamide-based chemotherapy is absorbed by the body.
- Conditions
- Sarcoma, Chemotherapy-induced Nausea and Vomiting, Effects of Chemotherapy, Adverse Effects of Medical Drugs
- Trial name
- NCT01490060
- Testing
- Fosaprepitant, Dexamethasone, 5HT3 receptor antagonist
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- M.D. Anderson Cancer Center
Alcohol Metabolism Modifier Adverse Reaction, Bariatric Surgery Candidate
Alcohol Metabolism After Sleeve Gastrectomy
This prospective study aimed to determine the alcohol intake symptoms and alcohol metabolism before and 12 months after sleeve gastrectomy (SG) by evaluating blood alcohol content (BAC) and urinary alcohol metabolite levels…
- Trial name
- NCT04079023
- Testing
- Sleeve Gastrectomy
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Roma La Sapienza
Lidocaine Adverse Reaction, Prilocaine Adverse Reaction
Efficacy of a Topical Anesthetic Containing Lidocaine and Prilocaine in Treatment With CO2 Fractional Laser
This is a study aimed at evaluating the efficacy of a topical anesthesia (test product) compared to placebo in adult patients of phototypes I to III, with indication of treatment of CO2 fractional laser in the forehead.
- Trial name
- CO2 (NCT03366246)
- Testing
- Lidocaine / Prilocaine Cream
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Galeno Desenvolvimento de Pesquisas Clínicas
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