Clinical trials: Reactions Adverse
Drug-Related Side Effects and Adverse Reactions
DOAC ADRs Retrospective Study
This retrospective study's objective is to evaluate if Cipherome's algorithm could have predicted the serious adverse drug reactions (ADRs) experienced by patients while on direct oral anti-coagulants (DOACs).
- Trial name
- NCT04247919
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Cipherome, Inc.
Heat Illness, Allergic Rhinitis
Over-the-Counter Antihistamines & Heat Stress
Allergic rhinitis (AR) currently affects ~25% of Canadians, and due to factors of climate change, this number is expected to increase over the coming decade.
- Conditions
- Heat Illness, Allergic Rhinitis, Heat Injury, Sudomotor Sympathetic Dysfunction
- Trial name
- NCT06217367
- Testing
- 50 mg Diphenhydramine, 10 mg Loratadine, 5 mg Desloratadine
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Lakehead University
Protamine Adverse Reaction
Effect of Anti-histamine in Prevention Systolic Hypotension After Protamine
Protamine remains the anticoagulant of choice for cardiopulmonary bypass (CPB). The process of protamine neutralization of heparin came with the side effects sometimes; it can be life threatening or fetal reaction.
- Trial name
- NCT03583567
- Testing
- Chlorpheniramine and ranitidine, 0.9% Normal Saline
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Mahidol University
Adverse Drug Events, Adverse Drug Reactions
The Effect of Medication Review in High-risk Emergency Department Patients
Adverse drug events are unintended and harmful events related to medication use and a leading cause of emergency department visits, unplanned hospital admissions and deaths.
- Conditions
- Adverse Drug Events, Adverse Drug Reactions, Medication-related Problems
- Trial name
- NCT02122965
- Testing
- Pharmacist-led medication review
- Where
- 3 sites in Canada
- Volunteers
- 10,805 people
- Sponsor
- University of British Columbia
Small Intestinal NET, Carcinoid Heart Disease
Lanreotide Combined With Telotristat Ethyl or Placebo for the First-line Treatment in Patients With Advanced Well Differentiated Small Intestinal Neuroendocrine Tumours (siNET) With Highly-functioning Carcinoid Syndrome
This is a randomized phase III clinical trial of Lanreotide combined with Telotristat ethyl or placebo for the first-line treatment in patients with advanced well differentiated small intestinal neuroendocrine tumours (siNET)…
- Trial name
- TELEFIRST (NCT04065165)
- Testing
- Telotristat Ethyl, Lanreotide
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Transfusion Adverse Reaction, Major Trauma
Blood Storage Related Mortality and Adverse Effects in Trauma Patients
The purpose of this retrospective study is to examine the following factors related to blood storage time in severely injured trauma patients who received large blood transfusions: 1.
- Conditions
- Transfusion Adverse Reaction, Major Trauma, Blood Product Transfusion for All Conditions
- Trial name
- NCT07341139
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Kocaeli City Hospital
Delirium in Old Age, Anesthesia; Adverse Effect
Postoperative Dexmedetomidine in Prevention of Postoperative Delirium
The goal of this clinical trial is to learn how postoperative infusion of dexmedetomidine would influence postoperative delirium in elderly patients undergoing lung surgery. The main questions it aims to answer are : 1.
- Trial name
- NCT06382961
- Testing
- Dexmedetomidine injection, Sufentanil injection
- Where
- China
- Volunteers
- 287 people
- Sponsor
- Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd.
Cerebral Infarction, Stroke
In the Real World Study, the Efficacy and Adverse Reactions of Ticagrelor on Ischemic Cerebrovascular Disease
This is a forward-looking, open, one-arm, and real clinical trial world. The researchers plan to recruit at least 50 qualified patients.
- Conditions
- Cerebral Infarction, Stroke, Nervous System Diseases, Ischemic Cerebrovascular Disease
- Trial name
- NCT05716646
- Volunteers
- 50 people
- Sponsor
- Qianfoshan Hospital
Overdose, Drug, Drug Use
ASSIST: A Surveillance Study of Illicit Substance Toxicity
There is a drug-related death crisis in Scotland. This study aims to collaborate with Public Health Scotland in order to assess the feasibility of introducing a surveillance system to the Emergency Department to highlight illicit…
- Conditions
- Overdose, Drug, Drug Use, Drug Abuse, Drug Toxicity
- Trial name
- ASSIST (NCT05329142)
- Testing
- Surplus sample toxicology analysis
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- NHS Greater Glasgow and Clyde
Bupivacaine Adverse Reaction, Regional Anesthesia Morbidity
Sequential and Mixture Injection of Opioids and Hyperbaric Bupivacaine
Neuraxial anesthesia, especially the subarachnoid block, is the preferred method for LSCS. The intrathecal spread of local anesthetic drugs is unpredictable.
- Conditions
- Bupivacaine Adverse Reaction, Regional Anesthesia Morbidity, Cesarean Section Complications
- Trial name
- NCT04403724
- Testing
- Bupivacaine-fentanyl-Morphine.
- Where
- Egypt
- Volunteers
- 126 people
- Sponsor
- Assiut University
Diabetes Mellitus, Type 2, Dyslipidemia Associated With Type II Diabetes Mellitus
Effects of High Intensity Statin Therapy on Steroid Hormones and Vitamin D in Type 2 Diabetic Men
The aim of the study was to assess the effect of high intensity statin therapy on testicular and adrenal steroids and vitamin D levels in type 2 diabetes males.It is a prospective study, conducted between march 2021 and July…
- Conditions
- Diabetes Mellitus, Type 2, Dyslipidemia Associated With Type II Diabetes Mellitus, Statin Adverse Reaction, Hypogonadism, Male
- Trial name
- NCT05806723
- Testing
- Atorvastatin 40 Mg Oral Tablet
- Where
- Tunisia
- Volunteers
- 104 people
- Sponsor
- Hopital La Rabta
Colorectal Cancer, Metastases
S-1 Versus Capecitabine in the First Line Treatment of MCC Patients.
The study is a two-arm randomised phase III trial. Patients will be randomised to receive capecitabine (arm A) or S-1 (arm B). Bevacizumab may be added according to the choice of the investigator.
- Trial name
- SALTO (NCT01918852)
- Testing
- Capecitabine, Teysuno, Bevacizumab
- Where
- 24 sites in Netherlands
- Volunteers
- 161 people
- Sponsor
- Dutch Colorectal Cancer Group
Local Anesthetic Drug Adverse Reaction, Local Infiltration
: Pulpal Blood Flow With the Use of Intra-nasal Anesthetic
Anesthetics with vasoconstrictors decrease pulpal blood flow but the impact of intranasal local anesthetics on blood flow is unknown.
- Conditions
- Local Anesthetic Drug Adverse Reaction, Local Infiltration, Pulp Disease, Dental
- Trial name
- NCT03368391
- Testing
- tetracaine HCl and oxymetazoline HCL, 2% Lidocaine with 1:100,000 epinephrine, 3% Mepivacaine with 1:100,000 epinephrine
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Hot Weather; Adverse Effect, Kidney Dysfunction
Renal Considerations in the Heat Stress Recommendations
An epidemic of chronic kidney disease is occurring in laborers who undertake physical work outdoors in hot conditions. The reason for this is unknown, but may be related to kidney dysfunction caused by increases in body…
- Conditions
- Hot Weather; Adverse Effect, Kidney Dysfunction, Kidney Injury, Hyperthermia
- Trial name
- Aim1 (NCT04767347)
- Testing
- 23.0°C WBGT - Fixed Work Rate, 25.5°C WBGT - Fixed Work Rate, 27.5°C WBGT - Fixed Work Rate
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Indiana University
Colorectal Cancer Stage III, Adjuvant Chemotherapy
SOX Versus XELOX as Adjuvant Chemotherapy for Stage III Colorectal Cancer Patients
Fluorouracil combined with oxaliplatin are routinely recommended to patients with pathological stage III (p-stage III) colorectal cancer, leading to significant improvement of 5-year disease-free survival and overall survival…
- Trial name
- NCT03448549
- Testing
- Oxaliplatin, Tegafur，gimeracil and oteracil potassium, Xeloda
- Where
- China
- Volunteers
- 1,191 people
- Sponsor
- Peking University Cancer Hospital & Institute
Adverse Drug Event, Adverse Drug Reaction
Evaluating ActionADE in Reducing Adverse Drug Reactions
Repeat exposures to culprit medications are a common cause of preventable adverse drug events. Health information technologies have the potential to reduce repeat adverse drug events by improving information continuity.
- Trial name
- NCT04568668
- Testing
- ActionADE
- Volunteers
- 3,600 people
- Sponsor
- University of British Columbia
Hepatectomy, Analgesia, Epidural
Bupivacaine Levels in Liver Resection Patients
Bupivacaine is a local anesthetic commonly used to manage postoperative pain. Liver resection patients typically have an epidural catheter placed preoperatively through which they receive a continuous infusion of bupivacaine and…
- Trial name
- NCT03145805
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Jessica Burjorjee, MD, FRCPC
Poison;Medicinal, Extracorporeal Membrane Oxygenation
Treatment of Extracorporeal Membrane Oxygenation in Severe Poisoning
This is a prospective, multicentre clinical study to determine the value of the Extracorporeal Membrane Oxygenation in the treatment of critically ill poisoning patients and whether there are significant differences in the…
- Trial name
- NCT05762029
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Affiliated Hospital of Nantong University
Breast Cancer
Efficacity of Deep Inspiration Breath Hold and Intensity-modulated Radiotherapy in Preventing PErfusion Defect for Left Sided Breast Cancer (EDIPE)
Breast irradiation is known to cause radiation-induced heart disease (RIHD) many years later after radiotherapy. Recent studies suggest that RIHD could be an earlier complication and that subclinical cardiac injury can be…
- Trial name
- EDIPE (NCT05454553)
- Testing
- myocardial perfusion SPECT
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Institut de cancérologie Strasbourg Europe
Adverse Effect of Oral Contraceptives, Subsequent Encounter
The Effect of Oral Contraceptive Pills On Eyes
The investigators aimed to evaluate the effect of oral contraceptive pills(OCP) on macula, retinal nerve fiber layer and choroid thickness by using Optical Coherence Tomography (OCT).
- Trial name
- NCT02841202
- Testing
- oral contraceptive pills
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kayseri Education and Research Hospital
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