Clinical trials: Reactions Adverse
Adverse Drug Event
Improving Wisely - Polypharmacy
This is a randomized controlled trial that uses an audit and feedback intervention to alert primary care physicians who are outliers in one or more metrics related to high risk prescribing of participants' outlier status.
- Trial name
- NCT03857100
- Testing
- Audit and feedback - letter and report
- Where
- United States
- Volunteers
- 11,000 people
- Sponsor
- Johns Hopkins University
Limbal Stem Cell Deficiency, Stevens-johnson Syndrome
Clinical Trial on the Effect of Autologous Oral Mucosal Epithelial Sheet Transplantation
To investigate the effect of ocular surface reconstruction and assess the safety in cultivated oral mucosal epithelial cell sheet transplantation (COMET) regarding patients with cicatricial change of ocular surface.
- Conditions
- Limbal Stem Cell Deficiency, Stevens-johnson Syndrome, Ocular Cicatricial Pemphigoid, Chemical Burn
- Trial name
- NCT02149732
- Testing
- cultivated oral mucosal epithelial sheet transplantation
- Where
- 2 sites in South Korea
- Sponsor
- Seoul National University Hospital
Anesthesia; Adverse Effect, Spinal and Epidural
Paramedian Incidence Angles in Spinal Anaesthesia
The objective here is to quantify the number of punctures and redirections during routine practice in the anesthesiology department, verify the final angle of incidence and the sac-skin distance by ultrasound, and determine the…
- Trial name
- NCT07210892
- Testing
- Measurement of needle insertion angles
- Where
- Spain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Consorci Sanitari de Terrassa
Adverse Drug Effect, Drug Effect
Effects of Switching From Racemic Methadone to R-methadone on QTc Intervals
Effects of switching from racemic methadone to R-methadone on serum methadone concentrations and QTc intervals
- Conditions
- Adverse Drug Effect, Drug Effect, Heart Arrhythmia
- Trial name
- MePhaCard (NCT04254731)
- Testing
- Same individuals treated with racemic methadone and switched to levomethadone (R-methadone)
- Where
- 3 sites in Norway
- Volunteers
- 10 people
- Sponsor
- Oslo University Hospital
Drug Allergy, Neuromuscular Blockade
High Dimensional Analysis of Immune Cells in Pediatric Patients
The purpose of this study is to characterize immune cells using single-cell transcriptomic analysis in pediatric patients aged 2 to 18 years undergoing general anesthesia who are expected to receive Rocuronium, a non-depolarizing…
- Trial name
- NCT05820802
- Where
- South Korea
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Hand-Foot Syndrome
The Efficacy and Safety of Liangxue Ointment in the Treatment of Hand-foot Syndrome Caused by VEGFR-TKI Drugs
This study was a prospective, single-center randomized controlled trial. The subject of this study is to evaluate the effectiveness and safety of traditional Chinese medicine Liangxue Ointment in the treatment of hand-foot…
- Trial name
- NCT06583369
- Testing
- Liangxue ointment（Traditional Chinese Ointment）, Urea cream
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Peking University Cancer Hospital & Institute
Ovarian Cancer, Endometrial Cancer
Proactive Immune Tolerance Induction in Chemotherapy for Gynecologic Cancer
The goal of this clinical trial is to evaluate the efficacy of proactive immune tolerance induction of chemotherapy (paclitaxel and carboplatin) for patients with gynecologic cancer.
- Conditions
- Ovarian Cancer, Endometrial Cancer, Cervical Cancer
- Trial name
- NCT06977594
- Testing
- Proactive immune tolerance induction, Standard Treatment, Paclitaxel and carboplatin
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Seoul National University Hospital
MRI Contrast Media Adverse Reaction, Bladder Cancer
Can VI-RADS/ADC Accurately Stage Bladder Cancer??
Vesical Imaging-Reporting And Data System (VI-RADS) is proposed for predicting muscle invasive bladder cancer (MIBC) using multi-parametric MRI. However, No validation study on VI-RADS has been reported yet.
- Conditions
- MRI Contrast Media Adverse Reaction, Bladder Cancer, Bladder Disease, Bladder Neoplasm
- Trial name
- NCT04167631
- Testing
- Multi-parametric MRI
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Mansoura University
Chemo Fog
Ashwagandha for Cognitive Dysfunction
This is a 1:1 randomized double blinded placebo controlled trial. • To determine if ashwagandha can improve cognitive dysfunction when compared with placebo in patients undergoing chemotherapy for cancer.
- Trial name
- NCT04092647
- Testing
- Ashwagandha
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Sutter Health
Breast Cancer, Colorectal Cancer
Pyridoxine in Preventing Hand-Foot Syndrome in Patients Who Are Receiving Capecitabine for Advanced Colorectal Cancer or Breast Cancer
RATIONALE: Pyridoxine (vitamin B6) may prevent or lessen hand-foot syndrome caused by chemotherapy. It is not yet known whether pyridoxine is more effective than a placebo in preventing hand-foot syndrome.
- Conditions
- Breast Cancer, Colorectal Cancer, Palmar-plantar Erythrodysesthesia
- Trial name
- NCT00559858
- Testing
- pyridoxine hydrochloride, quality-of-life assessment
- Where
- 16 sites in United Kingdom
- Volunteers
- 270 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Toxicity by Bleach
The Use of Disinfectants Among Women in Egypt and the Toxicity by Bleach During the Coronavirus Lock-down.
This study examines the use of disinfectants by Egyptian women during the coronavirus lockdown. Data will be collected via an online self-administered questionnaire that will be distributed to Egyptian women via social media…
- Trial name
- NCT04405284
- Testing
- use and exposure to disinfectants during the coronavirus pandemic
- Where
- Egypt
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- Helwan University
Drug-induced Liver Injury
Establishment of Drug-induced Liver Injury Databases and Application of Circulating microRNA(miRNA)
The purpose of the study is to establish drug-induced liver injury databases in China, make criteria for Chinese drug-induced liver injury patients and evaluate the application of certain circulating miRNA in diagnosis or…
- Trial name
- NCT02061826
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Beijing Ditan Hospital
Prostate Cancer, Cardiotoxicity
Mechanisms, Predictors, and Social Determinants of Cardiotoxicity in Prostate Cancer
This is an observational study for patients with prostate cancer that will be treated with Androgen Deprivation Therapy. The study will help the investigators learn more about how these medications affect the heart and how those…
- Conditions
- Prostate Cancer, Cardiotoxicity, Drug-Related Side Effects and Adverse Reactions, Cardiovascular Diseases
- Trial name
- PCT (NCT05096338)
- Testing
- Social Determinants of Health
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Drug-Related Side Effects and Adverse Reactions
Effect of a trAnSitional Pharmacist Intervention in geRiatric Inpatients on Hospitals Visits After dischargE
A randomized controlled trial will be performed in geriatric inpatients to investigate the impact of a multifaceted clinical pharmacy intervention on health related outcomes.
- Trial name
- ASPIRE (NCT04617340)
- Testing
- Multifaceted clinical pharmacy intervention
- Where
- Belgium
- Volunteers
- 827 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Adverse Effect
Comparison of Hydroxyethyl Starch and Crystalloid Coload Combined With Norepinephrine Infusion for Hypotension
The purpose of this study is to investigate the ED50 and ED90 for an effective 6% Hydroxyethyl starch (130/0.4) or crystalloid coload combined with prophylactic norepinephrine infusion dose for postspinal anesthesia hypotension…
- Trial name
- NCT05475990
- Testing
- Hydroxyethyl starch, Crystalloid
- Where
- China
- Volunteers
- 80 people
- Sponsor
- General Hospital of Ningxia Medical University
Cardiotoxicity, Acute Myeloid Leukemia in Children
Prevention of Chemotherapy Induced Cardiotoxicity in Children With Bone Tumors and Acute Myeloid Leukemia
Prevention and early detection of chemotherapy-induced cardiotoxicity in children with bone tumors and Acute Myeloid Leukemia by giving capoten
- Conditions
- Cardiotoxicity, Acute Myeloid Leukemia in Children, Bone Tumor
- Trial name
- NCT03389724
- Testing
- Capoten®
- Where
- Egypt
- Volunteers
- 245 people
- Sponsor
- Children's Cancer Hospital Egypt 57357
Injection Site Reaction
A Study Comparing the Local Tolerability of Two Subcutaneous Heparins in Healthy Volunteers.
A Phase IV, Randomised, Double-blind, Single-centre clinical trial in healthy male and female participants aged 18 to 55, that was designed to assess and compare the pain intensity at an injection site as well as the duration of…
- Trial name
- NCT03841396
- Testing
- Sodium chloride
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Aspen Global Incorporated
Esophagus Cancer
Impact of Dose to Cardiac Substructures on Survival in Patients With Esophageal Cancer Treated With Radiotherapy or Chemoradiotherapy (SATIATION)
Treatment of non-operable esophageal cancers is based on radiochemotherapy, or exclusive radiotherapy. The cardiac toxicity of radiotherapy in the treatment of thoracic tumor localizations is well documented, however, more and…
- Trial name
- SATIATION (NCT05996276)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Brest
Myopathy
SAPhIRE Statin Adverse Drug Reaction
To find out the pharmacokinetic and genetic risk factors involved in muscular side effects (myalgia) associated with statin therapy.
- Trial name
- STATIN (NCT03042286)
- Where
- Singapore
- Volunteers
- 1,500 people
- Sponsor
- National Heart Centre Singapore
Older Adults (65 Years and Older)
Quantifying the Attentive Behaviors of Older Adults During Over-the-counter Drug Selection
Per-capita consumption of medication is higher in older adults than any other sector of the population. In fact, it has been estimated that although older adults comprise 13% of the population they take 34% of all prescriptions…
- Trial name
- NCT02188134
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Michigan State University
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