Clinical trials: Real-world Study
Newly-diagnosed Cancers, Non-cancer Controls
The Sanderson Study: A Case Control Study for the Development of Multiomics Blood Tests for Cancer Screening
This protocol is a prospective, case-control multi-center diagnostic study to assess the sensitivity and specificity of blood-based screening tests for the early detection of multiple cancers.
- Trial name
- NCT05516927
- Testing
- Freenome Test
- Where
- 23 sites in United States
- Volunteers
- 788 people, healthy volunteers welcome
- Sponsor
- Freenome Holdings Inc.
Alzheimer's Disease(AD), Mild Cognitive Impairment (MCI)
Community-based Screening for Alzheimer's Disease
The goal of this prospective, multicenter, observational cohort study is to evaluate the screening performance of blood-based biomarkers for Alzheimer's disease (AD) in a real-world community screening setting, and to establish…
- Conditions
- Alzheimer's Disease(AD), Mild Cognitive Impairment (MCI), Cognitive Impairment
- Trial name
- CSAD (NCT07570719)
- Testing
- No study-specific intervention
- Where
- 4 sites in China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Kuang XiaoJun
Basal Cell Carcinoma
Real-world Evaluation of Diagnostic and Treatment Strategies in Low-Risk Basal Cell Carcinoma
Basal cell carcinoma (BCC) is the most prevalent form of cancer among the Caucasian population. There are several subtypes of BCC with different clinical characteristics and treatment strategies.
- Trial name
- REDT-BCC (NCT06252857)
- Testing
- Imiquimod Topical
- Where
- Netherlands
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
HIV/AIDS
Oregon PrEP at Home Study
This demonstration study will evaluate the real-world implementation of long-acting cabotegravir (CAB-LA) for HIV pre-exposure prevention (PrEP) through a partnership between the OHSU Tele-PrEP Program (TPP) and the OHSU Home…
- Trial name
- OR-PrEP@Home (NCT05949203)
- Testing
- Cabotegravir Injection
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Hair Fall and Pre-mature Graying
Proof-of-Science, Prospective, Interventional, Three-arm, Double-Blind, Randomized, Safety and Efficacy Real World Evidence Study.
This is proof-of-science, prospective, interventional, three-arm, double-blind, randomized, safety and efficacy real world evidence study of herbal and non herbal formulations in healthy human subjects having complaint of hair…
- Trial name
- NCT06552039
- Testing
- Polyherbal Hair Oil, Minoxidil Herbal Hair Oil + Minoxidil 5 (%) Hair Serum, Minoxidil Hair Serum
- Where
- India
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Uterine Bleeding Profile Prediction
A Study to Learn More About How a Smartphone App Called MyIUS Predicts Future Menstrual Bleeding in Women After They Have Begun Using Intrauterine Birth Control Method (a Birth Control Device is Inserted Into a Woman's Uterus by Her Doctor)
Researchers are looking to learn more about future menstrual bleeding in women who have started using intrauterine contraception methods.
- Trial name
- MyIUS (NCT04989595)
- Testing
- MyIUS app
- Where
- 6 sites in Brazil, Denmark and 4 more
- Volunteers
- 3,045 people, healthy volunteers welcome
- Sponsor
- Bayer
Multiple Myeloma, Caregiver Subjective Burden
The Burden of Multiple Myeloma on Patients and Caregivers Quality of Life: a Canadian Real-World Study
The purpose of this observational study is to estimate the burden of multiple myeloma on patients and caregivers in terms of QoL.
- Conditions
- Multiple Myeloma, Caregiver Subjective Burden, Quality of Life (QOL)
- Trial name
- NCT06610045
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- PeriPharm
Hyperphosphatemia
Multicenter, Open, Prospective, 48 Weeks, Observational Study ,Evaluate the Safety and Efficacy of Nephoxil Capsule
The purpose of this study is to evaluate the safety and efficacy of Nephoxil capsule administration for the improvement of hyperphosphatemia in CKD patients undergoing hemodialysis under actual conditions of routine medical care.
- Trial name
- NCT06206135
- Testing
- the low-dose group (1.5 g/day) or the standard-dose group (4 g/day)
- Where
- South Korea
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- LG Chem
Cardiovascular Diseases, Myocardial Infarction
Real World Evidence Study of Statin Use in Brazil
A cross-sectional real-world data study designed to assess the use of statins in individuals assisted within the primary care system in Brazil.
- Conditions
- Cardiovascular Diseases, Myocardial Infarction, Stroke, Hypertension
- Trial name
- RWE-Statins (NCT05285085)
- Testing
- Statin
- Where
- Brazil
- Volunteers
- 2,133,900 people, healthy volunteers welcome
- Sponsor
- Hospital Israelita Albert Einstein
SARS-CoV-2, COVID-19
A Study of the Effectiveness of Moderna COVID-19 Vaccine
This is an observational cohort study to evaluate real-world vaccine effectiveness and durability of Moderna COVID-19 vaccine among a diverse population at Kaiser Permanente Southern California (KPSC).
- Trial name
- NCT05933304
- Where
- United States
- Volunteers
- 927,004 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
Pain, Sleep Disturbance
Radicle ACES: A Study of Commercially Available CBD Used in the Real-world Setting
A randomized, open-label study of commercially available, orally ingestible, Cannabidiol (CBD) products used in the real-world setting for pain, sleep, and anxiety.
- Conditions
- Pain, Sleep Disturbance, Anxiety
- Trial name
- RWE-ACES (NCT05003882)
- Testing
- Commercially available, orally ingestible CBD product
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Radicle Science
Food Selection
Salt Warning Label Restaurant Study
This between-subjects randomised controlled trial aims to test the effect of a menu featuring salt warning labels on perceived message effectiveness relative to a menu with no labels in a real-world restaurant environment.
- Trial name
- NCT06458270
- Testing
- Salt warning label
- Where
- United Kingdom
- Volunteers
- 465 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Type II Diabetes Mellitus, Efficacy, Self
Real World Safety & Efficacy Experience of Empagliflozin With or Without Metformin in T2DM Patients - EASE Study
Study Objective To evaluate the safety and tolerability of Empagliflozin with or without metformin in patients with Type II Diabetes Mellitus in the Pakistani population.
- Conditions
- Type II Diabetes Mellitus, Efficacy, Self, Safety Issues
- Trial name
- EASE (NCT05164263)
- Testing
- Empagliflozin
- Where
- 6 sites in Afghanistan, Kenya and 3 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Getz Pharma
Tumor Immunity, Immunosuppression
RFA Plus Carrizumab vs Carrizumab Alone for HCC
The study aims to find whether patients with advanced HCC can get more benefits from RFA +PD-1 immunosuppressant (carrizumab) compared with carrizumab alone, considering with the result of PFS.
- Conditions
- Tumor Immunity, Immunosuppression, Radiofrequency Ablation
- Trial name
- NCT04150744
- Testing
- radiofrequency ablation
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Canker Sore
Luminance RED for Canker Sores
Canker sores, also called aphthous ulcers, are small, shallow lesions that develop on the soft tissues in your mouth or at the base of your gums.
- Trial name
- NCT04914533
- Testing
- Luminance RED Low Level Laser Therapy Device
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- ProofPilot
Healthy Children
An Exploratory RWE Study Exploring Effects of a Goat Milk Based Young Child Formula on Health Benefits
This is an exploratory real-world study designed to gain insight into the role of the product in terms of health benefits in toddlers, with the potential to generate hypotheses on key and other exploratory objectives.
- Trial name
- NCT06287385
- Testing
- Goat-milk Based Formula
- Where
- China
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Danone Nutricia
COVID-19, Vaccine-Preventable Diseases
The Efficacy of the 2023-2024 Updated COVID-19 Vaccines Against COVID-19 Infection
The purpose of this research study is to find out how well two different 2023-2024 updated COVID-19 vaccines protect people from COVID-19 (the disease caused by the SARS-CoV-2 virus), and to determine if getting a 2023-2024…
- Conditions
- COVID-19, Vaccine-Preventable Diseases, SARS CoV 2 Infection, Upper Respiratory Tract Infection
- Trial name
- BEEHIVE (NCT06065176)
- Testing
- Novavax COVID-19 vaccine (2023-2024 formula XBB containing), Pfizer COVID-19 mRNA vaccine (2023-2024 formula XBB containing)
- Where
- United States
- Volunteers
- 1,188 people, healthy volunteers welcome
- Sponsor
- Sarang K. Yoon, DO, MOH
Arterial Hypertension, Menopause
Blood Pressure and Cardiometabolic Risk (Diet-to-HTN)
Obesity is a significant health issue that increases the risk of serious cardiovascular problems. In recent years, two dietary methods, the Ketogenic Diet (KD) and Intermittent Fasting (IF), have become popular for their…
- Conditions
- Arterial Hypertension, Menopause, Obesity, Cardiometabolic Syndrome
- Trial name
- NCT06457711
- Testing
- Free diet Group (FDG), Very low Calorie Ketogenic Diet Group (VLCKDG), Intermittent Fasting Group (IFG)
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Well-being
Evaluation of a Personalised Digital Intervention (EviBody) for Healthy and Sustained Lifestyle Behaviors and Well-being Among Adults: a Real-world Quasi-experimental Study
The goal of this quasi-experimental observational study is to evaluate the impact of a personally tailored digital intervention aimed to support a healthy lifestyle on well-being, lifestyle behaviors, and mental health among the…
- Trial name
- NCT05973383
- Testing
- EviBody- Basic, EviBody- Standard, EviBody- Premium
- Where
- Sweden
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Sophiahemmet University
Skin Aging
A Clinical Study to Evaluate the Efficacy and Satisfaction of Ultrasound Therapy Combined With SkinCeuticals A.G.E for Improving Facial Aging
A Prospective, Single-center, Single-blind, Randomized split-face, controlled trial will be conducted. The goal of this clinical trial is to evaluate the efficacy and satisfaction of ultrasound therapy combined with SkinCeuticals…
- Trial name
- NCT05748470
- Testing
- SkinCeuticals A.G.E, standard cream
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yes Skin Medical Group