Clinical trials: Rectal Adenoma
Colorectal Cancer, Colorectal Disorders
Reducing Colonoscopies in Patients Without Significant Bowel Disease
Investigating people with bowel symptoms uses a test that detects traces of blood in the stools, the FIT test. There are many possible reasons for positive tests. A few people have cancer.
- Conditions
- Colorectal Cancer, Colorectal Disorders, Colorectal Adenoma, Colorectal Polyp
- Trial name
- RECEDE (NCT04516785)
- Testing
- FIT and VOC
- Where
- 4 sites in United Kingdom
- Volunteers
- 1,181 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Colorectal Cancer, Colorectal Adenoma
Adenoma Detection Rate With Endocuff-Assisted Colonoscopy - an Italian Trial
In European countries, colorectal cancer (CRC) represents an important public health problem. It is widely held view that most carcinomas develop from an adenoma-carcinoma progression.
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colorectal Polyp, Colorectal Neoplasms
- Trial name
- ITAvision (NCT03612674)
- Testing
- Standard colonoscopy, ARC Endocuff Vision
- Where
- 12 sites in Italy
- Volunteers
- 2,100 people
- Sponsor
- Cancer Prevention and Research Institute, Italy
Colorectal Cancer, Adenoma
Effect of an Advanced Notification Letter on Screening Colonoscopy Participation
Participation in a primary screening colonoscopy programs remains low. Advanced notification letter has been shown to increase participation in colorectal cancer screening with fecal occult blood testing and to be cost effective…
- Conditions
- Colorectal Cancer, Adenoma, Rectal Cancer
- Trial name
- NCT02188927
- Testing
- Implementation of ANL, No included ANL
- Where
- Poland
- Volunteers
- 6,800 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Colorectal Cancer
Non-invasive Identification of Colorectal Cancer and Adenomas in Early Stages
The NICE study is a prospective, multi-site study to train and validate a blood-based, glycoproteomic test for the early detection of advanced adenoma and colorectal cancer by collecting blood samples and associated relevant…
- Trial name
- NICE (NCT05445570)
- Testing
- Non-Interventional
- Where
- 12 sites in United States
- Volunteers
- 3,002 people
- Sponsor
- Venn Biosciences Corporation
Colorectal Cancer, Colorectal Adenoma
Accuracy of Real Time Characterization in Artificial Intelligence-assisted Colonoscopy
The goal of this substudy is to investigate the accuracy of a computer-aided polyp characterization (CADx) system. The main question[s] it aims to answer are: How high is the specificity of the AI system when characterizing…
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colorectal Neoplasms
- Trial name
- NCT05754229
- Testing
- AI-assisted colonoscopy
- Where
- 4 sites in Denmark
- Volunteers
- 395 people, healthy volunteers welcome
- Sponsor
- Ismail Gögenur
Flat Colorectal Lesion
Comparison of Flat Colorectal Lesion Detection by Artificial Intelligence-assisted Colonoscopy Versus Endoscopists
The development of artificial intelligence (AI) systems in the field of colorectal endoscopy is currently booming, colorectal cancer being, by its frequency and severity, a real public health problem.
- Trial name
- AIChallengeMed (NCT05942677)
- Testing
- proportion of colorectal lesions
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Hospices Civils de Lyon
Colorectal Cancer
Aspirin and/or Folic Acid in Preventing Recurrent Colorectal Polyps
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of aspirin and/or folic acid may be effective in preventing recurrent polyps in patients who have…
- Trial name
- NCT00033319
- Testing
- folic acid, acetylsalicylic acid
- Where
- 32 sites in United Kingdom
- Sponsor
- Queen's Medical Center
Colorectal Neoplasms, Colonic Polyp
Effectiveness of Artificial Intelligence-Assisted Colonoscopy for Adenoma Detection in Routine Clinical Practice : a Prospective Multicenter Randomized Trial
This study is a multi-center, randomized controlled trial designed to evaluate whether an artificial intelligence (AI) system can assist endoscopists to improve the detection rate of colorectal adenomas and cancers during…
- Conditions
- Colorectal Neoplasms, Colonic Polyp, Adenoma, Colorectal Cancer
- Trial name
- AI-COLOADR (NCT07307547)
- Testing
- AI-Assisted Colonoscopy
- Where
- China
- Volunteers
- 3,300 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Colorectal Cancer, Adenoma Colon
Liquid Biopsy and Machine Learning for Early Colorectal Cancer, Adenomas, Lynch Cancers, and Residual Disease Detection
This is an multicenter study that will test the diagnostic accuracy of a blood test (i.e., a liquid biopsy) for the diagnosis of colorectal cancer (CRC), advanced adenomas (AAs), as well as Lynch-syndrome associated cancers.
- Conditions
- Colorectal Cancer, Adenoma Colon, Adenoma Colon Polyp, Colon Adenoma
- Trial name
- BEACON (NCT07450612)
- Testing
- BEACON
- Where
- 4 sites in Italy
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- San Raffaele University
Rectal Adenoma
Efficiency of Two Dimensional High Definition vs Three Dimensional Endoscopic Systems in Transanal Endoscopic Surgery
Introduction: The usual surgical technique for large adenomatous tumors and rectal cancer is anterior resection of the rectum or abdominoperineal resection.
- Trial name
- NCT01498354
- Testing
- 2-D high definition vision systems, transanal endoscopic operation (TEO), Transanal endoscopic microsurgery (TEM)
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Corporacion Parc Tauli
Biliary Tract Cancer, Breast Cancer
Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors
This study is designed to characterize the safety, tolerability, and anti-tumor activity of MDX2001 in patients with advanced solid tumors.
- Conditions
- Biliary Tract Cancer, Breast Cancer, Cervical Cancer, Colon Cancer
- Trial name
- NCT06239194
- Testing
- MDX2001
- Where
- 6 sites in United States
- Volunteers
- 330 people
- Sponsor
- ModeX Therapeutics, An OPKO Health Company
Colorectal Cancer, Adenomatous Polyps
Multi-omics Study for Early Detection of Colorectal Cancer (MOED-CRC)
The primary objective of the study is to screen multi-omics markers in blood samples and construct a prediction model for CRC based on liquid biopsy, and we will further optimize the prediction model by validating its clinical…
- Conditions
- Colorectal Cancer, Adenomatous Polyps, Adenoma, Advanced Adenoma
- Trial name
- NCT06220617
- Where
- 6 sites in China
- Volunteers
- 3,600 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Colorectal Neoplasms
Comparison of AMR and ADR Between Endocuff Vision-assisted and Conventional Colonoscopy: a Multicenter Randomized Trial
The aim of this international multicenter study is to compare the adenoma detection rate and adenoma miss rate of conventional and Endocuff Vision-assisted colonoscopy.
- Trial name
- EXCEED (NCT03418948)
- Testing
- CC followed by EC, EC followed by CC, 2x EC
- Where
- 3 sites in Greece, Netherlands
- Volunteers
- 708 people
- Sponsor
- Radboud University Medical Center
Adenoma, Colorectal Neoplasms
Conventional Endoscopic Mucosal Resection vs Underwater Resection for Colorectal Non-pedunculated Colorectal Lesions
Randomized, comparative and prospective study between Conventional Endoscopic Mucosal Resection for the removal of flat or sessile colorectal lesions without previous attempt to resection.
- Trial name
- NCT03021135
- Testing
- Conventional Endoscopic Mucosal Resection, Underwater Endoscopic Mucosal Resection
- Where
- Brazil
- Volunteers
- 105 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Colorectal Neoplasms, Colonic Polyp
Adenoma Detection Rate Using Endocuff Vision in China
The primary aim of this study is to explore the usefulness of Endocuff Vision in colonoscopy on adenoma detection rate (ADR). Other aims include to explore the data below when Endocuff Vision is used.
- Conditions
- Colorectal Neoplasms, Colonic Polyp, Adenoma
- Trial name
- SinoEVADR (NCT03839277)
- Testing
- Endocuff Vision
- Where
- 5 sites in China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Colorectal Cancer
Clinical Validation of PolyDeep: an Artificial Intelligence-based Computer-aided Polyp Detection (CADe) and Characterization (CADx) System. Polydeep Advance 3
This study is a clinical validation of PolyDeep, a computer-aided polyp detection (CADe) and characterization (CADx) system. PolyDeep Advance 3 is a multicentric randomized clinical trial comparing high definition colonoscopy…
- Trial name
- NCT05513261
- Testing
- High definition colonoscopy (standard colonoscopy) in Adenoma Detection Rate, PolyDeep assisted high definition colonoscopy (CAD system) in Adenoma Detection Rate
- Where
- 3 sites in Spain
- Volunteers
- 857 people
- Sponsor
- Fundacin Biomedica Galicia Sur
Colorectal Neoplasms, Adenoma Colon
Omega-3 Fatty Acid and Colorectal Adenoma
Patients aged >40 years who underwent elective colonoscopies were recruited from ten institutions. Patients with a history of colorectal cancer or long-term dietary interventions were excluded.
- Trial name
- NCT06427109
- Testing
- Dietary intake of omega-3 fatty acid
- Where
- South Korea
- Volunteers
- 798 people
- Sponsor
- DongGuk University
Cutaneous Melanoma, Non-small Cell Lung Cancer
A Study of PF-08046049/SGN-BB228 in Advanced Melanoma and Other Solid Tumors
This study will test the safety of a drug called PF-08046049/SGN-BB228 in participants with melanoma and other solid tumors that are hard to treat or have spread through the body. It will also study the side effects of this drug.
- Conditions
- Cutaneous Melanoma, Non-small Cell Lung Cancer, Colorectal Neoplasms, Pancreatic Neoplasms
- Trial name
- NCT05571839
- Testing
- PF-08046049
- Where
- 37 sites in United States, Canada and 4 more
- Volunteers
- 41 people
- Sponsor
- Seagen, a wholly owned subsidiary of Pfizer
Breast Cancer, Colorectal Cancer
Cyclophosphamide Plus Vaccine Therapy in Treating Patients With Advanced Cancer
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Vaccines made from a patient's tumor tissue may make the body build an immune response to kill tumor…
- Conditions
- Breast Cancer, Colorectal Cancer, Kidney Cancer, Lung Cancer
- Trial name
- NCT00002475
- Testing
- allogeneic tumor cell vaccine, autologous tumor cell vaccine, recombinant interferon alfa
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- St. Vincent Medical Center - Los Angeles
Colorectal Adenoma, Colorectal Polyp
Endocuff Vision Colonoscopy vs. AmplifEYE Colonoscopy
The study aims to compare the results between colonoscopies with two different attachments on the distal end of the colonoscope.
- Conditions
- Colorectal Adenoma, Colorectal Polyp, Colorectal Cancer
- Trial name
- NCT03560128
- Testing
- Endocuff Vision device, AmplifEYE device
- Where
- United States
- Volunteers
- 634 people, healthy volunteers welcome
- Sponsor
- Indiana University