Clinical trials: Rectal Cancer, Radiotherapy
Colorectal Cancer, Liver Metastases
Preventive Effect of Enoxaparin, Pentoxifylline and Ursodeoxycholic Acid to Radiation Induced Liver Toxicity
To evaluate whether a combination regimen of pentoxifylline, ursodeoxycholic acid and enoxaparin provides a protective effect on the liver parenchyma after high dose rate (HDR) brachytherapy.
- Conditions
- Colorectal Cancer, Liver Metastases, Irradiation Damage, Radiation Induced Liver Disease
- Trial name
- ELDORADO (NCT01149304)
- Testing
- Pentoxifylline, Ursodeoxycholic Acid, Enoxaparin
- Where
- Germany
- Volunteers
- 22 people
- Sponsor
- University of Magdeburg
Bone Cancer, Brain Cancer
Enhanced Assistance During Radiotherapy for Unmet Essential Needs
This is a prospective single-arm study of an enhanced assistance intervention for patients with unmet essential needs undergoing >10 fractions of radiotherapy comparing delay-free completion of radiotherapy in study participants…
- Conditions
- Bone Cancer, Brain Cancer, Colorectal Cancer, Esophagus Cancer
- Trial name
- EARN (NCT06582849)
- Testing
- Standard assistance, Enhanced assistance
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Washington University School of Medicine
Colorectal Cancer
Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as fluorouracil, oxaliplatin, and leucovorin, work in different ways to stop the growth of tumor cells, either by killing…
- Trial name
- NCT00335816
- Testing
- fluorouracil, leucovorin calcium, oxaliplatin
- Where
- 15 sites in United States, Canada
- Volunteers
- 248 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Stage IV Rectal Cancer, Liver Metastasis, Resectable
Short Course Radiotherapy Combined With Chemotherapy in Stage IV Rectal Cancer With Resectable Liver Metastases
Patients with rectal cancer and resectable liver metastases receive short course radiotherapy(5Gy/f x 5f) to the pelvis and XELOX consolidating chemotherapy al least 4 cycles after 2 weeks.
- Trial name
- NCT02510378
- Testing
- Short course radiotherapy
- Where
- 2 sites in China
- Volunteers
- 47 people
- Sponsor
- Chinese Academy of Medical Sciences
Colorectal Cancer
Oxaliplatin, Capecitabine, and Radiation Therapy With or Without Cetuximab in Treating Patients Undergoing Surgery for High-Risk Rectal Cancer
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- EXPERT-C (NCT00383695)
- Testing
- cetuximab, capecitabine, oxaliplatin
- Where
- 13 sites in Spain, Sweden and 1 more
- Volunteers
- 164 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Anal Cancer
Topical MTS-01 for Dermatitis During Radiation and Chemotherapy for Anal Cancer
Background: Radiation and chemotherapy treatments for anal cancer can cause irritation of the skin that can lead to redness and tenderness, and in some cases can be so severe that it results in blistering or peeling of the skin…
- Trial name
- NCT01324141
- Testing
- Tempol, 5-Fluorouracil, Mitomycin-C
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Cancer Institute (NCI)
Rectal Cancer
Ketogenic Diet Compliance in Patients Undergoing Radiotherapy for Pelvic Cancers
Patients with locally advanced non-metastatic adenocarcinoma of the rectum undergoing chemoradiation therapy will be assigned to 2 groups: the intervention group will be prescribed an individualized ketogenic eating plan to be…
- Trial name
- KOMPARC (NCT05938322)
- Testing
- Ketogenic Diet, Standard Diet
- Where
- Italy
- Volunteers
- 194 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Metastatic Colorectal Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8
Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial
This phase III trial compares the addition of total ablative therapy to the usual systemic therapy versus the usual systemic therapy alone in treating patients with advanced colorectal cancer that has spread to up to 4 body sites…
- Conditions
- Metastatic Colorectal Adenocarcinoma, Stage IV Colorectal Cancer AJCC v8, Oligometastatic Colorectal Carcinoma
- Trial name
- NCT05673148
- Testing
- Stereotactic Ablative Radiotherapy, Resection, Microwave Ablation
- Where
- 189 sites in United States, Canada
- Volunteers
- 146 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Rectal Adenocarcinoma
Optimisation of Radiotherapy in Rectal Cancer (ORREC)
This is a retrospective study using images acquired routinely for diagnosis of rectal cancer to see if these could be used to predict responses to radiotherapy treatment and if it can, whether the treatment can be optimised to…
- Trial name
- ORREC (NCT04090450)
- Testing
- chemo-radiotherapy
- Where
- United Kingdom
- Volunteers
- 1,500 people
- Sponsor
- University of Manchester
Colorectal Cancer
Low and Intermediate Risk OliGometastatic ColoREctal CancEr PatieNts Treated with Stereotactic ABlative Radiotherapy
This is an experimental study without drug or device, randomized, open-label, non-profit, sponsored by the IRCCS Sacro Cuore Don Calabria Hospital in Negrar, which will take place at the Department of Advanced Oncological…
- Trial name
- GREENLaIT-SABR (NCT06310564)
- Testing
- SABR
- Where
- Italy
- Volunteers
- 204 people
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Liver Metastases, Non-Small Cell Lung Cancer
Intestinal Low-Dose Radiotherapy Combined With Immune Checkpoint Inhibitors in Solid Tumors With Liver Metastases
This study aims to evaluate the effectiveness and safety of combining low-dose radiotherapy to the intestines with immune checkpoint inhibitors (ICIs) in patients with liver metastases from solid tumors.
- Conditions
- Liver Metastases, Non-Small Cell Lung Cancer, Colorectal Cancer (Diagnosis), Pancreatic Cancer Metastatic
- Trial name
- ILDR-ICI-LM (NCT07875465)
- Testing
- Intestinal Low-Dose Radiotherapy (ILDR), PD-1/PD-L1 inhibitors, Combined Chemotherapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Bing Xia
Rectal Cancer
Dose Escalation Trial of Nitroglycerin, 5-flourouracil and Rad Therapy for Rectal Cancer
The purpose of this study is to determine whether topical nitroglycerin in addition to 5-flourouracil and radiation therapy are effective in the treatment of operable rectal cancer.
- Trial name
- NCT01407107
- Testing
- Nitroglycerin 0.2 MG/HR, Nitroglycerin 0.4 MG/HR, Nitroglycerin 0.6 MG/HR
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Texas Southwestern Medical Center
Malignant Neoplasm, Malignant Neoplasm of Rectum
Dietary Fiber During Radiotherapy - a Placebo-controlled Randomized Trial
The investigators hypothesize that an increase in dietary fiber intake during radiation therapy may provide better long-term intestinal health for the cancer survivor.
- Conditions
- Malignant Neoplasm, Malignant Neoplasm of Rectum, Malignant Neoplasm of Anus, Malignant Neoplasm of Urinary Bladder
- Trial name
- FIDURA (NCT04534075)
- Where
- Sweden
- Volunteers
- 354 people
- Sponsor
- Sahlgrenska University Hospital
Rectal Cancer, Quality of Life
Prospective Observational Trial to Evaluate Quality of Life After Neoadjuvant Radiation or Chemoradiation Followed by Surgery in Patients With Rectal Cancer
Observational study to evaluate longitudinal quality of life according to standardized EORTC questionaires as well as functional Outcome, oncological outcome and toxicity in patients treated with neoadjuvant short term radiation…
- Conditions
- Rectal Cancer, Quality of Life, Radiation Therapy, Chemoradiation
- Trial name
- NEOCARE (NCT03731130)
- Testing
- EORTC QLQ C30, EORTC QLQ CR29
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Anal Carcinoma
Effects of Deep Regional Hyperthermia in Patients With Anal Carcinoma Treated by Standard Radiochemotherapy
Randomized study to investigate the efficacy of deep regional hyperthermia in patients with anal carcinoma treated by standard radiochemotherapy with MMC and 5-FU.
- Trial name
- HYCAN (NCT02369939)
- Testing
- Irradiation, Mitomycin C, 5-Fluorouracil
- Where
- Germany
- Volunteers
- 118 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Rectal Cancer, Moderately Hypofractionated Radiotherapy
Neoadjuvant Moderately Hypofractionated Radiotherapy Combined With Chemotherapy and Immunotherapy for High-risk pMMR/MSS Locally Advanced Rectal Cancer: A Prospective, Multi-center Randomized Control Phase II Trial
This study aims to observe and evaluate the efficacy and safety of moderately hypofractionated radiotherapy combined with chemotherapy and immunotherapy, compared with conventional neoadjuvant chemoradiotherapy, in patients with…
- Conditions
- Rectal Cancer, Moderately Hypofractionated Radiotherapy, Serplulimab, pMMR/MSS
- Trial name
- NCT07527520
- Testing
- Moderately Hypofractionated Radiotherapy, Serplulimab, CapOx+Long-course radiotherapy
- Where
- China
- Volunteers
- 165 people
- Sponsor
- Fudan University
Rectal Adenocarcinoma
Monitoring Treatment Response With On-board DWI During Neo-adjuvant Chemo-radiation for Rectal Cancer Using Magnetic Resonance-guided-radiotherapy Systems
feasibility of using a diffusion sequence of a MRgRT system as an early marker of treatment response during nRCT of rectal adenocarcinoma.
- Trial name
- DWI_RECT_MRGRT (NCT03961776)
- Testing
- MRI-guided radiotherapy by on-board DWI sequences
- Where
- 2 sites in United States, France
- Volunteers
- 39 people
- Sponsor
- Institut Paoli-Calmettes
Rectal Cancer
Sexual Function and Wellbeing in Females With Rectal Cancer
Preoperative radiotherapy (RT) and pelvic surgery is recommended to many patients with rectal cancer. For women there are theoretical reasons to believe that the treatment may affect hormone levels, sexual function and wellbeing.
- Trial name
- NCT01216189
- Testing
- Preoperative radiotherapy
- Where
- 5 sites in Sweden
- Volunteers
- 142 people
- Sponsor
- Karolinska Institutet
Rectal Neoplasms
Prediction of Response to Neoadjuvant Therapy in Rectal Cancer
The purpose of this study is to determine whether 18F-FDG-PET-CT and texture analysis of MRI performed 9 weeks after Neoadjuvant Chemo-radiotherapy in patients with locally advanced rectal cancer has the ability to identify…
- Trial name
- PRENT-LARC (NCT02439086)
- Testing
- PET-CT Scan
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Colchester General Hospital
Rectal Cancer
Pucotenlimab Plus Radiotherapy and Chemotherapy for Neoadjuvant Treatment of Locally Advanced Rectal Cance(PUCRT)
Colorectal cancer is a common gastrointestinal tumor, with rising incidence in China. Rectal cancer accounts for nearly half of new cases, and many patients are diagnosed at a locally advanced stage.
- Trial name
- PUCRT (NCT06770270)
- Testing
- Pucotenlimab
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine