Clinical trials: Rectal Cancer, Radiotherapy
Colorectal Cancer
Radiation Therapy, Surgery, and Chemotherapy in Treating Patients With Rectal Cancer That Can Be Surgically Removed
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug, giving the drugs in different ways, and combining radiation therapy and surgery…
- Trial name
- NCT00002523
- Testing
- fluorouracil, leucovorin calcium, conventional surgery
- Where
- 35 sites in Belgium, France and 8 more
- Volunteers
- 1,011 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Colorectal Cancer
Celecoxib, Fluorouracil, and Radiation Therapy in Treating Patients With Stage II or Stage III Rectal Cancer That Can Be Removed By Surgery
RATIONALE: Celecoxib may stop the growth of tumor cells by blocking blood flow to the tumor and by blocking some of the enzymes needed for cell growth.
- Trial name
- NCT00336960
- Testing
- celecoxib, fluorouracil, conventional surgery
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Rectum Cancer
Rectal Study: Value of Repeated FDG-PET-CT Scans in Rectal Cancer
To investigate the evolution of the 18F-deoxyglucose (FDG) uptake and the tumour characteristics determined in the plasma of patients with rectal cancer during and after radiotherapy or combined radiotherapy and chemotherapy.
- Trial name
- NCT00576563
- Testing
- FDG
- Where
- Netherlands
- Volunteers
- 103 people
- Sponsor
- Maastricht Radiation Oncology
Breast Cancer, Colorectal Cancer
Growth Factor Levels in the Blood of Patients Undergoing Radiation Therapy for Epithelial Cancer
RATIONALE: Measuring levels of transforming growth factor-beta (TGF-beta) in the blood of patients with epithelial cancers (head and neck, lung, breast, colorectal, and prostate) may help doctors predict how patients will respond…
- Conditions
- Breast Cancer, Colorectal Cancer, Head and Neck Cancer, Lung Cancer
- Trial name
- NCT00897793
- Testing
- venipuncture, radiation therapy
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Pancreatic Ductal Adenocarcinoma, Gastric Cancer
Lead-212 PSV359 Therapy for Patients With Solid Tumors
Phase I/IIa image-guided, alpha-particle therapy study of [203Pb]Pb-PSV359 and [212Pb]Pb-PSV359 in patients with solid tumors that are known to be Fibroblast Activation Protein (FAP)-positive.
- Conditions
- Pancreatic Ductal Adenocarcinoma, Gastric Cancer, Esophageal Cancer, Colorectal Cancer
- Trial name
- NCT06710756
- Testing
- [203Pb]Pb-PSV359, [212Pb]Pb-PSV359
- Where
- 16 sites in United States
- Volunteers
- 112 people
- Sponsor
- Perspective Therapeutics
Rectal Neoplasms
Functional Outcome of Organ Preservation After Neo-adjuvant Chemo Radiation for Rectal Cancer
The primary objective is to describe the functional outcome of patients that choose for organ saving treatment.
- Trial name
- NCT02278653
- Testing
- Questionnaires for the evaluation of Quality of Life, Manometry
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Maastricht University Medical Center
Colorectal Cancer, Neoplasms
Adoptive Cell Therapy Plus Chemotherapy and Radiation After Surgery in Treating Patients With Colorectal Cancer
The purpose of this study is to evaluate the efficacy of autologous tumor lysate-pulsed dendritic and cytokine-induced killer cells (DC-CIK) for colorectal cancer (CRC).
- Conditions
- Colorectal Cancer, Neoplasms, Intestinal Neoplasms, Digestive System Neoplasms
- Trial name
- NCT02202928
- Testing
- DC-CIK, Radiotherapy, Chemotherapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shenzhen Hornetcorn Bio-technology Company, LTD
Locally Advanced Rectal Carcinoma, Rectal Adenocarcinoma
Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer
This phase I trial investigates how well short-course radiation therapy followed by combination chemotherapy works in treating patients with stage II-III rectal cancer.
- Conditions
- Locally Advanced Rectal Carcinoma, Rectal Adenocarcinoma, Stage II Rectal Cancer AJCC v8, Stage IIA Rectal Cancer AJCC v8
- Trial name
- NCT04703101
- Testing
- Capecitabine, Fluorouracil, Intensity-Modulated Radiation Therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Colorectal Cancer
Neoadjuvant Radiation Therapy and Capecitabine in Treating Patients With Stage III or Stage IV Colorectal Adenocarcinoma
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy, such as capecitabine, use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00075556
- Testing
- capecitabine, conventional surgery, neoadjuvant therapy
- Where
- 12 sites in France
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Rectal Cancer
Xeloda and Bevacizumab to Treat Rectal Cancer
The project objective is to evaluate the efficacy of the neoadjuvant treatment with bevacizumab, capecitabine and radiotherapy, in patients with rectal adenocarcinoma resectable locally advanced (stage T3 or T4), with or without…
- Trial name
- xeberecto (NCT00847119)
- Testing
- Bevacizumab, capecitabine (Xeloda), Rectal Radiotherapy
- Where
- Spain
- Volunteers
- 43 people
- Sponsor
- Institut Català d'Oncologia
Rectal Cancer
Dose Escalation Trial of Nitroglycerin, 5-flourouracil and Rad Therapy for Rectal Cancer
The purpose of this study is to determine whether topical nitroglycerin in addition to 5-flourouracil and radiation therapy are effective in the treatment of operable rectal cancer.
- Trial name
- NCT01407107
- Testing
- Nitroglycerin 0.2 MG/HR, Nitroglycerin 0.4 MG/HR, Nitroglycerin 0.6 MG/HR
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Texas Southwestern Medical Center
Anal Squamous Cell Carcinoma
MR-Adaptive Radiation Therapy for Anal Cancer With EScalated-Treatment in a Risk-Optimized Approach
The proposed study is a phase II, single arm, open-label trial of MR-guided radiation therapy (RT) with risk stratified RT dose selection in patients with anal cancer.
- Trial name
- MAESTRO (NCT06050707)
- Testing
- Radiotherapy - Low risk group, Radiotherapy - Standard risk group, Radiotherapy - Intermediate risk group
- Where
- 5 sites in United States, Australia and 1 more
- Volunteers
- 80 people
- Sponsor
- University Health Network, Toronto
Rectal Neoplasms
Safety Study of Capecitabine With Radiation in Elderly Rectal Cancer
This phase I study is designed to determine the maximum tolerant dose of capecitabine when used in preoperative concurrent chemo-radiation for locally advanced rectal patients over 75 years old.
- Trial name
- NCT01584544
- Testing
- capecitabine
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Chinese Academy of Medical Sciences
Prostatic Neoplasms
Amifostine to Protect the Rectum During External Beam Radiotherapy for Prostate Cancer
This study will evaluate the safety and effectiveness of a drug called amifostine in reducing the bowel side effects of radiation treatment for prostate cancer.
- Trial name
- NCT00040365
- Testing
- Amifostine trihydrate, Radiation therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Rectal Cancer
Capecitabine, Irinotecan Hydrochloride, Cetuximab, and Radiation Therapy in Treating Patients Undergoing Surgery for Locally Advanced Rectal Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine and irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- EXCITE (NCT00972881)
- Testing
- cetuximab, capecitabine, irinotecan hydrochloride
- Where
- 5 sites in United Kingdom
- Volunteers
- 82 people
- Sponsor
- University College, London
Rectal Cancer
BReak Interval Delayed Surgery for Gastrointestinal Extraperitoneal Rectal Cancer
This is a randomized multicentric clinical trial in patients affected by resectable rectal cancer, cT2N1-2, cT3N0-2, MRF -, aiming to evaluate the impact of the interval between chemoradiotherapy and surgery on the pathological…
- Trial name
- BRIDGE (NCT03581344)
- Testing
- Repetition of Re-staging
- Where
- Italy
- Volunteers
- 148 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Colorectal Cancer
Chemotherapy and Radiation Therapy Before Surgery Followed by Capecitabine With or Without Oxaliplatin in Treating Patients With Locally Advanced Rectal Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- PETACC-6 (NCT00766155)
- Testing
- capecitabine, oxaliplatin
- Volunteers
- 1,094 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Anal Squamous Cell Carcinoma
Adaptive Radiation in Anal Cancer
This is a 20 patient pilot study to examine the feasibility of dose-adapted radiation therapy for the treatment of locally advanced anal squamous cell cancer.
- Trial name
- NCT05838391
- Testing
- Artificial Intelligence Guided Daily Radiotherapy Treatment Planning and Delivery, Mitomycin-C, 5-Fluorouracil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Columbia University
Stage IV Rectal Cancer, Liver Metastasis, Resectable
Short Course Radiotherapy Combined With Chemotherapy in Stage IV Rectal Cancer With Resectable Liver Metastases
Patients with rectal cancer and resectable liver metastases receive short course radiotherapy(5Gy/f x 5f) to the pelvis and XELOX consolidating chemotherapy al least 4 cycles after 2 weeks.
- Trial name
- NCT02510378
- Testing
- Short course radiotherapy
- Where
- 2 sites in China
- Volunteers
- 47 people
- Sponsor
- Chinese Academy of Medical Sciences
Rectal Cancer
Dual REctcal Angiogenesis or MEK Inhibition radioTHERAPY Trial
To determine the maximum tolerated dose (MTD) of AZD6244 or AZD2171 when combined with pre-operative capecitabine and radiotherapy in patients with locally advanced rectal cancer.
- Trial name
- DREAMtherapy (NCT01160926)
- Testing
- AZD6244, Cediranib (AZD2171)
- Where
- United Kingdom
- Volunteers
- 31 people
- Sponsor
- The Christie NHS Foundation Trust