Clinical trials: Rectal Cancer Surgery
Rectal Neoplasms
Endoscopic Submucosal Dissection vs Local Laparoscopic Surgical Resection (TAMIS/TEO) in Early Rectal Neoplasias
A multicenter non-inferiority randomized clinical trial to compare Endoscopic treatment (ESD) and Minimally Invasive Laparoscopic Local Surgical Treatment (TAMIS or TEO) for early rectal neoplastic lesions (adenoma \& T1CRC)…
- Trial name
- DSETAMIS2018 (NCT03959839)
- Testing
- ESD, TAMIS, TEO
- Where
- 3 sites in Spain
- Volunteers
- 70 people
- Sponsor
- Dr. Alberto Herreros de Tejada Echanojáuregui
Colorectal Cancer
Clinical Trial to Evaluate Safety and Efficacy of Hyperthermic Intra-peritoneal Chemotherapy (HIPEC) With Mitomycin C Used During Surgery for Treatment of Locally Advanced Colorectal Carcinoma
The purpose of this study is to determine whether Hyperthermic Intra-peritoneal Chemotherapy (HIPEC) with Mitomycin C used during surgery for treatment of locally advanced colorectal carcinoma is effective in the treatment of…
- Trial name
- HIPECT4 (NCT02614534)
- Testing
- MITOMYCIN-C 30 mg, Proactive cytoreductive surgery
- Where
- 19 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Colorectal Neoplasms
Effect of TroVax in Patients Having Colorectal Cancer With Liver Metastases Removed
This study will test the safety and efficacy of TroVax in patients undergoing surgical resection of colorectal cancer with liver metastases.
- Trial name
- NCT00259844
- Testing
- TroVax
- Volunteers
- 20 people
- Sponsor
- Cancer Research UK
Rectal Cancer
Short-course Preoperative Chemoradiotherapy for Rectal Cancer
The purpose of this study is to evaluate the early clinical outcome of the short-course preoperative chemoradiotherapy, 33Gy/10 fx and delayed operation after chemoradiation, the investigators initiated the clinical trial of KROG…
- Trial name
- KROG 11-02 (NCT01431599)
- Testing
- short-course radiation
- Where
- 3 sites in South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Jong Hoon Lee
Rectal Cancer
Economic Analysis of Robotic Rectal Resection in German Health Care System
Analysis of cost effectiveness of robotic rectal resection, either sphincter preserving or abdominoperineal extirpation, in the German diagnosis related groups (DRG) system.
- Trial name
- NCT06113796
- Testing
- Surgery
- Where
- Germany
- Volunteers
- 65 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Low Anterior Resection Syndrome (LARS), Rectal Neoplasm Malignant
Efficacy and Safety of Transcutaneous Posterior Tibial Nerve Stimulation on Fecal Continence in Patients Undergoing Surgery for Rectal Neoplasia
Rectal neoplasia is one of the most prevalent cancers in Spain, and the treatment of choice is total mesorectal excision (TME), as it has demonstrated significant oncological improvements.
- Conditions
- Low Anterior Resection Syndrome (LARS), Rectal Neoplasm Malignant, Quality of Life (QOL), Fecal Incontinence (FI)
- Trial name
- NCT07632196
- Testing
- Posterior tibial nerve stimulation intervention group, Control group
- Where
- 2 sites in Spain
- Volunteers
- 84 people
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Rectum Cancer, Anastomotic Leak
Betacyanin for Early Diagnosis and Recovery of Anastomotic Leakage After Rectal Cancer Surgery: A Single-Center, Prospective, Controlled Trial
This single-center, prospective, controlled trial compares betacyanin versus conventional methods for early diagnosis and healing assessment of anastomotic leakage after rectal cancer surgery.
- Trial name
- NCT07726966
- Testing
- Betacyanin, Pelvic Drainage Fluid Betacyanin Assay
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Southwest Hospital, China
Colorectal Cancer
Radiation Therapy and Chemotherapy Followed by Surgery and Combination Chemotherapy in Treating Patients With Rectal Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00021398
- Testing
- fluorouracil, leucovorin calcium, conventional surgery
- Where
- 17 sites in United States
- Volunteers
- 23 people
- Sponsor
- Fox Chase Cancer Center
Rectal Cancer
Adjuvant Chemotherapy After Preoperative Chemoradiotherapy to Treat Rectal Cancer
The purpose of this study is to evaluate the disease-free survival in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy with fluoropyrimidines and surgery followed by adjuvant combination…
- Trial name
- NCT00807911
- Testing
- Adjuvant FL, Adjuvant FOLFOX
- Where
- 6 sites in South Korea
- Volunteers
- 322 people
- Sponsor
- Asan Medical Center
Colorectal Cancer, Circulating Tumor Cell
Influence of Opioid Analgesia on Circulating Tumor Cells in Open Colorectal Cancer Surgery
To compare the effects of three types of perioperative analgesia on the number of circulating tumor cells following radical colorectal cancer surgery.
- Trial name
- POACC-1 (NCT03700411)
- Testing
- Morphine, Piritramid, Epidural
- Where
- 3 sites in Czechia
- Volunteers
- 125 people
- Sponsor
- The Institute of Molecular and Translational Medicine, Czech Republic
Advanced Malignant Neoplasm, Colorectal Cancer
The Real Clinical Background of Advanced Colorectal Cancer Treatment Situation Survey
Collect the real clinical background of advanced colorectal cancer c of China.
- Trial name
- Sprit (NCT01549067)
- Where
- 2 sites in China
- Volunteers
- 3,700 people
- Sponsor
- Chinese Medical Doctor Association
Rectal Carcinoma
PR in Endoscopic LAR for Rectal Cancer
The anastomotic leakage remains the major early complication after laparoscopic anterior resection(LAR) for medium \& low rectal cancer.
- Trial name
- NCT04078828
- Testing
- Pelvic floor Reconstruction
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Southwest Hospital, China
Colorectal Cancer, Sleep Apnea Syndromes
Prevalence of Sleep Apnea in Patients Undergoing Surgery for Colorectal Cancer
212 patients with colorectal cancer will be investigated before surgery and 100 of them after surgery. 597 individuals from a previous population based study will serve as controls to the prevalence of sleep apnea in the general…
- Conditions
- Colorectal Cancer, Sleep Apnea Syndromes, Hypoxia
- Trial name
- NCT02323464
- Testing
- Surgery for colorectal cancer, No Interventions
- Where
- Sweden
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Karl A Franklin
Colorectal Cancer, Surgery
Perioperative Immune Function in Patients Undergoing Colorectal Cancer Surgery
At Zealand University Hospital, Denmark, the investigators will examine the immune function of patients with colorectal cancer before and after tumor resection.
- Trial name
- TruCulture (NCT04127864)
- Testing
- Colorectal cancer surgery
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Copenhagen
Colorectal Cancer
To Explore the Effect of Huaier Granule on the Negative Conversion Rate After the CEA Level Increases Again After Colorectal Cancer Surgery
This study is a prospective, observational and exploratory study to explore the effect of Huaier Granule on the negative conversion rate of patients with increased CEA levels after colorectal cancer surgery.
- Trial name
- NCT06665334
- Testing
- Huaier granule
- Volunteers
- 134 people
- Sponsor
- Fudan University
Rectal Cancer Surgery, Perfusion Imaging
Effect of Preserving the Left Colic Artery on Proximal Bowel Perfusion
Patients with rectal or rectosigmoid cancer undergoing radical resection will be randomly assigned to either high-tie (HT) or low-tie (LT) ligation of the Inferior Mesenteric Artery (IMA).
- Conditions
- Rectal Cancer Surgery, Perfusion Imaging, Anastomosis, Leaking
- Trial name
- NCT06982664
- Testing
- High Tie of Inferior Mesenteric Artery, Low Tie of Inferior Mesenteric Artery
- Volunteers
- 143 people
- Sponsor
- Ningbo Medical Center Lihuili Hospital
Rectal Adenocarcinoma
GRECCAR 8: Primary Tumor Resection in Rectal Cancer With Unresectable Metastasis
A prospective, open, multicenter, randomized III trial with two arms: Arm A: Primary tumor resection , followed by chemotherapy Arm B: Chemotherapy alone.
- Trial name
- GRECCAR8 (NCT02314182)
- Testing
- Primary tumor resection + chemotherapy, Oxaliplatin/irinotecan + capecitabine, 5-FUI ± bevacizumab
- Where
- 3 sites in France
- Volunteers
- 5 people
- Sponsor
- Hospices Civils de Lyon
Rectal Cancer
Rectal Cancer Neoadjuvant Therapy-Real World Study
This study aims to utilise a real-world data platform to integrate multi-omics data-including radiomics, gut microbiota, pathological quality control and liquid biopsy-to construct a multidimensional predictive model for the…
- Trial name
- RC-NAT-RWS (NCT07566559)
- Testing
- This study is a multicenter, real-world, non-interventional study.
- Where
- China
- Volunteers
- 869 people
- Sponsor
- Beijing Friendship Hospital
Colorectal Cancer
Factors Influencing Quality of Bowel Cleansing for Colonoscopy in Patients With Colorectal Cancer Surgery; Prospective Observational Study
The aim of this study is to clarify the factors influencing quality of bowel cleansing for colonoscopy in patients with colorectal cancer surgery and confirm the adequate bowel cleaning method for patients with colorectal cancer…
- Trial name
- NCT02139475
- Testing
- Colonoscopy
- Where
- South Korea
- Volunteers
- 273 people
- Sponsor
- Yonsei University
Colorectal Cancer
Short-term Effects of LASI Surgery Versus Conventional Laparotomy for Colorectal Liver Metastasis
Surgical resection is still recommended as the optional treatment for colorectal liver metastasis (CLM) patients. There are two main concerns for resectable colorectal liver metastasis which remain controversial: surgical time…
- Trial name
- NCT02350166
- Testing
- laparoscopic surgery
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- West China Hospital