Clinical trials: Rectal Diseases
Cancer of the Rectum, Neoplasms, Rectal
Immunoscore in Rectal Cancer
This is an observational study of tumor samples and MRI imaging in patients with colorectal cancers. A tumor sample, MRI scans, and treatment outcome data will be used for research purposes to see if it is possible to predict…
- Conditions
- Cancer of the Rectum, Neoplasms, Rectal, Rectal Cancer, Rectal Tumors
- Trial name
- NCT02017509
- Testing
- Diagnostic Biopsy and Surgical Procedure, Intravoxel incoherent motion MRI (IVIM), Dynamic Contrast Enhanced MRI (DCE-MRI)
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Providence Health & Services
PMMR/MSS Adenocarcinoma of the Colon or Rectum, Neoadjuvant Chemoradiotherapy
Study on the Applicability of CCR Criteria in Rectal Cancer
This study aims to explore how well the usual ways of checking if rectal cancer patients are free of disease signs after treatment work for a new treatment method.
- Conditions
- PMMR/MSS Adenocarcinoma of the Colon or Rectum, Neoadjuvant Chemoradiotherapy, Immunotherapy, Complete Response
- Trial name
- NCT06794099
- Where
- China
- Volunteers
- 177 people
- Sponsor
- Peking University Cancer Hospital & Institute
Non-Small Cell Lung Cancer, Nonsmall Cell Lung Cancer
MEDI4736 (Durvalumab) in Patients With Brain Metastasis From Epithelial-derived Tumors
Brain metastases are the most common intracranial malignancy occurring in 20-40% of all cancers, and the presence of CNS metastases is associated with a poor prognosis.
- Conditions
- Non-Small Cell Lung Cancer, Nonsmall Cell Lung Cancer, Breast Cancer, Cancer of Breast
- Trial name
- NCT02669914
- Testing
- MEDI4736
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Washington University School of Medicine
Colorectal Cancer, Stomach Cancer
Study of CEA Targeting CAR-T (PTC13) in the Treatment of CEA-Positive Advanced Malignant Solid Tumors
This is a phase I clinical study to evaluate the safety and tolerability of FAST targeted chimeric antigen receptor (CAR)-T cells (PTC13) in patients with carcinoembryonic antigen (CEA)-positive advanced malignant solid tumors…
- Conditions
- Colorectal Cancer, Stomach Cancer, Pancreatic Cancer, Metastatic Cancer
- Trial name
- NCT06821048
- Testing
- Intraperitoneal infusion of FAST CEA-targeted CAR-T
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Weijia Fang, MD
Colorectal Adenocarcinoma
Efficacy and Safety Study of a Modified XELOX Regimen in First-Line Treatment of Metastatic Colorectal Adenocarcinoma
This is an open-label, phase II study to evaluate the efficacy and safety of a modified regimen of oxaliplatin and capecitabine on metastatic colorectal adenocarcinoma in the first-line therapy.
- Trial name
- mXELOX (NCT01552967)
- Testing
- Capecitabine
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Metastatic Colorectal Cancer
Study of Modified FOLFOX6 Plus or Minus Sorafenib in Stage IV Metastatic Colorectal Carcinoma (mCRC) Subjects
To determine if sorafenib when added to chemotherapy will slow disease progression more than chemotherapy alone in patients previously untreated for metastatic colorectal cancer.
- Trial name
- NCT00865709
- Testing
- Sorafenib (Nexavar, BAY43-9006) + mFOLFOX6 (5-FU, levo-leucovorin, oxaliplatin)
- Where
- 116 sites in United States, Belgium and 8 more
- Volunteers
- 198 people
- Sponsor
- Bayer
Depressive Symptoms, Fatigue
Programs to Support You During Chemotherapy (Pro-You)
This randomized pilot clinical trial studies Yoga Skills Training or attention control in reducing fatigue and depressive symptoms during chemotherapy in patients with stage II-IV colorectal cancer.
- Conditions
- Depressive Symptoms, Fatigue, Psychosocial Effects of Cancer and Its Treatment, Stage IIA Colon Cancer
- Trial name
- Pro-You (NCT02148406)
- Testing
- Yoga Skills Training (YST), questionnaire administration, fatigue and depressive symptom assessment and management
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Rectal Cancer
Benchmarking Trial Between France and Australia Comparing Management of Primary Rectal Cancer Beyond TME (Total Mesorectum Excision) and Locally Recurrent Rectal Cancer
The incidence of rectal cancers is at 15,000 new cases per year in France of which 10 to 15% are locally advanced (T4bNxM0) at the moment of diagnosis.
- Trial name
- PELVICARE (NCT02551471)
- Testing
- Blinded inter-country reading of pelvic MRI (Magnetic Resonance Imaging), MDT (Multidisciplinary team) meeting observation, Semi-structured exploratory interviews and focus group with MDT health professional attendees
- Where
- 12 sites in Australia, France
- Volunteers
- 165 people
- Sponsor
- University Hospital, Bordeaux
Colorectal Neoplasms
Brazilian Total Neoadjuvant Therapy Trial
Standard therapy for localized rectal cancer includes chemotherapy and radiation therapy, followed by a "recovery" period of 7-12 weeks, surgery and adjuvant chemotherapy for 3-6 months.
- Trial name
- BRAZIL-TNT (NCT05081687)
- Testing
- Folfirinox
- Where
- Brazil
- Volunteers
- 150 people
- Sponsor
- Hospital Israelita Albert Einstein
Metastatic Colorectal Cancer
The CHOICE Registry
The CHOICE Registry will describe real-world treatment patterns and physician and patient (and caregiver)-reported outcomes associated with patients who have progressed beyond 2nd line metastatic colorectal cancer.
- Trial name
- NCT03148093
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Taiho Oncology, Inc.
Gastrointestinal Neoplasms
Outcomes of Side-to-end Versus End-to-end Colorectal Anastomosis in Non-emergent Sigmoid and Rectal Cancers: Randomized Controlled Clinical Trial
Introduction: Cancer rectum and sigmoid is increasing nowadays. Resection and anastomosis is done laparoscopic approach with various techniques of anastomosis.
- Trial name
- NCT04694521
- Testing
- openSide to end colorectal anastomosis ., open end end to end stapler anastomosis
- Volunteers
- 74 people
- Sponsor
- Zagazig University
Colorectal Cancer, Colorectal Neoplasms
Home-based HIIT to Improve CRC Survivorship: Feasibility and Relationship With Novel Surrogate Biomarkers of CRC Recurrence
This 12-week, exercise study will assess the feasibility of a home-based high-intensity interval training (HIIT) program among colorectal cancer survivors and explore the impact of home-based HIIT compared to a standard…
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Carcinoma, Colonic Neoplasms
- Trial name
- NCT04080414
- Testing
- Home-based high-intensity interval training, Home-based moderate-intensity continuous exercise
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- University of Utah
Colorectal Cancer
The Safety of Ropivacaine TAP Block Combined With Intravenous Lidocaine in Patients Undergoing Colorectal Cancer Surgery
Many studies have confirmed the analgesic effect of intravenous infusion of lidocaine in abdominal surgery. Transversus abdominis plane (TAP) block is also often recommended for abdominal surgery.
- Trial name
- NCT06006026
- Testing
- Ropivacaine Hydrochloride 10 MG/ML [Naropin]
- Where
- China
- Volunteers
- 9 people
- Sponsor
- West China Hospital
Colorectal Cancer
Intensity-Modulated Radiation Therapy With Incorporated Boost and Capecitabine Before Surgery in Treating Patients With Locally Advanced Rectal Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Intensity-modulated radiation therapy (radiation directed at the tumor more precisely than in standard radiation therapy) with incorporated boost (an…
- Trial name
- NCT00084591
- Testing
- capecitabine, conventional surgery, neoadjuvant therapy
- Where
- United States
- Sponsor
- Fox Chase Cancer Center
Rectal Cancer, Surgery
Safety and Efficacy Study of Single-port Robotic Versus Multi-port Robotic Radical Rectal Cancer Surgery
This study is designed to evaluate the safety and efficacy of single-port robotic surgery compared to multi-port robotic surgery for rectal cancer.
- Trial name
- NCT06943690
- Testing
- Single-port robotic surgery, Multi-port robotic surgery
- Where
- 4 sites in China
- Volunteers
- 212 people
- Sponsor
- Ruijin Hospital
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
SU5416 and Irinotecan in Treating Patients With Advanced Colorectal Cancer
Phase I/II trial to study the effectiveness of combining SU5416 and irinotecan in treating patients who have advanced colorectal cancer. SU5416 may stop the growth of colorectal cancer by stopping blood flow to the tumor.
- Conditions
- Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum, Recurrent Colon Cancer, Recurrent Rectal Cancer
- Trial name
- NCT00005818
- Testing
- irinotecan hydrochloride, semaxanib, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Neoplasms
A Translational Study of Bevacizumab in Participants With Metastatic Colorectal Cancer
This open-label, prospective, single-arm, multicenter study will evaluate the relationship of the markers of inflammation and progression-free survival (PFS) in participants with previously untreated metastatic colorectal cancer.
- Trial name
- ASCENT (NCT01588990)
- Testing
- Oxaliplatin, Capecitabine, Bevacizumab
- Where
- 17 sites in Australia
- Volunteers
- 128 people
- Sponsor
- Hoffmann-La Roche
Colorectal Cancer Metastatic
Evaluation of CTCs Combined With Tumor Marker Detection of Efficacy of Chemotherapy in mCRC
Evaluation of individual peripheral blood circulating tumor cells combined with tumor marker detection of efficacy of chemotherapy in patients with advanced colorectal cancer: A observational clinical trial
- Trial name
- NCT02948985
- Testing
- treated with FOLFIRI±cetuximab
- Volunteers
- 100 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Rectal Cancer, Abdominoperineal Resection
APEMESH- Preventing Perineal Complications After Abdominoperineal Resection
Abdominoperineal resection leaves an empty space to be filled by mesh or musculocutaneus flap. Several studies have reported over 30% morbidity with perineal wound healing after abdominoperineal resection.
- Conditions
- Rectal Cancer, Abdominoperineal Resection, Wound Heal
- Trial name
- NCT04334421
- Testing
- Composite mesh
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Elisa Mäkäräinen
Colorectal Cancer (CRC)
Normobaric Oxygen Therapy in Colorectal Cancer Patients
Colorectal cancer (CRC) patients undergoing chemotherapy often experience anemia, oxidative stress, and immune suppression, significantly impacting their quality of life and treatment outcomes.
- Trial name
- NBO-ONCO (NCT06946004)
- Testing
- Normobaric oxygen therapy
- Where
- Poland
- Volunteers
- 254 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland