Clinical trials: Rectal Surgery
Loopileostomy, Fast Track Program,(Enhanced Recovery After Surgery (ERAS))
Defunctioning Stoma and Postoperative Morbidity
In an attempt to reduce the risk for anastomotic leakage after low anterior resection it is common to create a diverting stoma at the same procedure.
- Trial name
- NCT01789515
- Where
- Sweden
- Volunteers
- 287 people
- Sponsor
- Karolinska Institutet
Rectal Cancer, Organ Preservation
Treatment Strategy for Rectal Cancer Patients With Complete Clinical Response
This was a propensity-score matched observational analysis, comparing the oncological outcome of surgical resection vs watch and wait apporach for rectal cancer patients with a cCR.
- Trial name
- NCT03846726
- Testing
- standard TME surgery
- Where
- China
- Volunteers
- 513 people
- Sponsor
- Yuan-hong Gao
Peritoneal Malignancy, Ovarian Cancer
Perioperative Exercise and Nutritional Optimisation Prehabilitation Before Surgery for Patients With Peritoneal Malignancy
People who are diagnosed with cancer of the colon/rectum/appendix/ovaries that spreads into the lining of the tummy and some ovarian cancers or people with pseudomyxoma peritonei can often undergo intensive treatment including…
- Conditions
- Peritoneal Malignancy, Ovarian Cancer, Rectum Cancer, Appendix Cancer
- Trial name
- PANO (NCT05305820)
- Testing
- Exercise, Nutrition
- Where
- 3 sites in Ireland
- Volunteers
- 36 people
- Sponsor
- Dublin City University
Low Anterior Resection Syndrome, Rectal Cancer Surgery
Transanal Irrigation for Low Anterior Resection Syndrome
The preservation surgery of the anal sphincter muscle has become the standard procedure in the treatment of rectal cancer and, thanks to advancements in surgical techniques, can now be performed for tumors located closer to the…
- Conditions
- Low Anterior Resection Syndrome, Rectal Cancer Surgery, Insomnia
- Trial name
- TraLARS (NCT06796296)
- Testing
- Transanal Irrigation (TAI)
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Seoul National University Hospital
Colorectal Cancer
Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as fluorouracil, oxaliplatin, and leucovorin, work in different ways to stop the growth of tumor cells, either by killing…
- Trial name
- NCT00335816
- Testing
- fluorouracil, leucovorin calcium, oxaliplatin
- Where
- 15 sites in United States, Canada
- Volunteers
- 248 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer, Colon Cancer Liver Metastasis
Diffusion-Weighted MRI for Liver Metastasis
The DREAM study will assess the diagnostic accuracy of diffusion-weighted MRI in combination with other imaging modalities (multiparametric MRI and CT Scan) in determining the true status of disappearing liver metastasis (DLM)…
- Conditions
- Colorectal Cancer, Colon Cancer Liver Metastasis, Malignant Neoplasm of Rectum Metastatic to Liver
- Trial name
- DREAM (NCT02781935)
- Testing
- DW-MRI
- Where
- 21 sites in United States, Austria and 3 more
- Volunteers
- 233 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Colorectal Neoplasms
Clinical Analysis of HIPEC for T4 Colorectal Cancer After Surgery
This multicentric study aims to determine if hyperthermic intraperitoneal chemotherapy (HIPEC) will help to prevent the development of peritoneal carcinomatosis in addition to the standard adjuvant systemic treatment after…
- Trial name
- NCT03221608
- Testing
- Surgery and HIPEC with Lobaplatin, Surgery without HIPEC
- Volunteers
- 300 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Constipation by Outlet Obstruction
Surgical Treatment for ODS With Rectal Prolapse Surgical Treatment for Rectal Prolapse
Chronic obstinate constipation is hard to deal with in clinic. Especially for obstructed defecation syndrome(ODS). Rectal prolapse is the most common type of ODS.
- Trial name
- NCT03487640
- Testing
- TARMR, LARSC
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Third Military Medical University
Breast Cancer, Colorectal Cancer
Positron Emission Tomography/Computed Tomography Scanning Before Surgery in Patients With Non-Small Cell Lung Cancer, Colorectal Cancer, Breast Cancer, Esophageal Cancer, or Head and Neck Cancer
RATIONALE: Diagnostic procedures, such as positron emission tomography/computed tomography (PET/CT) scanning before surgery, may help measure the extent of disease.
- Conditions
- Breast Cancer, Colorectal Cancer, Esophageal Cancer, Head and Neck Cancer
- Trial name
- NCT01254591
- Testing
- 18F-fluoromisonidazole, fluorescence angiography, laboratory biomarker analysis
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- University College London (UCL) Cancer Institute
Rectal Adenocarcinoma, Stage IIA Rectal Cancer AJCC v8
FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery
This phase II trial tests how well fluorouracil, oxaliplatin and leucovorin calcium (folinic acid) (FOLFOX) with botensilimab and balstilimab given before surgery (neoadjuvant) works in treating patients with rectal…
- Conditions
- Rectal Adenocarcinoma, Stage IIA Rectal Cancer AJCC v8, Stage III Rectal Cancer AJCC v8
- Trial name
- NCT06780787
- Testing
- Balstilimab, Biospecimen Collection, Botensilimab
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- City of Hope Medical Center
Rectal Cancer, Surgery
Multicenter Study on Suprapubic Catheterization Versus Transurethral Catheterization in Laparoscopic Surgery for Rectal Cancer
Compared with traditional open proctectomy, laparoscopic surgery is associated with less pain, earlier recovery, and better cosmetic outcome, and its long-term oncologic outcomes have been demonstrated.
- Trial name
- MSSPC (NCT02728427)
- Testing
- Suprapubic catheterization using central venous catheter(CVC-2 7F), Transurethral catheterization using Foley catheter
- Where
- 3 sites in China
- Volunteers
- 120 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Colorectal Cancer, Incisional Hernia
Comparing Polypropylene Mesh and "Small Bites" Technique in Emergency Colorectal Surgery's Midline Laparotomy Closure. Study for Incisional Hernia Prevention.
The 2023 World Journal of Emergency Surgery guidelines couldn't provide a recommendation for emergency abdominal wall closure due to insufficient consensus (>80% required).
- Conditions
- Colorectal Cancer, Incisional Hernia, Wound Infection
- Trial name
- BITEME (NCT06220058)
- Testing
- Closure of the midline laparotomy using the "small bites" technique, Closure of the midline laparotomy using the "small bites" technique with an absorbable PP mesh
- Where
- Spain
- Volunteers
- 148 people
- Sponsor
- Fernandez Zamora
Hemorrhoid, Anal Fistulas
Effect of Listening to Standardized Music Sequences on Preventing Postoperative Pain in Proctologic Surgery
The study, "Effect of Listening to Standardized Music Sequences on Preventing Postoperative Pain in Proctologic Surgery," aims to evaluate the impact of preoperative listening to standardized music sequences on postoperative pain…
- Conditions
- Hemorrhoid, Anal Fistulas, MUSICAL THERAPY, Anal Fissure and Fistula
- Trial name
- MUSICOPROCTO (NCT06798155)
- Testing
- Standardized Music Listening Therapy
- Where
- 2 sites in Reunion
- Volunteers
- 550 people
- Sponsor
- Clinique Saint-Vincent
Rectal Cancer
Functional Outcomes and Quality of Life in Patients Undergoing Surgery for Rectal Cancer
The purpose of this study is to find out what happens to patients after they have surgery for rectal cancer. After being treated for rectal cancer, patients tell us that their bowel, bladder and sexual function have changed.
- Trial name
- NCT00579579
- Testing
- Questionaires
- Where
- United States
- Volunteers
- 229 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer, Colorectal Cancer
Satisfaction & Efficacy of Compression Using Surgical Gloves in Chemo-induced Peripheral Neuropathies
Evaluation of Satisfaction \& Efficacy of Compression Using Surgical Gloves in Peripheral Neuropathies Due to Chemotherapy
- Trial name
- ELEGANT (NCT03872908)
- Testing
- Chilled gloves, Surgical gloves
- Where
- 2 sites in France
- Volunteers
- 177 people
- Sponsor
- Centre Leon Berard
Colorectal Cancer
Chemotherapy With DNA Damaging Agents In Colorectal Cancer
Chemotherapy Treatment alone with DNA damaging drugs might be as effective as chemotherapy combined with surgery in colorectal cancer (CRC) avoiding surgery complications.
- Trial name
- NCT01456923
- Testing
- Treatment with chemotherapy, Only chemotherapy treatment for study cohort, surgery
- Sponsor
- Centro Hospitalar Nordeste
Rectal Cancer
The Stockholm III Trial on Different Preoperative Radiotherapy Regimens in Rectal Cancer
Preoperative radiotherapy (RT) is recommended to many patients with localised rectal cancer, not previously treated with pelvic RT.
- Trial name
- Stockholm III (NCT00904813)
- Testing
- Short-course RT, Long-course RT
- Where
- 18 sites in Sweden
- Volunteers
- 840 people
- Sponsor
- Karolinska Institutet
Antibiotic, Bowel Cancer
Mechanical Bowel Preparation With or Without Oral Antibiotics for Colorectal Cancer Surgery
Investigation of the role of adding oral antibiotics to preoperative mechanical bowel preparation before colorectal surgery for cancer.
- Conditions
- Antibiotic, Bowel Cancer, Colorectal Cancer, Surgical Site Infection
- Trial name
- MECCA (NCT03563586)
- Testing
- Bowel Preparation plus antibiotics, Bowel Preparation
- Where
- Greece
- Volunteers
- 210 people
- Sponsor
- National and Kapodistrian University of Athens
Rectal Cancer, Adenocarcinoma
Comparison Between Tailored Surgery Versus Total Mesorectal Excision in ycT2-3N0M0
The purpose of this study is to show that tailored treatment based on local excision can expand the target of non-radical treatment in ycT2-3N0M0 patients after neoadjuvant chemoradiotherapy for low rectal cancer and that the…
- Trial name
- NCT05164315
- Testing
- Tailored surgery, Total mesorectal excision (TME)
- Where
- South Korea
- Volunteers
- 14 people
- Sponsor
- Seoul National University Hospital
Colon Rectal Cancer, Surgical Site Infection
Surveillance and Implementation of a Bundle of Care to Reduce Surgical Site Infection in Colorectal Surgery (CCR-VINCat)
The Nosocomial Infection Surveillance Program in Catalonia (VINCat) monitors surgical site infection (SSI) in elective colorectal surgery since 2007 in 55 public and private acute care hospitals.
- Trial name
- CCR-VINCat (NCT04496635)
- Testing
- Implementation of a bundle of care
- Where
- Spain
- Volunteers
- 60,000 people
- Sponsor
- Hospital de Granollers