Clinical trials: Rectum Neoplasms
Colorectal Cancer
Studying DNA and Outcome in Patients With Advanced Colorectal Cancer Treated With Fluorouracil and Oxaliplatin With or Without Bevacizumab on Clinial Trial E-3200
RATIONALE: Studying samples of blood, urine, and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00897819
- Testing
- DNA methylation analysis, loss of heterozygosity analysis, microsatellite instability analysis
- Volunteers
- 350 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Colon and Rectal Cancer
Gemcitabine, Cisplatin, Nab-paclitaxel (GAP) and Cemiplimab for Locally Advanced Biliary Tract Cancer (BTC)
This study is being conducted to find out if treatment with gemcitabine, cisplatin, nab-paclitaxel, and cemiplimab can shrink previously inoperable tumors enough for surgery.
- Trial name
- GAP Cemi (NCT07433673)
- Testing
- Cemiplimab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Columbia University
Anal Cancer
Radiation Dosimetry Study Comparing 2 Different Patient Setups in Anal/Rectal Cancer Patients
The study compares two patient setups (Standard Prone vs. Genital Drop Technique) with identical radiation treatment technique and parameters.
- Trial name
- NCT00693173
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Rectal Cancer
Neoadjuvant Radiochemotherapy Combined With QL1706 for Low Rectal Cancer
This study investigates the efficacy of neoadjuvant radiotherapy combined with QL1706 in MSS-type low-grade rectal cancer. This study is a prospective multicohort study, with cohort 1 intended to include patients with low grade…
- Trial name
- NCT06931873
- Testing
- SCRT+Capoex+QL706, LCRT+Capoex+QL706
- Volunteers
- 60 people
- Sponsor
- Changhai Hospital
Cancer
Hepatic Arterial Infusion of Melphalan With Hepatic Perfusion in Treating Patients With Unresectable Liver Cancer
RATIONALE: Hepatic arterial infusion uses a catheter to deliver anticancer substances directly into the liver. Drugs used in chemotherapy, such as melphalan, work in different ways to stop tumor cells from dividing so they stop…
- Trial name
- NCT00096083
- Testing
- isolated perfusion, melphalan
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Delcath Systems Inc.
Colon Cancer, Rectal Cancer
Effects of Abdominal Nerve Block on Postoperative Recovery in Patients Undergoing Gastrointestinal Surgery
To explore the effect of general anesthesia combined with transversus abdominis plane block (TAPB) and/or rectus sheath block (RSB) on the recovery of patients with gastrointestinal tumor after surgical treatment.
- Conditions
- Colon Cancer, Rectal Cancer, Gastric Cancer
- Trial name
- NCT04147481
- Testing
- Group Abdominal Nerve Block with local anesthetics, Group Abdominal Nerve Block with saline
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Yi Liu
Rectal Neoplasms
Evaluation of Delayed Coloanal Anastomosis
After rectal resection for cancer of the lower rectum, the restoration of continuity is done by a colo-anal anastomosis with a protective ileostomy. However, the ileostomy is very little accepted by patients.
- Trial name
- ACAD (NCT04248634)
- Testing
- Delayed colo-anal anastomosis
- Where
- Morocco
- Volunteers
- 20 people
- Sponsor
- Institut National d'Oncologie, Morocco
Rectal Cancer, Pancreatic Cancer
Multimodal Imaging in Rectal Cancer & Pancreatic Cancer
Most digestive cancers show (over)expression of the tumour marker carcinoembryonic antigen (CEA). Therefore, interest in CEA-targeting tracers has increased over the past years.
- Trial name
- MIRCA & MIPAC (NCT06395337)
- Testing
- [111In]In-DOTA-ANTI-CEA antibody injection, SPECT/CT scan, Resection surgery
- Where
- 2 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Esophageal Cancer, Kidney Cancer
GI Organ Tracking Via Balloon Applicators
The hypothesis of this study is that an occlusion balloon catheter placed in the stomach via an oral or nasogastric route will be safe and permit tracking of the stomach during radiation therapy.
- Conditions
- Esophageal Cancer, Kidney Cancer, Larynx Cancer, Liver Cancer
- Trial name
- NCT05471401
- Testing
- Balloon-tipped catheter
- Sponsor
- Washington University School of Medicine
Advanced Adenocarcinoma of the Colon or Rectum
Crossover Evaluation of Effect of Atorvastatin on PK of Irinotecan in CRC Patients Receiving FOLFIRI
The purpose of this study is to evaluate the effect of atorvastatin on the pharmacokinetic profile of irinotecan and SN-38. To further evaluate the safety of atorvastatin in combination with FOLFIRI.
- Trial name
- NCT01605344
- Testing
- FOLFIRI., Atorvastatin
- Where
- United States
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Rectal Cancer
Short-course Preoperative Chemoradiotherapy for Rectal Cancer
The purpose of this study is to evaluate the early clinical outcome of the short-course preoperative chemoradiotherapy, 33Gy/10 fx and delayed operation after chemoradiation, the investigators initiated the clinical trial of KROG…
- Trial name
- KROG 11-02 (NCT01431599)
- Testing
- short-course radiation
- Where
- 3 sites in South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Jong Hoon Lee
Rectal Cancer
Comparison of Preoperative and Postoperative Radiotherapy and Capecitabine in Locally Advanced Rectal Cancer
Based on the potential advantaged of preoperative chemoradiotherapy and oral fluoropyrimidine, the investigators planned a prospective randomized phase III trial which compares preoperative chemoradiotherapy and postoperative…
- Trial name
- NCT01186081
- Testing
- Preoperative chemoradiotherapy, Postoperative chemoradiotherapy
- Where
- South Korea
- Volunteers
- 240 people
- Sponsor
- Asan Medical Center
Gynaecological, Urological or Rectal Cancer
Prospective Study in Pelvic Radiotherapy Patients
Symptoms such as diarrhoea and abdominal discomfort are common side effects of radiotherapy for tumours in the pelvis and usually occur within 2 weeks of starting treatment.
- Trial name
- NCT00220181
- Volunteers
- 100 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Colorectal Cancer, Metastatic Cancer
Intravenous Compared With Intrahepatic Chemotherapy in Treating Patients With Colorectal Cancer Metastatic to the Liver
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00002692
- Testing
- fluorouracil, isolated perfusion, leucovorin calcium
- Where
- United Kingdom
- Volunteers
- 312 people
- Sponsor
- Medical Research Council
Rectal Cancer
Simultaneous Integrated Boost Preoperative Radiotherapy for Rectum Cancer
The investigators propose a randomized non-inferiority trial that compares preoperative Fluoro Uracil (FU)-based chemoradiotherapy to radiotherapy with a simultaneous integrated boost.
- Trial name
- RectumSIB (NCT01224392)
- Testing
- Chemoradiotherapy, Radiotherapy with boost
- Where
- 2 sites in Belgium
- Volunteers
- 156 people
- Sponsor
- Universitair Ziekenhuis Brussel
Advanced Solid Tumors or Non-Hodgkin's Lymphoma (NHL)
A Phase 1/2 Trial of SRA737 in Subjects With Advanced Cancer
The purpose of this clinical study is to establish the safety profile, determine the maximum tolerated dose (MTD) and recommend a Phase 2 dose and schedule of SRA737; and to evaluate the efficacy of SRA737 in…
- Trial name
- NCT02797964
- Testing
- SRA737
- Where
- 15 sites in United Kingdom
- Volunteers
- 107 people
- Sponsor
- Sierra Oncology LLC - a GSK company
Colorectal Cancer
Eniluracil and Surgery in Treating Patients With Primary or Metastatic Colorectal Cancer
RATIONALE: Eniluracil may increase the effectiveness of chemotherapy by blocking tumor enzymes that break down chemotherapy drugs.
- Trial name
- NCT00004195
- Testing
- eniluracil, conventional colon surgery
- Volunteers
- 28 people
- Sponsor
- University of Alabama at Birmingham
Anal Cancer, HIV Infection
Anal HPV Tests in Screening for Cell Changes in the Anus in Patients With HIV
This clinical trial studies anal human papillomavirus (HPV) tests in screening for cell changes in the anus in patients with human immunodeficiency virus (HIV).
- Conditions
- Anal Cancer, HIV Infection, Human Papilloma Virus Infection
- Trial name
- NCT01946139
- Testing
- comparison of screening methods, laboratory biomarker analysis, questionnaire administration
- Where
- 12 sites in United States, Puerto Rico
- Volunteers
- 276 people
- Sponsor
- AIDS Malignancy Consortium
Sarcopenia, Colon Cancer
Preoperative Sarcopenia and Surgical Outcomes in Colorectal Cancer Patients
Colorectal cancer is the third most common malignant neoplasm worldwide and the fourth leading cause of cancer-related deaths. Muscle mass loss in oncology patients is most often the result of cancer-related malnutrition.
- Conditions
- Sarcopenia, Colon Cancer, Rectal Cancer, Surgical Outcomes
- Trial name
- NCT06698289
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Mersin University
Rectal Cancer
Efficacy of Ondansetron in LARS Treatment
Patients will be randomized (1:1 ratio) to receive either 4 weeks of Ondansetron followed by 4 weeks of placebo (O-P sequence) or 4 weeks of placebo followed by 4 weeks of Ondansetron (P-O sequence).
- Trial name
- Hodolar (NCT03182179)
- Testing
- Ondansetron 4 MG
- Where
- 2 sites in Switzerland
- Volunteers
- 48 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
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