Clinical trials: Rectum Neoplasms
Locally-advanced Rectal Cancer
Preoperative Radiotherapy And ASTX660 in Rectum Cancer
Compare two arms: Chemotherapy followed by tolinapant (ASTX660) in combination with Long-Course Radio Chemotherapy (LCRT), and Tolinapant (ASTX660) in combination with Short-Course Radiotherapy (SCRT) followed by chemotherapy For…
- Trial name
- PRAAR1 (NCT05912075)
- Testing
- mFOLFIRINOX, Pelvic radiotherapy LCRT, Capecitabine
- Where
- 2 sites in France
- Volunteers
- 78 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Anal Cancer, Colorectal Cancer
Assessment of Symptom-Related Cytokines in Lung and Gastrointestinal (GI) Cancer Patients
Primary Objectives: To determine the feasibility of a study that would describe changes of certain circulating inflammatory cytokines (interleukin-1, 6, 8, 10, 12, and tumor necrosis factor-alpha [TNF] and symptoms related to…
- Conditions
- Anal Cancer, Colorectal Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00502502
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 205 people
- Sponsor
- M.D. Anderson Cancer Center
Rectal Cancer
Treatment of Rectal Cancer With Long-term Concurrent Chemoradiotherapy Combined With Camrelizumab
This is a single-arm, phase II clinical study aim to evaluate the efficacy and safety of long-term concurrent chemoradiotherapy combined with camrelizumab as a neoadjuvant therapy in the treatment of locally advanced/low rectal…
- Trial name
- NCT06304545
- Testing
- Camrelizumab, Chemotherapy, Radiotherapy
- Volunteers
- 48 people
- Sponsor
- Harbin Medical University
Recurrent Malignant Solid Neoplasm, Stage IV Breast Cancer
Canady Helios Cold Plasma Scalpel Treatment at the Surgical Margin and Macroscopic Tumor Sites
The study designed is to evaluate the safety of Canady Helios™ Cold Plasma Scalpel (CHCPS) in patients with solid tumors with carcinomatosis scheduled to undergo surgical resection for cytoreduction.
- Conditions
- Recurrent Malignant Solid Neoplasm, Stage IV Breast Cancer, Stage IV Prostate Cancer, Stage IV Pancreatic Cancer
- Trial name
- NCT04267575
- Testing
- Canady Helios Cold Plasma Scalpel
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Jerome Canady, M.D.
Colorectal Cancer
Capecitabine, Oxaliplatin, Selenomethionine, and Radiation Therapy in Treating Patients Undergoing Surgery For Newly Diagnosed Stage II or III Rectal Adenocarcinoma
RATIONALE: Drugs used in chemotherapy, such as capecitabine and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00625183
- Testing
- selenomethionine, capecitabine, oxaliplatin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Roswell Park Cancer Institute
RECTAL CANCER
Neoadjuvant Radiotherapy Followed by Transanal Endoscopic Microsurgery for T1-T2 Extraperitoneal Rectal Cancer
Objective: Recent randomized and non-randomized studies suggest that neoadjuvant radiotherapy followed by Transanal Endoscopic Microsurgery (TEM) show comparative results to abdominal resection in pT2 extraperitoneal cancer.
- Trial name
- NERATEM (NCT02127645)
- Testing
- SRT-TEM, LRT-TEM, Transanal Endoscopic Microsurgery (TEM)
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- European Association for Endoscopic Surgery
Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum
Cholecalciferol(25-[OH]-Vitamin D) in Treating Patients With Colorectal Cancer
This pilot clinical trial studies cholecalciferol in treating patients with colorectal cancer. The use of cholecalciferol may slow disease progression in patients with colorectal cancer.
- Conditions
- Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum, Signet Ring Adenocarcinoma of the Colon, Signet Ring Adenocarcinoma of the Rectum
- Trial name
- NCT01403103
- Testing
- cholecalciferol, biopsy, protein expression analysis
- Sponsor
- Case Comprehensive Cancer Center
Colorectal Cancer, Precancerous Condition
Biological, Genetic, and Lifestyle Risk Factors for Developing Colorectal Adenomas or Polyps in Participants Undergoing Colonoscopy
RATIONALE: Collecting and storing samples of tissue, blood, and other body fluids to test in the laboratory and gathering information about health and lifestyle from participants may help doctors learn more about cancer risk…
- Trial name
- NCT00625066
- Testing
- biologic sample preservation procedure, cytology specimen collection procedure, medical chart review
- Where
- 4 sites in United States
- Volunteers
- 8,108 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Colorectal Cancer
Comparison of Barium Enema, Computed Tomographic Colonography, and Colonoscopy in Detecting Colon Cancer
RATIONALE: Screening tests may help doctors detect cancer cells early and plan more effective treatment for cancer. New diagnostic procedures such as computed tomographic colonography may provide a less invasive method of…
- Trial name
- NCT00016029
- Testing
- screening questionnaire administration, barium enema injection, computed tomography
- Where
- 14 sites in United States
- Volunteers
- 775 people
- Sponsor
- Duke University
Rectal Cancer, Rectal Neoplasms
Organ Preservation in Locally Advanced Rectal Cancer by Radiochemotherapy Followed by Consolidation Chemotherapy.
There is a growing body of evidence that surgery and associated morbidities can be omitted without compromising oncological safety in selected patients who have achieved a clinical complete response after radiochemotherapy.
- Conditions
- Rectal Cancer, Rectal Neoplasms, Rectal Cancer Stage II, Rectal Cancer Stage III
- Trial name
- CAO/ARO/AIO-16 (NCT03561142)
- Testing
- Radiotherapy, Chemotherapy, Deep regional hyperthermia
- Where
- 4 sites in Germany
- Volunteers
- 94 people
- Sponsor
- University Hospital Tuebingen
Squamous Cell Carcinoma of the Anal Canal
Carboplatin-paclitaxel With Retifanlimab or Placebo in Participants With Locally Advanced or Metastatic Squamous Cell Anal Carcinoma (POD1UM-303/InterAACT 2).
This study is a Phase 3 global, multicenter, placebo-controlled double-blind randomized study that will enroll participants with inoperable locally recurrent or metastatic SCAC not previously treated with systemic chemotherapy.
- Trial name
- NCT04472429
- Testing
- carboplatin, paclitaxel, retifanlimab
- Where
- 84 sites in United States, Australia and 11 more
- Volunteers
- 308 people
- Sponsor
- Incyte Corporation
Rectal Cancer
Total Neoadjuvant Therapy Versus Standard Neoadjuvant Chemoradiation for Locally Advanced Rectal Cancer
The National Comprehensive Cancer Network (NCCN) guidelines recommend trimodality treatment for patients with middle and low LARC with neoadjuvant chemoradiotherapy (NA-CRT), surgical resection with TME, plus additional…
- Trial name
- NCT05274945
- Testing
- Radiotherapy, consolidation chemotherapy, TME or APR
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Alexandria University
Rectal Cancer
Fluorescent Lymphography-Guided Lymphadenectomy In Laparoscopic Proctectomy
The purpose of this study is to compare the number of lymph nodes retrieved with or without the use of intraoperative fluorescence lymphography in laparoscopic radical resection of rectal cancer.
- Trial name
- NCT03854890
- Testing
- Indocyanine Green
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Colorectal Cancer
Celecoxib, Fluorouracil, and Radiation Therapy in Treating Patients With Stage II or Stage III Rectal Cancer That Can Be Removed By Surgery
RATIONALE: Celecoxib may stop the growth of tumor cells by blocking blood flow to the tumor and by blocking some of the enzymes needed for cell growth.
- Trial name
- NCT00336960
- Testing
- celecoxib, fluorouracil, conventional surgery
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Total Neoadjuvant Treatment, Chemoradiotherapy
Total Neoadjuvant Treatment vs. Chemoradiotherapy in Local Advanced Rectal Cancer With High Risk Factors
Purpose:To compare the efficacy and the safety of total neoadjuvant chemotherapy + TME with standard neoadjuvant concurrent chemoradiotherapy + TME + adjuvant chemotherapy for locally advanced rectal cancer patients with high…
- Conditions
- Total Neoadjuvant Treatment, Chemoradiotherapy, Local Advanced Rectal Cancer, High Risk Factors
- Trial name
- TNTCRT (NCT03177382)
- Testing
- Total neoadjuvant treatment, concurrent chemoradiotherapy, TME
- Where
- 2 sites in China
- Volunteers
- 458 people
- Sponsor
- West China Hospital
Rectal Cancer, Recurrence
Re-irradiation for Pelvic Recurrences in Rectal Cancer Patients
This study investigates the potential benefit of re-irradiation of patients with locally advanced rectal recurrences, by a prospective phase II clinical, imaging and translational research study.
- Conditions
- Rectal Cancer, Recurrence, Radiation Toxicity
- Trial name
- Re-RAD-I (NCT05816980)
- Testing
- Hyperfractionated external beam radiation
- Where
- 2 sites in Denmark, Norway
- Volunteers
- 16 people
- Sponsor
- Aarhus University Hospital
Anal Carcinoma
Evaluation by MRI of Anal Canal Cell Carcinoma: is There Predictive Factor?
Anal canal cell carcinoma is a very rare cancer but well treated. If the morphological test are well established in the initial evaluation, it's not the case of the follow up evaluation particularly by MRI.About 1/3 of patient…
- Trial name
- NCT03469596
- Testing
- MRI sequence
- Where
- France
- Volunteers
- 87 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Nutrition Related Neoplasm/Cancer
Dietary Factors Associated to Colorectal Premalignant Lesions (COLOMAR-1)
This study aims to find a correlation between fish protein intake and other dietary habits and colorectal premalignant lesions in healthy volunteers.
- Trial name
- NCT06368661
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fundación Vithas
Colorectal Cancer
Erlotinib, Modified FOLFOX6, and Bevacizumab as First-Line Therapy Metastatic Colorectal Cancer
RATIONALE: Erlotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as oxaliplatin, leucovorin, and fluorouracil, work in different ways to stop the…
- Trial name
- NCT00118261
- Testing
- bevacizumab, erlotinib hydrochloride, fluorouracil
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- Case Comprehensive Cancer Center
Breast Cancer, Colorectal Cancer
Printed Education Materials in Patients Who Are Finishing Treatment for Stage I, Stage II, or Stage IIIA Breast Cancer, Colorectal Cancer, Prostate Cancer, or Chest Cancer
RATIONALE: Printed educational materials, such as the Facing Forward Series: Life After Cancer Treatment manual, may help make the transition from cancer patient to cancer survivor easier in patients who are finishing treatment…
- Conditions
- Breast Cancer, Colorectal Cancer, Lung Cancer, Malignant Mesothelioma
- Trial name
- NCT00372840
- Testing
- educational intervention, psychosocial assessment and care, quality-of-life assessment
- Where
- United States
- Volunteers
- 340 people
- Sponsor
- Fox Chase Cancer Center
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