Clinical trials: Rectum Neoplasms
Rectal Cancer, Erectile Dysfunction
Stem Cell Therapy Combined With NeuroRegen Scaffold™ in Patients With Erectile Dysfunction After Rectal Cancer Surgery
Erectile dysfunction (ED) is one of the commonest complications in men after rectal cancer treatment. The purpose of this study is to assess the safety and efficacy of autologous bone marrow mononuclear cells (BMMCs) or…
- Trial name
- NCT02648386
- Testing
- Laparoscopic surgery, NeuroRegen scaffold transplantation, NeuroRegen scaffold/BMMCs transplantation
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Chinese Academy of Sciences
Rectal Cancer, Ileostomy; Functional Disturbance
Trial Evaluating the Tailored Versus the Systematic Use of Defunctioning Stoma After Total Mesorectal Excision for Rectal Cancer (GRECCAR17)
GRECCAR 17 will be the first prospective and randomized trial to assess a tailored policy in the use of defunctioning stoma after TME according to the personalized risk of anastomotic leakage.
- Trial name
- GRECCAR17 (NCT05233787)
- Testing
- Tailored use of defunctioning stoma after TME, Systematic use of defunctioning stoma
- Where
- 28 sites in France
- Volunteers
- 212 people
- Sponsor
- University Hospital, Bordeaux
Colorectal Cancer
Irinotecan With or Without Capecitabine as Second-Line Therapy in Treating Older Patients With Progressive, Metastatic Colorectal Cancer That Cannot Be Removed By Surgery
RATIONALE: Drugs used in chemotherapy, such as irinotecan and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00303745
- Testing
- capecitabine, irinotecan hydrochloride
- Where
- 23 sites in France
- Volunteers
- 78 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Colorectal Cancer, Colonic Neoplasms
Single-incision Versus Conventional Laparoscopic Surgery for Colorectal Cancer
This study is designed to evaluate the short-term and long-term results after single incision laparoscopic surgery for colorectal cancer（SILSC） compared with conventional laparoscopic surgery for colorectal cancer（CLSC）.
- Conditions
- Colorectal Cancer, Colonic Neoplasms, Rectal Neoplasms, Colon Disease
- Trial name
- mSILSC (NCT03633539)
- Testing
- Single-incision Laparoscopic Surgery, Conventional Laparoscopic Surgery
- Where
- China
- Sponsor
- Ruijin Hospital
Rectal Adenocarcinoma, Non Metastatic
A Global, Integrated, Personalized, Stage-related, Multimodal Therapeutic Approach for Rectal Adenocarcinoma Based on Organ Sparing and Mininvasivity
A phase II, single-center, non-profit, interventional study on patients affected by rectal adenocarcinoma. Patients will be stratified into three groups based on pre-treatment clinical stage.
- Trial name
- INTERPRETE (NCT06952101)
- Testing
- Sparing Approach, experimental chemoradiotherapy, Standard Chemotherapy
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Rectal Cancer
Comparison of Low and High Ligation in the Rectal Cancer
The purpose of this study is to evaluate the defecatory function when nerve fibers around the inferior mesenteric artery(IMA) and left colic artery(LCA) are preserved(so called low ligation ) or not(high ligation) in the…
- Trial name
- NCT00701012
- Testing
- preservation of nerve fibers around IMA, resection of nerve fibers around IMA
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Wakayama Medical University
Rectal Cancer
Lateral Nodal Recurrence in Rectal Cancer
Local recurrence rates in rectal cancer have reduced dramatically since the introduction of the total mesorectal excision (TME) technique and neoadjuvant (chemo)radiotherapy (C))RT) to overall rates of 5-year local recurrence to…
- Trial name
- LaNoReC (NCT04486131)
- Where
- Netherlands
- Volunteers
- 200 people
- Sponsor
- Amsterdam UMC, location VUmc
Prostate Cancer, Head and Neck Cancer
Online Adaptive Radiotherapy Using a Novel Linear Accelerator (ETHOS)
The study focuses on the scientific and clinical evaluation of online adaptive radiotherapy (ART) using the Varian/SHS ETHOS treatment system.
- Conditions
- Prostate Cancer, Head and Neck Cancer, NSCLC, SCLC
- Trial name
- ART-02 (NCT06116019)
- Testing
- Online adaptive radiation therapy
- Where
- Germany
- Volunteers
- 649 people
- Sponsor
- Charite University, Berlin, Germany
Rectal Cancer, Synchronous Liver Metastases
FOLFIRINOX Induction Chemotherapy for Synchronous Liver Metastases
SYNCHRONOX is a multicenter cohort (retrospective then prospective) intending to include 550 patients with mid or low rectal adenocarcinoma (pMMR, T3-T4 and/or N+) and resectable synchronous liver metastases, treated upfront with…
- Conditions
- Rectal Cancer, Synchronous Liver Metastases, Antineoplastic Combined Chemotherapy Protocols, Surgical Therapy
- Trial name
- SYNCHRONOX (NCT07467434)
- Where
- France
- Volunteers
- 550 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Rectal Cancer, Neoplasm Metastasis
Study of Panitumumab Given First With Capecitabine and Oxaliplatin (CAPOX) and Then With Capecitabine and Radiation of the Pelvis for Treatment of Patients With Rectal Cancers That May or May Not Have Spread Beyond the Rectum
Panitumumab is a monoclonal antibody. It works by attaching to a protein called epidermal growth factor receptor found on normal and cancer cells.
- Trial name
- NCT00346099
- Testing
- Panitumumab with capecitabine and oxaliplatin (CAPOX) followed by, Panitumumab with capecitabine and radiation
- Sponsor
- NSABP Foundation Inc
Anal Cancer
ANCA II - Quality of Life and Functional Outcome in Patients With Anal Cancer
Anal cancer is a rare disease, but the incidence is rising. About 200 patients will get this type of cancer yearly in Sweden. Curative treatment includes chemotherapy and radiotherapy.
- Trial name
- ANCAII (NCT04792892)
- Testing
- Questionnaires
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Sahlgrenska University Hospital
Rectal Cancer, Adaptive Radiotherapy
the Efficacy of MR-guided Online Adaptive Radiotherapy for Locally Advanced Rectal Cancer
Based on preliminary findings on the motion error of the clinical target volume (CTV) in MR-guided adaptive radiotherapy (MRgART) for locally advanced rectal cancer (LARC), this study aims to reduce CTV-to-PTV margins and…
- Trial name
- NCT07080411
- Testing
- short course radiotherapy using MR-linac
- Volunteers
- 49 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Rectal Cancer
Effect of a Post-operative Protocol of Early Mobilization on Functional Recovery and Postoperative Complications After Immediate Internal Pudendal Artery Perforator Flap Reconstruction for Irradiated Abdominoperineal Resection Defects: a Prospective, Randomized and Controlled Clinical Study.
Major abdominal oncology surgery is associated with substantial postoperative loss of functional capacity, and exercise may be an effective intervention to improve outcomes.
- Trial name
- NCT04795609
- Testing
- Early mobilization strategy adapted after immediate internal pudendal artery perforator flap reconstruction for abdominoperineal resection (intervention group).
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Adenocarcinoma of the Rectum
Short Course or Long Course Radiotherapy as Total Neoadjuvant Therapy in Locally Advanced Rectal Cancer
This study compares two standard radiotherapy approaches (short-course vs. long-course) given before surgery in patients with locally advanced rectal cancer.
- Trial name
- SHOOL (NCT07258797)
- Testing
- SCRT : 25 Gy in 5 fractions over 1 week to the pelvis using IGRT technique, LCRT + Consolidation Chemotherapy
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Rajiv Gandhi Cancer Institute & Research Center, India
Erectile Dysfunction, Sigmoid Colon Cancer
Efficacy of Udenafil After Radical Resection for Sigmoid Colon and Rectal Cancer
The purpose of this study is to evaluate the efficacy of Udenafil (Zydena®, Dong-A Pharmaceutical co., Ltd, Seoul, Korea) in treatment of erectile dysfunction after radical resection for sigmoid colon and rectal cancer.
- Conditions
- Erectile Dysfunction, Sigmoid Colon Cancer, Rectal Cancer
- Trial name
- NCT00607282
- Testing
- Udenafil
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Seoul National University Hospital
Recurrent Colon Cancer, Recurrent Rectal Cancer
Short-Infusion Ziv-aflibercept in Treating Patients With Metastatic Colorectal Cancer Receiving Combination Chemotherapy
This pilot clinical trial studies short-infusion ziv-aflibercept in treating patients with metastatic colorectal cancer receiving combination chemotherapy.
- Conditions
- Recurrent Colon Cancer, Recurrent Rectal Cancer, Stage IVA Colon Cancer, Stage IVA Rectal Cancer
- Trial name
- NCT01941173
- Testing
- ziv-aflibercept, leucovorin calcium, irinotecan hydrochloride
- Where
- 3 sites in United States
- Sponsor
- City of Hope Medical Center
Rectal Cancer
Feasibility of Microdialysis by Laparoscopy
The aim of this pilot study is to evaluate the feasibility of microdialysis by laparoscopy in order to identify anastomotic leaks after rectal surgery.
- Trial name
- MTM-COLON-I (NCT01786694)
- Testing
- cma microdialysis catheter placement
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Adenocarcinoma of the Lung, Mucinous Adenocarcinoma of the Colon
Adherence to Survivorship Care Guidelines in Health Care Providers for Non-Small Cell Lung Cancer and Colorectal Cancer Survivor Care
This clinical trial studies adherence to survivorship care guidelines in health care providers for non-small cell lung cancer or colorectal cancer survivor care.
- Conditions
- Adenocarcinoma of the Lung, Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum, Signet Ring Adenocarcinoma of the Colon
- Trial name
- NCT01726296
- Testing
- educational intervention, medical chart review
- Where
- United States
- Volunteers
- 1,440 people
- Sponsor
- Fox Chase Cancer Center
Rectal Cancer
Contact Radiotherapy for Rectal Cancer
The aim of the CORRECT phase 2 study is to show non-inferiority of Contact x-ray brachytherapy (CXB) + short-course radiotherapy (SCRT) compared to the experimental arm of the OPERA trial in organ preservation for early and early…
- Trial name
- CORRECT (NCT06501053)
- Testing
- Radiotherapy, Short-course radiotherapy, Contact x-ray brachytherapy
- Where
- 2 sites in Sweden
- Volunteers
- 110 people
- Sponsor
- Alexander Valdman
Rectal Cancer, Low Anterior Resection Syndrome
Feasibility and Impact of a Prehabilitation and Rehabilitation Program for the Continuity of Care in Severe Low Anterior Resection Syndrome.
Patients with sphincter saving procedures of rectal cancer usually experience intestinal dysfunction, including difficulty emptying the bowel and faecal incontinence, leading to a detriment in the quality of life.
- Conditions
- Rectal Cancer, Low Anterior Resection Syndrome, Faecal Incontinence
- Trial name
- PRELARS (NCT04612569)
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital Donostia
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